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1. 发明授权

US07507860B2 Androgen modulators 失效
标题翻译：雄激素调节剂
公开(公告)号：US07507860B2
公开(公告)日：2009-03-24
申请号：US10599143
申请日：2005-04-01
申请人： Lain-Yen Hu , Huangshu Lei , Daniel Y. Du , Bruce A. Lefker , Yvonne Dorothy Smith , Victor Fedij
发明人： Lain-Yen Hu , Huangshu Lei , Daniel Y. Du , Bruce A. Lefker , Yvonne Dorothy Smith , Victor Fedij
IPC分类号： C07C211/08
CPC分类号： C07C255/54 , C07C323/41 , C07C2601/02 , C07C2602/08 , C07D209/16 , C07D213/40 , C07D285/01 , C07D307/52 , C07D307/81 , C07D311/76 , C07D317/58 , C07D333/20 , C07D471/04
摘要： The present invention is directed to a new class of 4-cyano-phenoxy-alkyl carboxyl derivatives and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
摘要翻译：本发明涉及一类新的4-氰基 - 苯氧基 - 烷基羧基衍生物及其作为雄激素受体调节剂的用途。本发明的其它方面涉及这些化合物用于减少过量的皮脂分泌和刺激毛发生长的用途。

2. 发明申请

US20060252796A1 Androgen modulators 失效
标题翻译：雄激素调节剂
公开(公告)号：US20060252796A1
公开(公告)日：2006-11-09
申请号：US11415935
申请日：2006-05-02
申请人： Stephen Barrett , Victor Fedij , Lain-Yen Hu , Donna Iula , Bruce Lefker , Raj Raheja , Karen Sexton , Jennifer Van Camp
发明人： Stephen Barrett , Victor Fedij , Lain-Yen Hu , Donna Iula , Bruce Lefker , Raj Raheja , Karen Sexton , Jennifer Van Camp
IPC分类号： A61K31/445 , A61K31/4015
CPC分类号： C07D207/273 , C07D207/27 , C07D401/06 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The present invention is directed to a new class of benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
摘要翻译：本发明涉及一类新的苯腈和它们作为雄激素受体调节剂的用途。本发明的其它方面涉及这些化合物用于减少过量的皮脂分泌和刺激毛发生长的用途。

3. 发明授权

US06380400B1 Methods of making dihydropyrone HIV protease inhibitors 失效
标题翻译：制备二氢吡喃酮HIV蛋白酶抑制剂的方法
公开(公告)号：US06380400B1
公开(公告)日：2002-04-30
申请号：US09674381
申请日：2000-10-31
申请人： Victor Fedij , Christopher Andrew Gajda , Brian Keith Huckabee , Brian Stuart Moon , Kenneth Thomas Porter , Denis Martin Sobieray , Timothy Lee Stuk , Bradley Dean Tait , James Norton Wemple
发明人： Victor Fedij , Christopher Andrew Gajda , Brian Keith Huckabee , Brian Stuart Moon , Kenneth Thomas Porter , Denis Martin Sobieray , Timothy Lee Stuk , Bradley Dean Tait , James Norton Wemple
IPC分类号： C07D30932
CPC分类号： C07D309/32 , C07C45/00 , C07C45/513 , C07C45/62 , C07C45/74 , C07C205/45 , C07C205/56 , C07C229/42 , C07C233/33 , C07C233/54 , C07C319/14 , C07C331/12 , C07C333/04 , C07C333/20 , C07C381/04 , C07C47/565 , C07C49/255 , C07C323/29
摘要： The present invention relates to methods of making dihydropyrone HIV inhibitors.
摘要翻译：本发明涉及制备二氢吡喃酮HIV抑制剂的方法

