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1. 发明授权

US5541186A Sulfonylaminopyrimidines 失效
标题翻译：磺酰氨基嘧啶
公开(公告)号：US5541186A
公开(公告)日：1996-07-30
申请号：US266072
申请日：1994-06-27
申请人： Volker Breu , Kaspar Burri , Jean-Marie Cassal , Martine Clozel , Georges Hirth , Bernd-Michael L offler , Marcel M uller , Werner Neidhart , Henri Ramuz
发明人： Volker Breu , Kaspar Burri , Jean-Marie Cassal , Martine Clozel , Georges Hirth , Bernd-Michael L offler , Marcel M uller , Werner Neidhart , Henri Ramuz
IPC分类号： A61K31/505 , A61K20060101 , A61K31/33 , A61K31/495 , A61K31/535 , A61K31/55 , A61K31/63 , A61K31/635 , A61P1/04 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , A61P27/02 , C07C311/20 , C07D20060101 , C07D233/46 , C07D239/02 , C07D239/22 , C07D239/24 , C07D239/28 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/49 , C07D239/50 , C07D239/52 , C07D239/545 , C07D239/56 , C07D239/69 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/00 , C07D405/10 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/00 , C07D409/04 , C07D409/10 , C07D409/12 , C07D409/14 , C07D413/00 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号： C07D401/14 , C07D239/69 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要： A compound of the formula ##STR1## wherein R.sup.1 to R, R.sup.a, R.sup.b X, Y, Z, m and n have the significance given in the description, can be used as medicaments, especially for the treatment and prophylaxix of conditions which are associated with endothelin activities.
摘要翻译：其中R1至R，Ra，RbX，Y，Z，m和n具有在描述中给出的含义的式I化合物可用作药物，特别是用于治疗和预防相关的病症与内皮素活动。

