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1. 发明授权

US4361482A Chromatograph for pressure chromatography 失效
标题翻译：色谱柱进行压力色谱
公开(公告)号：US4361482A
公开(公告)日：1982-11-30
申请号：US309455
申请日：1981-10-07
申请人： Volker Teetz , Rainer Uhmann , Rudolf Knapp
发明人： Volker Teetz , Rainer Uhmann , Rudolf Knapp
IPC分类号： G01J3/46 , B01D15/08 , G01N21/01 , G01N30/36 , G01N30/60
CPC分类号： B01D15/22 , G01N30/6021 , G01N30/36
摘要： In this chromatograph for pressure chromatography, a plunger having a plunger stem is arranged so that it can move within the separation column (3). On the front face of the plunger there is a collecting space (7) for liquid, which is covered by a frit (6) and which has a connecting line (8) to the face of the plunger opposed to the front face. In order to prevent abrasive and chemical attack by the column packing on the plunger, its seal and the cylinder wall of the separation column, the plunger should comprise a lower part (2) having a device (4) to accommodate the plunger stem (5), and an upper part (1), the two parts being arranged so that they can move in relation to one another. The upper part (1) has a centering peg (9) which projects into the lower part (2). A spring (12) on which the upper part (1) is supported, is located concentrically in relation to the peg (9). The upper part (1) has recesses on its circumference to accommodate at least two seals (19 and 21) and a ring channel (16) which is formed by a retaining ring (13) for one seal (19) and is connected to the collecting space (7). The other seal (21) is held in its recess by a ring (23) which is located concentrically around the spring and is supported by the lower part.
摘要翻译：在这种压力色谱色谱仪中，具有柱塞杆的柱塞被布置成使其能够在分离柱（3）内移动。在柱塞的前表面上有用于液体的收集空间（7），其被玻璃料（6）覆盖，并且具有与前表面相对的柱塞的表面的连接线（8）。为了防止柱塞上的柱填料，其密封件和分离柱的气缸壁的研磨和化学侵蚀，柱塞应包括具有装置（4）的下部（2），以容纳柱塞杆（5））和上部（1），两个部分被布置成使得它们可以相对于彼此移动。上部（1）具有突出到下部（2）中的定心栓（9）。支撑上部（1）的弹簧（12）相对于钉（9）同心地定位。上部（1）在其圆周上具有凹部以容纳至少两个密封件（19和21）和环形通道（16），该通道由用于一个密封件（19）的保持环（13）形成，并且连接到收集空间（7）。另一个密封件（21）通过环（23）保持在其凹部中，环（23）同心地位于弹簧周围并由下部支撑。

2. 发明授权

US4457866A Chromogenic compounds and their use as enzyme substrates 失效
标题翻译：显色化合物及其作为酶底物的用途
公开(公告)号：US4457866A
公开(公告)日：1984-07-03
申请号：US435610
申请日：1982-10-19
申请人： Hermann E. Karges , Helmut Heber , Rainer Uhmann , Volker Teetz , Rolf Geiger
发明人： Hermann E. Karges , Helmut Heber , Rainer Uhmann , Volker Teetz , Rolf Geiger
IPC分类号： E04F15/02 , C07K5/04 , C07K5/062 , C07K5/072 , C07K5/083 , C07K5/087 , C07K5/103 , C07K5/107 , C07K7/06 , C12Q1/37 , C07C103/52 , C12Q1/00
CPC分类号： C07K7/06 , C07K5/06026 , C07K5/06052 , C07K5/06078 , C07K5/06086 , C07K5/06095 , C07K5/06104 , C07K5/0808 , C07K5/0812 , C07K5/1013 , C07K5/1016 , C12Q1/37 , C12Q2337/12 , Y10S530/802 , Y10S930/28
摘要： What are disclosed are chromogenic peptides useful as substrates for the detection and determination of enzymes having a hydrolytic action and methods for detecting and determining enzymes with such peptides.
摘要翻译：所公开的是可用作检测和测定具有水解作用的酶的底物的显色肽以及用这些肽检测和测定酶的方法。

