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1. 发明授权

US09056850B2 Process for the preparation of compounds useful as inhibitors of SGLT 有权
公开(公告)号：US09056850B2
公开(公告)日：2015-06-16
申请号：US12578934
申请日：2009-10-14
申请人： Walter Ferdinand Maria Filliers , Rudy Laurent Maria Broeckx , Patrick Hubert J. Nieste , Masanori Hatsuda , Masahiko Yoshinaga , Mitsuhiro Yada , Christopher Teleha
发明人： Walter Ferdinand Maria Filliers , Rudy Laurent Maria Broeckx , Patrick Hubert J. Nieste , Masanori Hatsuda , Masahiko Yoshinaga , Mitsuhiro Yada , Christopher Teleha
IPC分类号： C07D409/04 , C07D333/12 , C07D409/10
CPC分类号： C07D333/12 , C07D409/10 , C07H7/04 , C07H13/04
摘要： The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney.

2. 发明申请

US20100099883A1 PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL AS INHIBITORS OF SGLT 有权
标题翻译：制备作为SGLT抑制剂的化合物的方法
公开(公告)号：US20100099883A1
公开(公告)日：2010-04-22
申请号：US12578934
申请日：2009-10-14
申请人： Walter Ferdinand Maria Fillers , Rudy Laurent Maria Broeckx , Patrick Hubert J. Nieste , Masanori Hatsuda , Masahiko Yoshinaga , Mitsuhiro Yada
发明人： Walter Ferdinand Maria Fillers , Rudy Laurent Maria Broeckx , Patrick Hubert J. Nieste , Masanori Hatsuda , Masahiko Yoshinaga , Mitsuhiro Yada
IPC分类号： C07D409/04 , C07D409/10 , C07D333/12
CPC分类号： C07D333/12 , C07D409/10 , C07H7/04 , C07H13/04
摘要： The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney.
摘要翻译：本发明涉及一种制备具有抑制活性的化合物的新方法，所述化合物对存在于肠或肾中的钠依赖性葡萄糖转运蛋白（SGLT）具有抑制活性。

3. 发明授权

US09181217B2 Method for producing optically active naphthalene compound 有权
标题翻译：光学活性萘化合物的制造方法
公开(公告)号：US09181217B2
公开(公告)日：2015-11-10
申请号：US14240466
申请日：2012-08-24
申请人： Koji Matsuyama , Masanori Hatsuda , Masahiko Yoshinaga , Mitsuhiro Yada , Koichi Tanimoto
发明人： Koji Matsuyama , Masanori Hatsuda , Masahiko Yoshinaga , Mitsuhiro Yada , Koichi Tanimoto
IPC分类号： C07B53/00 , C07C25/06 , C07C255/03 , C07D401/04
CPC分类号： C07D401/04 , C07B53/00 , C07C25/06 , C07C255/03
摘要： The present invention provides an industrially advantageous method for producing an optically active naphthalene compound useful as a therapeutic agent for dermatitis or the like. Specifically, the present invention provides a method for producing an optically active naphthalene compound [I], which comprises: a step of reacting a compound [a-1] and a compound [b-1] with each other in the presence of a base and a catalyst that is composed of a Pd compound and a tertiary phosphine ligand (step a); a step of asymmetrically hydrogenating a compound [c-1] in the presence of a hydrogen donor and a complex that is prepared from a ruthenium compound and a chiral ligand, or alternatively in the presence of an optically active oxazaborolidine compound (a CBS catalyst) and a boron hydride compound (step b); and a step of treating a compound [d-1] with a reducing agent (step c). (In the above formulae, Ra and Rb represent the same or different lower alkyl groups; and X1 represents a halogen atom.).
摘要翻译：本发明提供了用于制造用作皮炎等的治疗剂的光学活性萘化合物的工业上有利的方法。具体而言，本发明提供了一种光学活性萘化合物[I]的制造方法，其特征在于，在碱的存在下，使化合物[a-1]和化合物[b-1] 和由Pd化合物和叔膦配体组成的催化剂（步骤a）; 在氢供体和由钌化合物和手性配体制备的络合物的存在下，或者在光学活性的恶唑硼烷化合物（CBS催化剂）存在下，不对称地氢化化合物[c-1] 和硼氢化合物（步骤b）; 和用还原剂处理化合物[d-1]（步骤c）的步骤。（上述式中，Ra和Rb表示相同或不同的低级烷基，X1表示卤素原子。

