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1. 发明授权

US09179922B2 Method of making interventional medical device system having a slotted section and radiopaque marker 有权
标题翻译：具有开槽部分和不透射线标记的介入医疗装置系统的方法
公开(公告)号：US09179922B2
公开(公告)日：2015-11-10
申请号：US13469375
申请日：2012-05-11
申请人： Keith Balgobin , Vladimir Mitelberg , Jason Rainer , John H. Thinnes, Jr.
发明人： Keith Balgobin , Vladimir Mitelberg , Jason Rainer , John H. Thinnes, Jr.
IPC分类号： A61M25/098 , B21D39/04 , A61B17/12 , A61M25/01 , A61M25/00 , A61B17/00 , A61B19/00
CPC分类号： A61B17/1214 , A61B17/00234 , A61B17/12022 , A61B90/39 , A61B90/80 , A61B2017/00292 , A61B2017/00526 , A61B2017/12054 , A61B2090/3966 , A61M25/0012 , A61M25/0108 , B21D39/046 , Y10T29/49904 , Y10T29/49908
摘要： A system is provided that includes an elongated introducer navigable through body vessels of a human subject and a pusher component for incorporation within the introducer. The pusher component includes a tubular portion with a slotted section. A radiopaque marker is secured to at least a portion of the slotted section such that an outer surface of the radiopaque marker is substantially flush with an outer surface of the tubular portion immediately proximal and/or immediately distal the radiopaque marker. According to a method of manufacturing such a component, the slotted section is formed by a laser cutting operation and a pre-assembly radiopaque marker member is crimped onto the slotted section.
摘要翻译：提供了一种系统，其包括可通过人体受试者的身体血管通过的细长导引器和用于结合在导引器内的推动器部件。推动器部件包括具有开槽部分的管状部分。不透射线的标记被固定到开槽部分的至少一部分，使得不透射线标记的外表面基本上与管状部分的外表面基本上齐平，并且和/或紧邻不透射线标记的远侧。根据制造这种部件的方法，通过激光切割操作形成开槽部分，并将预组装不透射线的标记部件压接到开槽部分上。

2. 发明授权

US08062325B2 Implantable medical device detachment system and methods of using the same 有权
标题翻译：植入式医疗装置拆卸系统及其使用方法
公开(公告)号：US08062325B2
公开(公告)日：2011-11-22
申请号：US11461245
申请日：2006-07-31
申请人： Vladimir Mitelberg , John H. Thinnes, Jr. , Keith Balgobin
发明人： Vladimir Mitelberg , John H. Thinnes, Jr. , Keith Balgobin
IPC分类号： A61M29/00
CPC分类号： A61F2/95 , A61F2002/9505 , A61F2002/9511 , Y10T29/49826
摘要： An implantable medical device detachment system is provided with a carrier member having a compressible portion at a distal end thereof. The compressible portion is moved to a compressed condition to allow an engagement member of the system to releasably engage an implantable device, such as an embolic coil. The carrier member and associated implantable device are fed through a body vessel to a target location, where the device is disengaged from the engagement member. The compressible portion then moves from the compressed condition to an elongated condition to completely separate the implantable device from the engagement member.
摘要翻译：可植入式医疗装置拆卸系统设置有在其远端具有可压缩部分的承载构件。可压缩部分被移动到压缩状态，以允许系统的接合构件可释放地接合诸如栓塞线圈的可植入装置。承载构件和相关联的可植入装置通过身体容器进给到目标位置，在该位置处，装置与接合构件脱开。可压缩部分然后从压缩状态移动到细长状态以将可植入装置与接合构件完全分开。

3. 发明申请

US20120222286A1 METHOD OF MAKING INTERVENTIONAL MEDICAL DEVICE SYSTEM HAVING A SLOTTED SECTION AND RADIOPAQUE MARKER 有权
标题翻译：制造具有插槽部分和放射性标记的传统医疗装置系统的方法
公开(公告)号：US20120222286A1
公开(公告)日：2012-09-06
申请号：US13469375
申请日：2012-05-11
申请人： Keith Balgobin , Vladimir Mitelberg , Jason Rainer , John H. Thinnes, JR.
发明人： Keith Balgobin , Vladimir Mitelberg , Jason Rainer , John H. Thinnes, JR.
IPC分类号： B23P11/00
CPC分类号： A61B17/1214 , A61B17/00234 , A61B17/12022 , A61B90/39 , A61B90/80 , A61B2017/00292 , A61B2017/00526 , A61B2017/12054 , A61B2090/3966 , A61M25/0012 , A61M25/0108 , B21D39/046 , Y10T29/49904 , Y10T29/49908
摘要： A system is provided that includes an elongated introducer navigable through body vessels of a human subject and a pusher component for incorporation within the introducer. The pusher component includes a tubular portion with a slotted section. A radiopaque marker is secured to at least a portion of the slotted section such that an outer surface of the radiopaque marker is substantially flush with an outer surface of the tubular portion immediately proximal and/or immediately distal the radiopaque marker. According to a method of manufacturing such a component, the slotted section is formed by a laser cutting operation and a pre-assembly radiopaque marker member is crimped onto the slotted section.
摘要翻译：提供了一种系统，其包括可通过人体受试者的身体血管通过的细长导引器和用于结合在导引器内的推动器部件。推动器部件包括具有开槽部分的管状部分。不透射线的标记被固定到开槽部分的至少一部分，使得不透射线标记的外表面基本上与管状部分的外表面基本上齐平，并且和/或紧邻不透射线标记的远侧。根据制造这种部件的方法，通过激光切割操作形成开槽部分，并将预组装不透射线的标记部件压接到开槽部分上。

