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1. 发明申请

US20070082843A1 Implantable pump for protein delivery for obesity control by drug infusion into the brain 有权
标题翻译：用于通过药物输注到大脑中进行肥胖控制的蛋白质递送的可植入泵
公开(公告)号：US20070082843A1
公开(公告)日：2007-04-12
申请号：US11245653
申请日：2005-10-07
申请人： Vedrana Stojanovic-Susulic , Ramakrishna Venugopalan , Mark Cunningham
发明人： Vedrana Stojanovic-Susulic , Ramakrishna Venugopalan , Mark Cunningham
IPC分类号： A61K38/22 , A61K38/30 , A61K38/17
CPC分类号： A61K38/34 , A61K47/6811 , A61K47/6849
摘要： Methods and compositions are provided for suppressing appetite by surgically implanting a drug infusion pump into a site in a subject, and delivering a stable suspension of an appetite suppressing agent a region in a central nervous system of the subject. The appetite suppressing agent binds to a target receptor on a neural cell in the central nervous system and modifies the receptor function to suppress appetite.
摘要翻译：提供了通过将药物输注泵手术植入受试者的部位来抑制食欲的方法和组合物，并且在受试者的中枢神经系统中输送食欲抑制剂的稳定的悬浮液。食欲抑制剂与中枢神经系统中的神经细胞上的靶受体结合并改变受体功能以抑制食欲。

2. 发明授权

US07790671B2 Implantable pump for protein delivery for obesity control by drug infusion into the brain 有权
标题翻译：用于通过药物输注到大脑中进行肥胖控制的蛋白质递送的可植入泵
公开(公告)号：US07790671B2
公开(公告)日：2010-09-07
申请号：US11245653
申请日：2005-10-07
申请人： Vedrana Stojanovic-Susulic , Ramakrishna Venugopalan , Mark Cunningham
发明人： Vedrana Stojanovic-Susulic , Ramakrishna Venugopalan , Mark Cunningham
IPC分类号： A61K38/00
CPC分类号： A61K38/34 , A61K47/6811 , A61K47/6849
摘要： Methods and compositions are provided for suppressing appetite by surgically implanting a drug infusion pump into a site in a subject, and delivering a stable suspension of an appetite suppressing agent a region in a central nervous system of the subject. The appetite suppressing agent binds to a target receptor on a neural cell in the central nervous system and modifies the receptor function to suppress appetite.
摘要翻译：提供了通过将药物输注泵手术植入受试者的部位来抑制食欲的方法和组合物，并且在受试者的中枢神经系统中输送食欲抑制剂的稳定的悬浮液。食欲抑制剂与中枢神经系统中的神经细胞上的靶受体结合并改变受体功能以抑制食欲。

3. 发明授权

US08252744B2 Implantable pump for protein delivery for obesity control by drug infusion into the brain 有权
标题翻译：用于通过药物输注到大脑中进行肥胖控制的蛋白质递送的可植入泵
公开(公告)号：US08252744B2
公开(公告)日：2012-08-28
申请号：US12709920
申请日：2010-02-22
申请人： Vedrana Stojanovic-Susulic , Ramakrishna Venugopalan , Mark Cunningham
发明人： Vedrana Stojanovic-Susulic , Ramakrishna Venugopalan , Mark Cunningham
IPC分类号： A61K38/34 , C07K2/00
CPC分类号： A61K38/34 , A61K47/6811 , A61K47/6849
摘要： Methods and compositions are provided for suppressing appetite by surgically implanting a drug infusion pump into a site in a subject, and delivering a stable suspension of an appetite suppressing agent a region in a central nervous system of the subject. The appetite suppressing agent binds to a target receptor on a neural cell in the central nervous system and modifies the receptor function to suppress appetite.
摘要翻译：提供了通过将药物输注泵手术植入受试者的部位来抑制食欲的方法和组合物，并且在受试者的中枢神经系统中输送食欲抑制剂的稳定的悬浮液。食欲抑制剂与中枢神经系统中的神经细胞上的靶受体结合并改变受体功能以抑制食欲。

4. 发明申请

US20100183700A1 IMPLANTABLE PUMP FOR PROTEIN DELIVERY FOR OBESITY CONTROL BY DRUG INFUSION INTO THE BRAIN 有权
标题翻译：用于通过药物输入到脑中进行肥胖控制的蛋白质递送的可植入泵
公开(公告)号：US20100183700A1
公开(公告)日：2010-07-22
申请号：US12709920
申请日：2010-02-22
申请人： Vedrana Stojanovic-Susulic , Ramakrishna Venugopalan , Mark Cunningham
发明人： Vedrana Stojanovic-Susulic , Ramakrishna Venugopalan , Mark Cunningham
IPC分类号： A61K9/00 , A61K38/34 , A61K39/395 , A61P1/00 , A61P3/04
CPC分类号： A61K38/34 , A61K47/6811 , A61K47/6849
摘要： Methods and compositions are provided for suppressing appetite by surgically implanting a drug infusion pump into a site in a subject, and delivering a stable suspension of an appetite suppressing agent a region in a central nervous system of the subject. The appetite suppressing agent binds to a target receptor on a neural cell in the central nervous system and modifies the receptor function to suppress appetite.
摘要翻译：提供了通过将药物输注泵手术植入受试者的部位来抑制食欲的方法和组合物，并且在受试者的中枢神经系统中输送食欲抑制剂的稳定的悬浮液。食欲抑制剂与中枢神经系统中的神经细胞上的靶受体结合并改变受体功能以抑制食欲。

