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1. 发明申请

US20120252735A1 TREATMENT OF SKIN CONDITIONS BY DICKKOPF1 (DKK1) 有权
标题翻译： DICKKOPF1（DKK1）治疗皮肤病症
公开(公告)号：US20120252735A1
公开(公告)日：2012-10-04
申请号：US13492990
申请日：2012-06-11
申请人： Vincent Hearing , Yuji Yamaguchi , Thierry Passeron
发明人： Vincent Hearing , Yuji Yamaguchi , Thierry Passeron
IPC分类号： A61K38/17 , A61P17/00 , A61P17/02 , A61P35/00
CPC分类号： A61K38/1709 , A61K8/64 , A61Q7/02 , A61Q19/02
摘要： The present disclosure is generally related to methods of inducing non-palmoplantar skin to develop a palmoplantar phenotype, for example, methods for increasing skin thickness, decreasing skin pigmentation, and/or decreasing hair growth. In particular, disclosed herein are methods of using topical administration of DKK1 to increase skin thickness, decrease skin pigmentation, or reduce hair growth. Also disclosed are topical DKK1 compositions for inducing non-palmoplantar skin to develop a palmoplantar phenotype.
摘要翻译：本公开通常涉及诱导非掌跖皮肤发展掌跖表型的方法，例如增加皮肤厚度，减少皮肤色素沉着和/或减少毛发生长的方法。特别地，本文公开了使用局部施用DKK1以增加皮肤厚度，减少皮肤色素沉着或减少毛发生长的方法。还公开了用于诱导非掌跖皮肤发展掌跖表型的局部DKK1组合物。

2. 发明申请

US20100317590A1 REGULATION OF SKIN CHARACTERISTICS BY DICKKOPF1 (DKK1) 有权
标题翻译： DICKKOPF1（DKK1）皮肤特性调节
公开(公告)号：US20100317590A1
公开(公告)日：2010-12-16
申请号：US12518052
申请日：2007-12-07
申请人： Vincent Hearing , Yuji Yamaguchi , Thierry Passeron
发明人： Vincent Hearing , Yuji Yamaguchi , Thierry Passeron
IPC分类号： A61K38/17 , C12N5/07 , A61P17/00 , A61P35/00 , A61P17/02
CPC分类号： A61K38/1709 , A61K8/64 , A61Q7/02 , A61Q19/02
摘要： The present disclosure is generally related to methods of inducing non-palmoplantar skin to develop a palmoplantar phenotype, for example, methods for increasing skin thickness, decreasing skin pigmentation, and/or decreasing hair growth. In particular, disclosed herein are methods of using topical administration of DKK1 to increase skin thickness, decrease skin pigmentation, or reduce hair growth. Also disclosed are topical DKK1 compositions for inducing non-palmoplantar skin to develop a palmoplantar phenotype.
摘要翻译：本公开通常涉及诱导非掌跖皮肤发展掌跖表型的方法，例如增加皮肤厚度，减少皮肤色素沉着和/或减少毛发生长的方法。特别地，本文公开了使用局部施用DKK1以增加皮肤厚度，减少皮肤色素沉着或减少毛发生长的方法。还公开了用于诱导非掌跖皮肤发展掌跖表型的局部DKK1组合物。

3. 发明授权

US08476236B2 Treatment of skin conditions by Dickkopf1 (DKK1) 有权
标题翻译： Dickkopf1（DKK1）治疗皮肤病症
公开(公告)号：US08476236B2
公开(公告)日：2013-07-02
申请号：US13492990
申请日：2012-06-11
申请人： Vincent Hearing , Yuji Yamaguchi , Thierry Passeron
发明人： Vincent Hearing , Yuji Yamaguchi , Thierry Passeron
IPC分类号： A61K38/00
CPC分类号： A61K38/1709 , A61K8/64 , A61Q7/02 , A61Q19/02
摘要： The present disclosure is generally related to methods of inducing non-palmoplantar skin to develop a palmoplantar phenotype, for example, methods for increasing skin thickness, decreasing skin pigmentation, and/or decreasing hair growth. In particular, disclosed herein are methods of using topical administration of DKK1 to increase skin thickness, decrease skin pigmentation, or reduce hair growth. Also disclosed are topical DKK1 compositions for inducing non-palmoplantar skin to develop a palmoplantar phenotype.
摘要翻译：本公开通常涉及诱导非掌跖皮肤发展掌跖表型的方法，例如增加皮肤厚度，减少皮肤色素沉着和/或减少毛发生长的方法。特别地，本文公开了使用局部施用DKK1以增加皮肤厚度，减少皮肤色素沉着或减少毛发生长的方法。还公开了用于诱导非掌跖皮肤发展掌跖表型的局部DKK1组合物。

4. 发明授权

US08198244B2 Regulation of skin characteristics by DICKKOPF1 (DKK1) 有权
标题翻译：通过DICKKOPF1（DKK1）调节皮肤特征
公开(公告)号：US08198244B2
公开(公告)日：2012-06-12
申请号：US12518052
申请日：2007-12-07
申请人： Vincent Hearing , Yuji Yamaguchi , Thierry Passeron
发明人： Vincent Hearing , Yuji Yamaguchi , Thierry Passeron
IPC分类号： A61K38/00
CPC分类号： A61K38/1709 , A61K8/64 , A61Q7/02 , A61Q19/02
摘要： The present disclosure is generally related to methods of inducing non-palmoplantar skin to develop a palmoplantar phenotype, for example, methods for increasing skin thickness, decreasing skin pigmentation, and/or decreasing hair growth. In particular, disclosed herein are methods of using topical administration of DKK1 to increase skin thickness, decrease skin pigmentation, or reduce hair growth. Also disclosed are topical DKK1 compositions for inducing non-palmoplantar skin to develop a palmoplantar phenotype.
摘要翻译：本公开通常涉及诱导非掌跖皮肤发展掌跖表型的方法，例如增加皮肤厚度，减少皮肤色素沉着和/或减少毛发生长的方法。特别地，本文公开了使用局部施用DKK1以增加皮肤厚度，减少皮肤色素沉着或减少毛发生长的方法。还公开了用于诱导非掌跖皮肤发展掌跖表型的局部DKK1组合物。

