专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20060205799A1 Anti-cancer and anti-microbial oxazolidinones 失效
标题翻译：抗癌和抗微生物恶唑烷酮
公开(公告)号：US20060205799A1
公开(公告)日：2006-09-14
申请号：US11358961
申请日：2006-02-21
申请人： Venkata Macherla , Benjamin Nicholson , Kin Lam
发明人： Venkata Macherla , Benjamin Nicholson , Kin Lam
IPC分类号： C07D263/38 , C07C249/02 , A61K31/421
CPC分类号： C07D263/40 , C07C257/06 , C12P17/14
摘要： Disclosed herein are various novel oxazolidinone, imidazolidinone, and thiazolidinone analogs and methods of treating cancer and/or microbial infection using these analogs. Particular 4-oxazolidinone compounds are shown to have anti-cancer and anti-microbial activity.
摘要翻译：本文公开了各种新的恶唑烷酮，咪唑啉酮和噻唑烷酮类似物以及使用这些类似物治疗癌症和/或微生物感染的方法。特定的4-恶唑烷酮化合物显示具有抗癌和抗微生物活性。

2. 发明申请

US20080070969A1 [3.2.0] HETEROCYCLIC COMPOUNDS AND METHODS OF USING THE SAME 有权
标题翻译： [3.2.0]杂环化合物及其使用方法
公开(公告)号：US20080070969A1
公开(公告)日：2008-03-20
申请号：US11865704
申请日：2007-10-01
申请人： Barbara Potts , Venkat Macherla , Scott Mitchell , Ram Manam , Katherine Reed , Kin Lam , Saskia Neuteboom , Ta-Hsiang Chao , Benjamin Nicholson , Cheryl Billstrom
发明人： Barbara Potts , Venkat Macherla , Scott Mitchell , Ram Manam , Katherine Reed , Kin Lam , Saskia Neuteboom , Ta-Hsiang Chao , Benjamin Nicholson , Cheryl Billstrom
IPC分类号： A61K31/407 , A61P29/00 , A61P31/00 , A61P35/00 , C07D491/044
CPC分类号： C07D491/04 , C07D207/28 , C07F5/025
摘要： Compounds of Formulae I-VI and derivatives thereof having anti-cancer, anti-inflammatory, and anti-microbial properties and to compositions that include one or more of compounds and their derivatives or analogs having anti-cancer, anti-inflammatory and anti-microbial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating cancer, inflammatory conditions, and microbial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.
摘要翻译：具有抗癌，抗炎和抗微生物性质的式I-VI及其衍生物的化合物和包含一种或多种具有抗癌，抗炎和抗微生物的化合物及其衍生物或类似物的组合物属性被公开。还公开了包含这些化合物的药物组合物和用所公开的化合物或所公开的药物组合物治疗癌症，炎性病症和微生物感染的方法。

3. 发明申请

US20050288352A1 [3.2.0] Heterocyclic compounds and methods of using the same 有权
标题翻译： [3.2.0]杂环化合物及其使用方法
公开(公告)号：US20050288352A1
公开(公告)日：2005-12-29
申请号：US11118260
申请日：2005-04-29
申请人： Barbara Potts , Venkat Macherla , Scott Mitchell , Ram Manam , Katherine Reed , Kin Lam , Saskia Neuteboom , Ta-Hsiang Chao , Benjamin Nicholson , Cheryl Billstrom
发明人： Barbara Potts , Venkat Macherla , Scott Mitchell , Ram Manam , Katherine Reed , Kin Lam , Saskia Neuteboom , Ta-Hsiang Chao , Benjamin Nicholson , Cheryl Billstrom
IPC分类号： A61K31/407 , C07D207/28 , C07D491/02 , C07D491/04
CPC分类号： C07D491/04 , C07D207/28 , C07F5/025
摘要： Compounds of Formulae I-VI and derivatives thereof having anti-cancer, anti-inflammatory, and anti-microbial properties and to compositions that include one or more of compounds and their derivatives or analogs having anti-cancer, anti-inflammatory and anti-microbial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating cancer, inflammatory conditions, and microbial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.
摘要翻译：具有抗癌，抗炎和抗微生物性质的式I-VI及其衍生物的化合物和包含一种或多种具有抗癌，抗炎和抗微生物的化合物及其衍生物或类似物的组合物属性被公开。还公开了包含这些化合物的药物组合物和用所公开的化合物或所公开的药物组合物治疗癌症，炎性病症和微生物感染的方法。

