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1. 发明申请

US20050014131A1 Methods and apparatus for investigating side effects 审中-公开
标题翻译：调查副作用的方法和装置
公开(公告)号：US20050014131A1
公开(公告)日：2005-01-20
申请号：US10621821
申请日：2003-07-16
申请人： Vadim Kutsyy , Eugeni Vaisberg , Daniel Coleman
发明人： Vadim Kutsyy , Eugeni Vaisberg , Daniel Coleman
IPC分类号： G01N33/50 , G06K9/00 , C12Q1/00 , G01N33/48 , G06F19/00
CPC分类号： G06K9/0014 , G01N33/5008 , G01N33/5014 , G01N33/502
摘要： Methods, apparatus, and computer programs for investigating and characterising side effects of a treatment having an intended or on-target effect on cells are described. The method can include identifying a group of on-target cellular features of the plurality of cells which are affected by the treatment and are related to the on-target effect. A group of off-target cellular features can also be identified which are different to the on-target cellular features and which are also affected by the treatment and which are related to the side effect. A measure of the side effect based on the off-target cellular features can be obtained. The treatment can then be characterised based on the measure of the side effect. A further method involves capturing an image of the population of treated cells and deriving cellular features from the image. An on-target effect signature, which is characteristic of the on-target effect is created from cellular features relating to cellular properties involved in the intended effect. A side effect signature, which is characteristic of a side effect to the on-target effect, is created using cellular features relating to cellular properties not involved in the intended effect. On-target effect and/or side effect metrics are obtained from the signatures which can be used to characterise the treatment.
摘要翻译：描述了用于调查和表征具有预期或靶向对细胞的作用的治疗的副作用的方法，装置和计算机程序。该方法可以包括识别受治疗影响并且与目标效应相关的多个细胞的一组目标上细胞特征。还可以鉴定一组离靶细胞特征，这些特征与目标细胞特征不同，并且还受到治疗的影响并且与副作用相关。可以获得基于离靶细胞特征的副作用的量度。然后可以基于副作用的测量来表征治疗。另一种方法包括捕获处理的细胞群体的图像并从图像中导出细胞特征。作为目标效果的特征的目标效果特征是从涉及预期效果的细胞特性的细胞特征产生的。使用与未涉及预期效果的细胞特性相关的细胞特征产生作为靶向效应的副作用特征的副作用特征。从可用于表征治疗的签名获得目标效应和/或副作用度量。

2. 发明申请

US20050137806A1 Characterizing biological stimuli by response curves 失效
标题翻译：通过响应曲线表征生物刺激
公开(公告)号：US20050137806A1
公开(公告)日：2005-06-23
申请号：US10892450
申请日：2004-07-16
申请人： Vadim Kutsyy , Daniel Coleman , Eugeni Vaisberg
发明人： Vadim Kutsyy , Daniel Coleman , Eugeni Vaisberg
IPC分类号： A61K49/00 , G01N33/48 , G06F20060101 , G06F19/00
CPC分类号： G06K9/6274 , G06K9/00147 , G06K9/00536
摘要： A method for calculating distances between stimulus response curves (e.g., dose response curves) allows classification of stimuli. The response curves show how the phenotype of one or more cells changes in response to varying levels of the stimulus. Each “point” on the curve represents quantitative phenotype or signature for cell(s) at a particular level of stimulus (e.g., dose of a therapeutic). The signatures are multivariate phenotypic representations of the cell(s). They include various features of the cell(s) obtained by image analysis. To facilitate the comparison of stimuli, distances between points on the response curves are calculated. First, the response curves may be aligned on a coordinate representing a separate distance, r, from a common point of negative control (e.g., the point where no stimulus is applied). Integration on r may be used to compute the distance between two response curves. The distance between response curves is used to classify stimuli.
摘要翻译：用于计算刺激响应曲线（例如，剂量响应曲线）之间的距离的方法允许对刺激进行分类。响应曲线显示了一种或多种细胞的表型如何响应刺激的不同水平而改变。曲线上的每个“点”表示特定刺激水平（例如，治疗剂的剂量）的细胞的定量表型或特征。签名是细胞的多变量表型表达。它们包括通过图像分析获得的细胞的各种特征。为了促进刺激的比较，计算响应曲线上的点之间的距离。首先，响应曲线可以在表示来自负控制的公共点（例如，不施加刺激的点）的单独距离r的坐标上对准。可以使用r上的积分来计算两个响应曲线之间的距离。响应曲线之间的距离用于对刺激进行分类。

