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1. 发明申请

US20060106202A1 Peripheral-type benzodiazepine receptor associated proteins, cloning, expression and methods of use 审中-公开
标题翻译：外周型苯二氮卓受体相关蛋白，克隆，表达及使用方法
公开(公告)号：US20060106202A1
公开(公告)日：2006-05-18
申请号：US11331940
申请日：2006-01-13
申请人： Vassilios Papadopoulos , Hua Li
发明人： Vassilios Papadopoulos , Hua Li
IPC分类号： C07K14/705 , C07K16/28 , C12Q1/68 , G01N33/53 , C07H21/04 , C12P21/06 , A61K39/395
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention relates to nucleic acids encoding PBR-associated proteins (PAPs) and methods for use in producing PAPs and methods of using PAPs. In this study we have identified proteins (PAPs) that interact with PBR protein by a yeast two-hybrid system. We used PBR as bait to screen a mouse testis cDNA library. Five clones were isolated based on their ability to interact with PBR. These proteins may be involved in the regulation of the function of PBR, serving as an endogenous ligand or allosteric modulator of the receptor.
摘要翻译：本发明涉及编码PBR相关蛋白（PAP）的核酸和用于产生PAP的方法和使用PAP的方法。在这项研究中，我们已经确定了通过酵母双杂交系统与PBR蛋白质相互作用的蛋白质（PAP）。我们使用PBR作为诱饵筛选小鼠睾丸cDNA文库。基于与PBR相互作用的能力分离出5个克隆。这些蛋白质可能参与调节PBR的功能，作为受体的内源性配体或变构调节剂。

2. 发明授权

US07056694B1 DNA encoding peripheral-type benzodiazipine receptor associated protein 7 and applications or methods of use 失效
标题翻译：编码外周型苯并二氮嗪受体相关蛋白的DNA 7及应用或使用方法
公开(公告)号：US07056694B1
公开(公告)日：2006-06-06
申请号：US09762594
申请日：1999-08-11
申请人： Vassilios Papadopoulos , Hua Li
发明人： Vassilios Papadopoulos , Hua Li
IPC分类号： C07H21/04 , C12N1/20 , C12N15/09 , C12N5/00 , C12P21/00
CPC分类号： C07K14/47
摘要： The present invention relates to nucleic acids encoding peripheral-type benzodiazepine receptor (PBR)-associated proteins (PAPs), and nucleic acids that hybridize or are variant of nucleic acids encoding the peripheral-type benzodiazepine receptor (PBR)-associated proteins (PAPs), which are capable of encoding proteins that regulate the function of PBRs affecting both steroid biosynthesis and mediating cholesterol delivery as well as other PBR-mediated functions.
摘要翻译：本发明涉及编码外周型苯并二氮杂受体（PBR）相关蛋白（PAP）的核酸和与编码外周型苯并二氮杂受体（PBR）相关蛋白（PAP））的核酸杂交或变异的核酸，，其能够编码调节影响类固醇生物合成和介导胆固醇递送以及其他PBR介导的功能的PBR功能的蛋白质。

3. 发明申请

US20090286876A1 NEUROPROTECTIVE BENZOATE AND BENZAMIDE COMPOUNDS 审中-公开
标题翻译：神经保护性苯甲酸和苯甲酸酯化合物
公开(公告)号：US20090286876A1
公开(公告)日：2009-11-19
申请号：US12269559
申请日：2008-11-12
申请人： Laurent Lecanu , Janet Greeson , Vassilios Papadopoulos
发明人： Laurent Lecanu , Janet Greeson , Vassilios Papadopoulos
IPC分类号： A61K31/24 , A61K31/166 , A61K31/164 , A61P25/28 , A61P25/02
CPC分类号： A61K31/135 , A61K31/16 , A61K31/165
摘要： The invention provides a therapeutic method for treating at least one symptom of a neurological disorder or disease such as Alzheimer's disease in a mammal, such as a human, wherein the toxicity of a pathogen of β amyloid peptide and/or glutamate in mammalian cells is implicated and inhibition of the subsequently-induced pathological pathways is desired comprising administering to a mammal in need of such therapy, an effective amount of an N-arylamide or an (N-aminoalkyl)benzamide, including pharmaceutically acceptable salts thereof.
摘要翻译：本发明提供在哺乳动物（例如人）中治疗至少一种神经障碍或疾病如阿尔茨海默病的症状的治疗方法，其中涉及哺乳动物细胞中β淀粉样肽和/或谷氨酸的病原体的毒性并且期望抑制随后诱导的病理学途径，包括向需要这种治疗的哺乳动物施用有效量的N-芳基酰胺或（N-氨基烷基）苯甲酰胺，包括其药学上可接受的盐。