4. 发明授权

US07879892B2 Anti-cancer and anti-microbial oxazolidinones 失效
标题翻译：抗癌和抗微生物恶唑烷酮
公开(公告)号：US07879892B2
公开(公告)日：2011-02-01
申请号：US12124909
申请日：2008-05-21
申请人： Venkata Rami Reddy Macherla , Benjamin Nicholson , Kin Sing Lam
发明人： Venkata Rami Reddy Macherla , Benjamin Nicholson , Kin Sing Lam
IPC分类号： A61K31/42 , C07D277/02
CPC分类号： C07D263/40 , C07C257/06 , C12P17/14
摘要： Disclosed herein are various novel oxazolidinone, imidazolidinone, and thiazolidinone analogs and methods of treating cancer and/or microbial infection using these analogs. Particular 4-oxazolidinone compounds are shown to have anti-cancer and anti-microbial activity.
摘要翻译：本文公开了各种新的恶唑烷酮，咪唑啉酮和噻唑烷酮类似物以及使用这些类似物治疗癌症和/或微生物感染的方法。特定的4-恶唑烷酮化合物显示具有抗癌和抗微生物活性。

5. 发明授权

US07112581B2 Macrocyclic lactams 失效
标题翻译：大环内酰胺
公开(公告)号：US07112581B2
公开(公告)日：2006-09-26
申请号：US10673036
申请日：2003-09-25
申请人： Scott C. Mitchell , Benjamin Nicholson
发明人： Scott C. Mitchell , Benjamin Nicholson
IPC分类号： A61K31/395 , A61K35/02 , A61P35/00 , C07D225/02
CPC分类号： C07D225/02
摘要： Compounds represented by the following structure (I), acid-addition salts and pro-drugs are disclosed: wherein the ring structure includes no substitutions, one substitution, or more than one substitution; and wherein n is equal to an integer grater than 1, preferably 2, 3, or 4; m is equal to a positive integer, preferably 1, 2 or 3, and each separate Xn and X are each separately selected from a nucleophilic residue, preferably —H, —OH, —O—CO-alkyl, —O-alkyl, —NH2, a halogen and the like; and wherein the dashed line represents a C—C bond or a C—H bond, and the dashed and solid line represents either a carbon-carbon single bond or a carbon-carbon double bond.
摘要翻译：公开了由以下结构（I）表示的化合物，酸加成盐和前药：其中环结构不包括取代，一个取代或多于一个取代; 并且其中n等于1，优选2,3或4的整数倍; m等于正整数，优选1,2或3，并且每个单独的X n和X各自独立地选自亲核残基，优选-H，-OH，-O-CO- 烷基，-O-烷基，-NH 2，卤素等; 并且其中虚线表示C-C键或C-H键，虚线和实线表示碳 - 碳单键或碳 - 碳双键。

6. 发明授权

US07935704B2 Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof 有权
标题翻译：脱氢苯基乙二烯和其类似物，以及脱氢苯基黑曲霉素及其类似物的合成
公开(公告)号：US07935704B2
公开(公告)日：2011-05-03
申请号：US11051268
申请日：2005-02-04
申请人： Michael A. Palladino , George Kenneth Lloyd , Yoshio Hayashi , Benjamin Nicholson
发明人： Michael A. Palladino , George Kenneth Lloyd , Yoshio Hayashi , Benjamin Nicholson
IPC分类号： A61K31/497
CPC分类号： A61K31/496
摘要： Compounds represented by the following structure (I) are disclosed: as are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R1, R1′, R1″, R2, R3, R4, R5, and R6, X1 and X2, Y, Z, Z1, Z2, Z3, and Z4 may each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating vascular proliferation are also disclosed.
摘要翻译：公开了由以下结构（I）表示的化合物：制备这种化合物的方法，其中所述方法包括使二酰基二酮哌嗪与第一醛反应以产生中间体化合物; 并使所述中间体化合物与第二醛反应以产生一类具有通式结构的化合物，其中第一种醛和第二种醛选自恶唑烷羧醛，咪唑甲醛，苯甲醛，咪唑甲醛衍生物和苯甲醛衍生物，从而形成上述化合物，其中R1，R1'，R1“，R2，R3，R4，R5和R6，X1和X2，Y，Z，Z1，Z2，Z3和Z4各自可以以一致的方式分别定义附带说明。还公开了治疗血管增生的组合物和方法。

