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1. 发明申请

US20130024956A1 ANTIBODIES TO CD40 审中-公开
标题翻译： CD40抗体
公开(公告)号：US20130024956A1
公开(公告)日：2013-01-24
申请号：US13619954
申请日：2012-09-14
申请人： Vahe Bedian , Ronald P. Gladue , Jose Corvalan , Xiao-Chi Jia , Xiao Feng
发明人： Vahe Bedian , Ronald P. Gladue , Jose Corvalan , Xiao-Chi Jia , Xiao Feng
IPC分类号： C07K16/28 , A61K51/10 , A61P35/00 , C12N15/13 , C07K1/14 , A61K48/00 , C12N15/63 , C12P21/08 , C12N5/16 , C12N5/20 , C12N5/10 , C12N1/21 , C12N1/19 , A01K67/027 , A01H5/00 , A61N5/10 , A61K39/395
CPC分类号： C07K16/2866 , A01K2217/05 , A61K39/3955 , A61K45/06 , A61K48/00 , A61K2039/505 , A61N5/062 , A61N5/10 , C07K16/2878 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/92
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-CD40 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-CD40 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CD40 antibodies. The invention also relates to transgenic animals comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及与CD40，优选人CD40特异性结合并且作为CD40激动剂起作用的抗体及其抗原结合部分。本发明还涉及人抗CD40抗体及其抗原结合部分。本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。本发明还涉及衍生自人抗CD40抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。本发明还涉及制备人抗CD40抗体的方法，包含这些抗体的组合物和使用抗体和组合物进行诊断和治疗的方法。本发明还提供使用编码包含人抗-CD40抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的转基因动物。

2. 发明申请

US20090169563A1 Antibodies to CD40 有权
公开(公告)号：US20090169563A1
公开(公告)日：2009-07-02
申请号：US11904295
申请日：2007-09-25
申请人： Vahe Bedian , Ronald P. Gladue , Jose Corvalan , Xiao-Chi Jia , Xiao Feng
发明人： Vahe Bedian , Ronald P. Gladue , Jose Corvalan , Xiao-Chi Jia , Xiao Feng
IPC分类号： A61K39/395 , C07K16/18 , C12P21/04 , C12N5/06
CPC分类号： C07K16/2866 , A01K2217/05 , A61K39/3955 , A61K45/06 , A61K48/00 , A61K2039/505 , A61N5/062 , A61N5/10 , C07K16/2878 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/92
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-CD40 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-CD40 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CD40 antibodies. The invention also relates to transgenic animals comprising nucleic acid molecules of the present invention.

3. 发明申请

US20120225014A1 ANTIBODIES TO CD40 有权
标题翻译： CD40抗体
公开(公告)号：US20120225014A1
公开(公告)日：2012-09-06
申请号：US13471395
申请日：2012-05-14
申请人： Vahe Bedian , Ronald P. Gladue , Jose Corvalan , Xiao-Chi Jia , Xiao Feng
发明人： Vahe Bedian , Ronald P. Gladue , Jose Corvalan , Xiao-Chi Jia , Xiao Feng
IPC分类号： A61K39/395 , A61K51/10 , A61P35/00 , C07K16/28 , A61P37/04
CPC分类号： C07K16/2866 , A01K2217/05 , A61K39/3955 , A61K45/06 , A61K48/00 , A61K2039/505 , A61N5/062 , A61N5/10 , C07K16/2878 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/92
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-CD40 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-CD40 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CD40 antibodies. The invention also relates to transgenic animals comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及与CD40，优选人CD40特异性结合并且作为CD40激动剂起作用的抗体及其抗原结合部分。本发明还涉及人抗CD40抗体及其抗原结合部分。本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。本发明还涉及衍生自人抗CD40抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。本发明还涉及制备人抗CD40抗体的方法，包含这些抗体的组合物和使用抗体和组合物进行诊断和治疗的方法。本发明还提供使用编码包含人抗-CD40抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的转基因动物。

