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1. 发明申请

US20050065434A1 Polymeric marker with high radiopacity for use in medical devices 审中-公开
标题翻译：具有高放射性不透性的聚合物标记用于医疗器械
公开(公告)号：US20050065434A1
公开(公告)日：2005-03-24
申请号：US10748016
申请日：2003-12-29
申请人： Vincent Bavaro , John Simpson , Peter D'Aquanni , Aaron Baldwin , Wayne Cornish
发明人： Vincent Bavaro , John Simpson , Peter D'Aquanni , Aaron Baldwin , Wayne Cornish
IPC分类号： A61B5/05 , A61B5/107 , A61B19/00 , A61F2/06 , A61F2/84 , A61K49/04 , A61L29/18 , A61L31/18 , A61M25/01
CPC分类号： A61M25/0108 , A61B5/1076 , A61B90/39 , A61B2562/17 , A61F2/958 , A61F2250/0098 , A61K49/0419 , A61L29/18 , A61L31/18
摘要： High radiopacity is achieved in a polymeric marker by combining a polymeric resin, a powdered radiopaque agent having uniformly shaped particles of a specific particle size distribution, and a wetting agent. The method to produce the marker calls for the blending and pelletization of these materials followed by extrusion onto support beading. The resulting supported tubing is subsequently cut to length with the beading still in place. After ejection of the beading remnant the marker is slipped into place on the device to be marked and attached by melt bonding. Marking of a guide wire allows lesions to be measured while the marking of balloon catheters allow the balloon to be properly positioned relative to a lesion.
摘要翻译：通过组合聚合物树脂，具有特定粒度分布的均匀成形颗粒的粉末状的不透射线剂和润湿剂，在聚合物标记物中实现高的射线不透性。生产标记的方法需要这些材料的混合和造粒，然后挤压到支撑珠上。随后将所得的支撑管切割成长度，同时将珠粒固定就位。在喷射后，将标记物滑入到要被标记并通过熔融粘合附着的装置上。引导线的标记允许测量病变，同时球囊导管的标记允许气囊相对于病变适当定位。

2. 发明申请

US20050255317A1 Polymeric marker with high radiopacity for use in medical devices 审中-公开
公开(公告)号：US20050255317A1
公开(公告)日：2005-11-17
申请号：US11148058
申请日：2005-06-07
申请人： Vincent Bavaro , John Simpson , Peter D'Aquanni , Aaron Baldwin , Wayne Cornish
发明人： Vincent Bavaro , John Simpson , Peter D'Aquanni , Aaron Baldwin , Wayne Cornish
IPC分类号： A61B5/05 , A61B5/107 , A61B19/00 , A61F2/958 , A61K49/04 , A61L31/18 , A61M25/01
CPC分类号： A61L31/18 , A61B5/1076 , A61B90/39 , A61B2562/17 , A61F2250/0098 , A61K49/0409 , A61K49/0419 , A61M25/0108 , Y10T428/2933
摘要： High radiopacity is achieved in a polymeric marker by combining a polymeric resin, a powdered radiopaque agent having uniformly shaped particles of a specific particle size distribution, and a wetting agent. The method to produce the marker calls for the blending and pelletization of these materials followed by extrusion onto support beading. The resulting supported tubing is subsequently cut to length with the beading still in place. After ejection of the beading remnant the marker is slipped into place on the device to be marked and attached by melt bonding. Marking of a guide wire allows lesions to be measured while the marking of balloon catheters allow the balloon to be properly positioned relative to a lesion.

3. 发明申请

US20050064224A1 Polymeric marker with high radiopacity 有权
标题翻译：聚合物标记物具有高辐射不透性
公开(公告)号：US20050064224A1
公开(公告)日：2005-03-24
申请号：US10945637
申请日：2004-09-21
申请人： Vincent Bavaro , John Simpson , Peter D'Aquanni , Aaron Baldwin
发明人： Vincent Bavaro , John Simpson , Peter D'Aquanni , Aaron Baldwin
IPC分类号： A61B5/107 , A61B19/00 , A61F2/06 , A61F2/84 , A61L29/18 , A61L31/18 , A61M25/01 , C25D5/10
CPC分类号： A61L31/125 , A61B5/1076 , A61B5/6851 , A61B5/6853 , A61B6/12 , A61B6/485 , A61B90/39 , A61B2562/17 , A61F2/958 , A61F2250/0098 , A61L29/18 , A61L31/18 , A61M25/0012 , A61M25/0108 , A61M25/09 , A61M25/1027 , Y10T156/1089 , Y10T428/12493 , Y10T428/1372 , Y10T428/139
摘要： High radiopacity is achieved in a polymeric marker by combining a polymeric resin, a powdered radiopaque agent having uniformly shaped particles of a specific particle size distribution and a wetting agent. The method to produce the marker calls for the blending and pelletization of these materials followed by extrusion onto support beading. The resulting supported tubing is subsequently cut to length with the beading still in place. After ejection of the beading remnant the marker is slipped into place on the device to be marked and attached by melt bonding. Marking of a guidewire allows lesions to be measured while the marking of balloon catheters allow the balloon to be properly positioned relative to a lesion.
摘要翻译：通过组合聚合物树脂，具有特定粒度分布的均匀成形颗粒的粉末状的不透射线剂和润湿剂，在聚合物标记物中实现高的射线不透性。生产标记的方法需要这些材料的混合和造粒，然后挤压到支撑珠上。随后将所得的支撑管切割成长度，同时将珠粒固定就位。在喷射后，将标记物滑入到要被标记并通过熔融粘合附着的装置上。引导线的标记允许测量损伤，同时气球导管的标记允许气囊相对于病变适当定位。

