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1. 发明申请

US20200276017A1 PERCUTANEOUS DELIVERY SYSTEMS FOR ANCHORING AN IMPLANT IN A CARDIAC VALVE ANNULUS 审中-公开
公开(公告)号：US20200276017A1
公开(公告)日：2020-09-03
申请号：US16786580
申请日：2020-02-10
申请人： Valavanur A. Subramanian , Michael L. Reo , Gary Hulme , Michael Baldwin , Kevin Bencini , Alex Rowson , Stephen Bower
发明人： Valavanur A. Subramanian , Michael L. Reo , Gary Hulme , Michael Baldwin , Kevin Bencini , Alex Rowson , Stephen Bower
IPC分类号： A61F2/24
摘要： Mitral valve prolapse and mitral regurgitation can be treating by implanting in the mitral annulus a transvalvular intraannular band. The band has a first end, a first anchoring portion located proximate the first end, a second end, a second anchoring portion located proximate the second end, and a central portion. The central portion is positioned so that it extends transversely across a coaptive edge formed by the closure of the mitral valve leaflets. The band may be implanted via translumenal access or via thoracotomy.

2. 发明授权

US12117213B1 Portable internal combustion engine with heating and cooling capabilities 有权
公开(公告)号：US12117213B1
公开(公告)日：2024-10-15
申请号：US17556554
申请日：2021-12-20
申请人： Justin Schaefer , Michael Baldwin
发明人： Justin Schaefer , Michael Baldwin
IPC分类号： F25B29/00 , B01D46/42 , F02B63/06 , F25B1/00
CPC分类号： F25B29/003 , B01D46/4263 , F02B63/06 , F25B1/00 , B01D2279/60 , F25B2327/001 , F25B2339/04
摘要： A portable internal combustion engine system includes an internal combustion engine having a first output shaft, the internal combustion engine rotates the first output shaft; a compressor rotably engaged with the first output shaft via a belt, the first output shaft is configured to provide energy thereto; a fan coupled to the internal combustion engine to pull air into a housing; an evaporative coil in communication with the housing and to receive air from the fan; a condenser coil in communication with the housing and to receive air from the fan; and a control system to operate the compressor, the internal combustion engine, and the fan to expel cool air.

3. 发明申请

US20090017495A1 ESCHERICHIA COLI-DERIVED VACCINE AND THERAPY AGAINST BOTULISM 有权
标题翻译： ESCHERICHIA派生的疫苗和治疗效果
公开(公告)号：US20090017495A1
公开(公告)日：2009-01-15
申请号：US12040542
申请日：2008-02-29
申请人： Michael Baldwin , Eric A. Johnson , Joseph T. Barbieri , Marite Bradshaw , William H. Tepp , Christina L. Pier
发明人： Michael Baldwin , Eric A. Johnson , Joseph T. Barbieri , Marite Bradshaw , William H. Tepp , Christina L. Pier
IPC分类号： C12N15/09 , C07K14/33
CPC分类号： C12N9/52 , A61K39/0258 , A61K39/08 , A61K2039/523 , C12Y304/24069 , Y02A50/469 , Y02A50/474
摘要： A method of producing botulinum toxin C-terminal receptor binding domain (HCR) is disclosed. The one embodiment, the method comprises the steps of (a) preparing E. coli transformed with an expression vector comprising DNA encoding HCR protein, (b) inducing expression of the HCR protein at a reduced temperature in a culture media, and (c) purifying the HCR protein via extraction, wherein the extraction comprises a clarification by centrifugation and a filtration, wherein the purified HCR protein is at least 10 mg/L of culture medium.
摘要翻译：公开了产生肉毒杆菌毒素C末端受体结合结构域（HCR）的方法。该方法包括以下步骤：（a）用包含编码HCR蛋白的DNA的表达载体转化大肠杆菌，（b）在培养基中降低温度诱导HCR蛋白的表达，和（c）通过提取纯化HCR蛋白质，其中提取物通过离心和过滤进行澄清，其中纯化的HCR蛋白质为至少10mg / L的培养基。

4. 发明授权

US07377305B2 Method and apparatus for production of a cast component 有权
标题翻译：用于生产铸件的方法和装置
公开(公告)号：US07377305B2
公开(公告)日：2008-05-27
申请号：US11209389
申请日：2005-08-23
申请人： Donald J. Frasier , Matthew Kush , Max Eric Schlienger , Michael Baldwin
发明人： Donald J. Frasier , Matthew Kush , Max Eric Schlienger , Michael Baldwin
IPC分类号： B22D27/04 , B22D35/00
CPC分类号： B29C67/0092 , B22C9/02 , B22C9/04 , B22C9/22 , B22D27/045 , B22D35/04 , B22D39/06 , B22D43/001 , B29C64/40 , B33Y80/00 , C30B11/00 , C30B11/002 , C30B11/14 , C30B29/52 , G03F7/0037 , G03F7/0047 , Y02P10/292
摘要： A system for producing cast components from molten metal. One form of the present invention includes a system for the precision pouring of molten metal within a casting mold.
摘要翻译：一种用于从熔融金属生产铸件的系统。本发明的一种形式包括用于在铸模内精确浇注熔融金属的系统。