2. 发明授权

US5962682A Aryl- and hetaryl-sulfonamide derivatives, their preparation and their use as endothelin antagonists 失效
标题翻译：芳基和杂芳基磺酰胺衍生物，它们的制备及其作为内皮素拮抗剂的用途
公开(公告)号：US5962682A
公开(公告)日：1999-10-05
申请号：US860985
申请日：1997-08-18
申请人： Volker Breu , Kaspar Burri , Jean-Marie Cassal , Martine Clozel , Georges Hirth , Bernd-Michael Loffler , Marcel Muller , Werner Neidhart , Henri Ramuz
发明人： Volker Breu , Kaspar Burri , Jean-Marie Cassal , Martine Clozel , Georges Hirth , Bernd-Michael Loffler , Marcel Muller , Werner Neidhart , Henri Ramuz
IPC分类号： C07D239/34 , A61K31/00 , A61K31/18 , A61K31/195 , A61K31/27 , A61K31/35 , A61K31/357 , A61K31/36 , A61K31/41 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/443 , A61K31/445 , A61K31/50 , A61K31/505 , A61K31/535 , A61P5/00 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P25/02 , A61P43/00 , C07C311/21 , C07C311/29 , C07C323/67 , C07D213/40 , C07D213/44 , C07D213/46 , C07D213/64 , C07D213/71 , C07D213/75 , C07D213/76 , C07D213/79 , C07D257/04 , C07D257/06 , C07D295/192 , C07D317/68 , C07D405/12 , C07D413/10
CPC分类号： C07D213/76 , C07C311/21 , C07C311/29 , C07C323/67 , C07D295/192
摘要： Compounds of formula (I) ##STR1## wherein R.sup.1 signifies phenyl, substituted phenyl or heterocyclyl; R.sup.2 signifies phenyl or substituted phenyl; R.sup.3 signifies hydrogen, lower-alkyl, cyano, carboxy, esterified carboxy, phenyl, substituted phenyl, heterocyclyl or a residue --CONR.sup.5 R.sup.6 or --NR.sup.5 COR.sup.7 ; R.sup.4 signifies hydrogen or lower-alkyl; R.sup.5 signifies hydrogen or a residue R.sup.7, and R.sup.6 signifies --(CH.sub.2).sub.m R.sup.7 ; or R.sup.5 and R.sup.6 together with the N atom associated with them signify a heterocyclic residue; R.sup.7 signifies phenyl, substituted phenyl, cycloalkyl, heterocyclyl, lower-alkyl, cyano-lower-alkyl, hydroxy-lower-alkyl, di-lower-alkylamino-lower-alkyl, carboxy-lower-alkyl, lower-alkoxycarbonyl-lower-alkyl, lower-alkoxycarbonylamino-lower-alkyl or phenyl-lower-alkoxycarbonyl; R.sup.a signifies hydrogen, lower-alkyl or hydroxy; R.sup.b signifies hydrogen or lower-alkyl; Z signifies hydroxy, amino or a residue --OR.sup.8, --OC(O)NHR.sup.8, --OC(O)OR.sup.8, --NHC(O)NHR.sup.8 or --NHC(O)OR.sup.8 ; R.sup.8 signifies heterocyclyl, phenyl, substituted phenyl or lower-alkyl; A and Y each independently signify oxygen or sulphur, X signifies nitrogen or CH; m signifies 0, 1 or 2; and n signifies 0, 1 or 2; and pharmaceutically usable salts thereof are inhibitors of endothelin receptors. They can therefore be used for the treatment of disorders which are associated with endothelin activities, especially circulatory disorders such as hypertension, ischaemia, vasospasms and angina pectoris.
摘要翻译： PCT No.PCT / EP95 / 04762 Sec。 371日期：1997年8月18日 102（e）日期1997年8月18日PCT提交1995年12月4日PCT公布。 WO96 / 19455 PCT公开号日期：1996年6月27日，式（I）的化合物，其中R 1表示苯基，取代的苯基或杂环基; R2表示苯基或取代的苯基; R3表示氢，低级烷基，氰基，羧基，酯化羧基，苯基，取代的苯基，杂环基或残基-CONR5R6或-NR5COR7; R4表示氢或低级烷基; R5表示氢或残基R7，R6表示 - （CH2）mR7; 或R 5和R 6与与它们相关的N原子一起表示杂环残基; R7表示苯基，取代的苯基，环烷基，杂环基，低级烷基，氰基 - 低级 - 烷基，羟基 - 低级 - 烷基，二 - 低级 - 烷基氨基 - 低级 - 烷基，羧基 - 低级 - 烷基，低级 - 烷氧基羰基 - 低级 - ，低级烷氧基羰基氨基 - 低级 - 烷基或苯基 - 低级 - 烷氧基羰基; R a表示氢，低级烷基或羟基; Rb表示氢或低级烷基; Z表示羟基，氨基或残基-OR8，-OC（O）NHR8，-OC（O）OR8，-NHC（O）NHR8或-NHC（O）OR8; R8表示杂环基，苯基，取代的苯基或低级烷基; A和Y各自独立地表示氧或硫，X表示氮或CH; m表示0，1或2; n表示0,1或2; 及其药学上可用的盐是内皮素受体的抑制剂。因此，它们可用于治疗与内皮素活性相关的疾病，特别是循环性疾病如高血压，局部缺血，血管痉挛和心绞痛。

