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1. 发明授权

US07572622B2 Heart preservation chamber 有权
标题翻译：心脏保存室
公开(公告)号：US07572622B2
公开(公告)日：2009-08-11
申请号：US10640867
申请日：2003-08-14
申请人： Waleed H. Hassanein , Richard L. Bringham , Ronald L. Taylor, Jr.
发明人： Waleed H. Hassanein , Richard L. Bringham , Ronald L. Taylor, Jr.
IPC分类号： A01N1/02
CPC分类号： A01N1/02 , A01N1/0247 , A01N1/0273
摘要： A heart preservation chamber is disclosed which comprises a housing, an inclined trough support surface, and inlet and outlet fluid connections for the major heart blood vessels.
摘要翻译：公开了一种心脏保存室，其包括壳体，倾斜槽支撑表面以及用于主要心脏血管的入口和出口流体连接。

2. 发明授权

US5120501A Integrated membrane blood oxygenator/heat exchanger 失效
标题翻译：集成膜血液氧化剂/热交换器
公开(公告)号：US5120501A
公开(公告)日：1992-06-09
申请号：US260164
申请日：1988-10-20
申请人： Wifred F. Mathewson , Richard L. Bringham , Philip L. Ritger , David Karshmer
发明人： Wifred F. Mathewson , Richard L. Bringham , Philip L. Ritger , David Karshmer
IPC分类号： A61M1/18 , A61M1/14 , A61M1/16 , A61M1/36 , B01D63/02
CPC分类号： A61M1/1698 , A61M1/1625 , A61M1/1629 , B01D63/02 , B01D2313/105 , B01D2313/125 , B01D2313/38 , Y10S128/03 , Y10S261/28
摘要： A device including an integrally formed membrane oxygenator and heat exchange device positioned in a single housing. The device includes a thermally conductive body formed with a plurality of blood pathways on its surface, and a gas permeable membrane, or membranes positioned in the housing in substantial contact with the heat exchange body to cover or lie within a portion of each of the pathways. The membrane defines a gas pathway separate from the blood pathway through which a gas is directed. The blood is directed through the individual blood pathways. The device also includes various ports and passageways for delivering the blood to the individual channels, and for collecting and removing the blood from the device.
摘要翻译：一种包括整体形成的膜氧合器和定位在单个壳体中的热交换装置的装置。该装置包括在其表面上形成有多个血液通道的导热体，以及透气膜，或位于外壳中的膜，与热交换体基本接触以覆盖或位于每个通路的一部分内。膜定义了与通过气体引导的血液通路分离的气体通路。血液通过个体血液通路。该装置还包括用于将血液输送到各个通道的各种端口和通道，以及用于从装置收集和移除血液。

3. 发明授权

US4876066A Integrated membrane oxygenator, heat exchanger and reservoir 失效
标题翻译：综合膜式氧合器，换热器和储液器
公开(公告)号：US4876066A
公开(公告)日：1989-10-24
申请号：US73261
申请日：1987-07-14
申请人： Richard L. Bringham , Lucas S. Gordon , Karl E. Mosch
发明人： Richard L. Bringham , Lucas S. Gordon , Karl E. Mosch
IPC分类号： A61M1/16 , A61M1/36 , B01D63/02
CPC分类号： A61M1/1698 , A61M1/1625 , A61M1/1629 , A61M1/3673 , B01D63/02 , A61M1/3627 , A61M2206/16 , B01D2313/38 , B01D2313/90 , Y10S128/03
摘要： A membrane oxygenator includes an upper nested arrangement of a hard shell venous reservoir, a bowl-like defoamer within the reservoir and a heat exchanger coil vertically supported within the defoamer, and includes a membrane oxygenator unit mounted on the bottom of the upper arrangement. The oxygenator unit includes an inlet chamber with a tangential inlet providing swirling blood flow to dislodge air bubbles and centrifuge air to an upper center region of an inlet chamber where gas is exhausted through a vent. A bottom blood outlet chamber of the blood oxygenator unit has a relatively thin vertical cross-sectional area such that priming flow velocity therein discharges all air from the outlet chamber.
摘要翻译：膜充氧器包括硬壳静脉储存器的上嵌套布置，储存器内的碗状消泡剂和垂直支撑在消泡剂内的热交换器盘管，并且包括安装在上部布置的底部的膜氧合器单元。充氧器单元包括具有切向入口的入口室，该入口提供旋转的血流以排出气泡并将空气离心到入口室的上中心区域，在该中心区域，气体通过排气口排出。血液充氧器单元的底部出血室具有相对薄的垂直横截面积，使得其中的起动流速从出口腔排出所有空气。