5. 发明申请

US20050269055A1 Method and apparatus for production of a cast component 有权
标题翻译：用于生产铸件的方法和装置
公开(公告)号：US20050269055A1
公开(公告)日：2005-12-08
申请号：US11089808
申请日：2005-03-25
申请人： Donald Frasier , Matthew Kush , Max Schlienger , Michael Baldwin
发明人： Donald Frasier , Matthew Kush , Max Schlienger , Michael Baldwin
IPC分类号： F01D25/00 , B22C7/02 , B22C9/04 , B22C9/22 , B22C9/24 , B22D27/04 , B22D35/04 , B22D39/06 , B22D43/00 , C30B11/00 , C30B11/14 , F02C7/00 , G03F7/00 , G03F7/004
CPC分类号： B29C67/0092 , B22C9/02 , B22C9/04 , B22C9/22 , B22D27/045 , B22D35/04 , B22D39/06 , B22D43/001 , B29C64/40 , B33Y80/00 , C30B11/00 , C30B11/002 , C30B11/14 , C30B29/52 , G03F7/0037 , G03F7/0047 , Y02P10/292
摘要： A system for producing cast components from molten metal. One form of the present invention includes a system for the precision pouring of molten metal within a casting mold.
摘要翻译：一种用于从熔融金属生产铸件的系统。本发明的一种形式包括用于在铸模内精确浇注熔融金属的系统。

6. 发明授权

US08851151B2 Method and apparatus for production of a cast component 有权
标题翻译：用于生产铸件的方法和装置
公开(公告)号：US08851151B2
公开(公告)日：2014-10-07
申请号：US11089808
申请日：2005-03-25
申请人： Donald J. Frasier , Matthew Kush , Max Eric Schlienger , Michael Baldwin
发明人： Donald J. Frasier , Matthew Kush , Max Eric Schlienger , Michael Baldwin
IPC分类号： B22D27/04 , B22C9/00 , B22C9/10 , B22C9/22 , B22D35/04 , B22C9/02 , B22D39/06 , G03F7/004 , B29C67/00 , C30B11/00 , G03F7/00 , B22C9/04 , B22D43/00 , C30B11/14
CPC分类号： B29C67/0092 , B22C9/02 , B22C9/04 , B22C9/22 , B22D27/045 , B22D35/04 , B22D39/06 , B22D43/001 , B29C64/40 , B33Y80/00 , C30B11/00 , C30B11/002 , C30B11/14 , C30B29/52 , G03F7/0037 , G03F7/0047 , Y02P10/292
摘要： A system for producing cast components from molten metal. One form of the present invention includes a system for the precision pouring of molten metal within a casting mold.
摘要翻译：一种用于从熔融金属生产铸件的系统。本发明的一种形式包括用于在铸模内精确浇注熔融金属的系统。

7. 发明授权

US07820411B2 Escherichia coli-derived vaccine and therapy against botulism 有权
标题翻译：大肠杆菌来源的疫苗和针对肉毒中毒的治疗
公开(公告)号：US07820411B2
公开(公告)日：2010-10-26
申请号：US12040542
申请日：2008-02-29
申请人： Michael Baldwin , Marite Bradshaw , William H. Tepp , Eric A. Johnson , Joseph T. Barbieri , Christina L. Pier
发明人： Michael Baldwin , Marite Bradshaw , William H. Tepp , Eric A. Johnson , Joseph T. Barbieri , Christina L. Pier
IPC分类号： C12P21/02
CPC分类号： C12N9/52 , A61K39/0258 , A61K39/08 , A61K2039/523 , C12Y304/24069 , Y02A50/469 , Y02A50/474
摘要： A method of producing botulinum toxin C-terminal receptor binding domain (HCR) is disclosed. The one embodiment, the method comprises the steps of (a) preparing E. coli transformed with an expression vector comprising DNA encoding HCR protein, (b) inducing expression of the HCR protein at a reduced temperature in a culture media, and (c) purifying the HCR protein via extraction, wherein the extraction comprises a clarification by centrifugation and a filtration, wherein the purified HCR protein is at least 10 mg/L of culture medium.
摘要翻译：公开了产生肉毒杆菌毒素C末端受体结合结构域（HCR）的方法。该方法包括以下步骤：（a）用包含编码HCR蛋白的DNA的表达载体转化大肠杆菌，（b）在培养基中降低温度诱导HCR蛋白的表达，和（c）通过提取纯化HCR蛋白质，其中提取物通过离心和过滤进行澄清，其中纯化的HCR蛋白质为至少10mg / L的培养基。