5. 发明授权

US08946291B2 Compositions and methods for treating pigmentary conditions and melanoma 有权
标题翻译：用于治疗色素病症和黑色素瘤的组合物和方法
公开(公告)号：US08946291B2
公开(公告)日：2015-02-03
申请号：US13059219
申请日：2008-08-15
申请人： Vincent J. Hearing , Thierry Passeron
发明人： Vincent J. Hearing , Thierry Passeron
IPC分类号： A61K31/203 , A61K31/5575 , A61P35/00 , A61K38/17
CPC分类号： A61K38/1709
摘要： A method of treating melanoma in a subject comprising administering an amount of SOX9 sufficient to treat melanoma is disclosed. A method of treating a hyperpigmentary condition in a subject comprising administering an amount of inhibitor of SOX9 activity sufficient to treat the condition is disclosed. A method of treating melanoma in a subject comprising administering an amount of SOX9 sufficient to treat melanoma is disclosed. A method of treating melanoma in a subject comprising increasing the amounts of retinoic acid and SOX9 in the subject by amounts sufficient to treat melanoma. A method of treating melanoma in a subject comprising administering an amount of prostaglandin D2 and retinoic acid sufficient to treat cancer is disclosed. A method of sensitizing a melanoma cell to RA comprising administering an amount of SOX9 sufficient to decrease PRAME expression is disclosed.
摘要翻译：公开了一种治疗受试者黑素瘤的方法，包括给予一定量的足以治疗黑素瘤的SOX9。公开了治疗患者色素沉着过度症状的方法，包括给予一定量的足以治疗病症的SOX9活性抑制剂。公开了一种治疗受试者黑素瘤的方法，包括给予一定量的足以治疗黑素瘤的SOX9。一种治疗受试者黑素瘤的方法，其包括以足以治疗黑素瘤的量增加受试者中视黄酸和SOX9的量。公开了一种治疗受试者黑色素瘤的方法，包括给予一定量的足以治疗癌症的前列腺素D2和视黄酸。公开了一种使黑素瘤细胞对RA敏感的方法，包括给予一定量足以降低PRAME表达的SOX9。

6. 发明申请

US20110269691A1 Compositions and Methods for Treating Pigmentary Conditions and Melanoma 有权
标题翻译：治疗色素条件和黑色素瘤的组合物和方法
公开(公告)号：US20110269691A1
公开(公告)日：2011-11-03
申请号：US13059219
申请日：2008-08-15
申请人： Vincent J. Hearing , Thierry Passeron
发明人： Vincent J. Hearing , Thierry Passeron
IPC分类号： A61K38/17 , A61P17/00 , A61P35/00 , A61K31/5575 , C12Q1/02
CPC分类号： A61K38/1709
摘要： A method of treating a hypopigmentary condition in a subject comprising administering to the subject an amount of SOX9 sufficient to treat melanoma is disclosed. The hypopigmentary condition can be a result of surgery, trauma or vitiligo. A method of treating a hyperpigmentary condition in a subject comprising administering to the subject an amount of inhibitor of SOX9 activity sufficient to treat melanoma is disclosed. A method of treating melanoma in a subject comprising administering to the subject an amount of SOX9 sufficient to treat melanoma is disclosed. A method of treating melanoma in a subject comprising increasing the amounts of retinoic acid and SOX9 in the subject by amounts sufficient to treat melanoma. A method of treating melanoma in a subject comprising administering to the subject an amount of prostaglandin D2 (PGD2) and retinoic acid (RA) sufficient to treat cancer. A method of sensitizing a melanoma cell to RA comprising administering to the subject an amount of SOX9 sufficient to decrease PRAME expression. A method of increasing p21 expression in a subject comprising administering to the subject an amount of SOX9 sufficient to increase p21 expression. Methods of screening for compounds that treat hypopigmentary conditions and/or melanoma are provided.
摘要翻译：公开了一种治疗受试者色素沉着状况的方法，包括对受试者施用足以治疗黑素瘤的量的SOX9。色素沉着状况可能是手术，创伤或白癜风的结果。公开了一种治疗受试者色素沉着过度症状的方法，包括给予受试者一定量的足以治疗黑素瘤的SOX9活性抑制剂。公开了一种治疗受试者黑色素瘤的方法，其包括向受试者施用足以治疗黑素瘤的量的SOX9。一种治疗受试者黑素瘤的方法，其包括以足以治疗黑素瘤的量增加受试者中视黄酸和SOX9的量。一种治疗受试者中的黑素瘤的方法，其包括给予受试者一定量的足以治疗癌症的前列腺素D2（PGD2）和视黄酸（RA）。一种使黑素瘤细胞对RA敏感的方法，包括向受试者施用足以降低PRAME表达的量的SOX9。增加受试者中p21表达的方法，其包括向受试者施用足以增加p21表达的量的SOX9。提供了筛选治疗色素缺乏症和/或黑素瘤的化合物的方法。

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