4. 发明申请

US20080065010A1 POLYMERIC MARKER WITH HIGH RADIOPACITY FOR USE IN MEDICAL DEVICES 有权
标题翻译：具有高放射性的聚合物标记用于医疗器械
公开(公告)号：US20080065010A1
公开(公告)日：2008-03-13
申请号：US11877905
申请日：2007-10-24
申请人： Vincent Bavaro , John Simpson , Peter D'Aquanni , Aaron Baldwin
发明人： Vincent Bavaro , John Simpson , Peter D'Aquanni , Aaron Baldwin
IPC分类号： A61F2/06
CPC分类号： A61L31/125 , A61B5/1076 , A61B5/6851 , A61B5/6853 , A61B6/12 , A61B6/485 , A61B90/39 , A61B2562/17 , A61F2/958 , A61F2250/0098 , A61L29/18 , A61L31/18 , A61M25/0012 , A61M25/0108 , A61M25/09 , A61M25/1027 , Y10T156/1089 , Y10T428/12493 , Y10T428/1372 , Y10T428/139
摘要： High radiopacity is achieved in a polymeric marker by combining a polymeric resin, a powdered radiopaque agent having uniformly shaped particles of a specific particle size distribution and a wetting agent. The method to produce the marker calls for the blending and pelletization of these materials followed by extrusion onto support beading. The resulting supported tubing is subsequently cut to length with the beading still in place. After ejection of the beading remnant the marker is slipped into place on the device to be marked and attached by melt bonding. Marking of a guidewire allows lesions to be measured while the marking of balloon catheters allow the balloon to be properly positioned relative to a lesion.
摘要翻译：通过组合聚合物树脂，具有特定粒度分布的均匀成形颗粒的粉末状的不透射线剂和润湿剂，在聚合物标记物中实现高的射线不透性。生产标记的方法需要这些材料的混合和造粒，然后挤压到支撑珠上。随后将所得的支撑管切割成长度，同时将珠粒固定就位。在喷射后，将标记物滑入到要被标记并通过熔融粘合附着的装置上。引导线的标记允许测量损伤，同时气球导管的标记允许气囊相对于病变适当定位。

5. 发明申请

US20050064223A1 Polymeric marker with high radiopacity 审中-公开
标题翻译：聚合物标记物具有高辐射不透性
公开(公告)号：US20050064223A1
公开(公告)日：2005-03-24
申请号：US10667710
申请日：2003-09-22
申请人： Vincent Bavaro , John Simpson , Peter D'Aquanni , Aaron Baldwin
发明人： Vincent Bavaro , John Simpson , Peter D'Aquanni , Aaron Baldwin
IPC分类号： A61B5/107 , A61B19/00 , A61F2/06 , A61F2/84 , A61L29/18 , A61L31/18 , A61M25/01 , C25D5/10
CPC分类号： A61L31/125 , A61B5/1076 , A61B5/6851 , A61B5/6853 , A61B6/12 , A61B6/485 , A61B90/39 , A61B2562/17 , A61F2/958 , A61F2250/0098 , A61L29/18 , A61L31/18 , A61M25/0012 , A61M25/0108 , A61M25/09 , A61M25/1027 , Y10T156/1089 , Y10T428/12493 , Y10T428/1372 , Y10T428/139
摘要： High radiopacity is achieved in a polymeric marker by combining a polymeric resin, a powdered radiopaque agent having uniformly shaped particles of a specific particle size distribution and a vetting agent. The method to produce the marker calls for the blending and pelletization of these materials followed by extrusion onto support beading. The resulting supported tubing is subsequently cut to length with the beading still in place. After ejection of the beading remnant the marker is slipped into place on the device to be marked and attached by melt bonding. Marking of a guidewire allows lesions to be measured while the marking of balloon catheters allow the balloon to be properly positioned relative to a lesion.
摘要翻译：通过组合聚合物树脂，具有特定粒度分布的均匀成形颗粒的粉末不透射线剂和检查剂，在聚合物标记物中实现高的射线不透性。生产标记的方法需要这些材料的混合和造粒，然后挤压到支撑珠上。随后将所得的支撑管切割成长度，同时将珠粒固定就位。在喷射后，将标记物滑入到要被标记并通过熔融粘合附着的装置上。引导线的标记允许测量损伤，同时气球导管的标记允许气囊相对于病变适当定位。