4. 发明申请

US20060194815A1 Methods and compositions for modulating serum cortisol levels 审中-公开
标题翻译：调节血清皮质醇水平的方法和组合物
公开(公告)号：US20060194815A1
公开(公告)日：2006-08-31
申请号：US11293866
申请日：2005-12-02
申请人： Laurent Lecanu , Janet Greeson , Vassilios Papadopoulos , Jing Xu
发明人： Laurent Lecanu , Janet Greeson , Vassilios Papadopoulos , Jing Xu
IPC分类号： A61K31/496
CPC分类号： A61K31/497 , A61K31/33 , A61K31/496
摘要： The present invention relates to cortisol-modulating compounds, including but not limited to benzamide and benzoic acid derivatives such as procaine and procaine derivatives, utilized in compositions and methods for treating cortisol-mediated disorders, including but not limited to age-related depression, hypertension, Alzheimer's disease, and acquired immunodeficiency syndrome.
摘要翻译：本发明涉及皮质醇调节化合物，包括但不限于苯甲酰胺和苯甲酸衍生物如普鲁卡因和普鲁卡因衍生物，用于治疗皮质醇介导的病症的组合物和方法，包括但不限于与年龄有关的抑郁症，高血压，阿尔茨海默病和获得性免疫缺陷综合征。

5. 发明申请

US20060194814A1 Benzamide compounds 审中-公开
标题翻译：苯甲酰胺化合物
公开(公告)号：US20060194814A1
公开(公告)日：2006-08-31
申请号：US11292797
申请日：2005-12-02
申请人： Vassilios Papadopoulos , Janet Greeson , Laurent Lecanu
发明人： Vassilios Papadopoulos , Janet Greeson , Laurent Lecanu
IPC分类号： A61K31/496
CPC分类号： A61K31/496
摘要： The invention provides a therapeutic method for preventing or treating a pathological condition or symptom in a mammal, such as a human, wherein the infectivity of a pathogen such as a retrovirus toward mammalian cells is implicated and inhibition of its infectivity is desired comprising administering to a mammal in need of such therapy, an effective amount of an N-benzamide derivative of a piperazinyl amide of an amino acid thereof that inhibits pathogenic infectivity, including pharmaceutically acceptable salts thereof. The invention also provides a therapeutic method for preventing or treating a neuropathological condition or symptom in a mammal, such as human, comprising administering to a mammal in need of such therapy, an effective amount of an N-benzamide derivative of a piperazinyl amide of an amino acid thereof, including pharmaceutically acceptable salts thereof.
摘要翻译：本发明提供了预防或治疗哺乳动物（例如人）中的病理状况或症状的治疗方法，其中牵涉到病原体如逆转录病毒对哺乳动物细胞的感染性，并且希望抑制其感染性，包括给予需要这种治疗的哺乳动物，有效量的抑制病原性感染性的氨基酸的哌嗪基酰胺的N-苯甲酰胺衍生物，包括其药学上可接受的盐。本发明还提供了用于预防或治疗哺乳动物（例如人）的神经病理学病症或症状的治疗方法，其包括对需要这种治疗的哺乳动物施用有效量的哌嗪基酰胺的N-苯甲酰胺衍生物其氨基酸，包括其药学上可接受的盐。

