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1. 发明申请

US20060100422A1 Pichia pastoris formate dehydrogenase and uses therefor 审中-公开
公开(公告)号：US20060100422A1
公开(公告)日：2006-05-11
申请号：US11180275
申请日：2005-07-13
申请人： Steven Goldberg , Paul Cino , Ramesh Patel , Venkata Nanduri , Robert Johnston
发明人： Steven Goldberg , Paul Cino , Ramesh Patel , Venkata Nanduri , Robert Johnston
IPC分类号： C07H21/04 , C12P21/06 , C12N9/04 , C12N15/74 , C12N1/18
CPC分类号： C12N9/0004 , C12Q1/26 , G01N2333/04
摘要： This invention relates to a recombinant Pichia pastoris formate dehydrogenase (FDH) enzyme that catalyzes the oxidation of formate to carbon dioxide and the simultaneous reduction of nicotinamide adenine dinucleotide (NAD+) to its reduced form (NADH). Also related are isolated nucleic acids encoding P. pastoris FDH polypeptides, and fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated, recombinant P. pastoris FDH polypeptides, and fragments and variants thereof, and antibodies that specifically bind to P. pastoris FDH polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolated P. pastoris FDH nucleic acids, polypeptides, and antibodies, and methods of using P. pastoris FDH in various reactions for industrial or pharmaceutical applications.

2. 发明申请

US20060292678A1 Gluconobacter oxydans 2-ketoreductase enzyme and applications thereof 审中-公开
标题翻译：氧化葡糖杆菌2-酮还原酶及其应用
公开(公告)号：US20060292678A1
公开(公告)日：2006-12-28
申请号：US11159690
申请日：2005-06-23
申请人： Venkata Nanduri , Robert Johnston , Steven Goldberg , Paul Cino , Ramesh Patel
发明人： Venkata Nanduri , Robert Johnston , Steven Goldberg , Paul Cino , Ramesh Patel
IPC分类号： C12P7/02 , C12P21/06 , C07H21/04 , C12N1/21 , C12N15/74
CPC分类号： C12N9/0004 , C12Q1/26 , C12Q1/32 , G01N2333/04
摘要： This invention relates to an novel Gluconobacter oxydans 2-ketoreductase useful for the synthesis of chiral alcohols. Also related are isolated nucleic acids encoding G. oxydans 2-ketoreductase enzymes, and enzyme fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated G. oxydans 2-ketoreductase polypeptides, and fragments and variants thereof, and antibodies that specifically bind to G. oxydans 2-ketoreductase polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolated G. oxydans 2-ketoreductase nucleic acids, polypeptides, and antibodies, and methods of using G. oxydans 2-ketoreductase in various reactions for industrial or pharmaceutical applications.
摘要翻译：本发明涉及可用于合成手性醇的新型氧化葡糖杆菌2-酮还原酶。还涉及编码G.oxydans 2-酮还原酶的分离的核酸及其酶片段及其变体，以及包含这些核酸的载体和宿主细胞。进一步相关的是分离的G.oxydans 2-酮还原酶多肽及其片段和变体，以及特异性结合G.oxydans 2-酮还原酶多肽，片段或变体的抗体。本发明还涉及获得分离的G.oxydans 2-酮还原酶核酸，多肽和抗体的方法，以及在工业或药物应用的各种反应中使用G.oxydans 2-酮还原酶的方法。

3. 发明申请

US20060246544A1 Manufacturing process for the production of peptides grown in insect cell lines 审中-公开
标题翻译：用于生产在昆虫细胞系中生长的肽的制备方法
公开(公告)号：US20060246544A1
公开(公告)日：2006-11-02
申请号：US11396215
申请日：2006-03-30
申请人： Yun Kang , Walter Willett , Thomas Klimek , Basil Campbell , Paul Cino , Bradley Thomas , John Bermel , Chun-Chiang Chen
发明人： Yun Kang , Walter Willett , Thomas Klimek , Basil Campbell , Paul Cino , Bradley Thomas , John Bermel , Chun-Chiang Chen
IPC分类号： C12P21/06 , C12N9/24 , C12N5/06 , C07K14/53 , C07K14/51
CPC分类号： C07K14/535 , C07K1/20 , C07K14/505 , C07K14/51 , C07K14/53 , C12N9/1081 , C12P21/02 , C12Y204/99003
摘要： The present invention provides a manufacturing method for the production of peptides that are grown in insect cell lines. The peptides are grown in insect cell cultures that are infected with baculovirus particles in a culture supplemented with a lipid mixture. The peptides are then isolated from the insect cell culture using a method that employs a tangential flow filtration cascade. The isolated peptides are glycopeptides having an insect specific glycosylation pattern. The glycopeptides may then be conjugated to a modifying group via linkage through a glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase.
摘要翻译：本发明提供了生产在昆虫细胞系中生长的肽的制备方法。这些肽在补充有脂质混合物的培养物中被杆状病毒颗粒感染的昆虫细胞培养物中生长。然后使用采用切向流过滤级联的方法从昆虫细胞培养物中分离肽。分离的肽是具有昆虫特异性糖基化模式的糖肽。然后可以通过插入在肽和修饰基团之间并且共价连接到肽和修饰基团上的糖基连接基团通过连接将糖肽与修饰基团缀合。通过糖基转移酶的作用，由糖基化肽形成缀合物。

