专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4459225A Peptide amides and process for their manufacture 失效
标题翻译：肽酰胺及其制造方法
公开(公告)号：US4459225A
公开(公告)日：1984-07-10
申请号：US359242
申请日：1982-03-18
申请人： Volker Teetz , Rolf Geiger , Hans G. Alpermann , Martin Bickel
发明人： Volker Teetz , Rolf Geiger , Hans G. Alpermann , Martin Bickel
IPC分类号： C07K5/08 , A61K38/00 , A61P25/04 , C07K5/087 , C07K5/10 , C07K5/107 , C07K7/06 , C07K14/70 , C07C103/52
CPC分类号： C07K5/0812 , C07K14/702 , C07K5/1016
摘要： New peptide amides of the formula IH--Tyr--D--Lys(For)--Gly--X (I)whereinFor is formyl,X is alkylamino, dehydro-Phe or Phe-alkylamido having up to 6 carbon atoms in the alkyl moiety, which moiety may be substituted by hydroxy and/or phenyl, Phe-cycloalkylamide or Phe-cycloalkylene amide having up to 8 carbon atoms in the cycloalkyl or cyclalkylene moiety, 1 to 2 CH.sub.2 groups being optionally replaced by --NH--, --O--, --S-- or --CO--, Phe-alkylene-cycloalkylamide having from 5 to 6 ring carbon atoms, which amide may be substituted by carbonamido,N-alkylcarbonamido or alkyl and 1 carbon atom whereof may be replaced by nitrogen, Phe-endo- or exo-norbornylamide or Phe-thiazolamide or Phe-thiazolidine-carboxylic acid amide, which may be substituted by 1 to 4 methyl groups each,and process for their manufacture are disclosed. These peptide amides are distinguished by an analgetic activity and suppress the motility of the ileum of the guinea pig.
摘要翻译：式I H-Tyr-D-Lys（For）-Gly-X（I）的新肽酰胺其中For为甲酰基，X为烷基部分中具有至多6个碳原子的烷基氨基，脱氢-Phe或Phe-烷基酰氨基，该部分可以被羟基和/或苯基取代，在环烷基或环亚烷基部分具有至多8个碳原子的Phe-环烷基酰胺或Phe-亚环烷基酰胺，1至2个CH 2基团任选地被-NH-，-O- ，具有5至6个环碳原子的-S-或-CO-，Phe-亚烷基 - 环烷基酰胺，该酰胺可以被碳酰氨基取代，N-烷基碳酰氨基或其烷基和碳原子可以被氮取代，Phe-内 - 或外 - 降冰片烷酰胺或Phe-噻唑胺或Phe-噻唑烷 - 羧酸酰胺，其可以各自被1至4个甲基取代，以及其制造方法。这些肽酰胺通过止痛活性来区分，并抑制豚鼠回肠的动力。

2. 发明授权

US5684016A Method of treating cardiac insufficiency 失效
标题翻译：治疗心功能不全的方法
公开(公告)号：US5684016A
公开(公告)日：1997-11-04
申请号：US445543
申请日：1995-05-22
申请人： Rainer Henning , Hansjorg Urbach , Volker Teetz , Rolf Geiger , Bernward Scholkens
发明人： Rainer Henning , Hansjorg Urbach , Volker Teetz , Rolf Geiger , Bernward Scholkens
IPC分类号： A61K38/00 , A61K38/55 , C07K5/02 , A61K31/47 , C07D217/26
CPC分类号： C07K5/0222 , A61K38/556
摘要： The invention relates to a method of treating cardiac insufficiency by using compounds of the formula I ##STR1## in which n is 1 or 2, R, R.sup.1, R.sup.2 and R.sup.3 are identical or different and each denote hydrogen or an organic radical and R.sup.4 and R.sup.5, together with the atoms carrying them, form a mono-, bi- or tri-cyclic heterocyclic ring system. The invention furthermore relates to compounds of the formula I and agents containing these for use in the treatment of the abovementioned disease.
摘要翻译：本发明涉及通过使用其中n为1或2的式I（I）的化合物治疗心功能不全的方法，R 1，R 2，R 2和R 3相同或不同，并且各自表示氢或有机基团并且R4和R5与携带它们的原子一起形成单环，双环或三环杂环体系。本发明还涉及式I化合物和含有这些化合物用于治疗上述疾病的药剂。