4. 发明授权

US4545286A Active armor 失效
标题翻译：主动装甲
公开(公告)号：US4545286A
公开(公告)日：1985-10-08
申请号：US620509
申请日：1984-06-14
申请人： Victor Fedij
发明人： Victor Fedij
IPC分类号： F41H5/013 , F41H5/02 , F41H5/04
CPC分类号： F41H5/007 , F41H5/013 , F41H5/023 , F41H5/0414 , F41H5/0421 , Y10S428/911
摘要： This disclosure depicts a novel apparatus for providing protection to armored personnel carriers such as tanks, or other military vehicles. The invention comprises a series of rectangular armor plates mounted to the surface area of the vehicle. The armor plates adjacent one another and each plate is secured to the tank surface by a threaded fastener. The threaded fasteners maintain the plates a predetermined distance from the tank surface and maintains the plates in a substantially parallel relationship to the surface of the tank wall. Each plate has three separate tiles adhered together, one tile comprising a steel material, one tile a soft material and one tile a thermally dissipating ceramic. The means for mounting the plates to the tank surface are designed such that the energy required to break the threaded fastener upon impact by a projectile is less than the energy required for the projectile to penetrate the plate.
摘要翻译：本公开描述了一种用于为装甲运兵车（例如坦克或其他军用车辆）提供保护的新型装置。本发明包括安装在车辆表面区域上的一系列矩形装甲板。铠装板彼此相邻，每个板通过螺纹紧固件固定到罐表面。螺纹紧固件将板保持与罐表面预定距离，并将板保持在与罐壁表面基本平行的关系。每个板具有粘合在一起的三个独立的瓦片，一个瓦片包括钢材料，一个瓦片是软材料，一个瓦片是散热陶瓷。用于将板安装到罐表面的装置被设计成使得在弹丸撞击时将螺纹紧固件打破所需的能量小于射弹穿透板所需的能量。

5. 发明授权

US07799823B2 Androgen modulators 失效
公开(公告)号：US07799823B2
公开(公告)日：2010-09-21
申请号：US11557225
申请日：2006-11-07
申请人： Stephen Douglas Barrett , Victor Fedij , Lain-Yen Hu , Donna M Iula , Bruce A Lefker , Raj Kumar Raheja , Karen Sexton , Jennifer Ann Van Camp
发明人： Stephen Douglas Barrett , Victor Fedij , Lain-Yen Hu , Donna M Iula , Bruce A Lefker , Raj Kumar Raheja , Karen Sexton , Jennifer Ann Van Camp
IPC分类号： A61K31/4015 , C07D207/12
CPC分类号： C07D207/273 , C07D207/27 , C07D401/06 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The present invention is directed to a new class of benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.

6. 发明申请

US20090192202A1 ANDROGEN MODULATORS 审中-公开
标题翻译：安德鲁调制器
公开(公告)号：US20090192202A1
公开(公告)日：2009-07-30
申请号：US12367887
申请日：2009-02-09
申请人： Lain-Yen Hu , Huangshu Lei , Daniel Y. Du , Bruce A. Lefker , Yvonne Dorothy Smith , Victor Fedij
发明人： Lain-Yen Hu , Huangshu Lei , Daniel Y. Du , Bruce A. Lefker , Yvonne Dorothy Smith , Victor Fedij
IPC分类号： A61K31/165 , C07C237/20 , C07D213/57 , A61K31/44 , A61P17/00
CPC分类号： C07C255/54 , C07C323/41 , C07C2601/02 , C07C2602/08 , C07D209/16 , C07D213/40 , C07D285/01 , C07D307/52 , C07D307/81 , C07D311/76 , C07D317/58 , C07D333/20 , C07D471/04
摘要： The present invention is directed to a new class of 4-cyano-phenoxy-alkyl carboxyl derivatives and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
摘要翻译：本发明涉及一类新的4-氰基 - 苯氧基 - 烷基羧基衍生物及其作为雄激素受体调节剂的用途。本发明的其它方面涉及这些化合物用于减少过量的皮脂分泌和刺激毛发生长的用途。