3. 发明授权

US5684016A Method of treating cardiac insufficiency 失效
标题翻译：治疗心功能不全的方法
公开(公告)号：US5684016A
公开(公告)日：1997-11-04
申请号：US445543
申请日：1995-05-22
申请人： Rainer Henning , Hansjorg Urbach , Volker Teetz , Rolf Geiger , Bernward Scholkens
发明人： Rainer Henning , Hansjorg Urbach , Volker Teetz , Rolf Geiger , Bernward Scholkens
IPC分类号： A61K38/00 , A61K38/55 , C07K5/02 , A61K31/47 , C07D217/26
CPC分类号： C07K5/0222 , A61K38/556
摘要： The invention relates to a method of treating cardiac insufficiency by using compounds of the formula I ##STR1## in which n is 1 or 2, R, R.sup.1, R.sup.2 and R.sup.3 are identical or different and each denote hydrogen or an organic radical and R.sup.4 and R.sup.5, together with the atoms carrying them, form a mono-, bi- or tri-cyclic heterocyclic ring system. The invention furthermore relates to compounds of the formula I and agents containing these for use in the treatment of the abovementioned disease.
摘要翻译：本发明涉及通过使用其中n为1或2的式I（I）的化合物治疗心功能不全的方法，R 1，R 2，R 2和R 3相同或不同，并且各自表示氢或有机基团并且R4和R5与携带它们的原子一起形成单环，双环或三环杂环体系。本发明还涉及式I化合物和含有这些化合物用于治疗上述疾病的药剂。

4. 发明授权

US5403856A Method of treating cardiac insufficiency using angiotensin-converting enzyme inhibitors 失效
标题翻译：使用血管紧张素转换酶抑制剂治疗心功能不全的方法
公开(公告)号：US5403856A
公开(公告)日：1995-04-04
申请号：US188745
申请日：1994-01-31
申请人： Rainer Henning , Hansjorg Urbach , Volker Teetz , Rolf Geiger , Bernward Scholkens
发明人： Rainer Henning , Hansjorg Urbach , Volker Teetz , Rolf Geiger , Bernward Scholkens
IPC分类号： C07K14/81 , A61K38/00 , A61K38/55 , A61P9/00 , A61P9/12 , A61P43/00 , C07K5/02 , C07K5/06 , C12N9/99 , A61K31/40
CPC分类号： A61K38/556 , C07K5/0222 , Y10S514/913
摘要： The invention relates to a method of treating cardiac insufficiency by using compounds of the formula I ##STR1## in which n is 1 or 2, R, R.sup.1, R.sup.2 and R.sup.3 are identical or different and each denote hydrogen or an organic radical and R.sup.4 R.sup.5, together with the atoms carrying them, form a mono-, bi- or tri-cyclic heterocyclic ring system. The invention furthermore relates to compounds of the formula I and agents containing these for use in the treatment of the abovementioned disease.
摘要翻译：本发明涉及通过使用其中n为1或2的式I（I）的化合物治疗心功能不全的方法，R 1，R 2，R 2和R 3相同或不同，并且各自表示氢或有机基团和R4 R5与携带它们的原子一起形成单环，双环或三环杂环体系。本发明还涉及式I化合物和含有这些化合物用于治疗上述疾病的药剂。

5. 发明授权

US5158959A Decahydroisoquinoline carboxylic acids 失效
标题翻译：十氢异喹啉羧酸
公开(公告)号：US5158959A
公开(公告)日：1992-10-27
申请号：US565900
申请日：1983-12-27
申请人： Rolf Geiger , Volker Teetz , Hansjorg Urbach , Bernward Scholkens , Rainer Henning
发明人： Rolf Geiger , Volker Teetz , Hansjorg Urbach , Bernward Scholkens , Rainer Henning
IPC分类号： A61K38/00 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/47 , A61K31/472 , A61P9/12 , C07D209/42 , C07D217/26 , C07D233/64 , C07D241/20 , C07D307/54 , C07D309/10 , C07D317/66 , C07D333/24 , C07D335/02 , C07D339/08 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07K1/02 , C07K1/113 , C07K5/02 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/078 , C07K14/81
CPC分类号： C07K5/0222 , C07D217/26 , A61K38/00
摘要： What are disclosed are aminoacid compounds of the formula ##STR1## wherein n is 0 or 1, and salts thereof, said compounds and salts having hypotensive properties; methods for making the compounds; pharmaceutical compositions containing the compounds or salts; and use of the compounds and salts for treating hypertension.
摘要翻译：所公开的是下式的氨基酸化合物，其中n为0或1，及其盐，所述化合物和具有降血压性质的盐; 制备化合物的方法; 含有该化合物或盐的药物组合物; 以及使用化合物和盐治疗高血压。

