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1. 发明授权

US4788211A Antifungal compound and AFC complex produced from actinomadura SCC 1838 失效
标题翻译：由放线菌SCC 1838生产的抗真菌化合物和AFC复合物
公开(公告)号：US4788211A
公开(公告)日：1988-11-29
申请号：US89297
申请日：1987-08-25
申请人： Vinod R. Hegde , Mahesh G. Patel , Ann C. Horan , Ingrid-Agneta Gunnarsson
发明人： Vinod R. Hegde , Mahesh G. Patel , Ann C. Horan , Ingrid-Agneta Gunnarsson
IPC分类号： C07D233/46 , C12P17/10 , A61K31/415 , C07D233/02
CPC分类号： C12P17/10 , C07D233/46 , Y10S435/825
摘要： The invention relates to an antifungal compound of the following structural formula ##STR1## which is isolated from the AFC complex elaborated by the microorganism Actinomadura sp: nov SCC 1838, ATCC 53656.
摘要翻译：本发明涉及从由微生物Actinomadura sp：nov SCC 1838，ATCC 53656制备的AFC复合物中分离出的以下结构式的抗真菌化合物（IMAGE）+ TR＆lt; IMAGE＆gt;。

2. 发明授权

US5837691A Actinomadura vulgaris subsp vulgaris and antimicrobial complex and antimicrobial 失效
标题翻译：寻常型Actinomadura寻常型和抗菌复合抗菌
公开(公告)号：US5837691A
公开(公告)日：1998-11-17
申请号：US747456
申请日：1991-08-12
申请人： Vinod R. Hegde , Ann C. Horan , Mahesh G. Patel , Ingrid-Agneta Gunnarsson
发明人： Vinod R. Hegde , Ann C. Horan , Mahesh G. Patel , Ingrid-Agneta Gunnarsson
IPC分类号： C07H17/02 , C12P19/60 , A61K31/71 , C07H17/08
CPC分类号： C12R1/03 , C07H17/02 , C12P19/60 , Y10S435/825
摘要： A novel macrolactam monosaccharide isolated from an antimicrobial complex 517 produced in fermentation under controlled conditions using a biologically pure culture of the microorganism Actinomadura vulgaris subsp. vulgaris ATCC 53748.
摘要翻译：从在受控条件下发酵生产的抗微生物复合物517分离的新型大环内酰胺单糖，其使用微生物Actinomadura vulgaris subsp。寻常型ATCC 53748。

3. 发明授权

US5342852A Macrocyclic lactone antibacterial antibiotic compounds 失效
标题翻译：大环内酯抗菌抗生素化合物
公开(公告)号：US5342852A
公开(公告)日：1994-08-30
申请号：US123656
申请日：1993-09-20
申请人： Vinod R. Hegde , Ann C. Horan , Joseph A. Marquez , Mahesh G. Patel
发明人： Vinod R. Hegde , Ann C. Horan , Joseph A. Marquez , Mahesh G. Patel
IPC分类号： C07D307/94 , C07H17/08 , A61K31/34 , C07D307/93
CPC分类号： C07H17/08 , C07D307/94 , Y10S435/822
摘要： Novel macrocyclic lactone antibacterials isolated from a culture containing the microorganism S. aerocolongenes sub sp. antibiotica SCC 1886, ATTC 55003 and their use for treating and/or preventing antibacterial infections, especially Chlamydia infections are disclosed.
摘要翻译：从含有微生物S. aerocolongenes sub sp。的培养物中分离的新型大环内酯抗菌剂。抗生素SCC 1886，ATTC 55003及其用于治疗和/或预防抗菌感染，特别是衣原体感染的用途。