6. 发明授权

US07615355B2 Peripheral-type benzodiazepine receptor expression level as an index of organ damage and regeneration 有权
标题翻译：外周型苯二氮卓受体表达水平作为器官损伤和再生的指标
公开(公告)号：US07615355B2
公开(公告)日：2009-11-10
申请号：US10512060
申请日：2003-04-22
申请人： Vassilios Papadopoulos , Thierry Hauet
发明人： Vassilios Papadopoulos , Thierry Hauet
IPC分类号： G01N33/53
CPC分类号： C12Q1/6883 , C12Q2600/158 , G01N33/6893 , G01N33/74 , G01N2800/245 , G01N2800/52
摘要： The present invention relates to methods, reagents, and kits for assessing organ damage, such as damage due to ischemia reperfusion injury, in the course of a transplantation therapy and/or for assessing organ regeneration following transplantation therapy. The invention provides a method for determining an index of organ health in the course of transplantation therapy comprising measuring the expression level of peripheral-type benzodiazepine receptor (PBR) in the organ. Measuring the expression level of PBR is also useful for assessing the progress of organ regeneration in the course of transplantation therapy by comparing the index of organ health. The expression level of PBR may be used as a predictor of the outcome of transplantation therapy.
摘要翻译：本发明涉及用于在移植治疗过程中评估器官损伤（例如由于缺血再灌注损伤引起的损伤）和/或用于评估移植治疗后的器官再生的方法，试剂和试剂盒。本发明提供了一种测定移植治疗过程中器官健康指数的方法，包括测量器官中外周型苯二氮卓受体（PBR）的表达水平。测量PBR的表达水平也可用于通过比较器官健康指数来评估移植治疗过程中器官再生的进展。 PBR的表达水平可以用作移植治疗结果的预测因子。

7. 发明申请

US20060247248A1 Sigma-1 receptor ligand with acetylcholinesterase 审中-公开
标题翻译：具有乙酰胆碱酯酶的Sigma-1受体配体
公开(公告)号：US20060247248A1
公开(公告)日：2006-11-02
申请号：US11347020
申请日：2006-02-03
申请人： Vassilios Papadopoulos , Laurent Lecanu , Janet Greeson
发明人： Vassilios Papadopoulos , Laurent Lecanu , Janet Greeson
IPC分类号： A61K31/495 , C07D241/04
CPC分类号： A61K31/495 , A61K31/661 , A61K31/662 , A61K45/06 , C07D295/13 , A61K2300/00
摘要： A novel compound and method for preventing or treating neurodegenerative diseases by inhibiting acetylcholinesterase and binding the sigma-1 receptor are disclosed. Dimethylcarbamic acid 2,3-bis-dimethylcarbamoyloxy-6-[4-(4-ethyl-piperazin-yl)-butyryl]-phenyl ester and its derivatives represent a novel therapeutic strategy against β-amyloid peptide induced neurotoxicity, in inhibiting acetylcholinesterase, in improving cholinergic transmission, in binding the sigma-1 receptor, and in releasing a metabolite that is active both as a sigma-1 receptor ligand and an antioxidant.
摘要翻译：公开了通过抑制乙酰胆碱酯酶和结合σ-1受体来预防或治疗神经变性疾病的新型化合物和方法。二甲基氨基甲酸2,3-双 - 二甲基氨基甲酰氧基-6- [4-（4-乙基 - 哌嗪基） - 丁酰基] - 苯酯及其衍生物代表了β-淀粉样肽诱导的神经毒性的新型治疗策略，用于抑制乙酰胆碱酯酶，改善胆碱能传递，结合σ-1受体，以及释放作为σ-1受体配体和抗氧化剂有活性的代谢物。

