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1. 发明授权

US08828442B2 Pharmaceutical solid dispersions 有权
标题翻译：药物固体分散体
公开(公告)号：US08828442B2
公开(公告)日：2014-09-09
申请号：US13610350
申请日：2012-09-11
申请人： Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Ravi M. Shanker
发明人： Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Ravi M. Shanker
IPC分类号： A61K31/44 , A61K9/16 , A61K9/14
CPC分类号： A61K9/1635 , A61K9/146 , A61K9/1652
摘要： A composition comprises a solid dispersion comprising a low-solubility drug and at least one polymer. In another aspect of the invention, a composition comprises a solid dispersion comprising a low-solubility drug and a stabilizing polymer. At least a major portion of the drug in the dispersion is amorphous. The composition also includes a concentration-enhancing polymer that increases the concentration of the drug in a use environment. The stabilizing polymer has a glass transition temperature that is greater than the glass transition temperature of the concentration-enhancing polymer at a relative humidity of 50%.
摘要翻译：组合物包含包含低溶解度药物和至少一种聚合物的固体分散体。在本发明的另一方面，组合物包含包含低溶解度药物和稳定化聚合物的固体分散体。分散体中药物的至少大部分是无定形的。组合物还包括增加使用环境中药物浓度的浓度增强聚合物。稳定化聚合物的玻璃化转变温度大于相对湿度为50％时浓度增强聚合物的玻璃化转变温度。

2. 发明申请

US20130029965A1 PHARMACEUTICAL SOLID DISPERSIONS 有权
标题翻译：药物固体分散体
公开(公告)号：US20130029965A1
公开(公告)日：2013-01-31
申请号：US13610350
申请日：2012-09-11
申请人： Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Ravi M. Shanker
发明人： Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Ravi M. Shanker
IPC分类号： A61K31/44 , A61K31/404 , A61P25/24 , A61K31/455
CPC分类号： A61K9/1635 , A61K9/146 , A61K9/1652
摘要： A composition comprises a solid dispersion comprising a low-solubility drug and at least one polymer. In another aspect of the invention, a composition comprises a solid dispersion comprising a low-solubility drug and a stabilizing polymer. At least a major portion of the drug in the dispersion is amorphous. The composition also includes a concentration-enhancing polymer that increases the concentration of the drug in a use environment. The stabilizing polymer has a glass transition temperature that is greater than the glass transition temperature of the concentration-enhancing polymer at a relative humidity of 50%.
摘要翻译：组合物包含包含低溶解度药物和至少一种聚合物的固体分散体。在本发明的另一方面，组合物包含包含低溶解度药物和稳定化聚合物的固体分散体。分散体中药物的至少大部分是无定形的。组合物还包括增加使用环境中药物浓度的浓度增强聚合物。稳定化聚合物的玻璃化转变温度大于相对湿度为50％时浓度增强聚合物的玻璃化转变温度。

3. 发明授权

US08501231B2 Pharmaceutical compositions providing enhanced drug concentrations 有权
公开(公告)号：US08501231B2
公开(公告)日：2013-08-06
申请号：US13527536
申请日：2012-06-19
申请人： William J. Curatolo , Ravi M. Shanker , Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Douglas A. Lorenz
发明人： William J. Curatolo , Ravi M. Shanker , Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Douglas A. Lorenz
IPC分类号： A61K9/14 , A61K9/16 , A61K9/22 , A61K47/32
CPC分类号： A61K47/38 , A61K9/146 , A61K9/1629 , A61K9/1652 , A61K31/135 , A61K31/404 , A61K31/4178 , A61K31/4375 , A61K31/496 , A61K31/517
摘要： A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.

4. 发明申请

US20120295988A1 Pharmaceutical Compositions of Dispersions of Amorphous Drugs Mixed with Polymers 有权
标题翻译：与聚合物混合的无定形药物分散体的药物组合物
公开(公告)号：US20120295988A1
公开(公告)日：2012-11-22
申请号：US13563536
申请日：2012-07-31
申请人： Walter C. Babcock , William J. Curatolo , Dwayne T. Friesen , Rodney J. Ketner , Julian B. Lo , James A. S. Nightingale , Ravi M. Shanker , James B. West
发明人： Walter C. Babcock , William J. Curatolo , Dwayne T. Friesen , Rodney J. Ketner , Julian B. Lo , James A. S. Nightingale , Ravi M. Shanker , James B. West
IPC分类号： A61K47/38 , A61P25/22 , A61P7/02 , A61P25/08 , A61P25/28 , A61P35/00 , A61P29/00 , A61P25/18 , A61P3/04 , A61P31/04 , A61P9/12 , A61P11/14
CPC分类号： A61K9/146
摘要： A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.
摘要翻译：药物组合物包含包含低溶解度药物和与浓度增强聚合物组合的基质的分散体。至少大部分药物在分散体中是无定形的。组合物改善药物在分散体中的稳定性和/或药物在使用环境中的浓度。