3. 发明授权

US5403856A Method of treating cardiac insufficiency using angiotensin-converting enzyme inhibitors 失效
标题翻译：使用血管紧张素转换酶抑制剂治疗心功能不全的方法
公开(公告)号：US5403856A
公开(公告)日：1995-04-04
申请号：US188745
申请日：1994-01-31
申请人： Rainer Henning , Hansjorg Urbach , Volker Teetz , Rolf Geiger , Bernward Scholkens
发明人： Rainer Henning , Hansjorg Urbach , Volker Teetz , Rolf Geiger , Bernward Scholkens
IPC分类号： C07K14/81 , A61K38/00 , A61K38/55 , A61P9/00 , A61P9/12 , A61P43/00 , C07K5/02 , C07K5/06 , C12N9/99 , A61K31/40
CPC分类号： A61K38/556 , C07K5/0222 , Y10S514/913
摘要： The invention relates to a method of treating cardiac insufficiency by using compounds of the formula I ##STR1## in which n is 1 or 2, R, R.sup.1, R.sup.2 and R.sup.3 are identical or different and each denote hydrogen or an organic radical and R.sup.4 R.sup.5, together with the atoms carrying them, form a mono-, bi- or tri-cyclic heterocyclic ring system. The invention furthermore relates to compounds of the formula I and agents containing these for use in the treatment of the abovementioned disease.
摘要翻译：本发明涉及通过使用其中n为1或2的式I（I）的化合物治疗心功能不全的方法，R 1，R 2，R 2和R 3相同或不同，并且各自表示氢或有机基团和R4 R5与携带它们的原子一起形成单环，双环或三环杂环体系。本发明还涉及式I化合物和含有这些化合物用于治疗上述疾病的药剂。

4. 发明授权

US5158959A Decahydroisoquinoline carboxylic acids 失效
标题翻译：十氢异喹啉羧酸
公开(公告)号：US5158959A
公开(公告)日：1992-10-27
申请号：US565900
申请日：1983-12-27
申请人： Rolf Geiger , Volker Teetz , Hansjorg Urbach , Bernward Scholkens , Rainer Henning
发明人： Rolf Geiger , Volker Teetz , Hansjorg Urbach , Bernward Scholkens , Rainer Henning
IPC分类号： A61K38/00 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/47 , A61K31/472 , A61P9/12 , C07D209/42 , C07D217/26 , C07D233/64 , C07D241/20 , C07D307/54 , C07D309/10 , C07D317/66 , C07D333/24 , C07D335/02 , C07D339/08 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07K1/02 , C07K1/113 , C07K5/02 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/078 , C07K14/81
CPC分类号： C07K5/0222 , C07D217/26 , A61K38/00
摘要： What are disclosed are aminoacid compounds of the formula ##STR1## wherein n is 0 or 1, and salts thereof, said compounds and salts having hypotensive properties; methods for making the compounds; pharmaceutical compositions containing the compounds or salts; and use of the compounds and salts for treating hypertension.
摘要翻译：所公开的是下式的氨基酸化合物，其中n为0或1，及其盐，所述化合物和具有降血压性质的盐; 制备化合物的方法; 含有该化合物或盐的药物组合物; 以及使用化合物和盐治疗高血压。