8. 发明申请

US20060009433A1 Neuroprotective spirostenol pharmaceutical compositions 审中-公开
标题翻译：神经保护螺螺甾醇药物组合物
公开(公告)号：US20060009433A1
公开(公告)日：2006-01-12
申请号：US11031538
申请日：2005-01-07
申请人： Zhi-Xing Yao , Laurent Lecanu , Gary Teper , Janet Greeson , Vassilios Papadopoulos
发明人： Zhi-Xing Yao , Laurent Lecanu , Gary Teper , Janet Greeson , Vassilios Papadopoulos
IPC分类号： A61K31/58
CPC分类号： A61K31/58
摘要： The present invention relates to methods, kits, combinations, and compositions for treating, preventing or reducing the risk of developing a disorder or disease related to, or the symptoms associated with a neurodegenerative disorder such as neurotoxicity or a neuropathology in a subject, particularly to beta-amyloid-induced neurotoxicity and Alzheimer's disease. The invention further provides a method for inducing stem cell differentiation into neuronal cells, by administering to the patient a therapeutically effective amount of a compound of the invention.
摘要翻译：本发明涉及用于治疗，预防或降低发生与神经变性疾病相关的病症或疾病或与神经变性疾病如神经毒性或神经病理学相关的症状的风险的方法，试剂盒，组合和组合物，特别是 β-淀粉样蛋白诱导的神经毒性和阿尔茨海默病。本发明还提供了通过向患者施用治疗有效量的本发明化合物来诱导干细胞分化成神经细胞的方法。

9. 发明授权

US07863010B2 Method of assessing progress of kidney regeneration 有权
标题翻译：评估肾脏再生进展的方法
公开(公告)号：US07863010B2
公开(公告)日：2011-01-04
申请号：US12569511
申请日：2009-09-29
申请人： Vassilios Papadopoulos , Thierry Hauet
发明人： Vassilios Papadopoulos , Thierry Hauet
IPC分类号： G01N33/53
CPC分类号： C12Q1/6883 , C12Q2600/158 , G01N33/6893 , G01N33/74 , G01N2800/245 , G01N2800/52
摘要： The present invention relates to methods, reagents, and kits for assessing organ damage, such as damage due to ischemia reperfusion injury, in the course of a transplantation therapy and/or for assessing organ regeneration following transplantation therapy. The invention provides a method for determining an index of organ health in the course of transplantation therapy comprising measuring the expression level of peripheral-type benzodiazepine receptor (PBR) in the organ. Measuring the expression level of PBR is also useful for assessing the progress of organ regeneration in the course of transplantation therapy by comparing the index of organ health. The expression level of PBR may be used as a predictor of the outcome of transplantation therapy.
摘要翻译：本发明涉及用于在移植治疗过程中评估器官损伤（例如由于缺血再灌注损伤引起的损伤）和/或用于评估移植治疗后的器官再生的方法，试剂和试剂盒。本发明提供了一种测定移植治疗过程中器官健康指数的方法，包括测量器官中外周型苯二氮卓受体（PBR）的表达水平。测量PBR的表达水平也可用于通过比较器官健康指数来评估移植治疗过程中器官再生的进展。 PBR的表达水平可以用作移植治疗结果的预测因子。

10. 发明申请

US20070269539A1 Ginkgo Biloba Extract as a Treatment for Therapeutic-Induced Neurotoxicity 审中-公开
标题翻译：银杏叶提取物作为治疗诱导的神经毒性的治疗
公开(公告)号：US20070269539A1
公开(公告)日：2007-11-22
申请号：US10555322
申请日：2004-05-03
申请人： John Marshall , Vassilios Papadopoulos
发明人： John Marshall , Vassilios Papadopoulos
IPC分类号： A61K36/16 , A61K38/16 , A61K38/13 , A61K31/7034
CPC分类号： A61K36/16 , A61K45/06 , A61K2300/00
摘要： The invention features methods for treating neurotoxicity associated with therapeutic agents, e.g., chemotherapeutic agents, and compositions and kits for use therein. The methods employ an extract of Ginkgo biloba to mitigate the neurotoxic effects of the therapeutic agents.
摘要翻译：本发明的特征在于治疗与治疗剂相关的神经毒性的方法，例如化学治疗剂，以及用于其中的组合物和试剂盒。该方法采用银杏提取物来缓解治疗剂的神经毒性作用。

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