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1. 发明授权

US09814773B2 Sustained release formulations for delivery of proteins to the eye and methods of preparing same 有权
公开(公告)号：US09814773B2
公开(公告)日：2017-11-14
申请号：US14124631
申请日：2012-06-11
申请人： Vernon G. Wong , Louis L. Wood , Carol Wood , Glenn T. Huang
发明人： Vernon G. Wong , Louis L. Wood , Glenn T. Huang
IPC分类号： A61K39/395 , A61K9/00 , A61K47/14 , A61K47/20 , A61K47/34 , A61K38/17 , A61K9/08
CPC分类号： A61K39/39541 , A61K9/0024 , A61K9/0051 , A61K9/08 , A61K38/1709 , A61K47/14 , A61K47/20 , A61K47/34
摘要： The present invention provides for injectable pharmaceutical sustained release formulations for delivery of active agents, particularly therapeutic proteins, to the eye. The formulations are biocompatible, biodegradable sustained release formulations comprising low-solubility liquid excipients and relatively small amounts (less than about 10%) of biocompatible, biodegradable polymer such as PLA or PLGA polymers. A unit dose of 5 μL to 100 μL of the formulation provides for sustained release of the agent for at least 14 days.

2. 发明申请

US20140140992A1 Sustained Release Formulations for Delivery of Proteins to the Eye and Methods of Preparing Same 有权
标题翻译：用于向蛋白质递送眼睛的持续释放制剂及其制备方法
公开(公告)号：US20140140992A1
公开(公告)日：2014-05-22
申请号：US14124631
申请日：2012-06-11
申请人： Vernon G. Wong , Louis L. Wood , Glenn T. Huang
发明人： Vernon G. Wong , Louis L. Wood , Glenn T. Huang
IPC分类号： A61K47/34 , A61K39/395 , A61K38/17
CPC分类号： A61K39/39541 , A61K9/0024 , A61K9/0051 , A61K9/08 , A61K38/1709 , A61K47/14 , A61K47/20 , A61K47/34
摘要： The present invention provides for injectable pharmaceutical sustained release formulations for delivery of active agents, particularly therapeutic proteins, to the eye. The formulations are biocompatible, biodegradable sustained release formulations comprising low-solubility liquid excipients and relatively small amounts (less than about 10%) of biocompatible, biodegradable polymer such as PLA or PLGA polymers. A unit dose of 5 μL to 100 μL of the formulation provides for sustained release of the agent for at least 14 days.
摘要翻译：本发明提供了用于将活性剂特别是治疗性蛋白质递送至眼睛的可注射药物缓释制剂。制剂是包含低溶解度液体赋形剂和相对少量（小于约10％）生物相容性，可生物降解的聚合物如PLA或PLGA聚合物的生物相容性，可生物降解的持续释放制剂。单位剂量为5μL至100μL的制剂可使药剂持续释放至少14天。

3. 发明授权

US09289428B2 Conveniently injectable or implantable sustained-release antioxidant formulations for therapies of ocular maladies or cancer 有权
标题翻译：方便注射或可植入的持续释放抗氧化剂配方，用于治疗眼部疾病或癌症
公开(公告)号：US09289428B2
公开(公告)日：2016-03-22
申请号：US14124592
申请日：2012-06-11
申请人： Vernon G. Wong , Louis L. Wood , Carol Wood
发明人： Vernon G. Wong , Louis L. Wood
IPC分类号： A61K31/5377 , A61K31/573 , A61K45/06 , A61K31/355 , A61K31/122 , A61K31/4045 , A61K31/375 , A61K31/05 , A61K9/00
CPC分类号： A61K31/5377 , A61K9/0019 , A61K9/0024 , A61K9/0048 , A61K9/0051 , A61K31/05 , A61K31/122 , A61K31/355 , A61K31/375 , A61K31/4045 , A61K31/573 , A61K45/06 , A61K2300/00
摘要： The present embodiments provide for sustained release formulations of antioxidants that are useful in treating afflictions of the eye and tumors.
摘要翻译：本实施方案提供可用于治疗眼睛和肿瘤的折磨的抗氧化剂的持续释放制剂。

4. 发明申请

US20140213646A1 Sustained Release Formulations for the Treatment of Intraocular Pressure or Glaucoma 有权
标题翻译：用于治疗眼内压或青光眼的持续释放制剂
公开(公告)号：US20140213646A1
公开(公告)日：2014-07-31
申请号：US14168139
申请日：2014-01-30
申请人： Vernon G. Wong , Mae W. Hu , Glenn T. Huang
发明人： Vernon G. Wong , Mae W. Hu , Glenn T. Huang
IPC分类号： A61K31/216
CPC分类号： A61K31/5575 , A61K9/0019 , A61K9/0048 , A61K47/14
摘要： The present embodiments provide for methods of treating elevated intraocular pressure or glaucoma using a sustained release medicament consisting of prostaglandin in benzyl benzoate that is injected intraocularly no more frequently than once every two months.
摘要翻译：本实施例提供了使用由前列腺素组成的持续释放药物治疗眼内压或青光眼的方法，所述缓释药物由苯甲酸苄酯组成，其眼内注射的频率不得超过每两个月一次。

5. 发明申请

US20140180245A1 DOSE GUIDES FOR INJECTION SYRINGE 有权
标题翻译：注射器剂量指导
公开(公告)号：US20140180245A1
公开(公告)日：2014-06-26
申请号：US14113803
申请日：2012-04-25
申请人： Vernon G. Wong , Tan Pham , William S. White , Glenn T. Huang , Mae W. Hu
发明人： Vernon G. Wong , Tan Pham , William S. White , Glenn T. Huang , Mae W. Hu
IPC分类号： A61M5/315
CPC分类号： A61M5/31536 , A61M5/315 , A61M5/3156 , A61M5/31591
摘要： Devices that guide the accurate loading and dispensing of predetermined doses of fluid from injection syringes are disclosed.
摘要翻译：公开了引导从注射器精确加载和分配预定剂量的流体的装置。

