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1. 发明授权

US11441521B2 Vaned valve for exhaust gas recirculation line 有权
公开(公告)号：US11441521B2
公开(公告)日：2022-09-13
申请号：US16627309
申请日：2017-08-15
申请人： VOLVO TRUCK CORPORATION , Jian Li , John Lowe
发明人： Jian Li , John Lowe
IPC分类号： F02M26/71 , F02M26/68 , F02M26/16 , F02M26/21 , F02M26/53 , F02M26/69
摘要： A valve for m exhaust gas recirculation Mae in an engine includes a first barrel connectable to a first group of cylinders, a second barrel connectable to a second group of cylinders, and a center barrel between the first and second barrels and connectable to an intake of the engine, A poppet valve with two valve heads mounted on a valve stem is provided to open and close openings between the first and second barrels, with one of the valve beads of the poppet valve opening into the center barrel Vanes are provided in the center barrel to direct flow from the opening by the valve bead that opens into the center barrel toward the outlet opening.

2. 发明授权

US07157085B2 Method for treating IgE-mediated disorders 有权
标题翻译：治疗IgE介导的疾病的方法
公开(公告)号：US07157085B2
公开(公告)日：2007-01-02
申请号：US10791619
申请日：2004-03-02
申请人： Henry B. Lowman , Leonard G. Presta , Paula M. Jardieu , John Lowe
发明人： Henry B. Lowman , Leonard G. Presta , Paula M. Jardieu , John Lowe
IPC分类号： A61K39/395
CPC分类号： C07K16/4291 , A61K39/39566 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , A61K2300/00
摘要： The present invention relates to a method for adjusting the affinity of a polypeptide to a target molecule by a combination of steps, including: (1) the identification of aspartyl residues which are prone to isomerization; (2) the substitution of alternative residues and screening the resulting mutants for affinity against the target molecule. In a preferred embodiment, the method of subtituting residues is affinity maturation with phage display (AMPD). In a further preferred embodiment the polypeptide is an antibody and the target molecule is an antigen. In a further preferred embodiment, the antibody is anti-IgE and the target molecule is IgE. In another embodiment, the invention relates to an anti-IgE antibody having improved affinity to IgE.
摘要翻译：本发明涉及通过以下步骤的组合来调节多肽与靶分子的亲和力的方法，包括：（1）鉴定易于异构化的天冬氨酰残基; （2）替代替代残基并筛选得到的突变体对靶分子的亲合力。在优选的实施方案中，残基残基的方法是用噬菌体展示（AMPD）进行亲和力成熟。在另一优选实施方案中，多肽是抗体，靶分子是抗原。在另一个优选的实施方案中，抗体是抗IgE，靶分子是IgE。在另一个实施方案中，本发明涉及对IgE具有改善的亲和力的抗IgE抗体。

3. 发明授权

US5714338A Methods for diagnosis of allergy 失效
标题翻译：过敏诊断方法
公开(公告)号：US5714338A
公开(公告)日：1998-02-03
申请号：US393014
申请日：1995-02-27
申请人： David Tai Wai Fei , John Lowe , Paula Jardieu
发明人： David Tai Wai Fei , John Lowe , Paula Jardieu
IPC分类号： G01N33/53 , G01N33/50 , G01N33/569 , G01N33/68 , C07K16/44 , C12N5/16 , G01N33/566
CPC分类号： G01N33/6857 , G01N33/5047 , G01N33/56972 , G01N33/6854
摘要： Provided are methods for the diagnosis of allergic disease wherein IgE specific for an allergen of interest is detected in a patient serum sample by using the patient serum sample to sensitize in the presence or absence of an IgE antagonist a mast cell or basophil host genetically engineered to display surface expression of a Fc.epsilon.RI subunit that is capable of mediating the host cells release of a pharmacological mediator upon induction with patient serum and allergen, challenging the sensitized host cells with the allergen of interest, and determining the presence or absence of IgE specific to the allergen of interest in the patient serum sample by comparing the release of the pharmacological mediator produced by host cells sensitized with patient serum in the presence of the IgE antagonist to the release of the pharmacological mediator produced by host cells sensitized with patient serum in the absence of the IgE antagonist.
摘要翻译： PCT No.PCT / US94 / 14282 Sec。 371日期：1995年2月27日 102（e）1995年2月27日PCT 1994年12月9日PCT PCT。公开号WO95 / 16203 日期1995年6月15日提供了用于诊断过敏性疾病的方法，其中通过使用患者血清样品在存在或不存在IgE拮抗剂的情况下在患者血清样品中检测到感兴趣的变应原的IgE，遗传工程改造的嗜碱性粒细胞宿主，以显示FcεRI亚基的表达表达，其能够在用患者血清和变应原诱导时介导宿主细胞释放药理学介质，并利用感兴趣的变应原对致敏宿主细胞进行挑战，并确定存在或不存在对患者血清样品中感兴趣的变应原特异性的IgE，通过比较由存在IgE拮抗剂的患者血清致敏的宿主细胞产生的药理学介质与由致敏的宿主细胞产生的药理学介质的释放相关的释放在没有IgE拮抗剂的情况下患有血清。