4. 发明授权

US5316724A Multiple blood path membrane oxygenator 失效
标题翻译：多路血管膜充氧器
公开(公告)号：US5316724A
公开(公告)日：1994-05-31
申请号：US945998
申请日：1992-09-15
申请人： Wilfred F. Mathewson , Richard L. Bringham , Philip L. Ritger , David Karshmer
发明人： Wilfred F. Mathewson , Richard L. Bringham , Philip L. Ritger , David Karshmer
IPC分类号： A61M1/16 , B01D63/04 , A61M1/14
CPC分类号： A61M1/1698 , A61M1/1625 , B01D63/024 , B01D63/04 , B01D2313/105 , B01D2313/20 , Y10S128/03
摘要： A membrane oxygenator designed to provide blood flow evenly across a gas permeable membrane in a direction substantially perpendicular to the longitudinal direction of the gas permeable membrane. In particular, the present invention is directed to a membrane oxygenator wherein the blood is distributed substantially evenly and at a substantially constant velocity, in a cross-wise direction across the gas permeable membrane. In accordance with a preferred embodiment, the membrane is a bundle of gas permeable hollow fibers with the blood being distributed in a direction substantially perpendicular to the longitudinal direction of the individual hollow fiber membranes.
摘要翻译：一种膜氧合器，设计用于在基本上垂直于气体可渗透膜的纵向方向的方向上使气流均匀地跨越透气膜。特别地，本发明涉及一种膜氧合器，其中血液基本上均匀地并且以基本上恒定的速度跨越气体可渗透膜的横向方向分布。根据优选实施方案，膜是一束透气中空纤维，其中血液沿基本上垂直于各个中空纤维膜的纵向的方向分布。

5. 发明授权

US5049146A Blood/gas separator and flow system 失效
标题翻译：血液/气体分离器和流量系统
公开(公告)号：US5049146A
公开(公告)日：1991-09-17
申请号：US359178
申请日：1989-05-31
申请人： Richard L. Bringham , R. Scott Bell
发明人： Richard L. Bringham , R. Scott Bell
IPC分类号： A61M5/36 , A61M1/14 , A61M1/32 , A61M1/36
CPC分类号： A61M1/3627 , A61M1/325 , A61M1/3632 , Y10S128/03
摘要： A blood reservoir is formed with a hard outer shell housing defining at least one blood compartment. A flexible bag is mounted in the outer shell and is connected to the reservoir inlet port to allow blood to directly enter the flexible bag. The bag includes two oppositely positioned ends, one of which includes a mircoporous screen and is situated to lie partially below a minimum level attained by blood in the reservoir. The second bag end is substantially open, and includes a porous element partially coated with an antifoaming agent. The coated portion of the element is positioned above a maximum level attained by the blood in the hard shell. The potential of excessive mixing between the blood and air is reduced by controlling the expansion of the bag during blood flow.

6. 发明授权

US5225161A Integrated membrane blood oxygenator/heat exchanger 失效
标题翻译：集成膜血液充氧器/换热器
公开(公告)号：US5225161A
公开(公告)日：1993-07-06
申请号：US848897
申请日：1992-03-10
申请人： Wilfred F. Mathewson , Richard L. Bringham , Philip L. Ritger , David L. Karshmer
发明人： Wilfred F. Mathewson , Richard L. Bringham , Philip L. Ritger , David L. Karshmer
IPC分类号： A61M1/16 , B01D63/02
CPC分类号： B01D63/02 , A61M1/1625 , A61M1/1629 , A61M1/1698 , B01D2313/38 , Y10S128/03 , Y10S261/28
摘要： A device including an integrally formed membrane oxygenator and heat exchange device positioned in a single housing. The device includes a thermally conductive body formed with a plurality of blood pathways on its surface, and a gas permeable membrane, or membranes positioned in the housing in substantial contact with the heat exchange body to cover or lie within a portion of each of the pathways. The membrane defines a gas pathway separate from the blood pathway through which a gas is directed. The blood is directed through the individual blood pathways. The device also includes various ports and passageways for delivering the blood to the individual channels, and for collecting and removing the blood from the device.
摘要翻译：一种包括整体形成的膜氧合器和定位在单个壳体中的热交换装置的装置。该装置包括在其表面上形成有多个血液通道的导热体，以及透气膜，或位于外壳中的膜，与热交换体基本接触以覆盖或位于每个通路的一部分内。膜定义了与通过气体引导的血液通路分离的气体通路。血液通过个体血液通路。该装置还包括用于将血液输送到各个通道的各种端口和通道，以及用于从装置收集和移除血液。