5. 发明申请

US20100280487A1 METHOD OF REMOVING A STYLETTE FROM A CATHETER 审中-公开
标题翻译：从导管中去除晶状体的方法
公开(公告)号：US20100280487A1
公开(公告)日：2010-11-04
申请号：US12834572
申请日：2010-07-12
申请人： Ramakrishna Venugopalan , Greg M. Schorn
发明人： Ramakrishna Venugopalan , Greg M. Schorn
IPC分类号： A61M25/01 , A61B17/34
CPC分类号： A61L31/08 , A61L29/08 , A61M25/0102 , A61M25/0194
摘要： A hydrophilic coated stylette is pre-loaded in an implantable catheter. The hydrophilic coated stylette is wetted with saline to activate the hydrophilic coating. The stylette loaded catheter is tunneled, typically through muscle and tissue, to a desired target site within the body. The hydrophilic coated stylette is then removed from the catheter while maintaining the catheter intact. The proximal end of the catheter can be connected to an outlet of an implantable infusion pump so that medicament can be delivered directly to the target site.
摘要翻译：将亲水涂层的通心粉预先加载到可植入的导管中。用盐水润湿亲水涂层的丝心碱以活化亲水涂层。通常将通过肌肉和组织的导管插入到体内期望的目标部位。然后从导管中取出亲水涂层的通孔，同时保持导管完好无损。导管的近端可以连接到可植入输液泵的出口，使得药物可以直接输送到目标部位。

6. 发明授权

US08231563B2 Electrokinetic actuator to titrate fluid flow 失效
标题翻译：电动执行器来滴定流体流动
公开(公告)号：US08231563B2
公开(公告)日：2012-07-31
申请号：US12655404
申请日：2009-12-30
申请人： Christophe P. Mauge , Ramakrishna Venugopalan
发明人： Christophe P. Mauge , Ramakrishna Venugopalan
IPC分类号： A61M5/00 , C02F1/40
CPC分类号： A61M27/006
摘要： An electrokinetic actuator for fluid flow titration including two chambers separated from one another by a porous dielectric disposed therebetween. A plurality of electrodes are disposed about a perimeter of the first and second chambers. Polar electrolyte disposed within the actuator is able to pass through the porous dielectric between the first and second chambers upon the application of an electric field or electric potential to the plural electrodes. A mechanical valve actuation mechanism connected to the second chamber allows for fine titration of fluid flow using electro-osmosis, including full-flow and/or complete cut-off. The polar electrolyte is isolated to prohibit intermixing with a fluid being titrated (such as cerebrospinal fluid).
摘要翻译：一种用于流体流滴定的电动致动器，包括通过设置在它们之间的多孔电介质彼此隔开的两个室。多个电极围绕第一和第二腔室的周边设置。设置在致动器内的极性电解质能够在向多个电极施加电场或电位时通过第一和第二室之间的多孔电介质。连接到第二室的机械阀致动机构允许使用电渗透（包括全流和/或完全截止）的精细滴定流体流动。分离极性电解质以禁止与被滴定的流体混合（如脑脊液）。

7. 发明申请

US20100286585A1 Shunt Delivery of Curcumin 审中-公开
标题翻译：分流送姜黄素
公开(公告)号：US20100286585A1
公开(公告)日：2010-11-11
申请号：US12696588
申请日：2010-01-29
申请人： Thomas M. DiMauro , Alan Dextradeur , Sean Lilienfeld , Ramakrishna Venugopalan
发明人： Thomas M. DiMauro , Alan Dextradeur , Sean Lilienfeld , Ramakrishna Venugopalan
IPC分类号： A61M5/00
CPC分类号： A61K36/9066 , A61K31/12 , C07D279/28
摘要： A method for reducing or preventing a human brain disorder relating to the presence of a pathogenic substance in cerebrospinal fluid by selecting a human for treatment as a patient and placing a proximal end of a first catheter, having at least a first lumen, in a first sub-dural location within the brain of the patient to establish open communication between the first lumen and cerebrospinal fluid of the patient. For an extended period of time, a curcumin agent selected from at least one of curcumin, a curcumin hybrid and a curcumin analog is delivered to the cerebrospinal fluid to interact with the pathogenic substance to attenuate its effect on the brain.
摘要翻译：一种减少或预防与脑脊髓液中存在病原物质有关的人脑疾病的方法，该方法是通过选择人作为患者进行治疗，并将具有至少第一管腔的第一导管的近端放置在第一在患者的脑内部的硬脑膜下位置以建立患者的第一腔和脑脊液之间的开放的连通。在长时间内，选自姜黄素，姜黄素混合物和姜黄素类似物中的至少一种的姜黄素被递送到脑脊液中以与致病物质相互作用以减弱其对脑的作用。