5. 发明授权

US4879403A Process for the preparation of cis, endo-2-azabicyclo-[3.3.0]-octane-3-carboxylic acids 失效
标题翻译：顺式，内-2-氮杂双环[3.3.0] - 辛烷-3-羧酸的制备方法
公开(公告)号：US4879403A
公开(公告)日：1989-11-07
申请号：US267753
申请日：1988-11-02
申请人： Volker Teetz , Rolf Geiger , Hansjorg Urbach , Reinhard Becker , Bernward Scholkens
发明人： Volker Teetz , Rolf Geiger , Hansjorg Urbach , Reinhard Becker , Bernward Scholkens
IPC分类号： C07C227/08 , A61K31/40 , A61K31/403 , A61K38/00 , A61P9/12 , C07C227/10 , C07C227/16 , C07C229/36 , C07C237/06 , C07D209/52 , C07D451/04 , C07K5/02 , C07K5/06
CPC分类号： C07K5/0222 , C07D209/52 , A61K38/00
摘要： Compounds of the formula I ##STR1## in which the carboxyl group on carbon atom 3 is orientated in the endo-position relative to the bicyclic ring system of cis-configuration, and in which R.sup.1 denotes hydrogen, allyl, vinyl or a side-chain of a naturally occurring .alpha.-aminoacid, which may be protected, R.sup.2 denotes hydrogen, alkyl, alkenyl or aralkyl, Y denotes hydrogen or hydroxyl and Z denotes hydrogen, or Y and Z together denote oxygen, and X denotes alkyl, alkenyl or cycloalkyl, or aryl which is optionally mono-, di- or tri-substituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino or methylenedioxy, or denotes indol-3-yl, a process for their preparation, agents containing these compounds and their use.
摘要翻译：其中碳原子3上的羧基相对于顺式构型的双环体系位于内部位置的式I（I）化合物，其中R 1表示氢，烯丙基，乙烯基或可以被保护的天然存在的α-氨基酸的侧链，R2表示氢，烷基，烯基或芳烷基，Y表示氢或羟基，Z表示氢，或Y和Z表示氧，X表示烷基，烯基或环烷基，或任选被烷基，烷氧基，羟基，卤素，硝基，氨基，烷基氨基，二烷基氨基或亚甲二氧基单，二或三取代的芳基，或表示吲哚-3-基，其制备方法，含有这些化合物的药剂及其用途。

6. 发明授权

US4621073A Cyclic peptides having somatostatin activity 失效
标题翻译：具有生长抑素活性的环肽
公开(公告)号：US4621073A
公开(公告)日：1986-11-04
申请号：US575703
申请日：1984-01-31
申请人： Axel Friedrich , Wolfgang Konig , Volker Teetz , Rolf Geiger , Jurgen K. Sandow
发明人： Axel Friedrich , Wolfgang Konig , Volker Teetz , Rolf Geiger , Jurgen K. Sandow
IPC分类号： C07K7/64 , A61K38/00 , A61K38/04 , A61P5/00 , A61P5/02 , C07C231/00 , C07K1/113 , C07K7/06 , C07K14/575 , C07K14/655 , A61K37/24 , C07K7/26
CPC分类号： C07K14/6555 , A61K38/00 , Y10S514/806 , Y10S930/16
摘要： The invention relates to cyclic hexapeptides of the general formula III ##STR1## in which X represents the radical of an L-aminoacid of the general formula IIIa ##STR2## in which A and B are identical or different and denote alkyl having 1 to 3 carbon atoms, or A and B together represent a saturated, unsaturated or aromatic monocyclic or bicyclic structure having 3 to 6 carbon atoms, n denotes 0 or 1, and Y represents an aliphatic or aromatic L-aminoacid the side chain of which can be hydroxylated, and their salts with physiologically tolerated acids, and to a process for their preparation and their use and their intermediates.
摘要翻译：本发明涉及通式III“IMAGE”的环状六肽，其中X表示通式IIIa（IIIa）的L-氨基酸的基团，其中A和B相同或不同，表示具有1 至3个碳原子，或A和B一起表示具有3至6个碳原子的饱和，不饱和或芳族单环或双环结构，n表示0或1，Y表示脂族或芳族L-氨基酸，其侧链可以羟基化，以及它们与生理上耐受的酸的盐，以及它们的制备方法及其用途及其中间体。

7. 发明授权

US4457866A Chromogenic compounds and their use as enzyme substrates 失效
标题翻译：显色化合物及其作为酶底物的用途
公开(公告)号：US4457866A
公开(公告)日：1984-07-03
申请号：US435610
申请日：1982-10-19
申请人： Hermann E. Karges , Helmut Heber , Rainer Uhmann , Volker Teetz , Rolf Geiger
发明人： Hermann E. Karges , Helmut Heber , Rainer Uhmann , Volker Teetz , Rolf Geiger
IPC分类号： E04F15/02 , C07K5/04 , C07K5/062 , C07K5/072 , C07K5/083 , C07K5/087 , C07K5/103 , C07K5/107 , C07K7/06 , C12Q1/37 , C07C103/52 , C12Q1/00
CPC分类号： C07K7/06 , C07K5/06026 , C07K5/06052 , C07K5/06078 , C07K5/06086 , C07K5/06095 , C07K5/06104 , C07K5/0808 , C07K5/0812 , C07K5/1013 , C07K5/1016 , C12Q1/37 , C12Q2337/12 , Y10S530/802 , Y10S930/28
摘要： What are disclosed are chromogenic peptides useful as substrates for the detection and determination of enzymes having a hydrolytic action and methods for detecting and determining enzymes with such peptides.
摘要翻译：所公开的是可用作检测和测定具有水解作用的酶的底物的显色肽以及用这些肽检测和测定酶的方法。