4. 发明授权

US07618633B2 Antibodies that bind CD40 and methods of treating cancer and enhancing immune responses 有权
标题翻译：结合CD40的抗体以及治疗癌症和增强免疫应答的方法
公开(公告)号：US07618633B2
公开(公告)日：2009-11-17
申请号：US11904295
申请日：2007-09-25
申请人： Vahe Bedian , Ronald P. Gladue , Jose Corvalan , Xiao-Chi Jia , Xiao Feng
发明人： Vahe Bedian , Ronald P. Gladue , Jose Corvalan , Xiao-Chi Jia , Xiao Feng
IPC分类号： A61K39/395 , C12N5/12 , C07K16/28
CPC分类号： C07K16/2866 , A01K2217/05 , A61K39/3955 , A61K45/06 , A61K48/00 , A61K2039/505 , A61N5/062 , A61N5/10 , C07K16/2878 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/92
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-CD40 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-CD40 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CD40 antibodies. The invention also relates to transgenic animals comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及与CD40，优选人CD40特异性结合并且作为CD40激动剂起作用的抗体及其抗原结合部分。本发明还涉及人抗CD40抗体及其抗原结合部分。本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。本发明还涉及衍生自人抗CD40抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。本发明还涉及制备人抗CD40抗体的方法，包含这些抗体的组合物和使用抗体和组合物进行诊断和治疗的方法。本发明还提供使用编码包含人抗-CD40抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的转基因动物。

5. 发明申请

US20090130715A1 Antibodies to CD40 有权
标题翻译： CD40抗体
公开(公告)号：US20090130715A1
公开(公告)日：2009-05-21
申请号：US12284605
申请日：2008-09-22
申请人： Vahe Bedian , Ronald P. Gladue , Jose Corvalan , Xiao-Chi Jia , Xiao Feng
发明人： Vahe Bedian , Ronald P. Gladue , Jose Corvalan , Xiao-Chi Jia , Xiao Feng
IPC分类号： C12N15/13 , C12N15/63 , C12N5/10 , C12N1/21 , C12N1/19 , C12P21/00
CPC分类号： C07K16/2866 , A01K2217/05 , A61K39/3955 , A61K45/06 , A61K48/00 , A61K2039/505 , A61N5/062 , A61N5/10 , C07K16/2878 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/92
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-CD40 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-CD40 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CD40 antibodies. The invention also relates to transgenic animals comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及与CD40，优选人CD40特异性结合并且作为CD40激动剂起作用的抗体及其抗原结合部分。本发明还涉及人抗CD40抗体及其抗原结合部分。本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。本发明还涉及衍生自人抗CD40抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。本发明还涉及制备人抗CD40抗体的方法，包含这些抗体的组合物和使用抗体和组合物进行诊断和治疗的方法。本发明还提供使用编码包含人抗-CD40抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的转基因动物。

6. 发明申请

US20100098694A1 ANTIBODIES TO CD40 审中-公开
标题翻译： CD40抗体
公开(公告)号：US20100098694A1
公开(公告)日：2010-04-22
申请号：US12576459
申请日：2009-10-09
申请人： Vahe Bedian , Ronald P. Gladue , Jose Corvalan , Xiao-Chi Jia , Xiao Feng
发明人： Vahe Bedian , Ronald P. Gladue , Jose Corvalan , Xiao-Chi Jia , Xiao Feng
IPC分类号： A61K39/395 , C07K16/00 , C12N5/00 , C07H21/00 , C12N15/63 , C12P21/00 , A01K67/00 , A01H5/00 , A61P35/00 , A61K31/7052
CPC分类号： C07K16/2866 , A01K2217/05 , A61K39/3955 , A61K45/06 , A61K48/00 , A61K2039/505 , A61N5/062 , A61N5/10 , C07K16/2878 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/92
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-CD40 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-CD40 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CD40 antibodies. The invention also relates to transgenic animals comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及与CD40，优选人CD40特异性结合并且作为CD40激动剂起作用的抗体及其抗原结合部分。本发明还涉及人抗CD40抗体及其抗原结合部分。本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。本发明还涉及衍生自人抗CD40抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。本发明还涉及制备人抗CD40抗体的方法，包含这些抗体的组合物和使用抗体和组合物进行诊断和治疗的方法。本发明还提供使用编码包含人抗-CD40抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的转基因动物。

7. 发明授权

US07288251B2 Antibodies to CD40 有权
标题翻译： CD40抗体
公开(公告)号：US07288251B2
公开(公告)日：2007-10-30
申请号：US10292088
申请日：2002-11-08
申请人： Vahe Bedian , Ronald P. Gladue , Jose Corvalan , Xiao-Chi Jia , Xiao Feng
发明人： Vahe Bedian , Ronald P. Gladue , Jose Corvalan , Xiao-Chi Jia , Xiao Feng
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2866 , A01K2217/05 , A61K39/3955 , A61K45/06 , A61K48/00 , A61K2039/505 , A61N5/062 , A61N5/10 , C07K16/2878 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/92
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-CD40 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-CD40 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CD40 antibodies. The invention also relates to transgenic animals comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及与CD40，优选人CD40特异性结合并且作为CD40激动剂起作用的抗体及其抗原结合部分。本发明还涉及人抗CD40抗体及其抗原结合部分。本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。本发明还涉及衍生自人抗CD40抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。本发明还涉及制备人抗CD40抗体的方法，包含这些抗体的组合物和使用抗体和组合物进行诊断和治疗的方法。本发明还提供使用编码包含人抗-CD40抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的转基因动物。