8. 发明申请

US20090182123A1 Method of Preparing Botulinum Neurotoxin Type E Light Chain 有权
标题翻译：肉毒杆菌神经毒素E型轻链的制备方法
公开(公告)号：US20090182123A1
公开(公告)日：2009-07-16
申请号：US12273157
申请日：2008-11-18
申请人： Eric A. Johnson , Marite Bradshaw , Michael Baldwin , Joseph T. Barbieri
发明人： Eric A. Johnson , Marite Bradshaw , Michael Baldwin , Joseph T. Barbieri
IPC分类号： C07K14/33
CPC分类号： C07K14/33
摘要： The present invention provides a preparation of botulinum toxin light chain type A or E, wherein the preparation is both catalytically active and soluble. Preferably, the preparation consists essentially of amino acid residues 1 through 425 of the botulinum toxin light chain type A. A method of screening inhibitors is also provided, wherein the method comprises exposing a test inhibitor to the preparation of botulinum toxin light chain type A and evaluating the biological activity of the preparation. In another embodiment, a method of providing a catalytically active, soluble preparation of botulinum toxin light chain, type A is provided, wherein the method comprises obtaining an expression vector comprising a DNA sequence encoding amino acid residues 1-425 and expressing a polypeptide.
摘要翻译：本发明提供了A型或E型轻链型肉毒杆菌毒素的制备方法，其中所述制剂既具有催化活性，又具有可溶性。优选地，制剂基本上由A型肉毒毒素轻链的氨基酸残基1至425组成。还提供了筛选抑制剂的方法，其中所述方法包括将测试抑制剂暴露于A型轻链A型肉毒杆菌毒素的制备中，评估制剂的生物活性。在另一个实施方案中，提供了提供A型肉毒毒素轻链的催化活性可溶性制剂的方法，其中所述方法包括获得包含编码氨基酸残基1-425的DNA序列并表达多肽的表达载体。

9. 发明申请

US20070208816A1 System and method for electronically facilitating, recording, and tracking transactions 审中-公开
标题翻译：用于电子方便，记录和跟踪交易的系统和方法
公开(公告)号：US20070208816A1
公开(公告)日：2007-09-06
申请号：US11701532
申请日：2007-02-02
申请人： Michael Baldwin , Kenneth Hansen , David Potter , Anthony Sorace , Paul Lustgarten , Uriel Orellana
发明人： Michael Baldwin , Kenneth Hansen , David Potter , Anthony Sorace , Paul Lustgarten , Uriel Orellana
IPC分类号： G06F15/16
CPC分类号： H04L51/04 , G06Q10/107 , G06Q30/04 , G06Q40/02 , H04L12/1831
摘要： A method to facilitate a transaction using an instant messaging client comprising, receiving a formatted transaction request from the client via a messaging protocol, identifying a recipient and transaction information, facilitating the transaction and sending a notification of completion of the transaction via the messaging protocol.
摘要翻译：一种促进使用即时消息传递客户端的事务的方法，包括：通过消息传送协议从客户端接收格式化的事务请求，识别接收方和事务信息，促进事务并通过消息传递协议发送完成交易的通知。

10. 发明授权

US06932145B2 Method and apparatus for production of a cast component 有权
公开(公告)号：US06932145B2
公开(公告)日：2005-08-23
申请号：US10132975
申请日：2002-04-26
申请人： Donald J. Frasier , Matthew Kush , Max Eric Schlienger , Michael Baldwin
发明人： Donald J. Frasier , Matthew Kush , Max Eric Schlienger , Michael Baldwin
IPC分类号： F01D25/00 , B22C7/02 , B22C9/04 , B22C9/22 , B22C9/24 , B22D27/04 , B22D35/04 , B22D39/06 , B22D43/00 , C30B11/00 , C30B11/14 , F02C7/00 , G03F7/00 , G03F7/004
CPC分类号： B29C67/0092 , B22C9/02 , B22C9/04 , B22C9/22 , B22D27/045 , B22D35/04 , B22D39/06 , B22D43/001 , B29C64/40 , B33Y80/00 , C30B11/00 , C30B11/002 , C30B11/14 , C30B29/52 , G03F7/0037 , G03F7/0047 , Y02P10/292
摘要： A system for producing cast components from molten metal. One form of the present invention includes a system for the precision pouring of molten metal within a casting mold.

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