6. 发明申请

US20060240059A1 Lubricious eluting polymer blend and coating made from the same 审中-公开
标题翻译：润滑的洗脱聚合物共混物和涂层由相同
公开(公告)号：US20060240059A1
公开(公告)日：2006-10-26
申请号：US11191868
申请日：2005-07-28
申请人： Vincent Bavaro , Nathalie Quiles
发明人： Vincent Bavaro , Nathalie Quiles
IPC分类号： A61F13/00 , A61K31/56
CPC分类号： A61L31/041 , A61K31/56 , A61L27/26 , A61L27/34 , A61L27/54 , A61L29/049 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/222 , C08L71/02
摘要： The present invention relates to a drug eluting polymer blend. More particularly, the present invention relates to a medical device with a drug eluting polymer blend incorporated therein wherein the drug elution rate is controlled by cross-linking the polymer blend. Once formed, the polymer blend can be used to create a medical device by itself or in combination with other materials. The drug, or other biologically active agent, can be loaded into the blend by soaking the polymer blend in a solution containing the agent before, during or after formation of the medical device. Alternatively, the drug or agent can be loaded into one of the polymers of the polymer blend before formation of the blend or during formation of the blend. Likewise, the polymer blend can be cross-linked before or after loading the selected drug or biologically active agent. Upon insertion into the body and exposure to the body's fluid, the blend releases the loaded biologically active agent at the desired rate.
摘要翻译：本发明涉及药物洗脱聚合物共混物。更具体地，本发明涉及其中掺入药物洗脱聚合物共混物的医疗装置，其中药物洗脱速率通过交联聚合物共混物来控制。一旦形成，聚合物共混物可以用于自身或与其它材料组合来形成医疗装置。通过在形成医疗装置之前，期间或之后将聚合物共混物浸泡在含有该试剂的溶液中，将药物或其它生物活性剂加载到共混物中。或者，可以在形成共混物之前或在形成共混物期间将药物或试剂加载到聚合物共混物的一种聚合物中。同样，聚合物共混物可以在加载所选择的药物或生物活性剂之前或之后交联。当插入身体并暴露于身体的流体时，共混物以所需的速率释放装载的生物活性剂。

7. 发明申请

US20060241000A1 Lubricious compound and medical device made of the same 审中-公开
标题翻译：润滑复合物和医疗器械相同
公开(公告)号：US20060241000A1
公开(公告)日：2006-10-26
申请号：US11112095
申请日：2005-04-22
申请人： Vincent Bavaro
发明人： Vincent Bavaro
IPC分类号： C10M149/06
CPC分类号： B29B9/12 , C10M111/04 , C10M2205/203 , C10M2209/1023 , C10M2209/1045 , C10M2217/0443 , C10M2217/0453 , C10M2229/025 , C10N2240/66 , C10N2250/08 , C10N2250/14 , C10N2250/18
摘要： A hydrophilic polymer blend where at least one of the polymer materials is a water insoluble polymer and one of the materials is a hydrophilic water-soluble polymer. The invention includes a method of forming the hydrophilic polymer blend by melt mixing the hydrophilic polymer and the insoluble polymer into a finely dispersed polymer blend, forming strands of the hydrophilic polymer blend, and then pelletizing the strands.
摘要翻译：一种亲水性聚合物共混物，其中至少一种聚合物材料是水不溶性聚合物，其中一种是亲水性水溶性聚合物。本发明包括通过将亲水性聚合物和不溶性聚合物熔融混合成精细分散的聚合物共混物形成亲水性聚合物共混物的方法，形成亲水性聚合物共混物的股线，然后造粒。