8. 发明申请

US20070100322A1 Method of removing a stylette from a catheter 审中-公开
标题翻译：从导管中去除一个胰岛素的方法
公开(公告)号：US20070100322A1
公开(公告)日：2007-05-03
申请号：US11262697
申请日：2005-10-31
申请人： Ramakrishna Venugopalan , Greg Schom
发明人： Ramakrishna Venugopalan , Greg Schom
IPC分类号： A61M31/00
CPC分类号： A61L31/08 , A61L29/08 , A61M25/0102 , A61M25/0194
摘要： A hydrophilic coated stylette is pre-loaded in an implantable catheter. The hydrophilic coated stylette is wetted with saline to activate the hydrophilic coating. The stylette loaded catheter is tunneled, typically through muscle and tissue, to a desired target site within the body. The hydrophilic coated stylette is then removed from the catheter while maintaining the catheter intact. The proximal end of the catheter can be connected to an outlet of an implantable infusion pump so that medicament can be delivered directly to the target site.
摘要翻译：将亲水涂层的通心粉预先加载到可植入的导管中。用盐水润湿亲水涂层的丝心碱以活化亲水涂层。通常将通过肌肉和组织的导管插入到体内期望的目标部位。然后从导管中取出亲水涂层的通孔，同时保持导管完好无损。导管的近端可以连接到可植入输液泵的出口，使得药物可以直接输送到目标部位。

9. 发明申请

US20120323161A1 Electrokinetic Actuator to Titrate Fluid Flow 审中-公开
标题翻译：电动执行器滴定流体流动
公开(公告)号：US20120323161A1
公开(公告)日：2012-12-20
申请号：US13544891
申请日：2012-07-09
申请人： Christophe P. Mauge , Ramakrishna Venugopalan
发明人： Christophe P. Mauge , Ramakrishna Venugopalan
IPC分类号： A61M1/00
CPC分类号： A61M27/006
摘要： An electrokinetic actuator for fluid flow titration including two chambers separated from one another by a porous dielectric disposed therebetween. A plurality of electrodes are disposed about a perimeter of the first and second chambers. Polar electrolyte disposed within the actuator is able to pass through the porous dielectric between the first and second chambers upon the application of an electric field or electric potential to the plural electrodes. A mechanical valve actuation mechanism connected to the second chamber allows for fine titration of fluid flow using electro-osmosis, including full-flow and/or complete cut-off. The polar electrolyte is isolated to prohibit intermixing with a fluid being titrated such as cerebrospinal fluid.
摘要翻译：一种用于流体流滴定的电动致动器，包括通过设置在它们之间的多孔电介质彼此隔开的两个室。多个电极围绕第一和第二腔室的周边设置。设置在致动器内的极性电解质能够在向多个电极施加电场或电位时通过第一和第二室之间的多孔电介质。连接到第二室的机械阀致动机构允许使用电渗透（包括全流和/或完全截止）的精细滴定流体流动。分离极性电解质以禁止与被滴定的液体混合，如脑脊液。

10. 发明申请

US20110160638A1 Electrokinetic actuator to titrate fluid flow 失效
标题翻译：电动执行器来滴定流体流动
公开(公告)号：US20110160638A1
公开(公告)日：2011-06-30
申请号：US12655404
申请日：2009-12-30
申请人： Christophe P. Mauge , Ramakrishna Venugopalan
发明人： Christophe P. Mauge , Ramakrishna Venugopalan
IPC分类号： A61M1/00
CPC分类号： A61M27/006
摘要： An electrokinetic actuator for fluid flow titration including two chambers separated from one another by a porous dielectric disposed therebetween. A plurality of electrodes are disposed about a perimeter of the first and second chambers. Polar electrolyte disposed within the actuator is able to pass through the porous dielectric between the first and second chambers upon the application of an electric field or electric potential to the plural electrodes. A mechanical valve actuation mechanism connected to the second chamber allows for fine titration of fluid flow using electro-osmosis, including full-flow and/or complete cut-off. The polar electrolyte is isolated to prohibit intermixing with a fluid being titrated (such as cerebrospinal fluid).
摘要翻译：一种用于流体流滴定的电动致动器，包括通过设置在它们之间的多孔电介质彼此隔开的两个室。多个电极围绕第一和第二腔室的周边设置。设置在致动器内的极性电解质能够在向多个电极施加电场或电位时通过第一和第二室之间的多孔电介质。连接到第二室的机械阀致动机构允许使用电渗透（包括全流和/或完全截止）的精细滴定流体流动。分离极性电解质以禁止与被滴定的流体混合（如脑脊液）。

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