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    • 9. 发明授权
    • Antimicrobial siloxane quat formulations and their preparation and use
    • 抗微生物硅氧烷季铵盐配方及其制备与应用
    • US06376696B1
    • 2002-04-23
    • US09596419
    • 2000-06-19
    • Klaus RaabWalter Bender
    • Klaus RaabWalter Bender
    • C07F710
    • C07F7/1892A01N55/00A61L2/16C07F7/1804A01N25/02A01N2300/00
    • Disclosed is a process for preparing an antimicrobial formulation by reacting a compound of the formula 1 (R1O)3Si—(CH2)3—X  (1) with a compound of the formula 2 (H3C)NR2R3  (2) where R1 is C1-C4-alkyl R2 is C8-C20-alkyl R3 is methyl or C8-C20-alkyl X is Cl or Br, excluding iodides, in a molar ratio of (1):(2)=1:0.9 to 1:1.4, which comprises conducting said reaction in a solvent conforming to the formula 3 where R4 is C1-C4-alkyl R5 is H or methyl R6 is H or methyl m is 2, 3, 4 or 5, subject to the proviso that when m is 2 R4 and R6 are not both methyl, and not removing this solvent after said reaction, or adding this solvent after said reaction. Further disclosed is an antimicrobial formulation obtainable by the process described above.
    • 公开了通过使式1的化合物与式2的化合物反应制备抗微生物制剂的方法,其中R 1是C 1 -C 4 - 烷基,R 2是C 8 -C 20 - 烷基R 3是甲基或C 8 -C 20 - 烷基X是Cl或Br,不包括碘化物 (1):(2)= 1:0.9至1:1.4的摩尔比,其包括在符合式3的溶剂中进行所述反应,其中R 4为C 1 -C 4 - 烷基,R 5为H或甲基,R 6为H或甲基m 2,3,4或5,条件是当m为2 R 4且R 6不是甲基时,并且在所述反应后不除去该溶剂,或在所述反应后加入该溶剂。进一步公开了抗微生物剂, 上述过程。