4. 发明授权

US07819891B2 Stretch resistant embolic coil delivery system with spring release mechanism 有权
标题翻译：具弹簧释放机构的抗张力线栓输送系统
公开(公告)号：US07819891B2
公开(公告)日：2010-10-26
申请号：US11395924
申请日：2006-03-31
申请人： Keith Balgobin , Donald K. Jones , Vladimir Mitelberg , John H. Thinnes, Jr.
发明人： Keith Balgobin , Donald K. Jones , Vladimir Mitelberg , John H. Thinnes, Jr.
IPC分类号： A61M29/00 , A61F2/06
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12154 , A61B2017/00477 , A61B2017/00862 , A61B2017/12054
摘要： A medical device for placing an embolic device at a predetermined site within a vessel of the body including a delivery catheter and a flexible pusher member slidably disposed within the lumen of the catheter. An embolic device is retained within the delivery catheter by a mechanical interlocking mechanism which includes an engagement member attached to the distal end of the pusher member and extends through a retaining ring at the proximal end of the embolic device. A detachment member extends through an aperture at the distal end of the engagement member thereby locking the embolic device onto the pusher member. A kicker member extends from the distal end of the pusher member and is biased so as to lift the retaining ring off of the engagement member to ensure the release of the embolic device when the detachment member is withdrawn from the aperture of the engagement member.
摘要翻译：一种用于将栓塞装置放置在主体容器内的预定位置处的医疗装置，包括输送导管和可滑动地设置在导管内腔内的柔性推动器构件。栓塞装置通过机械互锁机构保持在输送导管内，该机械互锁机构包括附接到推动器构件的远端的接合构件并延伸穿过栓塞装置的近端处的保持环。分离构件延伸穿过接合构件的远端处的孔，从而将栓塞装置锁定到推动器构件上。推动器构件从推动器构件的远端延伸并且被偏压以便将保持环从接合构件提起，以确保当分离构件从接合构件的孔中取出时栓塞装置的释放。

5. 发明授权

US07799052B2 Stretch resistant embolic coil delivery system with mechanical release mechanism 有权
标题翻译：具有机械释放机制的抗拉伸栓塞线圈输送系统
公开(公告)号：US07799052B2
公开(公告)日：2010-09-21
申请号：US11471801
申请日：2006-06-21
申请人： Keith Balgobin , Vladimir Mitelberg , Dirk Tenne , John H. Thinnes, Jr.
发明人： Keith Balgobin , Vladimir Mitelberg , Dirk Tenne , John H. Thinnes, Jr.
IPC分类号： A61M29/00 , A61F2/06
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12154 , A61B2017/00477 , A61B2017/12054
摘要： A medical device for placing an embolic device at a predetermined site within a vessel of the body including a delivery catheter and a flexible pusher member slidably disposed within the lumen of the catheter. An embolic device is retained within the delivery catheter by a mechanical interlocking mechanism which includes an engagement member attached to the distal end of the pusher member and extends through a retaining ring at the proximal end of the embolic device. A detachment member extends through an aperture at the distal end of the engagement member thereby locking the embolic device onto the pusher member. A kicker tongue which is formed as an extension of a portion of the wall of the pusher member extends distally from the distal end of the pusher member and is biased so as to lift the retaining ring off of the engagement member to ensure the release of the embolic device when the detachment member is withdrawn from the aperture of the engagement member.
摘要翻译：一种用于将栓塞装置放置在主体容器内的预定位置处的医疗装置，包括输送导管和可滑动地设置在导管内腔内的柔性推动器构件。栓塞装置通过机械互锁机构保持在输送导管内，该机械互锁机构包括附接到推动器构件的远端的接合构件并延伸穿过栓塞装置的近端处的保持环。分离构件延伸穿过接合构件的远端处的孔，从而将栓塞装置锁定到推动器构件上。形成为推动器构件的壁的一部分的延伸部的推杆舌片从推动器构件的远端向远侧延伸并且被偏压以将保持环从接合构件提升以确保释放当分离构件从接合构件的孔中取出时，栓塞装置。

