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1. 发明申请

US20160151346A1 N-ETHYL-N-PHENYL-1,2-DIHYDRO-4,5-DI-HYDROXY-1-METHYL-2-OXO-3-QUINOLINECARBOXAMIDE, PREPARATION AND USES THEREOF 审中-公开
公开(公告)号：US20160151346A1
公开(公告)日：2016-06-02
申请号：US15013633
申请日：2016-02-02
申请人： Vladimir Ioffe , Konstantin Ulanenko , Avital Laxer , Muhammad Safadi , Danit Licht , Ioana Lovinger , Ulf Tomas Fristedt
发明人： Vladimir Ioffe , Konstantin Ulanenko , Avital Laxer , Muhammad Safadi , Danit Licht , Ioana Lovinger , Ulf Tomas Fristedt
IPC分类号： A61K31/4704 , B65D50/00 , B65D41/04 , A61J1/03 , B65D1/02
CPC分类号： A61K31/4704 , A61J1/035 , A61K9/20 , A61K9/2813 , A61K9/48 , A61K9/4891 , B65D1/0207 , B65D41/04 , B65D41/0407 , B65D50/00 , B65D51/24 , B65D81/264 , C07D215/56
摘要： The subject invention provides a pharmaceutical composition containing laquinimod or a pharmaceutically acceptable salt thereof, and a compound of N-ethyl-N-phenyl-1,2-dihydro-4,5-di-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide or a salt thereof.

2. 发明申请

US20130217724A1 N-ETHYL-N-PHENYL-1,2-DIHYDRO-4,5-DI-HYDROXY-1-METHYL-2-OXO-3-QUINOLINECARBOXAMIDE, PREPARATION AND USES THEREOF 有权
标题翻译： N-乙基-N-苯基-1,2-二氢-4,5-二羟基-1-甲基-2-氧代-3-喹啉甲酰胺，其制备及其用途
公开(公告)号：US20130217724A1
公开(公告)日：2013-08-22
申请号：US13768919
申请日：2013-02-15
申请人： Vladimir Ioffe , Konstantin Ulanenko , Avital Laxer , Muhammad Safadi , Danit Licht , Ioana Lovinger , Ulf Tomas Fristedt
发明人： Vladimir Ioffe , Konstantin Ulanenko , Avital Laxer , Muhammad Safadi , Danit Licht , Ioana Lovinger , Ulf Tomas Fristedt
IPC分类号： C07D215/56 , A61J1/03 , A61K31/4704
CPC分类号： A61K31/4704 , A61J1/035 , A61K9/20 , A61K9/2813 , A61K9/48 , A61K9/4891 , B65D1/0207 , B65D41/04 , B65D41/0407 , B65D50/00 , B65D51/24 , B65D81/264 , C07D215/56
摘要： The subject invention provides a pharmaceutical composition containing laquinimod or a pharmaceutically acceptable salt thereof, and a compound of N-ethyl-N-phenyl-1,2-dihydro-4,5-di-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide or a salt thereof.
摘要翻译：本发明提供含有拉喹莫德或其药学上可接受的盐的药物组合物和N-乙基-N-苯基-1,2-二氢-4,5-二羟基-1-甲基-2-氧代 - 3-喹啉甲酰胺或其盐。

3. 发明授权

US09284276B2 N-ethyl-N-phenyl-1,2-dihydro-4,5-di-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide, preparation and uses thereof 有权
标题翻译： N-乙基-N-苯基-1,2-二氢-4,5-二羟基-1-甲基-2-氧代-3-喹啉甲酰胺的制备及其用途
公开(公告)号：US09284276B2
公开(公告)日：2016-03-15
申请号：US13768919
申请日：2013-02-15
申请人： Vladimir Ioffe , Konstantin Ulanenko , Avital Laxer , Muhammad Safadi , Danit Licht , Ioana Lovinger , Ulf Tomas Fristedt
发明人： Vladimir Ioffe , Konstantin Ulanenko , Avital Laxer , Muhammad Safadi , Danit Licht , Ioana Lovinger , Ulf Tomas Fristedt
IPC分类号： C07D215/56 , A61K31/4704 , A61J1/03
CPC分类号： A61K31/4704 , A61J1/035 , A61K9/20 , A61K9/2813 , A61K9/48 , A61K9/4891 , B65D1/0207 , B65D41/04 , B65D41/0407 , B65D50/00 , B65D51/24 , B65D81/264 , C07D215/56
摘要： The subject invention provides a pharmaceutical composition containing laquinimod or a pharmaceutically acceptable salt thereof, and a compound of N-ethyl-N-phenyl-1,2-dihydro-4,5-di-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide or a salt thereof.
摘要翻译：本发明提供含有拉喹莫德或其药学上可接受的盐的药物组合物和N-乙基-N-苯基-1,2-二氢-4,5-二羟基-1-甲基-2-氧代 - 3-喹啉甲酰胺或其盐。