3. 发明授权

US6133442A Aryl- and hetaryl-sulfonamide derivatives, their preparation and their use as endothelin antagonists 失效
标题翻译：芳基和杂芳基磺酰胺衍生物，它们的制备及其作为内皮素拮抗剂的用途
公开(公告)号：US6133442A
公开(公告)日：2000-10-17
申请号：US263034
申请日：1999-03-05
申请人： Volker Breu , Kaspar Burri , Jean-Marie Cassal , Martine Clozel , Georges Hirth , Bernd-Michael Loffler , Marcel Muller , Werner Neidhart , Henri Ramuz
发明人： Volker Breu , Kaspar Burri , Jean-Marie Cassal , Martine Clozel , Georges Hirth , Bernd-Michael Loffler , Marcel Muller , Werner Neidhart , Henri Ramuz
IPC分类号： C07D239/34 , A61K31/00 , A61K31/18 , A61K31/195 , A61K31/27 , A61K31/35 , A61K31/357 , A61K31/36 , A61K31/41 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/443 , A61K31/445 , A61K31/50 , A61K31/505 , A61K31/535 , A61P5/00 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P25/02 , A61P43/00 , C07C311/21 , C07C311/29 , C07C323/67 , C07D213/40 , C07D213/44 , C07D213/46 , C07D213/64 , C07D213/71 , C07D213/75 , C07D213/76 , C07D213/79 , C07D257/04 , C07D257/06 , C07D295/192 , C07D317/68 , C07D405/12 , C07D413/10
CPC分类号： C07D213/76 , C07C311/21 , C07C311/29 , C07C323/67 , C07D295/192
摘要： Compounds of formula I ##STR1## wherein R.sup.1 signifies phenyl, substituted phenyl or heterocyclyl;R.sup.2 signifies phenyl or substituted phenyl;R.sup.3 signifies hydrogen, lower-alkyl, cyano, carboxy, esterified carboxy, phenyl, substituted phenyl, heterocyclyl or a residue --CONR.sup.5 R.sup.6 or --NR.sup.5 COR.sup.7 ;R.sup.4 signifies hydrogen or lower-alkyl;R.sup.5 signifies hydrogen or a residue R.sup.7, andR.sup.6 signifies --(CH.sub.2).sub.m R.sup.7 ; orR.sup.5 and R.sup.6 together with the N atom associated with them signify a heterocyclic residue;R.sup.7 signifies phenyl, substituted phenyl, cycloalkyl, heterocyclyl, lower-alkyl, cyano-lower-alkyl, hydroxy-lower-alkyl, di-lower-alkylamino-lower-alkyl, carboxy-lower-alkyl, lower-alkoxycarbonyl-lower-alkyl, lower-alkoxycarbonylamino-lower-alkyl or phenyl-lower-alkoxycarbonyl;R.sup.a signifies hydrogen, lower-alkyl or hydroxy;R.sup.b signifies hydrogen or lower-alkyl;Z signifies hydroxy, amino or a residue --OR.sup.8, --OC(O)NHR.sup.8, --OC(O)OR.sup.8, --NHC(O)NHR.sup.8 or --NHC(O)OR.sup.8 ;R.sup.8 signifies heterocyclyl, phenyl, substituted phenyl or lower-alkyl;A and Y each independently signify oxygen or sulphur,X signifies nitrogen or CH;m signifies 0, 1 or 2; andn signifies 0, 1 or 2;and pharmaceutically usable salts thereof are inhibitors of endothelin receptors.They can therefore be used for the treatment of disorders which are associated with endothelin activities, especially circulatory disorders such as hypertension, ischaemia, vasospasms and angina pectoris.
摘要翻译：其中R 1表示苯基，取代的苯基或杂环基的式I化合物; R2表示苯基或取代的苯基; R3表示氢，低级烷基，氰基，羧基，酯化羧基，苯基，取代的苯基，杂环基或残基-CONR5R6或-NR5COR7; R4表示氢或低级烷基; R5表示氢或残基R7，R6表示 - （CH2）mR7; 或R 5和R 6与与它们相关的N原子一起表示杂环残基; R7表示苯基，取代的苯基，环烷基，杂环基，低级烷基，氰基 - 低级 - 烷基，羟基 - 低级 - 烷基，二 - 低级 - 烷基氨基 - 低级 - 烷基，羧基 - 低级 - 烷基，低级 - 烷氧基羰基 - 低级 - ，低级烷氧基羰基氨基 - 低级 - 烷基或苯基 - 低级 - 烷氧基羰基; R a表示氢，低级烷基或羟基; Rb表示氢或低级烷基; Z表示羟基，氨基或残基-OR8，-OC（O）NHR8，-OC（O）OR8，-NHC（O）NHR8或-NHC（O）OR8; R8表示杂环基，苯基，取代的苯基或低级烷基; A和Y各自独立地表示氧或硫，X表示氮或CH; m表示0，1或2; n表示0,1或2; 及其药学上可用的盐是内皮素受体的抑制剂。因此，它们可用于治疗与内皮素活性相关的疾病，特别是循环系统疾病如高血压，局部缺血，血管痉挛和心绞痛。

4. 发明授权

US6004965A Sulfonamides 失效
标题翻译：磺胺类
公开(公告)号：US6004965A
公开(公告)日：1999-12-21
申请号：US860107
申请日：1997-08-15
申请人： Volker Breu , Kaspar Burri , Jean-Marie Cassal , Martine Clozel , Georges Hirth , Bernd-Michael Loffler , Marcel Muller , Werner Neidhart , Henri Ramuz
发明人： Volker Breu , Kaspar Burri , Jean-Marie Cassal , Martine Clozel , Georges Hirth , Bernd-Michael Loffler , Marcel Muller , Werner Neidhart , Henri Ramuz
IPC分类号： C07D239/34 , A61K31/00 , A61K31/505 , A61K31/506 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , C07D239/46 , C07D239/69 , C07D401/04 , C07D401/14 , C07D403/10 , C07D405/14 , A01N43/54 , C07D401/00 , C07D403/00 , C07D413/00
CPC分类号： C07D401/04 , C07D239/69 , C07D401/14 , C07D403/10
摘要： Compounds of the formula: ##STR1## where A, B, R.sup.1 -R.sup.8 are as described herein are endothelin inhibitors that can be used in treating diseases associated with endothelin, such as high blood pressure. Chemical synthesis of these compounds and pharmaceutical compositions containing these compounds are also useful.
摘要翻译： PCT No.PCT / EP95 / 04843 Sec。 371日期：1997年8月15日 102（e）日期1997年8月15日PCT提交1995年12月8日PCT公布。 WO96 / 19459 PCT公开号日期1996年6月27日下列化学式：其中A，B，R 1 -R 8如本文所述，其可用于治疗与内皮素相关的疾病，例如高血压的内皮素抑制剂。这些化合物的化学合成和含有这些化合物的药物组合物也是有用的。