6. 发明授权

US08425537B2 Method of using interventional medical device system having an elongation retarding portion 有权
标题翻译：使用具有伸长延迟部分的介入医疗装置系统的方法
公开(公告)号：US08425537B2
公开(公告)日：2013-04-23
申请号：US13608532
申请日：2012-09-10
申请人： Vladimir Mitelberg , John H. Thinnes, Jr. , Keith Balgobin , William W. Sowers
发明人： Vladimir Mitelberg , John H. Thinnes, Jr. , Keith Balgobin , William W. Sowers
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B2017/12054 , A61B2090/037
摘要： Use of an interventional medical device system operable while within a body vessel is provided with a generally hollow tubular proximal portion, distal portion, and intermediate portion. The proximal portion and at least part of the distal portion remains outside of the body in use, with the remainder of the distal portion positioned within the body. The intermediate portion includes a spiral ribbon having adjacent turns, with at least one frangible bridge member between two adjacent turns. The proximal and distal portions are movable away from each other by elongating the spiral ribbon and, eventually, breaking the frangible bridge member. According to the method of using such a system to deploy an implantable medical device, such as an embolic coil, an actuation member is moved proximally with the proximal portion to disengage a bond or joint between the actuation member and the implantable medical device.
摘要翻译：在身体容器内可操作的介入医疗装置系统的使用设置有大致中空的管状近端部分，远侧部分和中间部分。近端部分和远侧部分的至少一部分在使用中保持在身体的外部，而远侧部分的其余部分位于体内。中间部分包括具有相邻匝的螺旋带，在两个相邻匝之间具有至少一个易碎的桥构件。近端部分和远端部分通过延长螺旋带并且最终破坏易碎的桥接部件而彼此远离。根据使用这种系统来部署诸如栓塞线圈的可植入医疗装置的方法，致动构件与近侧部分向近侧移动，以解除致动构件和可植入医疗装置之间的结合或接合。

7. 发明申请

US20120035707A1 METHODS OF USING IMPLANTABLE MEDICAL DEVICE DETACHMENT SYSTEM 审中-公开
标题翻译：使用可植入医疗器械分离系统的方法
公开(公告)号：US20120035707A1
公开(公告)日：2012-02-09
申请号：US13276651
申请日：2011-10-19
申请人： Vladimir Mitelberg , John H. Thinnes, JR. , Keith Balgobin
发明人： Vladimir Mitelberg , John H. Thinnes, JR. , Keith Balgobin
IPC分类号： A61F2/84 , B23P11/00
CPC分类号： A61F2/95 , A61F2002/9505 , A61F2002/9511 , Y10T29/49826
摘要： Implantable medical device detachment methods are provided using a carrier member having a compressible portion at a distal end thereof. The compressible portion is moved to a compressed condition to allow an engagement member of the system to releasably engage an implantable device, such as an embolic coil. The carrier member and associated implantable device are fed through a body vessel to a target location, where the device is disengaged from the engagement member. The compressible portion then moves from the compressed condition to an elongated condition to completely separate the implantable device from the engagement member.
摘要翻译：使用在其远端具有可压缩部分的载体构件提供植入式医疗装置拆卸方法。可压缩部分被移动到压缩状态，以允许系统的接合构件可释放地接合诸如栓塞线圈的可植入装置。承载构件和相关联的可植入装置通过身体容器进给到目标位置，在该位置处，装置与接合构件脱开。可压缩部分然后从压缩状态移动到细长状态以将可植入装置与接合构件完全分开。