4. 发明申请

US20170065576A1 N-ETHYL-N-PHENYL-1,2-DIHYDRO-4,5-DI-HYDROXY-1-METHYL-2-OXO-3-QUINOLINECARBOXAMIDE, PREPARATION AND USES THEREOF 审中-公开
标题翻译： N-乙基-N-苯基-1,2-二氢-4,5-二羟基-1-甲基-2-氧代-3-喹啉甲酰胺，其制备及其用途
公开(公告)号：US20170065576A1
公开(公告)日：2017-03-09
申请号：US15354836
申请日：2016-11-17
申请人： Vladimir Ioffe , Konstantin Ulanenko , Avital Laxer , Muhammad Safadi , Danit Licht , Ioana Lovinger , Ulf Tomas Fristedt
发明人： Vladimir Ioffe , Konstantin Ulanenko , Avital Laxer , Muhammad Safadi , Danit Licht , Ioana Lovinger , Ulf Tomas Fristedt
IPC分类号： A61K31/4704 , A61K9/20 , B65D81/26 , B65D1/02 , B65D41/04 , B65D51/24 , A61K9/48 , A61J1/03
CPC分类号： A61K31/4704 , A61J1/035 , A61K9/20 , A61K9/2813 , A61K9/48 , A61K9/4891 , B65D1/0207 , B65D41/04 , B65D41/0407 , B65D50/00 , B65D51/24 , B65D81/264 , C07D215/56
摘要： The subject invention provides a pharmaceutical composition containing laquinimod or a pharmaceutically acceptable salt thereof, and a compound of N-ethyl-N-phenyl-1,2-dihydro-4,5-di-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide or a salt thereof.
摘要翻译：本发明提供含有拉喹莫德或其药学上可接受的盐的药物组合物和N-乙基-N-苯基-1,2-二氢-4,5-二羟基-1-甲基-2-氧代 - 3-喹啉甲酰胺或其盐。

5. 发明申请

US20160151345A1 N-ETHYL-N-PHENYL-1,2-DIHYDRO-4,5-DI-HYDROXY-1-METHYL-2-OXO-3-QUINOLINECARBOXAMIDE, PREPARATION AND USES THEREOF 审中-公开
公开(公告)号：US20160151345A1
公开(公告)日：2016-06-02
申请号：US15013586
申请日：2016-02-02
申请人： Vladimir Ioffe , Konstantin Ulanenko , Avital Laxer , Muhammad Safadi , Danit Licht , Ioana Lovinger , Ulf Tomas Fristedt
发明人： Vladimir Ioffe , Konstantin Ulanenko , Avital Laxer , Muhammad Safadi , Danit Licht , Ioana Lovinger , Ulf Tomas Fristedt
IPC分类号： A61K31/4704 , B65D1/02 , A61J1/03 , A61K9/28 , A61K9/48
CPC分类号： A61K31/4704 , A61J1/035 , A61K9/20 , A61K9/2813 , A61K9/48 , A61K9/4891 , B65D1/0207 , B65D41/04 , B65D41/0407 , B65D50/00 , B65D51/24 , B65D81/264 , C07D215/56
摘要： The subject invention provides a pharmaceutical composition containing laquinimod or a pharmaceutically acceptable salt thereof, and a compound of N-ethyl-N-phenyl-1,2-dihydro-4,5-di-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide or a salt thereof.

