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1. 发明申请

US20050202006A1 EGFH2 genes and gene products 失效
标题翻译： EGFH2基因和基因产物
公开(公告)号：US20050202006A1
公开(公告)日：2005-09-15
申请号：US10931285
申请日：2004-08-31
申请人： W. Kavanaugh , Hui Cen , Pauline Lee
发明人： W. Kavanaugh , Hui Cen , Pauline Lee
IPC分类号： A61K38/00 , C07K14/475 , C07H21/02 , A61K39/395 , C07K14/485 , C07K16/22 , C12P21/06
CPC分类号： C07K14/4756 , A61K38/00
摘要： This invention relates to mouse and human EGFH2, and to variants thereof and to polynucleotides encoding EGFH2. This invention also relates to therapeutic agents related to the polynucleotides and proteins.
摘要翻译：本发明涉及小鼠和人EGFH2及其变体，以及编码EGFH2的多核苷酸。本发明还涉及与多核苷酸和蛋白质相关的治疗剂。

2. 发明申请

US20080004428A1 EGFH2 genes and gene products 失效
标题翻译： EGFH2基因和基因产物
公开(公告)号：US20080004428A1
公开(公告)日：2008-01-03
申请号：US11656882
申请日：2007-01-22
申请人： W. Kavanaugh , Hui Cen , Pauline Lee
发明人： W. Kavanaugh , Hui Cen , Pauline Lee
IPC分类号： C07K7/06 , C07K14/00
CPC分类号： C07K14/4756 , A61K38/00
摘要： This invention relates to mouse and human EGFH2, and to variants thereof and to polynucleotides encoding EGFH2. This invention also relates to therapeutic agents related to the polynucleotides and proteins.
摘要翻译：本发明涉及小鼠和人EGFH2及其变体，以及编码EGFH2的多核苷酸。本发明还涉及与多核苷酸和蛋白质相关的治疗剂。

3. 发明授权

US07276587B2 Antibodies to EGFH2 polypeptides 失效
标题翻译： EGFH2多肽的抗体
公开(公告)号：US07276587B2
公开(公告)日：2007-10-02
申请号：US10931285
申请日：2004-08-31
申请人： W. Michael Kavanaugh , Hui Cen , Pauline Lee
发明人： W. Michael Kavanaugh , Hui Cen , Pauline Lee
IPC分类号： C07K16/00
CPC分类号： C07K14/4756 , A61K38/00
摘要： This invention relates to mouse and human EGFH2, and to variants thereof and to polynucleotides encoding EGFH2. This invention also relates to therapeutic agents related to the polynucleotides and proteins.
摘要翻译：本发明涉及小鼠和人EGFH2及其变体，以及编码EGFH2的多核苷酸。本发明还涉及与多核苷酸和蛋白质相关的治疗剂。

4. 发明授权

US07705117B2 EGFH2 genes and gene products 失效
标题翻译： EGFH2基因和基因产物
公开(公告)号：US07705117B2
公开(公告)日：2010-04-27
申请号：US11656882
申请日：2007-01-22
申请人： W. Michael Kavanaugh , Hui Cen , Pauline Lee
发明人： W. Michael Kavanaugh , Hui Cen , Pauline Lee
IPC分类号： A61K38/00 , C07K14/00
CPC分类号： C07K14/4756 , A61K38/00
摘要： This invention relates to mouse and human EGFH2, and to variants thereof and to polynucleotides encoding EGFH2. This invention also relates to therapeutic agents related to the polynucleotides and proteins.
摘要翻译：本发明涉及小鼠和人EGFH2及其变体，以及编码EGFH2的多核苷酸。本发明还涉及与多核苷酸和蛋白质相关的治疗剂。

