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1. 发明申请

US20110039826A1 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CANCER AND OTHER DISEASES OR DISORDERS 审中-公开
标题翻译：用于治疗癌症及其他疾病或病症的药物组合物
公开(公告)号：US20110039826A1
公开(公告)日：2011-02-17
申请号：US12844920
申请日：2010-07-28
申请人： Vijayalakshmi Ramanan , Irene S. Tobias , Raymond D. Skwierczynski , Dauntel S. Verwijs
发明人： Vijayalakshmi Ramanan , Irene S. Tobias , Raymond D. Skwierczynski , Dauntel S. Verwijs
IPC分类号： A61K31/55 , A61P35/00 , B65B3/00
CPC分类号： A61K31/55 , A61K9/08 , A61K47/02 , A61K47/10 , A61K47/14 , A61K47/20 , A61K47/26 , C07D487/04
摘要： This invention provides novel pharmaceutical compositions of the compound of formula (I): or a pharmaceutically acceptable salt thereof, that are suitable for the bulk production of an oral pharmaceutical dosage form; processes for the production of said oral pharmaceutical dosage form; and the use of the pharmaceutical composition for the treatment of patients suffering from or subject to diseases, disorders, or conditions involving cell survival, proliferation and migration, including chronic inflammatory proliferative disorders, proliferative ocular disorders, benign proliferative disorders, and cancer.
摘要翻译：本发明提供了适用于大量生产口服药物剂型的式（I）化合物或其药学上可接受的盐的新型药物组合物：用于生产所述口服药物剂型的方法; 以及该药物组合物用于治疗患有或患有涉及细胞存活，增殖和迁移的疾病，病症或病症的患者的用途，包括慢性炎性增生性疾病，增殖性眼部疾病，良性增殖性疾病和癌症。

2. 发明授权

US08491929B2 Bioadhesive polymers 失效
标题翻译：生物粘合剂聚合物
公开(公告)号：US08491929B2
公开(公告)日：2013-07-23
申请号：US11922430
申请日：2006-06-23
申请人： Jules Jacob , Avinash Nangia , James Yeh , Vijayalakshmi Ramanan
发明人： Jules Jacob , Avinash Nangia , James Yeh , Vijayalakshmi Ramanan
IPC分类号： A61K9/48 , A61K9/32 , A61K6/00 , A61F2/00 , C08L35/00
CPC分类号： C08F8/00 , C08F222/00
摘要： Polymers and compositions, collectively “bioadhesive materials”, with improved bioadhesive properties have been developed. One or more compounds comprising: a) an aromatic moiety comprising two or more hydroxyl substituents, methoxy substituents, substituents hydrolyzable to hydroxyl substituents, or a combination thereof, and b) a primary or secondary amino moiety are either covalently attached to a polymer or are physically mixed with a polymer to form a bioadhesive material. These bioadhesive materials can be used, for example, to fabricate new drug delivery or diagnostic systems with increased residence time at tissue surfaces, and consequently increase the bioavailability of a drug or a diagnostic agent.
摘要翻译：已经开发了具有改善的生物粘合性质的聚合物和组合物，统称为“生物粘附材料”。一种或多种化合物，其包含：a）包含两个或更多个羟基取代基的芳族部分，甲氧基取代基，可羟基取代基可水解的取代基，或其组合，和b）伯或仲氨基部分共价连接至聚合物或与聚合物物理混合以形成生物粘附材料。这些生物粘附材料可以用于例如制备新的药物递送或诊断系统，其在组织表面上的停留时间增加，从而提高药物或诊断剂的生物利用度。

3. 发明申请

US20110086095A1 Bioadhesive Polymers 失效
标题翻译：生物粘合剂聚合物
公开(公告)号：US20110086095A1
公开(公告)日：2011-04-14
申请号：US11922430
申请日：2006-06-23
申请人： Jules Jacob , Avinash Nangia , James Yeh , Vijayalakshmi Ramanan
发明人： Jules Jacob , Avinash Nangia , James Yeh , Vijayalakshmi Ramanan
IPC分类号： A61K9/48 , C08F22/06 , A61K47/32 , A61K9/32
CPC分类号： C08F8/00 , C08F222/00
摘要： Polymers and compositions, collectively “bioadhesive materials”, with improved bioadhesive properties have been developed. One or more compounds comprising: a) an aromatic moiety comprising two or more hydroxyl substituents, methoxy substituents, substituents hydrolyzable to hydroxyl substituents, or a combination thereof, and b) a primary or secondary amino moiety are either covalently attached to a polymer or are physically mixed with a polymer to form a bioadhesive material. These bioadhesive materials can be used, for example, to fabricate new drug delivery or diagnostic systems with increased residence time at tissue surfaces, and consequently increase the bioavailability of a drug or a diagnostic agent.
摘要翻译：已经开发了具有改善的生物粘合性质的聚合物和组合物，统称为“生物粘附材料”。一种或多种化合物，其包含：a）包含两个或更多个羟基取代基的芳族部分，甲氧基取代基，可羟基取代基可水解的取代基，或其组合，和b）伯或仲氨基部分共价连接至聚合物或与聚合物物理混合以形成生物粘附材料。这些生物粘附材料可以用于例如制备新的药物递送或诊断系统，其在组织表面上的停留时间增加，从而提高药物或诊断剂的生物利用度。

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