5. 发明授权

US5856484A Sulfonylaminopyrimidine carboxylic acid derivatives having endothelin inhibiting activity 失效
标题翻译：具有内皮素抑制活性的磺酰氨基嘧啶羧酸衍生物
公开(公告)号：US5856484A
公开(公告)日：1999-01-05
申请号：US726712
申请日：1996-10-07
申请人： Volker Breu , Kaspar Burri , Jean-Marie Cassal , Martine Clozel , Georges Hirth , Bernd-Michael Loffler , Marcel Muller , Werner Neidhart , Henri Ramuz
发明人： Volker Breu , Kaspar Burri , Jean-Marie Cassal , Martine Clozel , Georges Hirth , Bernd-Michael Loffler , Marcel Muller , Werner Neidhart , Henri Ramuz
IPC分类号： C07D239/52 , A61K31/495 , A61K31/505 , A61K31/535 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , C07D239/46 , C07D239/557 , C07D239/56 , C07D239/58 , C07D239/69 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/04 , C07D239/47 , C07D403/14
CPC分类号： C07D239/69
摘要： Compounds of formula I: ##STR1## are disclosed. The compounds inhibit the binding of endothelin to its receptors.
摘要翻译：式I化合物：我公开了。该化合物抑制内皮素与其受体的结合。

6. 发明授权

US5837708A Sulphonamides 失效
标题翻译：磺酰胺
公开(公告)号：US5837708A
公开(公告)日：1998-11-17
申请号：US730422
申请日：1996-10-15
申请人： Volker Breu , Kaspar Burri , Jean-Marie Cassal , Martine Clozel , Georges Hirth , Bernd-Michael Loffler , Marcel Muller , Werner Neidhart , Henri Ramuz
发明人： Volker Breu , Kaspar Burri , Jean-Marie Cassal , Martine Clozel , Georges Hirth , Bernd-Michael Loffler , Marcel Muller , Werner Neidhart , Henri Ramuz
IPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D239/69 , A61K31/505 , C07D403/12
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要： Compounds of the formula ##STR1## wherein the variables are hereinbelow defined. The compounds of formula I are inhibitors for endothelin receptors. They can be used for the treatment of disorders which are associated with endothelin activities, especially circulatory disorders such as hypertension, ischaemia, vasospasms and angina pectoris.
摘要翻译：下式定义的式（Ⅰ）化合物。式I化合物是内皮素受体的抑制剂。它们可用于治疗与内皮素活性相关的疾病，特别是循环系统疾病如高血压，局部缺血，血管痉挛和心绞痛。

