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1. 发明授权

US10479784B2 Substituted pyrazin-2-amines as inhibitors of ATR kinase 有权
公开(公告)号：US10479784B2
公开(公告)日：2019-11-19
申请号：US15967110
申请日：2018-04-30
申请人： Vertex Pharmaceuticals Incorporated
发明人： Jean-Damien Charrier , Steven John Durrant , David Kay , Ronald Marcellus Alphonsus Knegtel , Somhairle MacCormick , Michael Paul Mortimore , Michael Edward O'Donnell , Joanne Pinder , Alistair Rutherford , Anisa Nizarali Virani , Stephen Clinton Young , Philip Michael Reaper
IPC分类号： A61K31/497 , C07D403/04 , C07D413/14 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04 , C07D241/28 , C07D401/10 , C07D403/14 , C07D405/14 , C07D417/14 , C07D401/04 , C07D403/10 , C07D405/04 , C07D405/12 , C07D409/04 , A61P35/00
摘要： The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.

2. 发明申请

US20170349596A1 COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE 审中-公开
公开(公告)号：US20170349596A1
公开(公告)日：2017-12-07
申请号：US15597806
申请日：2017-05-17
申请人： Vertex Pharmaceuticals Incorporated
发明人： Nadia Ahmad , Jean-Damien Charrier , Chris Davis , Gorka Etxebarria I Jardi , Damien Fraysse , Ronald Knegtel , Maninder Panesar , Francoise Pierard , Joanne Pinder , Pierre-Henri Storck , John Studley
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.The compounds of this invention have formula I-1 or I-A: wherein the variables are as defined herein.

3. 发明申请

US20160326180A1 COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE 审中-公开
标题翻译：化合物作为ATR激酶的抑制剂有用
公开(公告)号：US20160326180A1
公开(公告)日：2016-11-10
申请号：US15144921
申请日：2016-05-03
申请人： Vertex Pharmaceuticals Incorporated
发明人： Dean Boyall , Jean-Damien Charrier , Christopher John Davis , Steven John Durrant , Gorka Etxebarria I Jardi , Damien Fraysse , David Kay , Ronald Marcellus Alphonsus Knegtel , Joanne Pinder
IPC分类号： C07D487/04 , A61N5/10 , C07D471/04 , A61K31/437 , A61K31/5025 , A61K45/06
CPC分类号： C07D487/04 , A61K31/437 , A61K31/5025 , A61K45/06 , A61N5/10 , A61N2005/1098 , C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention are represented by formula I-A and formula I-B: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.
摘要翻译：或其药学上可接受的盐，其中变量如本文所定义。

4. 发明授权

US08912198B2 Compounds useful as inhibitors of ATR kinase 有权
标题翻译：可用作ATR激酶抑制剂的化合物
公开(公告)号：US08912198B2
公开(公告)日：2014-12-16
申请号：US14053737
申请日：2013-10-15
申请人： Vertex Pharmaceuticals Incorporated
发明人： Jean-Damien Charrier , Joanne Pinder , Pierre-Henri Storck
IPC分类号： A01N43/00 , A61K31/00 , A61K31/4965 , C07D413/12 , C07D413/04 , C07D413/14
CPC分类号： C07D413/14 , C07D413/04 , C07D413/12
摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.
摘要翻译：本发明涉及可用作ATR蛋白激酶抑制剂的化合物。本发明还涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 以及在体外应用中使用化合物的方法，如生物和病理现象中激酶的研究; 由这种激酶介导的细胞内信号转导途径的研究; 和新型激酶抑制剂的比较评估。本发明的化合物具有式I：或其药学上可接受的盐，其中变量如本文所定义。

5. 发明授权

US08841337B2 Compounds useful as inhibitors of ATR kinase 有权
公开(公告)号：US08841337B2
公开(公告)日：2014-09-23
申请号：US13672949
申请日：2012-11-09
申请人： Vertex Pharmaceuticals Incorporated
发明人： Jean-Damien Charrier , Pierre-Henri Storck , Joanne Pinder , John R. Studley
IPC分类号： C07D401/12 , C07D401/00 , A61K31/4965 , A61K31/555 , A61K31/497 , A61K31/454 , A61K31/4184 , A61K31/166 , C07D403/04 , A61K31/502 , A61K33/24 , A61K31/55 , A61K31/7068 , C07D413/04 , A61K31/7048 , A61K31/282 , A61K31/5025
CPC分类号： C07D403/04 , A61K31/166 , A61K31/282 , A61K31/4184 , A61K31/454 , A61K31/497 , A61K31/502 , A61K31/5025 , A61K31/55 , A61K31/555 , A61K31/7048 , A61K31/7068 , A61K33/24 , C07D413/04 , A61K2300/00
摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.