4. 发明申请

US20150152082A1 METHOD FOR PRODUCING OPTICALLY ACTIVE NAPHTHALENE COMPOUND 有权
标题翻译：用于生产光学活性萘基化合物的方法
公开(公告)号：US20150152082A1
公开(公告)日：2015-06-04
申请号：US14240466
申请日：2012-08-24
申请人： Koji Matsuyama , Masanori Hatsuda , Masahiko Yoshinaga , Mitsuhiro Yada , Koichi Tanimoto
发明人： Koji Matsuyama , Masanori Hatsuda , Masahiko Yoshinaga , Mitsuhiro Yada , Koichi Tanimoto
IPC分类号： C07D401/04 , C07C255/03 , C07C25/06
CPC分类号： C07D401/04 , C07B53/00 , C07C25/06 , C07C255/03
摘要： The present invention provides an industrially advantageous method for producing an optically active naphthalene compound useful as a therapeutic agent for dermatitis or the like. Specifically, the present invention provides a method for producing an optically active naphthalene compound [I], which comprises: a step of reacting a compound [a-1] and a compound [b-1] with each other in the presence of a base and a catalyst that is composed of a Pd compound and a tertiary phosphine ligand (step a); a step of asymmetrically hydrogenating a compound [c-1] in the presence of a hydrogen donor and a complex that is prepared from a ruthenium compound and a chiral ligand, or alternatively in the presence of an optically active oxazaborolidine compound (a CBS catalyst) and a boron hydride compound (step b); and a step of treating a compound [d-1] with a reducing agent (step c). (In the above formulae, Ra and Rb represent the same or different lower alkyl groups; and X1 represents a halogen atom.)
摘要翻译：本发明提供了用于制造用作皮炎等的治疗剂的光学活性萘化合物的工业上有利的方法。具体而言，本发明提供了一种光学活性萘化合物[I]的制造方法，其特征在于，在碱的存在下，使化合物[a-1]和化合物[b-1] 和由Pd化合物和叔膦配体组成的催化剂（步骤a）; 在氢供体和由钌化合物和手性配体制备的络合物的存在下，或者在光学活性的恶唑硼烷化合物（CBS催化剂）存在下，不对称地氢化化合物[c-1] 和硼氢化合物（步骤b）; 和用还原剂处理化合物[d-1]（步骤c）的步骤。（上式中，Ra和Rb表示相同或不同的低级烷基，X1表示卤素原子。）

5. 发明授权

US07096045B2 Portable communication terminal apparatus 失效
公开(公告)号：US07096045B2
公开(公告)日：2006-08-22
申请号：US09946315
申请日：2001-09-05
申请人： Masahiko Yoshinaga
发明人： Masahiko Yoshinaga
IPC分类号： H04B1/38
CPC分类号： H04B1/3833 , H04M1/72519 , H04M1/72547 , Y02D70/40
摘要： A portable communication terminal apparatus is disclosed which can announce termination of a call in various methods with a simple configuration and allows selection of a suitable annunciation method in accordance with a utilization situation of the portable communication terminal apparatus so that an annunciation operation can be performed appropriately thereby achieve reduction of the power consumption and the noise generation. An unfolded/folded state of a body of a foldable portable telephone set is supervised by an unfolded/folded state detection section. When an annunciation operation is to be performed upon termination of a call or the like, an annunciation method determination section selects one of a plurality annunciation methods stored in a storage section in response to the unfolded/folded state of the portable telephone set. A control section controls an annunciation section to drive a vibrator, a speaker or an LED to perform an annunciation operation in accordance with the selected annunciation method.

6. 发明授权

US6070069A Radio selective calling receiver and radio selective calling receiving method 失效
标题翻译：无线选呼接收机和无线选呼接收方式
公开(公告)号：US6070069A
公开(公告)日：2000-05-30
申请号：US956370
申请日：1997-10-23
申请人： Masahiko Yoshinaga
发明人： Masahiko Yoshinaga
IPC分类号： H04Q7/14 , G08B5/22 , H04Q7/16
CPC分类号： G08B5/227
摘要： A radio selective calling reception system for limiting recipients participating in a group call limited by setting up a radio selective calling receiver, includes a reception unit, a switch, a numerical string search unit, a numerical string storage unit, a message storage unit, a message unit, a display unit, and a controller connected to each of the foregoing. By manipulating the switch, a message received as a result of a conference call is demodulated by the reception unit, and its included numerical string is extracted by the controller and compared with numerical strings stored in the numerical string storage unit by the numerical string search unit. As a result of a search, a received message is stored in the message storage unit, and the message reception notification operation is performed by the message unit and a loudspeaker connected to the message unit. Since an arbitrary numerical string for sub-group identification is set in the radio selective calling receiver to limit reception for a group call, the storing of unnecessary messages is eliminated, and the memory space provided for message storage is more effectively employed. Accordingly, the load placed on a message transmitter is reduced, and superior radio selective calling receiver is provided for a user. Furthermore, a sub-group is flexibly set or altered and a waste of a finite source, such as individual numbers, is eliminated.
摘要翻译：一种无线电选呼接收系统，用于限制通过建立无线电选呼接收机而参与组呼的接收者，包括接收单元，开关，数字串搜索单元，数字串存储单元，消息存储单元，消息单元，显示单元和连接到上述各个的控制器。通过操纵开关，由接收单元解调作为电话会议结果接收到的消息，并且由控制器提取其包含的数字串，并通过数字串搜索单元与数字串存储单元中存储的数字串进行比较。作为搜索的结果，接收的消息被存储在消息存储单元中，并且消息接收通知操作由消息单元和连接到消息单元的扬声器执行。由于在无线电选择呼叫接收机中设置用于子组识别的任意数字串，以限制群组呼叫的接收，消除了不必要消息的存储，更有效地采用提供用于消息存储的存储空间。因此，放置在消息发送器上的负载减少，并且为用户提供了优越的无线电选呼接收机。此外，子组被灵活地设置或改变，并且消除诸如单个号码的有限源的浪费。

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