7. 发明授权

US5420129A Phenylsulfonylamide pyrimidine 失效
公开(公告)号：US5420129A
公开(公告)日：1995-05-30
申请号：US164167
申请日：1993-12-08
申请人： Volker Breu , Kaspar Burri , Jean-Marie Cassal , Martine Clozel , Georges Hirth , Bernd-Michael Loffler , Marcel Muller , Werner Neidhart , Henri Ramuz
发明人： Volker Breu , Kaspar Burri , Jean-Marie Cassal , Martine Clozel , Georges Hirth , Bernd-Michael Loffler , Marcel Muller , Werner Neidhart , Henri Ramuz
IPC分类号： A61K31/505 , A61K31/506 , A61K31/535 , A61K31/5377 , A61P9/00 , A61P9/10 , A61P9/12 , A61P43/00 , C07D239/46 , C07D239/47 , C07D239/48 , C07D239/52 , C07D239/56 , C07D239/69 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , A61K31/50
CPC分类号： C07D239/47 , C07D239/48 , C07D239/52 , C07D239/56 , C07D239/69 , C07D401/12 , C07D405/12
摘要： The invention is concerned with novel sulphonamides and their use as medicaments. In particular, the invention is concerned with compounds of the formula ##STR1## wherein R.sup.1 is hydrogen, lower-alkyl, lower-alkoxy, lower-alkylthio, halogen or trifluoromethyl;R.sup.2 is hydrogen, lower-alkyl, halogen, lower-alkoxy, trifluoromethyl or --OCH.sub.2 COOR.sup.9 ;R.sup.3 is hydrogen, lower-alkyl, halogen, lower-alkylthio, trifluoromethyl, lower-alkoxy or trifluoromethoxy;R.sup.2 and R.sup.3 together are butadienyl, methylenedioxy, ethylenedioxy or isopropylidenedioxy;R.sup.4 is hydrogen, lower-alkyl, trifluoromethyl, lower-alkoxy, lower-alkylthio, hydroxy-lower-alkyl, hydroxy-lower-alkoxy, hydroxy-lower-alkoxy-lower-alkyl, hydroxy-lower-alkoxy-lower-alkoxy, alkoxy-lower-alkyl, alkoxy-lower-alkyloxy, lower-alkylsulfinyl, lower-alkylsulfonyl, 2-methoxy-3-hydroxypropoxy, 2-hydroxy-3-phenylpropyl, amino-lower-alkyl, lower-alkylamino-lower-alkyl, di-lower-alkylamino-lower-alkyl, amino, lower-alkylamino, di-lower-alkylamino, arylamino, aryl, arylthio, aryloxy, aryl-lower-alkyl, heterocyclyl, heterocyclo-lower-alkyl, heterocyclylamino, heterocyclylthio, heterocyclyloxy, --CHO, --CH.sub.2 OH or --CH.sub.2 Cl;R.sup.5 to R.sup.8 are independently hydrogen, halogen, trifluoromethyl, lower-alkoxy, lower-alkylthio or cyano;R.sup.6 and R.sup.5 or R.sup.7 together are butadienyl, methylene-dioxy, ethylenedioxy or isopropylidenedioxy;X is --O-- or --S--;Y is --CHO, C.sub.1-4 -alkyl, --(CH.sub.2).sub.1-4 --Z--R.sup.9, --(CH.sub.2).sub.1-4 --OC(O)(CH.sub.2).sub.1-4 CH.sub.3, --(CH.sub.2).sub.1-4 OC(O)Het, --(CH.sub.2).sub.1-4 NHC(O)R.sup.10, --(CH.sub.2).sub.1-4 OCH.sub.2 CH(OH)CH.sub.2 OH and cyclic ketals thereof, --(CH.sub.2).sub.1-4 NR.sup.9 CH.sub.2 CH(OH)CH.sub.2 OH, --(CH.sub.2).sub.1-4 OCH.sub.2 CH.sub.2 SCH.sub.3, --(CH.sub.2).sub.1-4 OCH.sub.2 CH.sub.2 S(O)CH.sub.3, --(CH.sub.2).sub.1-4 O(CH.sub.2).sub.1-4 --Z H, --(CH.sub.2).sub.1-4 O(CH.sub.2).sub.1-4 OC(O)R.sup.10, --(CH.sub.2).sub.1-4 NR.sup.9 (CH.sub.2).sub.1-4 Z H, --(CH.sub.2).sub.1-4 O(CH.sub.2).sub.1-4 OC(O)Het, --(CH.sub.2).sub.0-3 CH(OH)R.sup.10, --(CH.sub.2).sub.0-3 CH(OH)(CH.sub.2).sub.1-4 Z H, --(CH.sub.2).sub.0-3 CH(OH)CH.sub.2 SCH.sub.3, --(CH.sub.2).sub.0-3 CH(OH)CH.sub. 2 S(O)CH.sub.3, --(CH.sub.2).sub.0-3 CH(OH)OCH.sub.2 CH.sub.2 OH, --(CH.sub.2).sub.0-3 C(O)(CH.sub.2).sub.1-4 CH.sub.3, --(CH.sub.2).sub.0-3 C(O)(CH.sub.2).sub.1-4 Z R.sup.11, --(CH.sub.2).sub.0-3 C(O)CH.sub.2 Hal, --(CH.sub.2).sub.1-4 Hal, --(CH.sub.2).sub.1-4 CN, --(CH.sub.2).sub.0-3 C(O)OR.sup.9, --OR.sup.12 or --SR.sup.12 ;R.sup.9 is hydrogen or C.sub.1-4 -alkyl;R.sup.10 is C.sub.1-4 -alkyl;R.sup.11 is hydrogen, C.sub.1-4 -alkanoyl or heterocyclylcarbonyl;R.sup.12 is C.sub.1-4 -alkyl or --(CH.sub.2).sub.0-4 -aryl;Z is --O--, --S-- or --NR.sup.9 --;Het is a heterocyclic residue;Hal is halogen; andn is 0 or 1; and salts thereof.