5. 发明授权

US08883209B2 Pharmaceutical solid dispersions 有权
标题翻译：药物固体分散体
公开(公告)号：US08883209B2
公开(公告)日：2014-11-11
申请号：US12760393
申请日：2010-05-25
申请人： Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Ravi M. Shanker
发明人： Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Ravi M. Shanker
IPC分类号： A61K31/404 , A61K9/16 , A61K9/14
CPC分类号： A61K9/1635 , A61K9/146 , A61K9/1652
摘要： A composition comprises a solid dispersion comprising a low-solubility drug and at least one polymer. At least a major portion of the drug in the dispersion is amorphous. The polymer has a glass transition temperature of at least 100° C. measured at a relative humidity of fifty percent. Another aspect of the invention comprises the same composition except that the dispersion has a glass transition temperature of at least 50° C. at a relative humidity of fifty percent. In another aspect of the invention, a composition comprises a solid dispersion comprising a low-solubility drug and a stabilizing polymer. At least a major portion of the drug in the dispersion is amorphous. The composition also includes a concentration-enhancing polymer that increases the concentration of the drug in a use environment. The stabilizing polymer has a glass transition temperature that is greater than the glass transition temperature of the concentration-enhancing polymer at a relative humidity of 50%.
摘要翻译：组合物包含包含低溶解度药物和至少一种聚合物的固体分散体。分散体中药物的至少大部分是无定形的。聚合物的玻璃化转变温度至少为100℃，相对湿度为百分之五十。本发明的另一方面包括相同的组成，不同之处在于分散体在50％的相对湿度下具有至少50℃的玻璃化转变温度。在本发明的另一方面，组合物包含包含低溶解度药物和稳定化聚合物的固体分散体。分散体中药物的至少大部分是无定形的。组合物还包括增加使用环境中药物浓度的浓度增强聚合物。稳定化聚合物的玻璃化转变温度大于相对湿度为50％时浓度增强聚合物的玻璃化转变温度。

6. 发明授权

US08481081B2 Pharmaceutical solid dispersions 有权
标题翻译：药物固体分散体
公开(公告)号：US08481081B2
公开(公告)日：2013-07-09
申请号：US10459808
申请日：2003-06-10
申请人： Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Ravi M. Shanker
发明人： Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Ravi M. Shanker
IPC分类号： A61K9/14
CPC分类号： A61K9/1635 , A61K9/146 , A61K9/1652
摘要： A composition comprises a solid dispersion comprising a low-solubility drug and at least one polymer. At least a major portion of the drug in the dispersion is amorphous. The polymer has a glass transition temperature of at least 100° C. measured at a relative humidity of fifty percent. Another aspect of the invention comprises the same composition except that the dispersion has a glass transition temperature of at least 50° C. at a relative humidity of fifty percent. In another aspect of the invention, a composition comprises a solid dispersion comprising a low-solubility drug and a stabilizing polymer. At least a major portion of the drug in the dispersion is amorphous. The composition also includes a concentration-enhancing polymer that increases the concentration of the drug in a use environment. The stabilizing polymer has a glass transition temperature that is greater than the glass transition temperature of the concentration-enhancing polymer at a relative humidity of 50%.
摘要翻译：组合物包含包含低溶解度药物和至少一种聚合物的固体分散体。分散体中药物的至少大部分是无定形的。聚合物的玻璃化转变温度至少为100℃，相对湿度为百分之五十。本发明的另一方面包括相同的组成，不同之处在于分散体在50％的相对湿度下具有至少50℃的玻璃化转变温度。在本发明的另一方面，组合物包含包含低溶解度药物和稳定化聚合物的固体分散体。分散体中药物的至少大部分是无定形的。组合物还包括增加使用环境中药物浓度的浓度增强聚合物。稳定化聚合物的玻璃化转变温度大于相对湿度为50％时浓度增强聚合物的玻璃化转变温度。