6. 发明授权

US10022502B2 Dose guides for injection syringe 有权
公开(公告)号：US10022502B2
公开(公告)日：2018-07-17
申请号：US14113803
申请日：2012-04-25
申请人： Vernon G. Wong , Tan Pham , William S. White , Glenn T. Huang , Mae W. Hu
发明人： Vernon G. Wong , Tan Pham , William S. White , Glenn T. Huang , Mae W. Hu
IPC分类号： A61M5/315
摘要： Devices that guide the accurate loading and dispensing of predetermined doses of fluid from injection syringes are disclosed.

7. 发明授权

US08722728B2 Composition and method for treating dry eye syndrome 有权
标题翻译：治疗干眼综合征的组合物和方法
公开(公告)号：US08722728B2
公开(公告)日：2014-05-13
申请号：US12576834
申请日：2009-10-09
申请人： Vernon G. Wong , Louis L. Wood
发明人： Vernon G. Wong , Louis L. Wood
IPC分类号： A61K31/355
CPC分类号： A61K31/355 , A61K9/0048 , A61K31/35
摘要： The present invention provides for compositions, medicaments, and methods for treating or alleviating the symptoms of dry eye syndrome or chronic dry eye. More specifically, the present embodiments provide for medicaments consisting of tocopherol or tocotrienol eyedrops. A single topical administration of tocopherol or tocotrienol eyedrops in the eyes of a subject suffering from dry eye alleviates symptoms for at least one day. In particular, the eyedrop medicament consists of α-tocopheryl acetate; α-tocopheryl acetate and about 0.5% aqueous component; or α-tocopheryl acetate, about 2.5% tocopherol emulsifier, and about 20% to about 30% aqueous excipient.
摘要翻译：本发明提供用于治疗或缓解干眼综合征或慢性干眼症状的组合物，药物和方法。更具体地，本实施方案提供了由生育酚或生育三烯酚滴眼剂组成的药物。在干眼症患者的眼睛中单次局部施用生育酚或生育三烯酚眼药水可缓解至少一天的症状。特别地，滴眼剂由α-生育酚乙酸酯组成; 乙酸α-生育酚和约0.5％的水性成分; 或α-生育酚乙酸酯，约2.5％生育酚乳化剂和约20％至约30％水性赋形剂。

8. 发明授权

US07906136B2 Conveniently implantable sustained release drug compositions 有权
标题翻译：方便地植入式缓释药物组合物
公开(公告)号：US07906136B2
公开(公告)日：2011-03-15
申请号：US11236426
申请日：2005-09-27
申请人： Vernon G. Wong , Louis L. Wood
发明人： Vernon G. Wong , Louis L. Wood
IPC分类号： A61F2/00
CPC分类号： A61K9/0051 , A61K9/0024 , A61K31/355 , A61K31/555
摘要： This invention provides for biocompatible and biodegradable syringeable liquid, implantable solid, and injectable gel pharmaceutical formulations useful for the treatment of systemic and local disease states.
摘要翻译：本发明提供用于治疗全身和局部疾病状态的生物相容性和可生物降解的可注射液体，可植入固体和可注射凝胶药物制剂。

9. 发明授权

US09011915B2 Conveniently implantable sustained release drug compositions 有权
标题翻译：方便地植入式缓释药物组合物
公开(公告)号：US09011915B2
公开(公告)日：2015-04-21
申请号：US13006801
申请日：2011-01-14
申请人： Vernon G. Wong , Louis L. Wood
发明人： Vernon G. Wong , Louis L. Wood
IPC分类号： A61K9/14 , A61K31/355 , A61K47/00 , A01N43/16 , A01N25/00 , A61K9/00 , A61K47/06
CPC分类号： A61K47/14 , A61K9/0019 , A61K9/0024 , A61K9/0048 , A61K9/0051 , A61K31/355 , A61K31/496 , A61K31/573 , A61K38/13 , A61K47/06
摘要： This invention provides for biocompatible and biodegradable syringeable liquid, implantable solid, and injectable gel pharmaceutical formulations useful for the treatment of systemic and local disease states.
摘要翻译：本发明提供用于治疗全身和局部疾病状态的生物相容性和可生物降解的可注射液体，可植入固体和可注射凝胶药物制剂。

10. 发明授权

US08541413B2 Sustained release eye drop formulations 有权
标题翻译：持续释放眼药水配方
公开(公告)号：US08541413B2
公开(公告)日：2013-09-24
申请号：US12236877
申请日：2008-09-24
申请人： Vernon G. Wong , Louis L. Wood
发明人： Vernon G. Wong , Louis L. Wood
IPC分类号： A61K31/535
CPC分类号： A61K31/573 , A61K9/0048 , A61K38/13 , A61K47/12 , A61K47/14 , A61K47/22
摘要： This invention provides for biocompatible, biodegradable eye drop pharmaceutical formulations useful for the treatment of ocular indications. In particular, tocopherols and their esters of low water solubility, notably α-tocopheryl acetate, are exceptional vehicles for biocompatible, nonirritating topical eye drop formulations that provide sustained release of active agents.
摘要翻译：本发明提供用于治疗眼部适应症的生物相容性，可生物降解的滴眼剂药物制剂。特别地，生育酚及其低水溶性的酯，特别是α-生育酚乙酸酯，是用于生物相容性，无刺激性的局部滴眼剂制剂的特殊载体，其提供活性剂的持续释放。

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