7. 发明授权

US4698207A Integrated membrane oxygenator, heat exchanger and reservoir 失效
标题翻译：综合膜式氧合器，换热器和储液器
公开(公告)号：US4698207A
公开(公告)日：1987-10-06
申请号：US885207
申请日：1986-07-14
申请人： Richard L. Bringham , Lucas S. Gordon , Karl E. Mosch
发明人： Richard L. Bringham , Lucas S. Gordon , Karl E. Mosch
IPC分类号： A61M1/36 , A61M1/16 , A61M1/18 , B01D63/02
CPC分类号： B01D63/02 , A61M1/1625 , A61M1/1629 , A61M1/1698 , A61M1/3673 , A61M1/3627 , A61M2206/16 , B01D2313/38 , B01D2313/90 , Y10S128/03
摘要： A membrane oxygenator includes an upper nested arrangement of a hard shell venous reservoir, a bowl-like defoamer within the reservoir and a heat exchanger coil vertically supported within the defoamer, and includes a membrane oxygenator unit mounted on the bottom of the upper arrangement. The oxygenator unit includes an inlet chamber with a tangential inlet providing swirling blood flow to dislodge air bubbles and centrifuge air to an upper center region of an inlet chamber where gas is exhausted through a vent. A bottom blood outlet chamber of the blood oxygenator unit has a relatively thin vertical cross-sectional area such that priming flow velocity therein discharges all air from the outlet chamber.

8. 发明授权

US5338512A Method for oxygenation of a patient's blood 失效
标题翻译：患者血液氧合的方法
公开(公告)号：US5338512A
公开(公告)日：1994-08-16
申请号：US024998
申请日：1993-03-02
申请人： Wilfred F. Mathewson , Richard L. Bringham , Philip L. Ritger , David L. Karshmer
发明人： Wilfred F. Mathewson , Richard L. Bringham , Philip L. Ritger , David L. Karshmer
IPC分类号： A61M1/18 , A61M1/14 , A61M1/16 , A61M1/36 , B01D63/02
CPC分类号： A61M1/1698 , A61M1/1625 , A61M1/1629 , B01D63/02 , B01D2313/105 , B01D2313/125 , B01D2313/38 , Y10S128/03 , Y10S261/28
摘要： A device including an integrally formed membrane oxygenator and heat exchange device positioned in a single housing. The device includes a thermally conductive body formed with a plurality of blood pathways on its surface, and a gas permeable membrane, or membranes positioned in the housing in substantial contact with the heat exchange body to cover or lie within a portion of each of the pathways. The membrane defines a gas pathway separate from the blood pathway through which a gas is directed. The blood is directed through the individual blood pathways. The device also includes various ports and passageways for delivering the blood to the individual channels, and for collecting and removing the blood from the device.
摘要翻译：一种包括整体形成的膜氧合器和定位在单个壳体中的热交换装置的装置。该装置包括在其表面上形成有多个血液通道的导热体，以及透气膜，或位于外壳中的膜，与热交换体基本接触以覆盖或位于每个通路的一部分内。膜定义了与通过气体引导的血液通路分离的气体通路。血液通过个体血液通路。该装置还包括用于将血液输送到各个通道的各种端口和通道，以及用于从装置收集和移除血液。

9. 发明授权

US4902476A Heat exchanger and blood oxygenator apparatus 失效
标题翻译：热交换器和血氧仪
公开(公告)号：US4902476A
公开(公告)日：1990-02-20
申请号：US56135
申请日：1987-05-29
申请人： Lucas S. Gordon , Richard L. Bringham
发明人： Lucas S. Gordon , Richard L. Bringham
IPC分类号： A61M1/16 , A61M1/32 , A61M1/36 , A61M5/44 , B01D63/02
CPC分类号： B01D63/02 , A61M1/1627 , A61M1/1629 , A61M1/1698 , A61M5/44 , A61M1/32 , A61M1/369 , A61M2205/366 , B01D2313/38 , Y10S128/03 , Y10S261/28
摘要： A heat exchanger and blood oxgenator apparatus includes a housing having a blood inlet portion, a blood outlet portion, and a housing wall defining an enclosed chamber disposed along a chamber axis between the blood input portion and the blood output portion through which to pass a quantity of blood to be temperature controlled. A heat exchanger tube having an exterior surface and a hollow interior through which to pass a heat exchange medium for purposes of exchanging heat with a quantity of blood brought into contact with the exterior surface, is disposed in a generally helical coil that is mounted within the chamber to encircle the chamber axis. A scalloped inner surface is included on the housing wall to face generally inward toward the heat exchanger tube. Spacing members disposed between the exterior surface of the heat exchanger tube and the scalloped inner surface of the housing wall retain the exterior surface spaced apart from the scalloped inner surface to define a flow passage through which to pass a quantity of blood so that the blood contacts a substantial portion of the exterior surface.
摘要翻译：热交换器和血液氧化器装置包括具有血液入口部分，血液出口部分和壳体壁的壳体，该壳体限定了沿着血液输入部分和血液输出部分之间的腔室轴线设置的封闭腔室，的血液要温度控制。具有外表面和中空内部的热交换器管被设置在大致螺旋状的线圈中，所述外部表面和中空内部通过热交换介质以通过与外部表面接触的一定量的血液进行热交换。腔室围绕腔室轴线。扇形内表面包括在壳体壁上，以朝向热交换器管大致向内。设置在热交换器管的外表面和壳体壁的扇形内表面之间的间隔构件保持与扇形内表面间隔开的外表面，以限定通过一定量血液的流动通道，使得血液接触外表面的大部分。

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