8. 发明授权

US07626012B2 Nucleic acid molecules which encode antibodies that bind CD40 有权
标题翻译：编码结合CD40的抗体的核酸分子
公开(公告)号：US07626012B2
公开(公告)日：2009-12-01
申请号：US12284605
申请日：2008-09-22
申请人： Vahe Bedian , Ronald P. Gladue , Jose Corvalan , Xiao-Chi Jia , Xiao Feng
发明人： Vahe Bedian , Ronald P. Gladue , Jose Corvalan , Xiao-Chi Jia , Xiao Feng
IPC分类号： C12N15/13 , C12N15/12 , C12N5/12 , C12N15/63
CPC分类号： C07K16/2866 , A01K2217/05 , A61K39/3955 , A61K45/06 , A61K48/00 , A61K2039/505 , A61N5/062 , A61N5/10 , C07K16/2878 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/92
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-CD40 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-CD40 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CD40 antibodies. The invention also relates to transgenic animals comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及与CD40，优选人CD40特异性结合并且作为CD40激动剂起作用的抗体及其抗原结合部分。本发明还涉及人抗CD40抗体及其抗原结合部分。本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。本发明还涉及衍生自人抗CD40抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。本发明还涉及制备人抗CD40抗体的方法，包含这些抗体的组合物和使用抗体和组合物进行诊断和治疗的方法。本发明还提供了使用编码包含人抗-CD40抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的转基因动物。

9. 发明授权

US07563442B2 Antibodies to CD40 and methods of treating cancer and enhancing immune responses 有权
标题翻译：抗CD40抗体和治疗癌症和增强免疫反应的方法
公开(公告)号：US07563442B2
公开(公告)日：2009-07-21
申请号：US11213575
申请日：2005-08-26
申请人： Vahe Bedian , Ronald P Gladue , Jose Corvalan , Xiao-Chi Jia , Xiao Feng
发明人： Vahe Bedian , Ronald P Gladue , Jose Corvalan , Xiao-Chi Jia , Xiao Feng
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2866 , A01K2217/05 , A61K39/3955 , A61K45/06 , A61K48/00 , A61K2039/505 , A61N5/062 , A61N5/10 , C07K16/2878 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/92
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-CD40 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-CD40 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CD40 antibodies. The invention also relates to transgenic animals comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及与CD40，优选人CD40特异性结合并且作为CD40激动剂起作用的抗体及其抗原结合部分。本发明还涉及人抗-CD40抗体及其抗原结合部分。本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。本发明还涉及衍生自人抗CD40抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。本发明还涉及制备人抗CD40抗体的方法，包含这些抗体的组合物和使用抗体和组合物进行诊断和治疗的方法。本发明还提供使用编码包含人抗-CD40抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的转基因动物。

10. 发明授权

US07338660B2 Methods of treating cancer and enhancing immune responses with antibodies that bind CD40 有权
标题翻译：用结合CD40的抗体治疗癌症和增强免疫反应的方法
公开(公告)号：US07338660B2
公开(公告)日：2008-03-04
申请号：US11211917
申请日：2005-08-25
申请人： Vahe Bedian , Ronald P Gladue , Jose Corvalan , Xiao-Chi Jia , Xiao Feng
发明人： Vahe Bedian , Ronald P Gladue , Jose Corvalan , Xiao-Chi Jia , Xiao Feng
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2866 , A01K2217/05 , A61K39/3955 , A61K45/06 , A61K48/00 , A61K2039/505 , A61N5/062 , A61N5/10 , C07K16/2878 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/92
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-CD40 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-CD40 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CD40 antibodies. The invention also relates to transgenic animals comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及与CD40，优选人CD40特异性结合并且作为CD40激动剂起作用的抗体及其抗原结合部分。本发明还涉及人抗CD40抗体及其抗原结合部分。本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。本发明还涉及衍生自人抗CD40抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。本发明还涉及制备人抗CD40抗体的方法，包含这些抗体的组合物和使用抗体和组合物进行诊断和治疗的方法。本发明还提供使用编码包含人抗-CD40抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的转基因动物。

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