3. 发明申请

US20050272073A1 Ploidy classification method 失效
标题翻译：倍性分类法
公开(公告)号：US20050272073A1
公开(公告)日：2005-12-08
申请号：US11097451
申请日：2005-04-01
申请人： Eugeni Vaisberg , Daniel Coleman
发明人： Eugeni Vaisberg , Daniel Coleman
IPC分类号： C12Q1/68 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： G01N33/5005
摘要： Image analysis methods and apparatus are used for determination of the ploidy of cells. The methods may involve segmenting an image to identify one or more discrete regions occupied by cells or nuclei, determining the presence of a particular ploidy indicator feature within the region(s), and providing a value of the indicator feature to a model that classifies cells' ploidy on the basis of the indicator feature. In some embodiments, the indicator feature is a level of DNA in a cell. In certain embodiments, the method further comprises treating one or more cells with a marker that highlights the ploidy indicator feature. In certain embodiments, the cells are treated prior to producing one or more images of the one or more cells. In certain embodiments, the ploidy indicator feature comprises DNA and the marker co-locates with DNA and provides a signal that is captured in the image. In certain embodiments, the signal comprises a fluorescent emission.
摘要翻译：图像分析方法和装置用于确定细胞的倍性。所述方法可以包括分割图像以识别由单元或核占据的一个或多个离散区域，确定区域内特定倍性指示符特征的存在，以及将指示符特征的值提供给将细胞分类的模型在指标特征的基础上进行倍性。在一些实施方案中，指示剂特征是细胞中的DNA水平。在某些实施方案中，所述方法还包括用突出所述倍性指示物特征的标记物处理一个或多个细胞。在某些实施方案中，在产生一个或多个细胞的一个或多个图像之前处理细胞。在某些实施方案中，倍性指示物特征包括DNA，并且标记物与DNA共定位并提供在图像中捕获的信号。在某些实施例中，信号包括荧光发射。

4. 发明申请

US20050009032A1 Methods and apparatus for characterising cells and treatments 审中-公开
标题翻译：用于表征细胞和治疗的方法和装置
公开(公告)号：US20050009032A1
公开(公告)日：2005-01-13
申请号：US10615116
申请日：2003-07-07
申请人： Daniel Coleman , Ge Cong , Aibing Rao , Eugeni Vaisberg
发明人： Daniel Coleman , Ge Cong , Aibing Rao , Eugeni Vaisberg
IPC分类号： G06K9/00 , G06T7/00 , C12Q1/68
CPC分类号： G06K9/0014 , G06T7/0012 , G06T2207/30024
摘要： Methods, data processing apparatus and computer program products for characterising cells and the affect of treatments administered to cells are disclosed. In particular methods of identifying bi-nuclear cells are described which include capturing an image of a plurality of marked cells and processing image to obtain features of the plurality of cells. The features are analyzed to determine whether the feature is indicative of bi-nuclear cells. Those cells for which the first feature is indicative of bi-nuclear cells are identified as being bi-nuclear. Three algorithms in particular are described. A first algorithm can be used to determine the number of nuclei in an image of a nuclear component by determining the number of concave regions within the outline of the image. A second algorithm uses a measure of the amount of cytoplasmic material between a pair of nuclei to identify bi-nuclear cells. A third algorithm uses the statistics of the spatial distribution of objects to identify isolated pairs of nuclei which can be considered to be from the same cell.
摘要翻译：公开了用于表征细胞的方法，数据处理装置和计算机程序产品以及对细胞施用的治疗的影响。描述了特定的识别双核细胞的方法，其包括捕获多个标记细胞的图像和处理图像以获得多个细胞的特征。分析特征以确定特征是否表示双核细胞。第一特征指示双核细胞的那些细胞被鉴定为双核的。具体描述三种算法。可以使用第一算法来确定图像轮廓内的凹区域的数量来确定核分量的图像中的核的数量。第二种算法使用一对核之间的细胞质材料的量的量度来识别双核细胞。第三种算法使用对象的空间分布的统计来识别可以被认为来自相同小区的孤立的核对。

