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1. 发明授权

US08460667B2 EPHA2 receptor antagonist antibodies 有权
标题翻译： EPHA2受体拮抗剂抗体
公开(公告)号：US08460667B2
公开(公告)日：2013-06-11
申请号：US12373574
申请日：2007-07-13
申请人： Veronique Blanc , Claudia Fromond , Fabienne Parker , Jiawen Han , Daniel Tavares , Chonghui Zhang , Min Li , Xiao-Mai Zhou , Michel Streuli
发明人： Veronique Blanc , Claudia Fromond , Fabienne Parker , Jiawen Han , Daniel Tavares , Chonghui Zhang , Min Li , Xiao-Mai Zhou , Michel Streuli
IPC分类号： A61K39/395 , C07K16/18 , C07K16/28
CPC分类号： C07K16/28 , A61K39/3955 , A61K45/06 , A61K47/6849 , A61K2039/505 , C07K16/2866 , C07K16/30 , C07K16/40 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57492 , G01N2333/705 , G01N2333/91205
摘要： Antagonistic antibodies that specifically bind to and inhibit Class A Eph receptors are provided. Also provided are cytotoxic conjugates, pharmaceutical compositions and kits comprising these antibodies.
摘要翻译：提供了特异性结合并抑制A类Eph受体的拮抗性抗体。还提供了包含这些抗体的细胞毒性缀合物，药物组合物和试剂盒。

2. 发明申请

US20100047257A1 ANTAGONIST ANTIBODY FOR THE TREATMENT OF CANCER 有权
标题翻译：用于治疗癌症的拮抗剂抗体
公开(公告)号：US20100047257A1
公开(公告)日：2010-02-25
申请号：US12373574
申请日：2007-07-13
申请人： Veronique Blanc , Claudia Fromond , Fabienne Parker , Jiawen Han , Daniel Tavares , Chonghui Zhang , Min Li , Xiao-Mai Zhou , Michel Streuli
发明人： Veronique Blanc , Claudia Fromond , Fabienne Parker , Jiawen Han , Daniel Tavares , Chonghui Zhang , Min Li , Xiao-Mai Zhou , Michel Streuli
IPC分类号： A61K39/395 , G01N33/574 , C12N5/00 , C12N15/63 , C07K16/28 , C07H21/04
CPC分类号： C07K16/28 , A61K39/3955 , A61K45/06 , A61K47/6849 , A61K2039/505 , C07K16/2866 , C07K16/30 , C07K16/40 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/57492 , G01N2333/705 , G01N2333/91205
摘要： Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of same with cytotoxic agents, which specifically bind to, and inhibit A class of Eph receptors, antagonize the effects of growth factors on the growth and survival of tumor cells, and which have minimal agonistic activity or are preferentially devoid of agonist activity. Said antibodies and fragments thereof may be used in the treatment of tumors that express elevated levels of A class of Eph receptors, such as breast cancer, colon cancer, lung cancer, ovarian carcinoma, synovial sarcoma and pancreatic cancer, and said derivatized antibodies may be used in the diagnosis and imaging of tumors that express elevated levels of A class of Eph receptors. Also provided are cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate are disclosed are all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the A class of Eph receptors.
摘要翻译：抗体，人源化抗体，表面抗体，抗体片段，衍生化抗体以及与细胞毒性试剂特异性结合并抑制A类Eph受体的结合物拮抗生长因子对肿瘤细胞生长和存活的影响，并且其具有最小的激动活性或优先没有激动剂活性。所述抗体及其片段可用于治疗表达升高水平的A类Eph受体（例如乳腺癌，结肠癌，肺癌，卵巢癌，滑膜肉瘤和胰腺癌）的肿瘤，并且所述衍生抗体可以是用于诊断和成像表达高水平A类Eph受体的肿瘤。还提供了包含细胞结合剂和细胞毒性剂的细胞毒性缀合物，包含缀合物的治疗组合物，用于抑制细胞生长和治疗疾病的方法以及包含细胞毒性缀合物的试剂盒是所有实施方案的本发明。特别地，细胞结合剂是识别和结合A类Eph受体的单克隆抗体及其表位结合片段。

3. 发明授权

US07193044B1 Compounds and methods for regulating apoptosis, and methods of making and screening for compounds that regulate apoptosis 失效
标题翻译：用于调节凋亡的化合物和方法，以及调节细胞凋亡的化合物的制备和筛选方法
公开(公告)号：US07193044B1
公开(公告)日：2007-03-20
申请号：US09580523
申请日：2000-05-30
申请人： Xiao-Mai Zhou
发明人： Xiao-Mai Zhou
IPC分类号： C07K14/00
CPC分类号： C07K14/4702 , C07K16/18
摘要： Novel forms of mutant BAD polypeptides or fragments thereof having amino acid substitutions for serine-155 are provided along with their encoding polynucleotides. Also disclosed are methods for preparation of the mutant BAD polypeptides, methods for screening candidate compounds and drugs for activity that promotes cell survival or apoptosis, methods for screening candidate compounds and drugs for phosphatase activity capable of dephosphorylating BAD, methods for screening candidate compounds and drugs for kinase activity capable of phosphorylating BAD, methods for screening candidate compounds and drugs for activity that promotes phosphorylation of BAD, anti-BAD antibodies, and methods for inhibiting and inducing apoptosis.
摘要翻译：与其编码多核苷酸一起提供了具有丝氨酸-155的氨基酸取代的突变体BAD多肽或其片段的新形式。还公开了用于制备突变体BAD多肽的方法，用于筛选候选化合物的方法和用于促进细胞存活或凋亡的活性的药物，用于筛选候选化合物的方法和用于能够脱磷酸化BAD的磷酸酶活性的药物，用于筛选候选化合物和药物的方法对于能够磷酸化BAD的激酶活性，用于筛选候选化合物和用于促进BAD磷酸化的活性的药物的方法，抗BAD抗体以及用于抑制和诱导凋亡的方法。

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