5. 发明授权

US06825333B1 EGFH2 genes and gene products 失效
标题翻译： EGFH2基因和基因产物
公开(公告)号：US06825333B1
公开(公告)日：2004-11-30
申请号：US09640041
申请日：2000-08-15
申请人： W. Michael Kavanaugh , Hui Cen , Pauline Lee
发明人： W. Michael Kavanaugh , Hui Cen , Pauline Lee
IPC分类号： C07H2104
CPC分类号： C07K14/4756 , A61K38/00
摘要： This invention relates to mouse and human EGFH2, and to variants thereof and to polynucleotides encoding EGFH2. This invention also relates to therapeutic agents related to the polynucleotides and proteins.
摘要翻译：本发明涉及小鼠和人EGFH2及其变体，以及编码EGFH2的多核苷酸。本发明还涉及与多核苷酸和蛋白质相关的治疗剂。

6. 发明授权

US08586325B2 Enzyme substrate comprising a functional dye and associated technology and methods 有权
标题翻译：酶底物包含功能染料及相关技术和方法
公开(公告)号：US08586325B2
公开(公告)日：2013-11-19
申请号：US13891406
申请日：2013-05-10
申请人： Fei Mao , Hui Cen
发明人： Fei Mao , Hui Cen
IPC分类号： C12Q1/37 , A61K38/14 , C07D279/08
CPC分类号： C12N9/96 , C07D263/60 , C07D417/06 , C07D501/00 , C07K7/06 , C12Q1/37 , C12Q1/48 , C12Q1/485 , G01N21/6486 , G01N33/582
摘要： Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.
摘要翻译：提供了本发明的酶底物和相关技术。本发明的酶底物可以包含生物功能性荧光染料和酶特异性底物部分，其功能性染料的官能度减弱。酶反应可以从酶底物切割底物部分的至少一部分以提供更多功能的产物染料。通常，在特定条件下，例如当结合到伴侣生物分子或伴侣生物分子的组合时，该产物染料通常可以是非荧光的或弱荧光的，并且是相对荧光的。因此，本发明的酶底物可用于荧光检测和/或各种有用应用中的任何一种，例如在无细胞系统或活细胞中检测酶活性，筛选药物，或疾病的诊断。

7. 发明授权

US08092784B2 Enzyme substrate comprising a functional dye and associated technology and methods 有权
标题翻译：酶底物包含功能染料及相关技术和方法
公开(公告)号：US08092784B2
公开(公告)日：2012-01-10
申请号：US12095322
申请日：2006-11-21
申请人： Fei Mao , Hui Cen , Wai-yee Leung
发明人： Fei Mao , Hui Cen , Wai-yee Leung
IPC分类号： A61B10/00 , C12Q1/68
CPC分类号： C12N9/96 , C07D263/60 , C07D417/06 , C07D501/00 , C07K7/06 , C12Q1/37 , C12Q1/48 , C12Q1/485 , G01N21/6486 , G01N33/582
摘要： Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.
摘要翻译：提供了本发明的酶底物和相关技术。本发明的酶底物可以包含生物功能性荧光染料和酶特异性底物部分，其功能性染料的官能度减弱。酶反应可以从酶底物切割底物部分的至少一部分以提供更多功能的产物染料。通常，在特定条件下，例如当结合到伴侣生物分子或伴侣生物分子的组合时，该产物染料通常可以是非荧光的或弱荧光的，并且是相对荧光的。因此，本发明的酶底物可用于荧光检测和/或各种有用应用中的任何一种，例如在无细胞系统或活细胞中检测酶活性，筛选药物，或疾病的诊断。

8. 发明申请

US20130236888A1 ENZYME SUBSTRATE COMPRISING A FUNCTIONAL DYE AND ASSOCIATED TECHNOLOGY AND METHODS 有权
公开(公告)号：US20130236888A1
公开(公告)日：2013-09-12
申请号：US13891406
申请日：2013-05-10
申请人： Fei Mao , Hui Cen
发明人： Fei Mao , Hui Cen
IPC分类号： G01N21/64 , C07K7/06 , C07D501/00 , C07D417/06
CPC分类号： C12N9/96 , C07D263/60 , C07D417/06 , C07D501/00 , C07K7/06 , C12Q1/37 , C12Q1/48 , C12Q1/485 , G01N21/6486 , G01N33/582
摘要： Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.