5. 发明授权

US4786125A Ocular protective apparatus 失效
标题翻译：眼睛保护装置
公开(公告)号：US4786125A
公开(公告)日：1988-11-22
申请号：US639661
申请日：1984-08-13
申请人： Jose Magarinos , Daniel Coleman
发明人： Jose Magarinos , Daniel Coleman
IPC分类号： A61F9/02 , G02B5/18 , G02B5/32 , G02C7/10 , G03H1/02
CPC分类号： A61F9/022 , G03H2001/043 , G03H2270/21
摘要： A laser shield (FIG. 3) for providing ocular protection against laser hazards, while still providing high photopic or scotopic transmittance and good color discrimination is disclosed. This laser shield comprises a holographic optical notch filter mirror (102) having an optical surface such that the angle (104) made by an incoming laser beam (114), which is aimed by the pupil of the user, with respect to the normal of the optical surface is less than the corresponding angle (108) made by the same incoming laser beam (114) with respect to the physical surface of the substrate. This decrease in the effective angle of incidence reduces the spectral shift of the notch (which defines the frequency that is reflected), thereby providing increased protection for the same range of angles of incidence. The holographic mirror optical surface formed can be the analog of a conventional spherical, hyperbolic, parabolic, elliptical or other aspheric mirror.
摘要翻译：公开了一种用于提供针对激光危险的眼睛保护的激光屏蔽（图3），同时仍然提供高的明视或透视透光率和良好的颜色鉴别。该激光屏包括具有光学表面的全息光学陷波滤光镜（102），使得由用户瞳孔瞄准的入射激光束（114）制成的角度（104）相对于光学表面小于由相同入射激光束（114）相对于衬底的物理表面制成的相应角度（108）。有效入射角的这种降低降低了凹口的光谱偏移（其定义了被反射的频率），从而为相同入射角范围提供了更大的保护。形成的全息镜光学表面可以是常规的球形，双曲线，抛物面，椭圆形或其他非球面镜的模拟。

6. 发明授权

US4802719A Infra-red laser shield 失效
标题翻译：红外线激光盾
公开(公告)号：US4802719A
公开(公告)日：1989-02-07
申请号：US758515
申请日：1985-07-24
申请人： Jose Magarinos , Daniel Coleman
发明人： Jose Magarinos , Daniel Coleman
IPC分类号： G03H1/02 , A61F9/02 , G02B5/32 , G03H1/04 , G02C7/10
CPC分类号： A61F9/022 , G02B5/32 , G03H2001/043 , Y10S359/90
摘要： A method of making a holographic optical element is disclosed. The method comprises the steps of determining the separation between interference pattern planes tangent to surfaces separated by a desired distance which achieves desired optical properties at a given first wavelength and angular orientation of light in a hologram disposed on a curved surface of first shape corresponding to the shape of a curved holographic element. The angular characteristics of exposure to achieve of this separation of planes in a planar analog of the desired curved holographic element is determined. The angles of exposure of interfering light rays to achieve this separation of planes in the planar analog by exposure of a sensitive substantially planar surface at a second wavelength in order to achieve the desired separation of planes and angular characteristics are determined. A source is constructed having the desired angular exposure characteristics and having a wavelength equal to the second wavelength, the source being constructed using a pair of source sets which are activated in sequence to make the desired interference pattern while shading parts of the substrate. An interference pattern is recorded in a photosensitive substantially planar film disposed on a substantially planar substrate using the constructed source. The interference pattern is developed. The developed interference pattern acts as a transmission hologram. The sensitive film with the interference pattern recorded in it is removed from the substantially planar substrate, the developing being done before removal of the sensitive layer in order that the removal may be carried out in a lighted area. The removed sensitive layer is the adhered to a substrate having the first shape, the removed layer being stretched and bent for adhesion to the substrate.
摘要翻译：公开了制造全息光学元件的方法。该方法包括以下步骤：确定在与给定第一波长分开的期望光学特性相隔的表面相切的干涉图案平面之间的间隔，以及设置在对应于第一波形的第一形状的曲面上的全息图中的光的角取向弯曲全息元件的形状。确定在期望的弯曲全息元件的平面模拟中实现平面分离的曝光的角度特性。确定干涉光线的曝光角度，以通过曝光第二波长的敏感基本上平坦的表面以实现平面和角度特性所需的分离来实现平面模拟中的平面的这种分离。源构造具有期望的角度曝光特性并且具有等于第二波长的波长，该源使用一对源组来构造，这些源组被依次激活以在衬底的一部分被遮蔽的同时形成所需的干涉图案。使用所构造的源将干涉图案记录在设置在基本平坦的基板上的光敏基本上平坦的膜中。开发了干涉图案。所形成的干涉图案用作透射全息图。记录在其中的干涉图案的敏感膜从基本上平面的基板上去除，在移除敏感层之前进行显影，以便可以在点亮的区域中进行去除。去除的敏感层粘附到具有第一形状的基底上，被去除的层被拉伸并弯曲以粘附到基底。