6. 发明授权

US5068351A Process for the preparation of n octahydropenta (6) pyrrole carboxylates 失效
标题翻译：制备N-甲基吗啉的方法（6）羧甲基纤维素
公开(公告)号：US5068351A
公开(公告)日：1991-11-26
申请号：US560004
申请日：1990-07-27
申请人： Volker Teetz , Hans Wissmann , Hansjorg Urbach
发明人： Volker Teetz , Hans Wissmann , Hansjorg Urbach
IPC分类号： C07K14/81 , A61K38/55 , A61P43/00 , C07K1/10 , C07K1/113 , C07K5/02 , C07K5/06 , C07K5/078
CPC分类号： C07K5/0222
摘要： The invention relates to a process for the preparation of compounds of the formula I ##STR1## in which n is 1 or 2, R denotes hydrogen or an organic radical, R.sup.1 denotes an organic radical, R.sup.2 and R.sup.3 are identical or different and denote hydrogen or an organic radical, and R.sup.4 and R.sup.5, together with the atoms bearing them, form a monocyclic, bicyclic or tricyclic heterocyclic ring system having 5 to 15 carbon atoms, which process comprises reacting compounds of the formula II defined in the description with compounds of the formula IV defined in the description, in the presence of phosphinic anhydrides of the formula III, where appropriate eliminating radicals which have been introduced to protect other functional groups and, where appropriate, esterifying free carboxyl groups in a manner known per se.
摘要翻译：本发明涉及一种制备式I化合物（I）的方法，其中n为1或2，R表示氢或有机基团，R1表示有机基团，R2和R3相同或不同并且表示氢或有机基团，并且R 4和R 5与带有它们的原子一起形成具有5至15个碳原子的单环，双环或三环杂环体系，该方法包括使在描述中定义的式II化合物在描述中定义的式IV化合物，在式III的次膦酸酐存在下，其中适当地除去已经引入以保护其它官能团的基团，并且在适当的情况下以本身已知的方式酯化游离羧基。

7. 发明授权

US4797471A Peptide derivatives having an inhibitory action on hydroxylating enzymes, a process for their preparation, agents containing them, and their use 失效
标题翻译：对羟化酶具有抑制作用的肽衍生物，其制备方法，含有它们的药剂及其用途
公开(公告)号：US4797471A
公开(公告)日：1989-01-10
申请号：US941066
申请日：1986-12-12
申请人： Volker Teetz , Stephan Henke , Dietrich Brocks , Hartmut Hanauske-Abel , Volkmar Gunzler
发明人： Volker Teetz , Stephan Henke , Dietrich Brocks , Hartmut Hanauske-Abel , Volkmar Gunzler
IPC分类号： C07K5/08 , C07K5/09 , C07K14/81
CPC分类号： C07K5/0815
摘要： The invention relates to peptide derivatives of the formula ##STR1## in which ##STR2## represents an acyl radical, B represents the radical of a dipeptide composed of a N.sup..omega. -acylated basic .alpha.-amino acid and another .alpha.-amino acid, and W represents hydroxyl or optionally substituted amino, to a process for their preparation, to agents containing them, and to their use.
摘要翻译：本发明涉及式“IMAGE”的肽衍生物，其中“IMAGE”表示酰基，B表示由Nω-酰化的碱式α-氨基酸和另一种α-氨基酸组成的二肽的基团，W表示W 表示羟基或任选取代的氨基，其制备方法，含有它们的试剂及其用途。

8. 发明授权

US4677192A Process for the separation of mixtures of insulin, insulin derivatives and, where appropriate, impurities 失效
标题翻译：分离胰岛素，胰岛素衍生物和适当的杂质的混合物的方法
公开(公告)号：US4677192A
公开(公告)日：1987-06-30
申请号：US804325
申请日：1985-12-04
申请人： Rainer Obermeier , Volker Teetz , Jurgen Ludwig
发明人： Rainer Obermeier , Volker Teetz , Jurgen Ludwig
IPC分类号： A61K38/28 , C07G15/00 , C07K1/14 , C07K1/16 , C07K1/20 , C07K14/575 , C07K14/62 , C07K14/625 , A61K37/26 , C07K7/40
CPC分类号： C07K14/625
摘要： A method for separating insulin or certain insulin derivatives from mixtures containing the same by chromatography of the mixture on a column filled with silica gel having a particle size between 40 and 500 microns with an eluant mixture comprising chloroform, methanol, water and triethylamine.
摘要翻译：一种通过色谱法分离胰岛素或某些胰岛素衍生物的方法，该混合物在填充有40-500微米粒度的硅胶柱上，用含有氯仿，甲醇，水和三乙胺的洗脱剂混合物进行色谱分离。