6. 发明申请

US20140249157A1 COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE 有权
公开(公告)号：US20140249157A1
公开(公告)日：2014-09-04
申请号：US14201037
申请日：2014-03-07
申请人： Vertex Pharmaceuticals Incorporated
发明人： Nadia Ahmad , Dean Boyall , Jean-Damien Charrier , Chris Davis , Rebecca Davis , Steven Durrant , Gorka Etxebarria I Jardi , Damien Fraysse , Juan-Miguel Jimenez , David Kay , Ronald Knegtel , Donald Middleton , Michael O'Donnell , Maninder Panesar , Francoise Pierard , Joanne Pinder , David Shaw , Pierre-Henri Storck , John Studley , Heather Twin
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , C07D453/02 , C07D471/08 , C07D487/08 , C07D491/107 , C07D498/04 , C07D498/10
摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

7. 发明申请

US20140163000A1 COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE 有权
标题翻译：化合物作为ATR激酶的抑制剂有用
公开(公告)号：US20140163000A1
公开(公告)日：2014-06-12
申请号：US14098606
申请日：2013-12-06
申请人： Vertex Pharmaceuticals Incorporated
发明人： Nadia Ahmad , Dean Boyall , Jean-Damien Charrier , Chris Davis , Rebecca Davis , Steven Durrant , Gorka Etxebarria I Jardi , Damien Fraysse , Juan-Miguel Jimenez , David Kay , Ronald Knegtel , Donald Middleton , Michael O'Donnell , Maninder Panesar , Francoise Pierard , Joanne Pinder , David Shaw , Pierre-Henri Storck , John Studley , Heather Twin
IPC分类号： C07D487/04 , C07D487/08 , C07D498/10 , C07D491/107 , C07D498/04 , C07D453/02 , C07D471/08
CPC分类号： C07D487/04 , C07D453/02 , C07D471/08 , C07D487/08 , C07D491/107 , C07D498/04 , C07D498/10
摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.
摘要翻译：本发明涉及可用作ATR蛋白激酶抑制剂的化合物。本发明还涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 以及在体外应用中使用化合物的方法，如生物和病理现象中激酶的研究; 由这种激酶介导的细胞内信号转导途径的研究; 和新型激酶抑制剂的比较评估。本发明的化合物具有式I：或其药学上可接受的盐，其中变量如本文所定义。此外，本发明的化合物具有式I-A或其药学上可接受的盐，其中变量如本文所定义。

8. 发明授权

US11370798B2 Compounds useful as inhibitors of ATR kinase 有权
公开(公告)号：US11370798B2
公开(公告)日：2022-06-28
申请号：US17007412
申请日：2020-08-31
申请人： Vertex Pharmaceuticals Incorporated
发明人： Nadia Ahmad , Dean Boyall , Jean-Damien Charrier , Chris Davis , Rebecca Davis , Steven Durrant , Gorka Etxebarria I Jardi , Damien Fraysse , Juan-Miguel Jimenez , David Kay , Ronald Knegtel , Donald Middleton , Michael O'Donnell , Maninder Panesar , Francoise Pierard , Joanne Pinder , David Shaw , Pierre-Henri Storck , John Studley , Heather Twin
IPC分类号： C07D487/04 , C07D453/02 , C07D471/08 , C07D487/08 , C07D491/107 , C07D498/04 , C07D498/10
摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.
The compounds of this invention have formula I: or a pharmaceutically acceptable salt, wherein the variables are as devined herein. Moreover, The compounds of this invention have formula I-A: or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

9. 发明申请

US20190256516A1 COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE 审中-公开
公开(公告)号：US20190256516A1
公开(公告)日：2019-08-22
申请号：US16192134
申请日：2018-11-15
申请人： Vertex Pharmaceuticals Incorporated
发明人： Jean-Damien Charrier , Christopher John Davis , Damien Fraysse , Gorka Etxebarria I Jardi , Simon Pegg , Francoise Pierard , Joanne Pinder , John Studley , Carl Zwicker , Tapan Sanghvi , Michael Waldo , Ales Medek , David Matthew Shaw , Maninder Panesar , Yuegang Zhang , Naziha Alem
IPC分类号： C07D487/04 , C07B59/00 , C07C45/63 , C07C45/00
摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention.The compounds of this invention have formula I-A or I-B: wherein the variables are as defined herein.

10. 发明申请

US20180170922A1 COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE 审中-公开
公开(公告)号：US20180170922A1
公开(公告)日：2018-06-21
申请号：US15608630
申请日：2017-05-30
申请人： Vertex Pharmaceuticals Incorporated
发明人： Jean-Damien Charrier , Steven Durrant , David Kay , Ronald Knegtel , Somhairle MacCormick , Michael Mortimore , Michael O'Donnell , Joanne Pinder , Alistair Rutherford , Anisa Nizarali Virani , Stephen Young , Philip Michael Reaper
IPC分类号： C07D413/14 , C07D471/04 , C07D241/28 , C07D417/12 , C07D417/04 , C07D413/12 , C07D409/14 , C07D409/04 , C07D405/14 , C07D405/12 , C07D405/04 , C07D403/14 , C07D403/12 , C07D403/10 , C07D403/04 , C07D401/14 , C07D401/10 , C07D401/04 , C07D417/14
CPC分类号： C07D413/14 , A61P35/00 , C07D241/28 , C07D401/04 , C07D401/10 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I: wherein the variables are as defined herein.

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