7. 发明授权

US08032432B2 System and method for tracking a billing cycle 失效
标题翻译：跟踪结算周期的系统和方法
公开(公告)号：US08032432B2
公开(公告)日：2011-10-04
申请号：US12581016
申请日：2009-10-16
申请人： Pam Brumfield , George W. Harper , Christina Reed , Daniel Coleman , Alec Bell
发明人： Pam Brumfield , George W. Harper , Christina Reed , Daniel Coleman , Alec Bell
IPC分类号： G07F19/00 , H04M15/00
CPC分类号： H04M15/70 , G06Q20/14 , G06Q30/04 , G06Q40/04 , G06Q50/06 , H04M15/41 , H04M15/43 , H04M15/44 , H04M2215/0104 , H04M2215/0164 , H04M2215/70
摘要： A system for tracking a billing cycle in a billing system includes a data tracking engine and a rule-based engine. The rule-based engine retrieves information from the billing system during the billing cycle based on a set of rules, and provides the data to the data tracking engine. The data tracking engine generates status information and reports based on the data. The status information and reports can be accessed via a web client to monitor the billing cycle. Additionally, the rule-based engine identifies events in the billing cycle and generates a notification to alert a person if the event is not successfully completed according to a billing schedule. The notification can be accessed via a web client or a wireless communications device. The rule-based engine can subsequently issue an escalated notification to alert another user if the event has not successfully completed at a later time.
摘要翻译：用于跟踪计费系统中的计费周期的系统包括数据跟踪引擎和基于规则的引擎。基于规则的引擎在计费周期内基于一组规则从计费系统中检索信息，并将数据提供给数据跟踪引擎。数据跟踪引擎根据数据生成状态信息和报告。可以通过网络客户端访问状态信息和报告，以监控结算周期。此外，基于规则的引擎识别结算周期中的事件，并且根据结算计划生成通知，以通知人员事件是否未成功完成。该通知可以通过网络客户机或无线通信设备访问。如果事件还未成功完成，则基于规则的引擎可以随后发出升级的通知来通知另一个用户。

8. 发明授权

US07606745B1 System and method for tracking a billing cycle 失效
标题翻译：跟踪结算周期的系统和方法
公开(公告)号：US07606745B1
公开(公告)日：2009-10-20
申请号：US10693311
申请日：2003-10-24
申请人： Pam Brumfield , George W. Harper , Christina Reed , Daniel Coleman , Alec Bell
发明人： Pam Brumfield , George W. Harper , Christina Reed , Daniel Coleman , Alec Bell
IPC分类号： G07F19/00 , H04M15/00
CPC分类号： H04M15/70 , G06Q20/14 , G06Q30/04 , G06Q40/04 , G06Q50/06 , H04M15/41 , H04M15/43 , H04M15/44 , H04M2215/0104 , H04M2215/0164 , H04M2215/70
摘要： A system for tracking a billing cycle in a billing system includes a data tracking engine and a rule-based engine. The rule-base engine retrieves information from the billing system during the billing cycle based on a set of rules, and provides the data to the data tracking engine. The data tracking engine generates status information and reports based on the data. The status information and reports can be accessed via a web client to monitor the billing cycle. Additionally, the rule-based engine identifies events in the billing cycle and generates a notification to alert a person if the event is not successfully completed according to a billing schedule. The notification can be accessed via a web client or a wireless communications device. The rule-based engine can subsequently issue an escalated notification to alert another user if the event has not successfully completed at a later time.
摘要翻译：用于跟踪计费系统中的计费周期的系统包括数据跟踪引擎和基于规则的引擎。规则库引擎基于一组规则在计费周期内从计费系统中检索信息，并将数据提供给数据跟踪引擎。数据跟踪引擎根据数据生成状态信息和报告。可以通过网络客户端访问状态信息和报告，以监控结算周期。此外，基于规则的引擎识别结算周期中的事件，并且根据结算计划生成通知，以通知人员事件是否未成功完成。该通知可以通过网络客户机或无线通信设备访问。如果事件还未成功完成，则基于规则的引擎可以随后发出升级的通知来通知另一个用户。

9. 外观设计

USD725308S1 Battery operated havdallah candle with multiple bulbs 有权
标题翻译：电池操作的havdallah蜡烛与多个灯泡
公开(公告)号：USD725308S1
公开(公告)日：2015-03-24
申请号：US29441026
申请日：2012-12-30
申请人： Daniel Coleman
设计人： Daniel Coleman

10. 外观设计

USD724933S1 Wall plate featuring embossed Sabbath candles 有权
标题翻译：墙板装饰着安息日蜡烛
公开(公告)号：USD724933S1
公开(公告)日：2015-03-24
申请号：US29441246
申请日：2013-01-02
申请人： Daniel Coleman
设计人： Daniel Coleman

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