9. 发明申请

US20090148386A1 ENZYME SUBSTRATE COMPRISING A FUNCTIONAL DYE AND ASSOCIATED TECHNOLOGY AND METHODS 有权
标题翻译：包含功能性染色及其相关技术和方法的酶基质
公开(公告)号：US20090148386A1
公开(公告)日：2009-06-11
申请号：US12095322
申请日：2006-11-21
申请人： Fei Mao , Hui Cen , Wai-yee Leung
发明人： Fei Mao , Hui Cen , Wai-yee Leung
IPC分类号： A61B10/00 , C12Q1/68 , G01N33/573
CPC分类号： C12N9/96 , C07D263/60 , C07D417/06 , C07D501/00 , C07K7/06 , C12Q1/37 , C12Q1/48 , C12Q1/485 , G01N21/6486 , G01N33/582
摘要： Enzyme substrates and associated technology of the present invention are provided. An enzyme substrate of the invention may comprise a biologically functional fluorescent dye and an enzyme-specific substrate moiety attached in such a way that the functionality of the functional dye is diminished. An enzymatic reaction may cleave at least a portion of the substrate moiety from the enzyme substrate to provide a more functional product dye. This product dye may be nonfluorescent or weakly fluorescent, in general, and relatively fluorescent, in a particular condition, such as when bound to a partner biological molecule or an assembly of partner biological molecules. An enzyme substrate of the present invention may thus be useful in fluorescence detection, and/or in any of a variety of useful applications, such as the detection of enzymatic activity in a cell-free system or in a living cell, the screening of drugs, or the diagnosis of disease.
摘要翻译：提供了本发明的酶底物和相关技术。本发明的酶底物可以包含生物功能性荧光染料和酶特异性底物部分，其功能性染料的官能度减弱。酶反应可以从酶底物切割底物部分的至少一部分以提供更多功能的产物染料。通常，在特定条件下，例如当结合到伴侣生物分子或伴侣生物分子的组合时，该产物染料通常可以是非荧光的或弱荧光的，并且是相对荧光的。因此，本发明的酶底物可用于荧光检测和/或各种有用应用中的任何一种，例如在无细胞系统或活细胞中检测酶活性，筛选药物，或疾病的诊断。

10. 发明申请

US20070161063A1 Identifying, monitoring, and treating women for breast precancer or cancer 审中-公开
标题翻译：识别，监测和治疗乳腺癌前期癌症或癌症的妇女
公开(公告)号：US20070161063A1
公开(公告)日：2007-07-12
申请号：US11713495
申请日：2007-03-02
申请人： Susan Love , David Hung , Hui Cen
发明人： Susan Love , David Hung , Hui Cen
IPC分类号： G01N33/574
CPC分类号： A61K31/4535 , A61K31/00 , A61K31/138 , A61K31/352 , A61K31/4196 , A61K31/437 , A61K31/566 , C12Q1/6886 , G01N33/5091 , G01N33/57415 , G01N2333/723 , A61K2300/00
摘要： The invention is to methods for screening women for breast cancer and precancer by determining a level of an estrogen-related marker. The invention further provides methods of treating such patients identified as having one or more abnormal ductal epithelial cells and an estrogen-related marker. The invention provides methods for screening patient for hormone replacement therapy (HRT), and of monitoring such patients once they begin HRT. The invention provides methods of treating peri-, menopausal or postmenopausal women for both cancer risk reduction and menopausal symptoms (or other conditions related to lowered systemic estrogen levels). The invention also provides kits for the screening, monitoring, and treating methods described.
摘要翻译：本发明是通过测定雌激素相关标志物的水平来筛选乳腺癌和癌前期妇女的方法。本发明还提供了治疗被鉴定为具有一种或多种异常导管上皮细胞和雌激素相关标志物的患者的方法。本发明提供了用于筛选患者激素替代疗法（HRT）的方法，以及一旦开始HRT就监测这些患者。本发明提供治疗绝经期或绝经后妇女的方法，用于癌症风险降低和绝经症状（或与降低的系统性雌激素水平相关的其它病症）。本发明还提供了用于所述的筛选，监测和处理方法的试剂盒。

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