8. 发明申请

US20060240060A1 Lubricious compound and medical device made of the same 审中-公开
标题翻译：润滑复合物和医疗器械相同
公开(公告)号：US20060240060A1
公开(公告)日：2006-10-26
申请号：US11274544
申请日：2005-11-15
申请人： Vincent Bavaro
发明人： Vincent Bavaro
IPC分类号： A61F13/00 , B29C49/08
CPC分类号： A61L29/14 , A61L27/34 , A61L27/50 , A61L29/049 , A61L29/085 , A61L31/041 , A61L31/10 , A61L31/14 , C08J3/005 , C08J3/28 , C08J2371/02 , C08L71/02 , C10M111/04 , C10M2209/104 , C10M2209/1045 , C10M2217/045 , C10M2217/0453 , C10N2220/14 , C10N2240/66 , C10N2270/00 , C08L77/12
摘要： The present invention includes a lubricious polymer blend wherein at least one of the polymer materials is a water insoluble polymer and one of the materials is a lubricious water-soluble polymer. The invention includes a method of forming a desired medical device by melt mixing the selected polymers and then forming the polymer blend into the desired shape. The method further includes cross-linking the polymer blend after or before being shaped into the medical device in order to improve the retention of the lubricous polymer during exposure to abrasive forces or to materials which would extract the lubricious surface, such as water. Cross-linking the polymer blend may be improved by adding a cross-linking agent and/or cross-linking he polymer blend in the presence of a selected inert atmosphere.
摘要翻译：本发明包括润滑聚合物共混物，其中至少一种聚合物材料是水不溶性聚合物，并且其中一种材料是光滑水溶性聚合物。本发明包括通过熔融混合所选择的聚合物然后将聚合物共混物形成所需形状来形成所需医疗器械的方法。该方法还包括将聚合物共混物在被成形为医疗装置之前或之后交联，以便改善在暴露于研磨力期间润滑聚合物的保留性，或改善将提取润滑表面（例如水）的材料。交联聚合物共混物可以通过在选定的惰性气氛存在下加入交联剂和/或交联聚合物共混物来改善。

9. 发明申请

US20060240253A1 Guidewire and tube with lubricious coating 审中-公开
标题翻译：导丝和管与光滑的涂层
公开(公告)号：US20060240253A1
公开(公告)日：2006-10-26
申请号：US11112649
申请日：2005-04-22
申请人： Vincent Bavaro , Jason Phillips , Emmanuel Biagtan
发明人： Vincent Bavaro , Jason Phillips , Emmanuel Biagtan
IPC分类号： B32B1/08
CPC分类号： A61L31/14 , A61L31/10 , A61L2400/10 , A61M25/0009 , A61M25/0045 , A61M25/09 , A61M2025/0046 , A61M2025/0047 , A61M2025/09133 , Y10T428/1393 , Y10T428/2933 , C08L71/02
摘要： A hydrophilic polymer blend where at least one of the polymer materials is a water insoluble polymer and one of the materials is a hydrophilic water-soluble polymer. The invention includes a method of forming the hydrophilic polymer blend by melt mixing the hydrophilic polymer and the insoluble polymer into a finely dispersed polymer blend, forming strands of the hydrophilic polymer blend, and then pelletizing the strands.
摘要翻译：一种亲水性聚合物共混物，其中至少一种聚合物材料是水不溶性聚合物，其中一种是亲水性水溶性聚合物。本发明包括通过将亲水性聚合物和不溶性聚合物熔融混合成精细分散的聚合物共混物形成亲水性聚合物共混物的方法，形成亲水性聚合物共混物的股线，然后造粒。

10. 发明授权

US06527741B1 Angioplasty catheter system with adjustable balloon length 有权
公开(公告)号：US06527741B1
公开(公告)日：2003-03-04
申请号：US09469966
申请日：1999-12-21
申请人： Jeong S. Lee , Florencia Lim , Cheryl Stiger , Carolyn Voyles , Vincent Bavaro
发明人： Jeong S. Lee , Florencia Lim , Cheryl Stiger , Carolyn Voyles , Vincent Bavaro
IPC分类号： A61M2900
CPC分类号： B29C49/00 , A61M25/1027 , A61M2025/1031 , A61M2025/1059 , B29C43/10 , B29C43/36 , B29C55/28 , B29K2105/258 , B29L2022/025 , B29L2031/7542
摘要： A resizable inflatable balloon, primarily for use with balloon catheters. The resizable inflatable balloon comprises a first portion and an adjacent second portion. The first portion is inflatable to a working diameter at a first pressure while the second portion does not substantially expand at the first pressure. The second portion does expand to the working diameter at a second pressure greater than the first pressure, so that subsequent inflation at the first pressure inflates the first portion and the second portion to the working diameter. The methods of resizing the inflatable members include placing the inflatable balloon in a mold and supplying inflation fluid to expand the second member to the working diameter. In practice, a catheter having the resizable inflatable balloon is guided through a patient's vasculature until the inflatable balloon is positioned in a desired region. Inflation fluid is supplied at the first pressure to inflate the first portion to the working diameter. The catheter is withdraw and the inflatable balloon is resized as described above. The catheter is reintroduced to the patient's vasculature and inflation fluid is then supplied at the first pressure to inflate both the first and second portions.

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