8. 发明授权

US5747504A Method of treating cardiac insufficiency using angiotensin-converting enzyme inhibitors 失效
公开(公告)号：US5747504A
公开(公告)日：1998-05-05
申请号：US709286
申请日：1996-09-06
申请人： Rainer Henning , Hansjorg Urbach , Volker Teetz , Rolf Geiger , Bernward Scholkens
发明人： Rainer Henning , Hansjorg Urbach , Volker Teetz , Rolf Geiger , Bernward Scholkens
IPC分类号： A61K38/00 , A61K38/55 , C07K5/02 , A61K31/47
CPC分类号： C07K5/0222 , A61K38/556
摘要： The invention relates to a method of treating cardiac insufficiency by using compounds of the formula I ##STR1## in which n is 1 or 2, R, R.sup.1, R.sup.2 and R.sup.3 are identical or different and each denote hydrogen or an organic radical and R.sup.4 and R.sup.5, together with the atoms carrying them, form a mono-, bi- or tri-cyclic heterocyclic ring system. The invention furthermore relates to compounds of the formula I and agents containing these for use in the treatment of the abovementioned disease.

9. 发明授权

US5401766A Aminoacid derivatives, a process for their preparation, agents containing these compounds, and the use thereof 失效
标题翻译：氨基酸衍生物，其制备方法，含有这些化合物的试剂及其用途
公开(公告)号：US5401766A
公开(公告)日：1995-03-28
申请号：US208443
申请日：1994-03-09
申请人： Rolf Geiger , Volker Teetz , Hansjorg Urbach , Bernward Scholkens , Rainer Henning
发明人： Rolf Geiger , Volker Teetz , Hansjorg Urbach , Bernward Scholkens , Rainer Henning
IPC分类号： A61K38/00 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/47 , A61K31/472 , A61P9/12 , C07D209/42 , C07D217/26 , C07D233/64 , C07D241/20 , C07D307/54 , C07D309/10 , C07D317/66 , C07D333/24 , C07D335/02 , C07D339/08 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07K1/02 , C07K1/113 , C07K5/02 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/078 , C07K14/81 , C07D209/34 , A61K31/405
CPC分类号： C07K5/0222 , C07D217/26 , A61K38/00
摘要： Aminoacid derivatives of the formula I ##STR1## A , n, R.sup.1, R.sup.2 and R.sup.3 have the meanings given, and salts thereof, a process for their preparation, pharmaceutical preparations based on these compounds, and their use as medicaments.
摘要翻译：式I的氨基酸衍生物A，n，R 1，R 2和R 3具有给定的含义及其盐，其制备方法，基于这些化合物的药物制剂及其作为药物的用途。

10. 发明授权

US5162362A Octahydroindole-2-carboxylic acids 失效
标题翻译：八氢吲哚-2-羧酸
公开(公告)号：US5162362A
公开(公告)日：1992-11-10
申请号：US565887
申请日：1983-12-27
申请人： Rolf Geiger , Volker Teetz , Hansjorg Urbach , Bernward Scholkens , Rainer Henning
发明人： Rolf Geiger , Volker Teetz , Hansjorg Urbach , Bernward Scholkens , Rainer Henning
IPC分类号： A61K38/00 , C07D217/26 , C07K5/02
CPC分类号： C07K5/0222 , C07D217/26 , A61K38/00
摘要： What are disclosed are aminoacid compounds of the formula ##STR1## wherein n is 0 or 1, and salts thereof, said compounds and salts having hypotensive properties; methods for making the compounds; pharmaceutical compositions containing the compounds or salts; and use of the compounds and salts for treating hypertension.
摘要翻译：所公开的是下式的氨基酸化合物，其中n为0或1，及其盐，所述化合物和具有降血压性质的盐; 制备化合物的方法; 含有该化合物或盐的药物组合物; 以及使用化合物和盐治疗高血压。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式