8. 发明授权

US5292740A Sulfonamides 失效
标题翻译：磺胺类
公开(公告)号：US5292740A
公开(公告)日：1994-03-08
申请号：US896015
申请日：1992-06-09
申请人： Kaspar Burri , Martine Clozel , Walter Fischli , Georges Hirth , Bernd-Michael Loffler , Werner Neidhart , Henri Ramuz
发明人： Kaspar Burri , Martine Clozel , Walter Fischli , Georges Hirth , Bernd-Michael Loffler , Werner Neidhart , Henri Ramuz
IPC分类号： A61K31/505 , A61K20060101 , A61K31/18 , A61K31/63 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P25/04 , A61P25/06 , C07C311/15 , C07D20060101 , C07D239/42 , C07D239/46 , C07D239/48 , C07D239/52 , C07D239/56 , C07D239/58 , C07D239/69 , C07D311/20 , C07D401/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D407/14 , C07D409/04 , C07D409/14 , C07D413/12 , C07D403/04 , C07D239/47 , C07D401/14 , C07D403/14 , C07D413/04
CPC分类号： C07D239/47 , C07D239/69 , C07D401/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D407/14 , C07D409/04 , C07D409/14 , C07D413/10
摘要： The novel sulfonamides of formula I, ##STR1## in which the symbols R.sup.1 -R.sup.9, R.sup.a, R.sup.b, X, Y and n have the significance given in the description and salts thereof can be used for the treatment of circulatory disorders, especially hypertension, ischemia, vasopasms and angina pectoris.
摘要翻译：其中符号R1-R9，Ra，Rb，X，Y和n具有在其描述中给出的含义及其盐的式I的新型磺酰胺，其中符号R1-R9，Ra，Rb，X，Y和n可用于治疗循环系统疾病，特别是高血压，缺血，血管扩张和心绞痛。

9. 发明授权

US5270313A Sulfonamides and uses 失效
标题翻译：磺酰胺和用途
公开(公告)号：US5270313A
公开(公告)日：1993-12-14
申请号：US869274
申请日：1992-04-15
申请人： Kaspar Burri , Martine Clozel , Walter Fischli , Georges Hirth , Bernd M. Loffler , Henri Ramuz
发明人： Kaspar Burri , Martine Clozel , Walter Fischli , Georges Hirth , Bernd M. Loffler , Henri Ramuz
IPC分类号： A61K31/505 , A61K31/495 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/48 , C07D239/69 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/12
CPC分类号： C07D401/12 , C07D239/69 , C07D405/12 , C07D409/12 , C07D413/10
摘要： Sulfonamides of formula I, in which the symbols R.sup.1 -R.sup.6, X, Y and n have the significance given in the description and which are in part novel compounds, and salts thereof, which can be used as active ingredients for the manufacture of medicaments for the treatment of circulatory disorders, especially hypertension, ischemia, vasospasms and angina pectoris, are described.
摘要翻译：式I的磺酰胺，其中符号R1-R6，X，Y和n具有在说明书中给出的并且部分新化合物的含义及其盐，其可以用作制备药物的活性成分描述了循环系统疾病，特别是高血压，局部缺血，血管痉挛和心绞痛的治疗。

10. 发明授权

US06242601B1 Heterocyclic sulfamides 失效
标题翻译：杂环磺酰胺
公开(公告)号：US06242601B1
公开(公告)日：2001-06-05
申请号：US09482810
申请日：2000-01-13
申请人： Volker Breu , Philippe Coassolo , Rolf Huber , Werner Neidhart , Henri Ramuz , Sébastien Roux , Hans Peter Wessel
发明人： Volker Breu , Philippe Coassolo , Rolf Huber , Werner Neidhart , Henri Ramuz , Sébastien Roux , Hans Peter Wessel
IPC分类号： C07D23928
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The compounds of formula (I) wherein R1, R2 and X have the significance as given in the description, are inhibitors of endothelin receptors and can therefore be used for the treatment of disorders which are associated with abnormal vascular tone and endothelial dysfunction.
摘要翻译：其中R1，R2和X具有如说明书中给出的含义的式（I）化合物是内皮素受体的抑制剂，因此可用于治疗与血管紧张素和内皮功能障碍异常有关的疾病。

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