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1. 发明申请

US20140212380A1 TARGETS AND AGENTS FOR THE TREATMENT OF IMPAIRED BONE FRACTURE HEALING 审中-公开
标题翻译：治疗有骨折骨折治疗的目标和药剂
公开(公告)号：US20140212380A1
公开(公告)日：2014-07-31
申请号：US14124165
申请日：2012-06-11
申请人： Valerie Gangji , Jean-Philippe Hauzeur , Dominique De Seny , Myrielle Mathieu , Aude Ingels , Sabrina Rigutto , Delphine Spruyt , Enrico Bastianelli , Valentina Albarani , Xavier Pesesse , Michel Malaise
发明人： Valerie Gangji , Jean-Philippe Hauzeur , Dominique De Seny , Myrielle Mathieu , Aude Ingels , Sabrina Rigutto , Delphine Spruyt , Enrico Bastianelli , Valentina Albarani , Xavier Pesesse , Michel Malaise
IPC分类号： C07K14/54
CPC分类号： C07K14/5421 , A61K38/2053 , G01N33/6863 , G01N33/6869 , G01N2333/522 , G01N2333/5412 , G01N2333/5421
摘要： The application teaches a composition comprising one or more pharmaceutical active ingredients selected from the group consisting of interleukin-8 (IL-8 or CXCL8), a functional fragment of IL-8, a functional variant of IL-8, and an agonist of IL-8 receptor, for therapeutic and/orprophylactic interventions in impaired bone fracture healing, such as but not limited to non-union fractures, mal-union fractures, or delayed union fractures.
摘要翻译：本申请教导了包含一种或多种选自白细胞介素-8（IL-8或CXCL8），IL-8的功能片段，IL-8的功能性变体和IL的激动剂的药物活性成分的组合物 -8受体，用于骨折愈合受损的治疗和/或预防性干预，例如但不限于非联合骨折，非联合骨折或延迟联合骨折。

2. 发明申请

US20140100137A1 MARKERS FOR IMPAIRED BONE FRACTURE HEALING 审中-公开
标题翻译：骨折骨折治疗标记
公开(公告)号：US20140100137A1
公开(公告)日：2014-04-10
申请号：US14124244
申请日：2012-06-11
申请人： Valerie Gangji , Jean-Philippe Hauzeur , Dominique De Seny , Myrielle Mathieu , Aude Ingels , Sabrina Rigutto , Delphine Spruyt , Enrico Bastianelli , Valentina Albarari , Xavier Pesesse , Michel Malaise
发明人： Valerie Gangji , Jean-Philippe Hauzeur , Dominique De Seny , Myrielle Mathieu , Aude Ingels , Sabrina Rigutto , Delphine Spruyt , Enrico Bastianelli , Valentina Albarari , Xavier Pesesse , Michel Malaise
IPC分类号： C12Q1/68 , G01N33/68
CPC分类号： C12Q1/6881 , G01N33/6869 , G01N33/6887 , G01N2333/5421 , G01N2800/10 , G01N2800/52
摘要： The present application discloses particularly interleukin-8 (IL-8) as a novel biomarker for the prediction, diagnosis, prognosis and/or monitoring of impaired bone fracture healing; and related methods, uses and kits.
摘要翻译：本申请特别公开了白细胞介素-8（IL-8）作为骨折愈合受损的预测，诊断，预后和/或监测的新型生物标志物; 及相关方法，用途和试剂盒。

3. 发明申请

US20090228012A1 SURGICAL BORING TOOL SET 审中-公开
标题翻译：手术镗刀套装
公开(公告)号：US20090228012A1
公开(公告)日：2009-09-10
申请号：US12278567
申请日：2006-02-16
申请人： Valerie Gangji , Jean-Philippe Hauzeur
发明人： Valerie Gangji , Jean-Philippe Hauzeur
IPC分类号： A61B17/00 , A61B17/58
CPC分类号： A61B17/3472 , A61B17/1637 , A61B17/32053 , A61B2017/320064
摘要： A surgical device (1) is disclosed for making a bore in a tissue or a joint. The device includes an external trephine (2) having an open distal end (6) provided with a cutting rim (9), an open proximal end (7) and a hollow tubular portion (8). An internal trephine (3) is disclosed which is adapted to be positioned and to slide inside the external trephine (2), which has an open distal end (10) which is provided with a cutting rim (13), an open proximal end (11), and a hollow tubular portion (12). A guiding rod (4) is adapted to be positioned and to slide inside the internal trephine (3). The surgical device may also include an awl (5) which slides inside the external trephine (2) and has a distal end (18) provided with a cutting blade (38), and a proximal end (19) provided with a handle (21) and a solid tubular portion (20). A syringe (32) may be coupled to the internal (3) and/or external (2) trephine so that the surgical device can be also operated as an injection device. The device is useful for making a bore in a tissue or joint and/or for delivering a medicament or material to a tissue or joint.
摘要翻译：公开了用于在组织或关节中形成孔的手术装置（1）。该装置包括具有设置有切割边缘（9），开口近端（7）和中空管状部分（8）的开口远端（6）的外部环钻（2）。公开了一种内部环钻（3），其适于定位并在外部环钻（2）内滑动，其具有敞开的远端（10），该远端具有切割边缘（13），开口近端 11）和中空管状部分（12）。引导杆（4）适于定位并在内部环钻（3）内滑动。手术装置还可以包括在外部环管（2）内滑动并具有设置有切割刀片（38）的远端（18）的锥（5）和设置有手柄（21）的近端（19））和固体管状部分（20）。注射器（32）可以联接到内部（3）和/或外部（2）环钻，使得手术装置也可以作为注射装置操作。该装置可用于在组织或关节中制造孔，和/或用于将药物或材料递送至组织或关节。

