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1. 发明申请

US20100255083A1 CONTROLLED-RELEASE PHARMACEUTICAL FORMULATION AND PROCESS FOR ITS PREPARATION 有权
标题翻译：控制释放药物制剂及其制备方法
公开(公告)号：US20100255083A1
公开(公告)日：2010-10-07
申请号：US12745816
申请日：2008-12-23
申请人： Vincenzo Russo , Elisa Liberati , Nicola Cazzolla , Leonardo Marchitto , Lorella Ragni
发明人： Vincenzo Russo , Elisa Liberati , Nicola Cazzolla , Leonardo Marchitto , Lorella Ragni
IPC分类号： A61K9/52 , A61K9/14 , A61P29/00 , A61P31/00 , A61P25/22 , A61P1/04 , A61P11/02 , A61P7/02 , A61P9/06 , A61P3/08 , A61P11/06 , A61P1/08 , A61K9/22 , A61K31/496 , A61K47/36
CPC分类号： A61K9/2009 , A61K9/1611 , A61K9/1652 , A61K9/205 , A61K9/2059 , A61K31/00
摘要： The present invention relates to a controlled-release pharmaceutical formulation comprising at least one active ingredient dispersed in a matrix comprising at least one slow-release excipient comprising an association of at least one glycogen and at least one alginate with alkaline-earth metal salts, and a process for its preparation. The invention also relates to a slow-release excipient comprising an association of at least one glycogen and at least one alginate with alkaline-earth metal salts, and the process for its preparation, and its use for the preparation of slow-release pharmaceutical formulations.
摘要翻译：本发明涉及包含分散在基质中的至少一种活性成分的控释药物制剂，其包含至少一种缓释赋形剂，其包含至少一种糖原和至少一种藻酸盐与碱土金属盐的缔合，以及其准备过程。本发明还涉及包含至少一种糖原和至少一种藻酸盐与碱土金属盐的缔合的缓释赋形剂及其制备方法及其用于制备缓释药物制剂的用途。

2. 发明授权

US08840923B2 Slow-release pharmaceutical formulation and process for its preparation 有权
标题翻译：缓释药物制剂及其制备方法
公开(公告)号：US08840923B2
公开(公告)日：2014-09-23
申请号：US12745816
申请日：2008-12-23
申请人： Vincenzo Russo , Elisa Liberati , Nicola Cazzolla , Leonardo Marchitto , Lorella Ragni
发明人： Vincenzo Russo , Elisa Liberati , Nicola Cazzolla , Leonardo Marchitto , Lorella Ragni
IPC分类号： A61K9/00 , A61K9/16 , A61K31/00 , A61K9/10 , A61K9/20 , A61K9/14 , A61K9/28 , A61K31/715
CPC分类号： A61K9/2009 , A61K9/1611 , A61K9/1652 , A61K9/205 , A61K9/2059 , A61K31/00
摘要： Slow-release excipients which comprise an association of at least one glycogen and at least one alginate with an alkaline-earth metal salt are useful for the preparation of slow-release pharmaceutical formulations.
摘要翻译：包含至少一种糖原和至少一种藻酸盐与碱土金属盐缔合的缓释赋形剂可用于制备缓释药物制剂。

3. 发明授权

US09125823B2 Controlled release pharmaceutical or food formulation and process for its preparation 有权
标题翻译：控制释放药物或食品配方及其制备方法
公开(公告)号：US09125823B2
公开(公告)日：2015-09-08
申请号：US13139192
申请日：2010-01-08
申请人： Stefano Selva , Leonardo Marchitto , Giovanni Battista Ciottoli , Lorella Ragni , Vincenzo Russo , Elisa Liberati
发明人： Stefano Selva , Leonardo Marchitto , Giovanni Battista Ciottoli , Lorella Ragni , Vincenzo Russo , Elisa Liberati
IPC分类号： A61K9/20
CPC分类号： A61K9/205 , A61K9/2054
摘要： The present invention relates to a controlled release pharmaceutical or food formulation comprising at least one active pharmaceutical or food ingredient dispersed in a mixture of a glycogen with a polysaccharide, and the process for its preparation. The invention also relates to a slow release system represented by a mixture of a glycogen with a polysaccharide, and its use for the preparation of slow release pharmaceutical or food formulations.
摘要翻译：本发明涉及包含分散在糖原与多糖的混合物中的至少一种活性药物或食品成分的控释药物或食品制剂及其制备方法。本发明还涉及由糖原与多糖的混合物表示的缓释系统及其用于制备缓释药物或食品制剂的用途。