4. 发明授权

US5682816A Two stage feeding apparatus and method for feeding articles to a printing machine 失效
标题翻译：用于将物品供给到印刷机的两阶段进料装置和方法
公开(公告)号：US5682816A
公开(公告)日：1997-11-04
申请号：US634579
申请日：1996-04-18
申请人： Pieter S. van der Griendt , Paul Cino
发明人： Pieter S. van der Griendt , Paul Cino
IPC分类号： B41F17/20 , B65G47/57 , B41F17/00
CPC分类号： B65G47/57 , B41F17/20
摘要： A two stage feeding apparatus and method for feeding articles to a printing machine are disclosed. The apparatus comprises a transfer tray between a conventional stack loading mechanism and a conventional printing machine feeding mechanism. The transfer tray is both movable between a horizontal loading position and an inclined transitional position, and rotatable between the inclined transitional position and an inclined unloading position. The method comprises two stages of which a first stage involves moving the transfer tray between the horizontal loading position and the inclined transitional position, and a second stage involves rotating the transfer tray between the inclined transitional position and the inclined unloading position.
摘要翻译：公开了一种用于将物品供给印刷机的两级供料装置和方法。该装置包括在常规堆叠装载机构和常规印刷机进给机构之间的转印盘。传送托盘可以在水平装载位置和倾斜的过渡位置之间移动，并且可以在倾斜的过渡位置和倾斜的卸载位置之间旋转。该方法包括两个阶段，其中第一阶段包括在水平装载位置和倾斜过渡位置之间移动传送托盘，第二阶段包括在倾斜过渡位置和倾斜卸载位置之间转动传送托盘。

5. 发明授权

US4805758A Crossed turret cup feeder 失效
标题翻译：十字架塔架喂料机
公开(公告)号：US4805758A
公开(公告)日：1989-02-21
申请号：US71099
申请日：1987-07-08
申请人： James Dominico , Paul Cino , Carlos E. Fardin
发明人： James Dominico , Paul Cino , Carlos E. Fardin
IPC分类号： B41F17/28 , B65G43/08
CPC分类号： B41F17/28
摘要： Apparatus for supplying rows of stacked frusto-conical cups to a feeding assembly of a cup printing apparatus includes a rotatable, hollow, crossed turret comprised of an outer turret section formed by four radially and equiangularly oriented connected tubes, and a central tubular section positioned centrally within the outer turret section, the crossed turret supplying a first row of stacked cups to the feeding assembly and automatically supplying a subsequent row of stacked cups in stacked relation on the first row after a level of the first row has decreased to a lower predetermined level and before a last cup of the first row has been supplied on a respective mandrel assembly of the cup printing apparatus; a rotary actuator which rotates the central tubular section; a motor driven assembly which rotates the outer turret section; a first sensor which senses when the level of the first row has decreased to the lower predetermined level to actuate the motor driven assembly to cause the outer turret section and central tubular section to rotate together by 90.degree. to supply the subsequent row of stacked containers in stacked relation on the first row of stacked containers; a second sensor which senses when the level of the subsequent row has decreased to a higher predetermined level and supplying a signal to the rotary actuator to cause the central tubular section to rotate 90.degree. with respect to the outer turret section so as to be oriented horizontally; and a pusher assembly which intermittently supplies rows of stacked containers to the crossed turret when the central tubular section has been rotated back to the horizontal position after the level of the subsequent row has decreased to the higher predetermined level.
摘要翻译：用于将杯形印刷装置的进给组件提供排的排列的截头圆锥形杯的装置包括一个可旋转的中空的十字架，包括由四个径向和等角度连接的管形成的外转塔部分，以及定位在中心的中心管状部分在外转塔部分内，十字转塔向供料组件供应第一排堆叠的杯子，并且在第一排的水平已经降低到较低的预定水平之后，在第一排上自动地将堆叠的杯子的堆叠关系提供给第一排并且在第一排的最后一杯被提供在杯形打印装置的相应的心轴组件之前; 旋转致动器，其使中心管状部分旋转; 旋转外转塔段的马达驱动组件; 第一传感器，其感测第一排的水平何时已经降低到较低的预定水平以致致动马达驱动组件，从而使外转塔段和中心管段一起旋转90度，以便将后续的堆叠容器排放置在在第一排堆放的集装箱上堆叠关系; 第二传感器，其感测随后的行的水平何时降低到更高的预定水平，并且向旋转致动器提供信号，以使中心管状部相对于外转塔段旋转90度，以便水平定向 ; 以及当后续行的水平已经降低到更高的预定水平之后，当中央管状部分已经旋转回到水平位置时，间歇地将排堆叠的容器排列到十字转台的推动器组件。

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