7. 发明授权

US08236328B2 Pharmaceutical compositions of dispersions of amorphous drugs mixed with polymers 有权
标题翻译：与聚合物混合的无定形药物的分散体的药物组合物
公开(公告)号：US08236328B2
公开(公告)日：2012-08-07
申请号：US12217700
申请日：2008-07-08
申请人： Walter C. Babcock , William J. Curatolo , Dwayne T. Friesen , Rodney J. Ketner , Julian B. Lo , James A. S. Nightingale , Ravi M. Shanker , James B. West
发明人： Walter C. Babcock , William J. Curatolo , Dwayne T. Friesen , Rodney J. Ketner , Julian B. Lo , James A. S. Nightingale , Ravi M. Shanker , James B. West
IPC分类号： A61K9/00 , A61K9/14
CPC分类号： A61K9/146
摘要： A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.
摘要翻译：药物组合物包含包含低溶解度药物和与浓度增强聚合物组合的基质的分散体。至少大部分药物在分散体中是无定形的。组合物改善药物在分散体中的稳定性和/或药物在使用环境中的浓度。

8. 发明授权

US08202912B2 Pharmaceutical compositions providing enhanced drug concentrations 有权
标题翻译：提供增强药物浓度的药物组合物
公开(公告)号：US08202912B2
公开(公告)日：2012-06-19
申请号：US13208305
申请日：2011-08-11
申请人： William J. Curatolo , Ravi M. Shanker , Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Douglas A. Lorenz
发明人： William J. Curatolo , Ravi M. Shanker , Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Douglas A. Lorenz
IPC分类号： A61K47/32 , A61K9/14 , A61K9/16 , A61K9/22
CPC分类号： A61K47/38 , A61K9/146 , A61K9/1629 , A61K9/1652 , A61K31/135 , A61K31/404 , A61K31/4178 , A61K31/4375 , A61K31/496 , A61K31/517
摘要： A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
摘要翻译：将溶解度改善形式的药物与足够量的浓度增强聚合物组合，使得组合在使用环境中相对于包含相同量的相同溶解度改善形式的药物的对照提供了显着增强的药物浓度没有浓度增强聚合物。

9. 发明授权

US08026286B2 Pharmaceutical compositions providing enhanced drug concentrations 有权
标题翻译：提供增强药物浓度的药物组合物
公开(公告)号：US08026286B2
公开(公告)日：2011-09-27
申请号：US09742785
申请日：2000-12-20
申请人： William J. Curatolo , Ravi M. Shanker , Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Douglas A. Lorenz
发明人： William J. Curatolo , Ravi M. Shanker , Walter C. Babcock , Dwayne T. Friesen , James A. S. Nightingale , Douglas A. Lorenz
IPC分类号： A61K47/32 , A61K9/14 , A61K9/16 , A61K9/22
CPC分类号： A61K47/38 , A61K9/146 , A61K9/1629 , A61K9/1652 , A61K31/135 , A61K31/404 , A61K31/4178 , A61K31/4375 , A61K31/496 , A61K31/517
摘要： A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
摘要翻译：将溶解度改善形式的药物与足够量的浓度增强聚合物组合，使得组合在使用环境中相对于包含相同量的相同溶解度改善形式的药物的对照提供了显着增强的药物浓度没有浓度增强聚合物。

10. 发明授权

US08703196B2 Pharmaceutical compositions of dispersions of amorphous drugs mixed with polymers 有权
标题翻译：与聚合物混合的无定形药物的分散体的药物组合物
公开(公告)号：US08703196B2
公开(公告)日：2014-04-22
申请号：US13563536
申请日：2012-07-31
申请人： Walter C. Babcock , William J. Curatolo , Dwayne T. Friesen , Rodney J. Ketner , Julian B. Lo , James A. S. Nightingale , Ravi M. Shanker , James B. West
发明人： Walter C. Babcock , William J. Curatolo , Dwayne T. Friesen , Rodney J. Ketner , Julian B. Lo , James A. S. Nightingale , Ravi M. Shanker , James B. West
IPC分类号： A61K9/14 , A61K47/38
CPC分类号： A61K9/146
摘要： A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.
摘要翻译：药物组合物包含包含低溶解度药物和与浓度增强聚合物组合的基质的分散体。至少大部分药物在分散体中是无定形的。组合物改善药物在分散体中的稳定性和/或药物在使用环境中的浓度。

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