4. 发明授权

US08337827B2 Method for osteogenic differentiation of bone marrow stem cells (BMSC) and uses thereof 有权
标题翻译：骨髓干细胞成骨分化方法（BMSC）及其用途
公开(公告)号：US08337827B2
公开(公告)日：2012-12-25
申请号：US12278557
申请日：2007-02-16
申请人： Dominique Egrise , Valerie Gangji , Jean-Philippe Hauzeur , Micheline Lambermont , Michel Toungouz
发明人： Dominique Egrise , Valerie Gangji , Jean-Philippe Hauzeur , Micheline Lambermont , Michel Toungouz
IPC分类号： A61K35/00 , A01N63/00
CPC分类号： C12N5/0654 , A61K2035/124 , C12N2500/84 , C12N2501/115
摘要： Methods for obtaining osteoprogenitors, osteoblasts or osteoblast phenotype cells, as well as cell populations including such cells, from human bone marrow stem cells in vitro or ex vivo are disclosed. Bone marrow stem cells are contacted with human serum or plasma and a growth factor or a biologically active variant or derivative thereof. In addition, osteoprogenitor, osteoblast or osteoblast phenotype cell types and cell populations are provided. The cell populations may include additional cell types, such as endothelial cells or progenitors. The osteoprogenitors, osteoblasts or osteoblast phenotype cells may be used in therapy, particularly bone therapy.
摘要翻译：公开了从人骨髓干细胞体外或离体获得骨祖细胞，成骨细胞或成骨细胞表型细胞以及包括这种细胞的细胞群的方法。将骨髓干细胞与人血清或血浆以及生长因子或其生物活性变体或衍生物接触。此外，提供了骨祖细胞，成骨细胞或成骨细胞表型细胞类型和细胞群体。细胞群体可以包括额外的细胞类型，例如内皮细胞或祖细胞。骨诱导剂，成骨细胞或成骨细胞表型细胞可用于治疗，特别是骨疗法。

5. 发明申请

US20090081169A1 METHOD FOR OSTEOGENIC DIFFERENTIATION OF BONE MARROW STEM CELLS (BMSC) AND USES THEREOF 有权
标题翻译：骨质疏松细胞（BMSC）的骨质疏松方法及其用途
公开(公告)号：US20090081169A1
公开(公告)日：2009-03-26
申请号：US12278557
申请日：2007-02-16
申请人： Dominique Egrise , Valerie Gangji , Jean-Philippe Hauzeur , Micheline Lambermont , Michel Toungouz
发明人： Dominique Egrise , Valerie Gangji , Jean-Philippe Hauzeur , Micheline Lambermont , Michel Toungouz
IPC分类号： A61K35/12 , C12N5/08
CPC分类号： C12N5/0654 , A61K2035/124 , C12N2500/84 , C12N2501/115
摘要： Methods for obtaining osteoprogenitors, osteoblasts or osteoblast phenotype cells, as well as cell populations including such cells, from human bone marrow stem cells in vitro or ex vivo are disclosed. Bone marrow stem cells are contacted with human serum or plasma and a growth factor or a biologically active variant or derivative thereof. In addition, osteoprogenitor, osteoblast or osteoblast phenotype cell types and cell populations are provided. The cell populations may include additional cell types, such as endothelial cells or progenitors. The osteoprogenitors, osteoblasts or osteoblast phenotype cells may be used in therapy, particularly bone therapy.
摘要翻译：公开了从人骨髓干细胞体外或离体获得骨祖细胞，成骨细胞或成骨细胞表型细胞以及包括这种细胞的细胞群的方法。将骨髓干细胞与人血清或血浆以及生长因子或其生物活性变体或衍生物接触。此外，提供了骨祖细胞，成骨细胞或成骨细胞表型细胞类型和细胞群体。细胞群体可以包括额外的细胞类型，例如内皮细胞或祖细胞。骨诱导剂，成骨细胞或成骨细胞表型细胞可用于治疗，特别是骨疗法。

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