4. 发明申请

US20110318321A1 CONTROLLED RELEASE PHARMACEUTICAL OR FOOD FORMULATION AND PROCESS FOR ITS PREPARATION 有权
标题翻译：控制释放药物或食品配方及其制备方法
公开(公告)号：US20110318321A1
公开(公告)日：2011-12-29
申请号：US13139192
申请日：2010-01-08
申请人： Stefano Selva , Leonardo Marchitto , Giovanni Battista Ciottoli , Lorella Ragni , Vincenzo Russo , Elisa Liberati
发明人： Stefano Selva , Leonardo Marchitto , Giovanni Battista Ciottoli , Lorella Ragni , Vincenzo Russo , Elisa Liberati
IPC分类号： A61K31/197 , A61K31/167 , A61K31/497 , A61K31/495 , A61K31/5513 , A61K31/341 , A61K31/345 , A61K31/4015 , A61K31/4365 , A61K31/40 , A61K31/137 , A61K31/195 , A61K31/135 , A61K31/496 , A61K31/4439 , A61K31/485 , A61K31/422 , A61K31/405 , A61K31/4196 , A61K36/00 , A61K33/00 , A61K33/42 , A61K33/30 , A61K33/24 , A61K36/16 , A61K36/28 , A61K36/8962 , A61K36/45 , A61K31/375 , A61K31/07 , A61K31/519 , A61K31/59 , A61K31/122 , A61K31/455 , A61K31/7008 , A61K31/715 , A61K31/047 , A61K31/385 , A61K31/4045 , A61K36/38 , A61K36/324 , A61P43/00 , A61K31/192
CPC分类号： A61K9/205 , A61K9/2054
摘要： The present invention relates to a controlled release pharmaceutical or food formulation comprising at least one active pharmaceutical or food ingredient dispersed in a mixture of a glycogen with a polysaccharide, and the process for its preparation. The invention also relates to a slow release system represented by a mixture of a glycogen with a polysaccharide, and its use for the preparation of slow release pharmaceutical or food formulations.
摘要翻译：本发明涉及包含分散在糖原与多糖的混合物中的至少一种活性药物或食品成分的控释药物或食品制剂及其制备方法。本发明还涉及由糖原与多糖的混合物表示的缓释系统及其用于制备缓释药物或食品制剂的用途。

5. 发明申请

US20090074867A1 ORALLY DISPERSIBLE PHARMACEUTICAL COMPOSITION AND PROCESS FOR THE PREPARATION THEREOF 审中-公开
标题翻译： ORALLY不可分割的药物组合物及其制备方法
公开(公告)号：US20090074867A1
公开(公告)日：2009-03-19
申请号：US11577762
申请日：2005-11-25
申请人： Leonardo Marchitto , Lorella Ragni , Luca Donati , Mauro Valenti
发明人： Leonardo Marchitto , Lorella Ragni , Luca Donati , Mauro Valenti
IPC分类号： A61K9/32 , A61K9/16
CPC分类号： A61K9/0056 , A61K9/2081 , A61K9/5078
摘要： A process for preparing an orally dispersible solid pharmaceutical form comprises the following steps: a) coating the active ingredient with at least one hydrophilic carboxylate polymer, b) granulating the coated active ingredient obtained in step (a) with at least one lipid compound having a melting point lower than that of the active ingredient, c) mixing the granulate obtained in step (b) with at least one hydrophilic natural polymer having high molecular weight, and d) mixing the granulate obtained in step (c) with ingredients suitable for obtaining an orally dispersible solid pharmaceutical form. An orally dispersible solid pharmaceutical form comprises an active ingredient coated with at least one hydrophilic carboxylate polymer and at least one lipid compound, in which the said coated active ingredient is embedded in a matrix comprising at least one hydrophilic natural polymer having high molecular weight.
摘要翻译：制备口服分散固体药物形式的方法包括以下步骤：a）用至少一种亲水性羧酸酯聚合物包被活性成分，b）将步骤（a）中获得的包被的活性成分与至少一种具有熔点低于活性成分，c）将步骤（b）中获得的颗粒与至少一种具有高分子量的亲水天然聚合物混合，和d）将步骤（c）中获得的颗粒与适于获得的成分口服分散固体药物形式。口服分散固体药物形式包含涂覆有至少一种亲水性羧酸酯聚合物和至少一种脂质化合物的活性成分，其中所述包被的活性成分包含在包含至少一种具有高分子量的亲水性天然聚合物的基质中。

6. 发明申请

US20080292606A1 Pharmaceutical Oral Dosage Form Comprising a Non-Steroidal Anti-Inflammatory Drug, and Having Good Palatability 有权
标题翻译：包含非甾体抗炎药物，具有良好的适口性的药物口服剂型
公开(公告)号：US20080292606A1
公开(公告)日：2008-11-27
申请号：US10582858
申请日：2004-12-16
申请人： Leonardo Marchitto , Francesca Mariotti , Lorella Ragni
发明人： Leonardo Marchitto , Francesca Mariotti , Lorella Ragni
IPC分类号： A61K31/4415 , A61K31/192
CPC分类号： A61K9/006 , A61K9/0095 , A61K47/183 , A61K47/22
摘要： Oral pharmaceutical dosage form comprising tromethamine and a NSAID selected from the group comprising ibuprofen, naproxen and flurbiprofen, characterized in that it also comprises a compound selected from the group comprising glycine, vitamin B6 and mixtures thereof.
摘要翻译：包含氨丁三醇和选自布洛芬，萘普生和氟比洛芬组的NSAID的口服药物剂型，其特征在于还包含选自甘氨酸，维生素B6及其混合物的化合物。