7. 发明申请

US20070197641A1 Androgen modulators 失效
标题翻译：雄激素调节剂
公开(公告)号：US20070197641A1
公开(公告)日：2007-08-23
申请号：US10599143
申请日：2005-04-01
申请人： Lain-Yen Hu , Huangshu Lei , Daniel Du , Bruce Lefker , Yvonne Smith , Victor Fedij
发明人： Lain-Yen Hu , Huangshu Lei , Daniel Du , Bruce Lefker , Yvonne Smith , Victor Fedij
IPC分类号： A61K31/277
CPC分类号： C07C255/54 , C07C323/41 , C07C2601/02 , C07C2602/08 , C07D209/16 , C07D213/40 , C07D285/01 , C07D307/52 , C07D307/81 , C07D311/76 , C07D317/58 , C07D333/20 , C07D471/04
摘要： The present invention is directed to a new class of 4-cyano-phenoxy-alkyl carboxyl derivatives and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
摘要翻译：本发明涉及一类新的4-氰基 - 苯氧基 - 烷基羧基衍生物及其作为雄激素受体调节剂的用途。本发明的其它方面涉及这些化合物用于减少过量的皮脂分泌和刺激毛发生长的用途。

8. 发明申请

US20070072936A1 ANDROGEN MODULATORS 失效
标题翻译：安德鲁调制器
公开(公告)号：US20070072936A1
公开(公告)日：2007-03-29
申请号：US11557225
申请日：2006-11-07
申请人： Stephen Barrett , Victor Fedij , Lain-Yen Hu , Donna Iula , Bruce Lefker , Raj Raheja , Karen Sexton , Jennifer Van Camp
发明人： Stephen Barrett , Victor Fedij , Lain-Yen Hu , Donna Iula , Bruce Lefker , Raj Raheja , Karen Sexton , Jennifer Van Camp
IPC分类号： A61K31/4015
CPC分类号： C07D207/273 , C07D207/27 , C07D401/06 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The present invention is directed to a new class of benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
摘要翻译：本发明涉及一类新的苯腈和它们作为雄激素受体调节剂的用途。本发明的其它方面涉及这些化合物用于减少过量的皮脂分泌和刺激毛发生长的用途。

9. 发明授权

US07674819B2 Androgen modulators 失效
标题翻译：雄激素调节剂
公开(公告)号：US07674819B2
公开(公告)日：2010-03-09
申请号：US11415935
申请日：2006-05-02
申请人： Stephen Douglas Barrett , Victor Fedij , Lain-Yen Hu , Donna M. Iula , Bruce A. Lefker , Raj Kumar Raheja , Karen Sexton , Jennifer Ann Van Camp
发明人： Stephen Douglas Barrett , Victor Fedij , Lain-Yen Hu , Donna M. Iula , Bruce A. Lefker , Raj Kumar Raheja , Karen Sexton , Jennifer Ann Van Camp
IPC分类号： A61K31/40 , C07D207/04
CPC分类号： C07D207/273 , C07D207/27 , C07D401/06 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The present invention is directed to a new class of benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
摘要翻译：本发明涉及一类新的苯腈和它们作为雄激素受体调节剂的用途。本发明的其它方面涉及这些化合物用于减少过量的皮脂分泌和刺激毛发生长的用途。

10. 发明授权

US5466828A Chiral 3-cyano-1-substituted-pyrrolidines 失效
标题翻译：手性3-氰基-1-取代吡咯烷
公开(公告)号：US5466828A
公开(公告)日：1995-11-14
申请号：US238404
申请日：1994-05-05
申请人： Victor Fedij , Mark J. Suto , James N. Wemple , James R. Zeller
发明人： Victor Fedij , Mark J. Suto , James N. Wemple , James R. Zeller
IPC分类号： C07D207/09 , C07D207/46
CPC分类号： C07D207/09
摘要： Chiral 3-cyanopyrrolidines of the following formula are disclosed, wherein R' is as defined herein. The compounds are useful as intermediates for naphthyridine and quinoline antibiotics. ##STR1##
摘要翻译：公开了下式的手性3-氰基吡咯烷，其中R'如本文所定义。该化合物可用作萘啶和喹啉类抗生素的中间体。

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