4. 发明授权

US5618809A Indolocarbazoles from saccharothrix aerocolonigenes copiosa subsp. nov SCC 1951 ATCC 53856 失效
标题翻译：来自糖酵母（Aerobolithrix aerocolonigenes copiosa subsp。）的Indolocarbazoles nov SCC 1951 ATCC 53856
公开(公告)号：US5618809A
公开(公告)日：1997-04-08
申请号：US394937
申请日：1995-02-27
申请人： Ellen B. Barrabee , Ann C. Horan , Frank A. Gentile , Mahesh G. Patel
发明人： Ellen B. Barrabee , Ann C. Horan , Frank A. Gentile , Mahesh G. Patel
IPC分类号： C12P17/18 , C07D498/22 , A61K31/55
CPC分类号： C12P17/18
摘要： N-alkanoyl derivatives of staurospodne represented by the formula I ##STR1## wherein R.sub.a and R.sub.b are each H or ##STR2## wherein R.sub.1 and R.sub.2 are independently H or --OH or --OCH.sub.3 and R.sub.3 is OH, NHCH.sub.3, NCH COCH.sub.3 or NHCOCH.sub.3 and R.sub.4 is OH or H and, stereochemical isomers thereof with the provisos that (1) when R.sub.a and R.sub.b .dbd.A, and R.sub.1.dbd.H.sub.2 or OH R.sub.3 is not NHCH.sub.3 ; (2) when R.sub.a and R.sub.b.dbd. B, then R.sub.1 .dbd.R.sub.4 .dbd.OH or R.sub.1 .dbd.R.sub.4 .dbd.H; (3) when R.sub.a .dbd.R.sub.b .dbd.H R.sub.1 .dbd.--OCH.sub.3, and (4) when R.sub.a and R.sub.b .dbd.A, and R.sub.1 .dbd.H and R.sub.2 .dbd.OCH.sub.3, then R3 is not and ##STR3## pharmaceutical compositions thereof useful for inhibiting myosin light chain kinase, protein kinase C or tumor cell proliferation as well as producing an antihypertensive effect and an anti-inflammatory effect in warm-blood animals such as man are disclosed.
摘要翻译：其中R a和R b各自为H或A，其中R 1和R 2独立地为H或-OH或-OCH 3且R 3为OH，NHCH 3， NCH COCH 3或NHCOCH 3和R 4是OH或H及其立体化学异构体，条件是（1）当R a和R b = A时，R 1 = H 2或OH R 3不是NHCH 3; （2）当Ra和Rb = B时，R1 = R4 = OH或R1 = R4 = H; （3）当Ra = Rb = H R1 = -OCH3时，和（4）当Ra和Rb = A，R1 = H和R2 = OCH3时，R3不是和其中用于抑制肌球蛋白光的药物组合物链激酶，蛋白激酶C或肿瘤细胞增殖，以及在温血动物如人中产生抗高血压作用和抗炎作用。

5. 发明授权

US5352707A Method for treating airway congestion 失效
标题翻译：治疗气道堵塞的方法
公开(公告)号：US5352707A
公开(公告)日：1994-10-04
申请号：US857889
申请日：1992-03-26
申请人： Shirley A. Pompni , Vincent P. Gullo , Ann C. Horan , Mahesh G. Patel , Stephen Coval
发明人： Shirley A. Pompni , Vincent P. Gullo , Ann C. Horan , Mahesh G. Patel , Stephen Coval
IPC分类号： A61K31/135
CPC分类号： A61K31/135 , Y10S514/826
摘要： A method for treating airway congestion which comprises administering an effective amount of the compound of formula II which follows ##STR1## or a pharmaceutically acceptable salt thereof.
摘要翻译：一种治疗气道充血的方法，其包括施用有效量的II型II化合物或其药学上可接受的盐。

6. 发明授权

US5217986A Anti-allergy agent 失效
标题翻译：抗过敏剂
公开(公告)号：US5217986A
公开(公告)日：1993-06-08
申请号：US858275
申请日：1992-03-26
申请人： Shirley A. Pomponi , Vincent P. Gullo , Ann C. Horan , Mahesh G. Patel , Stephen Coval
发明人： Shirley A. Pomponi , Vincent P. Gullo , Ann C. Horan , Mahesh G. Patel , Stephen Coval
IPC分类号： C07D233/54 , C07D233/64
CPC分类号： C07D233/64
摘要： The compound of the formula ##STR1## is described. This compound is active in an H.sub.3 receptor assay and is an H.sub.3 antagonist. Accordingly, the compound of formula I is useful in the treatment of diseases and conditions such as asthma, rhinitis, airway congestion, inflammation, cardiac arrhythmias, hypertension, hyper and hypo motility and acid secretion of the gastrointestinal tract, hypo and hyper activity of the central nervous system (CNS), migraine, and glaucoma.
摘要翻译：描述了式（IMAGE）I的化合物。该化合物在H3受体测定中是有活性的，并且是H3拮抗剂。因此，式I化合物可用于治疗诸如哮喘，鼻炎，呼吸道充血，炎症，心律失常，高血压，超低运动性和胃肠道酸分泌等疾病和病症，中枢神经系统（CNS），偏头痛和青光眼。