7. 发明申请

US20100273736A1 COSMETIC COMPOSITION COMPRISING GLYCOGEN FOR SKIN APPLICATION WITH VELVET EFFECT 审中-公开
标题翻译：化妆品组合物包含用于皮肤应用的GLYCOGEN与VELVET效应
公开(公告)号：US20100273736A1
公开(公告)日：2010-10-28
申请号：US12746878
申请日：2009-01-21
申请人： Leonardo Marchitto , Lorella Ragni , Francesca Mariotti
发明人： Leonardo Marchitto , Lorella Ragni , Francesca Mariotti
IPC分类号： A61K8/73 , A61Q19/00
CPC分类号： A61K8/73 , A61Q5/00 , A61Q17/04 , A61Q19/00 , A61Q19/001 , A61Q19/002
摘要： This invention relates to a cosmetic composition for skin application having a velvet effect on the skin comprising, as the cosmetic active ingredient, a glycogen having less than 1,000 ppm of nitrogen and less than 1% by weight of reducing sugars, in at least one cosmetically-acceptable vehicle.
摘要翻译：本发明涉及一种用于皮肤应用的化妆品组合物，其具有对皮肤的天鹅绒作用，其包含作为化妆品活性成分的至少一种化妆品中含有少于1,000ppm氮和小于1重量％的还原糖的糖原可接受的车辆

8. 发明授权

US09968552B2 Pharmaceutical oral dosage form comprising a non-steroidal anti-inflammatory drug, and having good palatability 有权
公开(公告)号：US09968552B2
公开(公告)日：2018-05-15
申请号：US10582858
申请日：2004-12-16
申请人： Leonardo Marchitto , Francesca Mariotti , Lorella Ragni
发明人： Leonardo Marchitto , Francesca Mariotti , Lorella Ragni
IPC分类号： A61K9/00 , A61K47/18 , A61K47/22
CPC分类号： A61K9/006 , A61K9/0095 , A61K47/183 , A61K47/22
摘要： Oral pharmaceutical dosage form comprising tromethamine and a NSAID selected from the group comprising ibuprofen, naproxen and flurbiprofen, characterized in that it also comprises a compound selected from the group comprising glycine, vitamin B6 and mixtures thereof.

9. 发明申请

US20060004089A1 Use of an l-ascorbic acid salt to prepare a pharmaceutical composition for ophthalmic topical use capable of improving the level of l-ascorbic acid in the eye 审中-公开
标题翻译：使用1-抗坏血酸盐制备能够改善眼睛中1-抗坏血酸水平的眼用局部用药物组合物
公开(公告)号：US20060004089A1
公开(公告)日：2006-01-05
申请号：US10507025
申请日：2003-03-05
申请人： Mario Pinza , Lucia Durando , Leonardo Marchitto , Michele Virno
发明人： Mario Pinza , Lucia Durando , Leonardo Marchitto , Michele Virno
IPC分类号： A61K31/375
CPC分类号： A61K31/375 , A61K9/0048 , A61K31/573 , A61K2300/00
摘要： Use of a salt of L-ascorbic acid with a pharmaceutically acceptable organic base to prepare a pharmaceutical composition, for ophthalmic topical use, capable of improving the level of L-ascorbic acid in a human eye.
摘要翻译：将L-抗坏血酸盐与药学上可接受的有机碱的用途制备用于眼部局部用途的能够改善人眼中L-抗坏血酸水平的药物组合物。

10. 发明授权

US06337087B1 Aqueous pharmaceutical composition comprising an active ingredient which is highly insoluble in water 有权
标题翻译：水性药物组合物，其包含高度不溶于水的活性成分
公开(公告)号：US06337087B1
公开(公告)日：2002-01-08
申请号：US09367699
申请日：1999-12-14
申请人： Giovanni Cavallo , Leonardo Marchitto
发明人： Giovanni Cavallo , Leonardo Marchitto
IPC分类号： A61K9127
CPC分类号： A61K9/1277 , A61K9/127 , Y10S977/907
摘要： Aqueous pharmaceutical composition comprising an active agent which is highly insoluble in water, dispersed in liposomes and method of preparation are disclosed.
摘要翻译：公开了包含高度不溶于水的分散在脂质体中的活性剂和制备方法的水性药物组合物。

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