6. 发明申请

US20170020854A1 PRIDOPIDINE BASE FORMULATIONS AND THEIR USE 审中-公开
标题翻译：孕激素基础配方及其使用
公开(公告)号：US20170020854A1
公开(公告)日：2017-01-26
申请号：US15217806
申请日：2016-07-22
申请人： Danit Licht , Ioana Lovinger , Muhammad Safadi
发明人： Danit Licht , Ioana Lovinger , Muhammad Safadi
IPC分类号： A61K31/451 , A61K9/28 , A61K9/48 , A61K9/00
CPC分类号： A61K31/451 , A61K9/0053 , A61K9/28 , A61K9/2846 , A61K9/4891
摘要： This invention provides modified release solid oral dosage form comprising a therapeutically effective amount of pridopidine base, and at least one pharmaceutically acceptable rate controlling excipient.
摘要翻译：本发明提供了包含治疗有效量的格列盼碱和至少一种药学上可接受的速率控制赋形剂的修饰释放固体口服剂型。

7. 发明申请

US20140018386A1 LAQUINIMOD FORMULATIONS WITHOUT ALKALIZING AGENT 审中-公开
标题翻译：没有碱化剂的LAQUINIMOD配方
公开(公告)号：US20140018386A1
公开(公告)日：2014-01-16
申请号：US13938733
申请日：2013-07-10
申请人： Gadi Sarfati , Ioana Lovinger , Danit Licht , Muhammad Safadi
发明人： Gadi Sarfati , Ioana Lovinger , Danit Licht , Muhammad Safadi
IPC分类号： A61K31/4704
CPC分类号： A61K31/4704 , A61K9/0053 , A61K9/2013 , A61K9/2018 , A61K9/2095 , A61K9/4858
摘要： The subject invention provides a stable pharmaceutical composition comprising a therapeutically effective amount of laquinimod, an amount of a filler, and an amount of a lubricant, wherein the stable pharmaceutical composition is free of an alkalizing agent or an oxidation reducing agent. Also provided are processes for making the stable pharmaceutical composition and sealed packages comprising the stable pharmaceutical composition. Also provided is a method for treating a subject afflicted with a form of multiple sclerosis (MS) or for alleviating a symptom of MS in a subject afflicted with a form of MS comprising administering to the subject a stable pharmaceutical composition as described herein. Also provided is use of a stable pharmaceutical composition as described herein for treating a subject afflicted with a form of MS or for alleviating a symptom of MS in a subject afflicted with a form of multiple MS.
摘要翻译：本发明提供了稳定的药物组合物，其包含治疗有效量的拉喹莫德，一定量的填充剂和一定量的润滑剂，其中稳定的药物组合物不含碱化剂或氧化还原剂。还提供了制备稳定的药物组合物和包含稳定的药物组合物的密封包装的方法。还提供了治疗患有多发性硬化症（MS）形式的受试者或用于减轻患有MS形式的受试者中的MS症状的方法，包括向受试者施用如本文所述的稳定的药物组合物。还提供了本文所述的稳定药物组合物的用途，用于治疗患有MS形式的受试者或用于减轻患有多发性MS形式的受试者的MS症状。

8. 发明申请

US20170028013A1 COMBINATION FORMULATION OF LAQUINIMOD AND GLATIRAMER ACETATE WITH AMINO ACIDS 审中-公开
标题翻译：氨基酸和氨基酸乙酯与氨基酸的组合配方
公开(公告)号：US20170028013A1
公开(公告)日：2017-02-02
申请号：US15222213
申请日：2016-07-28
申请人： Galina Linden , Rakefet Cohen , Danit Licht
发明人： Galina Linden , Rakefet Cohen , Danit Licht
IPC分类号： A61K38/02 , A61K47/02 , A61K9/00 , A61K47/26 , A61K31/4704 , A61K31/198
CPC分类号： A61K38/02 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K31/198 , A61K31/4704 , A61K47/02 , A61K47/183 , A61K47/26 , A61K2300/00
摘要： A stable pharmaceutical composition comprising a therapeutically effective amount of laquinimod, a therapeutically effective amount of glatiramer acetate related drug substance, and an amount of an amino acid. A process for making a stable pharmaceutical in liquid form, a sealed package comprising a stable pharmaceutical composition as described herein, and a use of a stable pharmaceutical composition as described herein. A method for treating a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome, alleviating a symptom of multiple sclerosis in a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome, and/or providing neuroprotection to a subject in need thereof, comprising administering to the subject a composition as described herein.
摘要翻译：一种稳定的药物组合物，其包含治疗有效量的拉喹莫德，治疗有效量的醋酸格拉默相关药物和一定量的氨基酸。制备液体形式的稳定药物的方法，包含本文所述的稳定的药物组合物的密封包装以及本文所述的稳定的药物组合物的用途。一种用于治疗患有多发性硬化或呈现临床分离综合征的受试者，减轻患有多发性硬化症或呈现临床分离综合征的受试者的多发性硬化症状和/或向有需要的受试者提供神经保护的方法，包括向受试者施用如本文所述的组合物。

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