7. 发明申请

US20100021941A1 METHODS OF IDENTIFYING MODULATORS OF UBIQUITIN LIGASES 审中-公开
标题翻译：识别UBIQUITIN LIGASES调制器的方法
公开(公告)号：US20100021941A1
公开(公告)日：2010-01-28
申请号：US12508128
申请日：2009-07-23
申请人： Jeffrey Gordon Marblestone , Suresh Kumar Kizhakkethil-George , Benjamin Nicholson
发明人： Jeffrey Gordon Marblestone , Suresh Kumar Kizhakkethil-George , Benjamin Nicholson
IPC分类号： G01N33/53
CPC分类号： C12Q1/25 , G01N33/573 , G01N2333/9015
摘要： Methods for identifying ubiquitin ligases and ubiquitin ligase modulators are disclosed. The methods comprise combining the components of a ubiquitylation reaction and using proteins that contain motifs that recognize ubiquitylated sites in the detection of ubiquitylation.
摘要翻译：公开了用于鉴定泛素连接酶和泛素连接酶调节剂的方法。所述方法包括组合泛素化反应的组分并使用含有在泛素化检测中识别泛素化位点的基序的蛋白质。

8. 发明申请

US20080221182A1 ANTI-CANCER AND ANTI-MICROBIAL OXAZOLIDINONES 审中-公开
标题翻译：抗癌和抗微生物毒素
公开(公告)号：US20080221182A1
公开(公告)日：2008-09-11
申请号：US12124896
申请日：2008-05-21
申请人： Venkata Rami Reddy Macherla , Benjamin Nicholson , Kin Sing Lam
发明人： Venkata Rami Reddy Macherla , Benjamin Nicholson , Kin Sing Lam
IPC分类号： A61K31/421 , C07D263/38 , C07C229/30 , A61K31/195
CPC分类号： C07D263/40 , C07C257/06 , C12P17/14
摘要： Disclosed herein are various novel oxazolidinone, imidazolidinone, and thiazolidinone analogs and methods of treating cancer and/or microbial infection using these analogs. Particular 4-oxazolidinone compounds are shown to have anti-cancer and anti-microbial activity.
摘要翻译：本文公开了各种新的恶唑烷酮，咪唑啉酮和噻唑烷酮类似物以及使用这些类似物治疗癌症和/或微生物感染的方法。特定的4-恶唑烷酮化合物显示具有抗癌和抗微生物活性。

9. 发明授权

US08680139B2 Anti-neoplastic compounds, compositions and methods 有权
标题翻译：抗肿瘤化合物，组合物和方法
公开(公告)号：US08680139B2
公开(公告)日：2014-03-25
申请号：US13262422
申请日：2010-03-31
申请人： Ping Cao , Joseph Weinstock , William D. Kingsbury , Craig A. Leach , Suresh Kumar Kizhakkethil-George , Benjamin Nicholson
发明人： Ping Cao , Joseph Weinstock , William D. Kingsbury , Craig A. Leach , Suresh Kumar Kizhakkethil-George , Benjamin Nicholson
IPC分类号： A61K31/381 , C07D333/18
CPC分类号： C07D409/12
摘要： Disclosed are novel compounds which are useful as therapeutics, especially in anti-neoplastic therapy and in other therapeutic regimes where cysteine protease inhibition is implicated.
摘要翻译：公开了可用作治疗剂的新化合物，特别是在抗肿瘤治疗和涉及半胱氨酸蛋白酶抑制的其它治疗方案中。

10. 发明申请

US20110143958A1 Methods of Identifying Modulators of Ubiquitin Ligases 审中-公开
标题翻译：识别泛素连接酶的调节剂的方法
公开(公告)号：US20110143958A1
公开(公告)日：2011-06-16
申请号：US13055042
申请日：2009-07-23
申请人： Jeffrey Gordon Marblestone , Benjamin Nicholson , Suresh Kumar Kizhakkethil-George
发明人： Jeffrey Gordon Marblestone , Benjamin Nicholson , Suresh Kumar Kizhakkethil-George
IPC分类号： C40B30/04 , G01N33/53
CPC分类号： C12Q1/25 , G01N33/573 , G01N2333/9015
摘要： Methods for identifying ubiquitin ligases and ubiquitin ligase modulators are disclosed. The methods comprise combining the components of a ubiquitylation reaction and using proteins that contain motifs that recognize ubiquitylated sites in the detection of ubiquitylation.
摘要翻译：公开了用于鉴定泛素连接酶和泛素连接酶调节剂的方法。所述方法包括组合泛素化反应的组分并使用含有在泛素化检测中识别泛素化位点的基序的蛋白质。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式