8. 发明授权

US07819892B2 Embolic coil delivery system with spring wire release mechanism 有权
标题翻译：带弹簧丝释放机构的栓塞线圈输送系统
公开(公告)号：US07819892B2
公开(公告)日：2010-10-26
申请号：US11541023
申请日：2006-09-29
申请人： Keith Balgobin , Vladimir Mitelberg , John H. Thinnes, Jr.
发明人： Keith Balgobin , Vladimir Mitelberg , John H. Thinnes, Jr.
IPC分类号： A61M29/00 , A61F2/06
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12154 , A61B2017/00477 , A61B2017/12054
摘要： A medical device for placing an embolic device at a predetermined site within a vessel of the body including a delivery catheter and a flexible pusher member slidably disposed within the lumen of the catheter. An embolic device is retained within the delivery catheter by a mechanical interlocking mechanism which includes an engagement member attached to the distal end of the pusher member and extends through a retaining ring at the proximal end of the embolic device. A detachment member extends through an aperture at the distal end of the engagement member thereby locking the embolic device onto the pusher member. A kicker member which takes the form of a generally U-shaped wire spring which extends from the distal end of the pusher member and is biased so as to lift the retaining ring off of the engagement member to ensure the release of the embolic device when the detachment member is withdrawn from the aperture of the engagement member.
摘要翻译：一种用于将栓塞装置放置在主体容器内的预定位置处的医疗装置，包括输送导管和可滑动地设置在导管内腔内的柔性推动器构件。栓塞装置通过机械互锁机构保持在输送导管内，该机械互锁机构包括附接到推动器构件的远端的接合构件并延伸穿过栓塞装置的近端处的保持环。分离构件延伸穿过接合构件的远端处的孔，从而将栓塞装置锁定到推动器构件上。采用大体上U形的线弹簧的形式的起动器构件，其从推动器构件的远端延伸并且被偏压以便将保持环从接合构件提起以确保当栓塞装置释放时脱离构件从接合构件的孔中取出。

9. 发明授权

US07708754B2 Stretch resistant embolic coil delivery system with mechanical release mechanism 有权
标题翻译：具有机械释放机制的抗拉伸栓塞线圈输送系统
公开(公告)号：US07708754B2
公开(公告)日：2010-05-04
申请号：US11755364
申请日：2007-05-30
申请人： Keith Balgobin , Vladimir Mitelberg , John H. Thinnes, Jr.
发明人： Keith Balgobin , Vladimir Mitelberg , John H. Thinnes, Jr.
IPC分类号： A61M29/00 , A61F2/06
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12154 , A61B2017/00477 , A61B2017/12054
摘要： A medical device for placing an embolic device at a predetermined site within a vessel of the body including a delivery catheter and a flexible pusher member slidably disposed within the lumen of the catheter. An embolic device is retained within the delivery catheter by a mechanical interlocking mechanism which includes an engagement member attached to the distal end of the pusher member and extends through a retaining ring at the proximal end of the embolic device. A detachment member extends through an aperture at the distal end of the engagement member thereby locking the embolic device onto the pusher member. A kicker member extends from the distal end of the pusher member and is comprised of a shape memory material adapted to lift the retaining ring off of the engagement member at human body temperature when the detachment member is withdrawn from the aperture of the engagement member.
摘要翻译：一种用于将栓塞装置放置在主体容器内的预定位置处的医疗装置，包括输送导管和可滑动地设置在导管内腔内的柔性推动器构件。栓塞装置通过机械互锁机构保持在输送导管内，该机械互锁机构包括附接到推动器构件的远端的接合构件并延伸穿过栓塞装置的近端处的保持环。分离构件延伸穿过接合构件的远端处的孔，从而将栓塞装置锁定到推动器构件上。冲击构件从推动器构件的远端延伸并且包括形状记忆材料，该形状记忆材料适合于当脱离构件从接合构件的孔中取出时将保持环从人体温度离开接合构件提升。

10. 发明授权

US07708704B2 Interventional medical device component having an interrupted spiral section and method of making the same 有权
标题翻译：具有中断螺旋段的介入医疗装置部件及其制造方法
公开(公告)号：US07708704B2
公开(公告)日：2010-05-04
申请号：US11461219
申请日：2006-07-31
申请人： Vladimir Mitelberg , John H. Thinnes, Jr. , Keith Balgobin , William W. Sowers
发明人： Vladimir Mitelberg , John H. Thinnes, Jr. , Keith Balgobin , William W. Sowers
IPC分类号： A61B5/00 , A61F2/24 , A61M5/178 , A61M25/00
CPC分类号： A61M25/0043 , A61M25/0054 , Y10T83/0524
摘要： A component for use as or for incorporation within a medical instrument navigable through body vessels of a human subject is provided. The component includes a tubular portion with an interrupted spiral defined by alternating cut and uncut sections. The sum of the arcuate extents of each bridge section and a cut section adjacent to the bridge section in end-to-end fashion is neither a whole number factor of 360 degrees nor a multiple of 90 degrees; this provides uniform rigidity, flexibility, and stretch resistance in all bending planes. The device further includes multiple sections, the pitch of the spiral varying from section to section in order to vary the sections' flexibilities.
摘要翻译：提供了用于或并入可以通过人类受试者身体血管通过的医疗器械中的部件。该部件包括具有由交替切割和未切割部分限定的中断螺旋的管状部分。每个桥接部分的弧形范围和与端部连接的桥接部分相邻的切割部分的总和既不是360度的整数，也不是90度的倍数; 这在所有弯曲平面中提供均匀的刚度，柔性和抗拉伸性。该装置还包括多个部分，螺旋桨的间距从部分变化到部分，以便改变部分的灵活性。

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