7. 发明授权

US5126350A Polycyclic aromatic antifungal compounds 失效
标题翻译：多环芳香族抗真菌化合物
公开(公告)号：US5126350A
公开(公告)日：1992-06-30
申请号：US537383
申请日：1990-06-13
申请人： Raymond Cooper , Ann C. Horan , Joseph A. Marquez , Mahesh G. Patel
发明人： Raymond Cooper , Ann C. Horan , Joseph A. Marquez , Mahesh G. Patel
IPC分类号： C07D491/16
CPC分类号： C07D491/16
摘要： A compound represented by the formula I: ##STR1## wherein R.sub.1 and R.sub.2 are independently hydrogen or (C.sub.2 -C.sub.10) alkanoyl in substantially chemically pure form, and pharmaceutical compositions thereof are disclosed.
摘要翻译：由式I表示的化合物：其中R 1和R 2独立地为氢或基本上化学纯的形式的（C 2 -C 10）烷酰基及其药物组合物。

8. 发明授权

US4956383A Antifungal triacetylenic dioxolone from Microbispora sp. SCC 1438, ATCC 53620 失效
标题翻译：来自微小双孢菌的抗真菌三乙酰二氧戊环 SCC 1438，ATCC 53620
公开(公告)号：US4956383A
公开(公告)日：1990-09-11
申请号：US89278
申请日：1987-08-25
申请人： Mahesh G. Patel , Ann C. Horan , Joseph A. Marquez , J. Allan Waitz
发明人： Mahesh G. Patel , Ann C. Horan , Joseph A. Marquez , J. Allan Waitz
IPC分类号： C07D317/36 , C12P17/04
CPC分类号： C12P17/04 , C07D317/36
摘要： The novel triacetylenic dioxolone antifungal compound of this invention is isolated from the EV-22 complex of this invention which is elaborated by the microorganism Microbispora sp. SCC 1438, ATCC 53620.
摘要翻译：从本发明的EV-22复合物中分离本发明的新型三乙酰二氧戊环抗真菌化合物，其由微生物微双孢菌（Microbispora sp。 SCC 1438，ATCC 53620。

9. 发明授权

US4597968A Antibiotic 13-384 complex from Micromonospora carbonacea var africana 失效
标题翻译：抗生素13-384复合物来自小单孢菌属碳酸亚乙酯
公开(公告)号：US4597968A
公开(公告)日：1986-07-01
申请号：US623266
申请日：1984-06-21
申请人： Jay A. Waitz , Mahesh G. Patel , Joseph A. Marquez , Manohar G. Kalyanpur , Ann C. Horan
发明人： Jay A. Waitz , Mahesh G. Patel , Joseph A. Marquez , Manohar G. Kalyanpur , Ann C. Horan
IPC分类号： C12P1/06 , A61K35/74
CPC分类号： C12P1/06
摘要： The antibiotic 13-384 complex is elaborated by a new variety of Micromonospora carbonacea; namely Micromonospora carbonacea var africana NRRL 15099.
摘要翻译：抗生素13-384复合物由新型微孢子虫碳化合物制成; 即微孢子虫属碳酸盐属非洲NRRL 15099。

10. 发明授权

US4440751A Broad spectrum antibiotic complex produced by a novel micromonospora 失效
标题翻译：广谱抗生素复合物由新型微单孢菌素生产
公开(公告)号：US4440751A
公开(公告)日：1984-04-03
申请号：US194490
申请日：1980-10-06
申请人： Jay A. Waitz , Joseph A. Marquez , Mahesh G. Patel , Ann C. Horan
发明人： Jay A. Waitz , Joseph A. Marquez , Mahesh G. Patel , Ann C. Horan
IPC分类号： A61K31/275 , A61K35/66 , C07C255/32 , C12P1/04 , C12P13/02 , A61K35/00 , C07C121/80
CPC分类号： C07C255/00 , C12P13/02 , C12R1/29
摘要： The novel antibiotic complex designated hazymicin consisting of eight components, is produced by a novel strain of Micromonospora herein designated Micromonospora echinospora var. challisensis SCC 1411. Also disclosed are the structures of the two components namely, Component 5 and Component 6.
摘要翻译：由八个组分组成的称为糜霉素的新型抗生素复合物，由本文命名为小单孢菌属（Micomonospora echinospora var。）的新型小单孢菌菌株产生。挑战性SCC 1411.还公开了两个组分的结构，即组分5和组分6。

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