9. 发明授权

US4562202A N-Acyl hexahydroindole-2-carboxylic acids and anti-hypertensive use thereof 失效
标题翻译： N-酰基六氢吲哚-2-羧酸及其抗高血压用途
公开(公告)号：US4562202A
公开(公告)日：1985-12-31
申请号：US477333
申请日：1983-03-21
申请人： Hansjorg Urbach , Rainer Henning , Volker Teetz , Hans Wissmann , Reinhard Becker
发明人： Hansjorg Urbach , Rainer Henning , Volker Teetz , Hans Wissmann , Reinhard Becker
IPC分类号： A61K31/403 , A61K31/404 , A61K31/405 , A61K38/00 , A61K38/55 , A61P9/12 , C07D209/42 , C07K1/02 , C07K1/113 , C07K5/02 , C07K5/06 , C07K14/81 , A61K31/40
CPC分类号： C07K5/0222 , C07D209/42 , A61K38/00
摘要： The invention relates to compounds of the formula I ##STR1## in which n denotes 0 or 1,R denotes hydrogen, alkyl or aralkyl, R.sup.1 denotes hydrogen or alkyl, which can optionally be substituted by amino, acylamino or benzoylamino, alkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, aryl or partially hydrogenated aryl, which each can be substituted by alkyl, alkoxy or halogen, arylalkyl or aroylalkyl, both of which can be substituted in the aryl radical as defined in the aforegoing, a monocyclic or bicyclic sulfur or oxygen and/or nitrogen heterocyclic radical, or a side chain of a naturally occurring aminoacid, R.sup.2 denotes hydrogen, alkyl, alkenyl or arylalkyl, Y denotes hydrogen or hydroxyl, Z denotes hydrogen or Y and Z together denote oxygen and X denotes alkyl, alkenyl, cycloalkyl, aryl, which is monosubstituted, disubstituted or trisubstituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino or methylenedioxy or 3-indolyl,and their physiologically acceptable salts, processes for their preparation, agents containing these and their use as medicaments and also bicyclic amino acids as their intermediates and processes for their preparation.
摘要翻译：本发明涉及式I的化合物，其中n表示0或1，R表示氢，烷基或芳烷基，R1表示氢或烷基，其可任选被氨基，酰氨基或苯甲酰基氨基取代，，环烷基，环烯基，环烷基烷基，芳基或部分氢化的芳基，其各自可以被烷基，烷氧基或卤素，芳基烷基或芳酰基烷基取代，二者可以在如上所定义的芳基中被取代，单环或双环硫或氧和/或氮杂环基或天然存在的氨基酸的侧链，R 2表示氢，烷基，烯基或芳烷基，Y表示氢或羟基，Z表示氢或Y，Z一起表示氧，X表示烷基，烯基，环烷基，芳基，其被烷基，烷氧基，羟基，卤素，硝基，氨基，烷基氨基，二烷基氨基或亚甲二氧基或3-吲哚基单取代或三取代，及其生理学表盐，其制备方法，含有这些物质的药剂及其作为药物的用途以及双环氨基酸作为其中间体及其制备方法。

10. 发明授权

US5500434A Combination of angiotensin-converting enzyme inhibitors with calcium antagonists as well as their use in drugs 失效
标题翻译：血管紧张素转换酶抑制剂与钙拮抗剂的组合以及它们在药物中的应用
公开(公告)号：US5500434A
公开(公告)日：1996-03-19
申请号：US225762
申请日：1994-04-11
申请人： Reinhard Becker , Henning: Rainer , Wolfgang Ruger , Volker Teetz , Hansjorg Urbach
发明人： Reinhard Becker , Henning: Rainer , Wolfgang Ruger , Volker Teetz , Hansjorg Urbach
IPC分类号： A61K31/40 , A61K31/401 , A61K31/435 , A61K31/44 , A61K38/05 , A61K38/55 , A61K45/06 , A61P3/00 , A61P3/14 , A61P9/12 , A61P43/00
CPC分类号： A61K38/556 , Y10S514/929
摘要： The invention relates to combinations of angiotensin-converting enzyme inhibitors with calcium antagonists, processes for their preparation and their use as medicaments.
摘要翻译：本发明涉及血管紧张素转换酶抑制剂与钙拮抗剂的组合，其制备方法及其作为药物的用途。

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