4. 发明申请

US20080071620A1 System, Methods, And Apparatus For Interactive Advertising 有权
标题翻译：互动广告的系统，方法和装置
公开(公告)号：US20080071620A1
公开(公告)日：2008-03-20
申请号：US11857328
申请日：2007-09-18
申请人： John Lowe
发明人： John Lowe
IPC分类号： G06Q30/00
CPC分类号： G06Q30/0625 , G06F17/3087 , G06Q30/02 , G06Q30/0256 , G06Q30/0277
摘要： The present invention relates to a system and methodology for searching and presenting merchant and advertised information to a user over a wide area network such as the Internet. The system and method actively links manufacturer and merchant information within a search query so as to enable a user to conduct more efficient searching when seeking products or services in a proximity or geographical area. This Abstract is provided for the sole purpose of complying with the Abstract requirement rules that allow a reader to quickly ascertain the subject matter of the disclosure contained herein. This Abstract is submitted with the explicit understanding that it will not be used to interpret or to limit the scope or the meaning of the claims.
摘要翻译：本发明涉及一种用于通过诸如因特网的广域网向用户搜索和呈现商户和通告信息的系统和方法。系统和方法主动地将搜索查询中的制造商和商家信息链接起来，以便使用户能够在邻近或地理区域寻求产品或服务时进行更有效的搜索。本摘要仅用于遵守允许读者快速确定本文所包含的披露的主题的抽象要求规则。本摘要以明确的理解提交，不会用于解释或限制权利要求的范围或含义。

5. 发明申请

US20060059013A1 Attached personal information device 审中-公开
标题翻译：附加个人信息设备
公开(公告)号：US20060059013A1
公开(公告)日：2006-03-16
申请号：US10938503
申请日：2004-09-13
申请人： John Lowe
发明人： John Lowe
IPC分类号： G06Q50/00 , G06Q10/00
CPC分类号： G06F19/323 , G06F19/00 , G06Q50/22 , G16H10/65
摘要： An information storage device may be semi-permanently attached to a wearer. The device can include an outer casing configured to be compatible with long term contact with a human body. A data storage component may store information of the wearer and a transceiver may wirelessly communicate information from the data storage component. The stored information can be, for example, the complete medical history of the wearer, “emergency” medical information, prescriptions, medical warnings (e.g., past history of coronary problems), financial information, social security numbers, or other useful information.
摘要翻译：信息存储装置可以半永久地附接到佩戴者。该装置可以包括配置成与人体长期接触兼容的外壳。数据存储部件可以存储佩戴者的信息，并且收发器可以从数据存储部件无线地传送信息。存储的信息可以是例如佩戴者的完整病历，“紧急”医疗信息，处方，医疗警告（例如，冠状动脉问题的过去历史），财务信息，社会保险号码或其他有用信息。

6. 发明申请

US20050050145A1 Second person review of email 有权
标题翻译：第二人评论电子邮件
公开(公告)号：US20050050145A1
公开(公告)日：2005-03-03
申请号：US10653259
申请日：2003-09-03
申请人： John Lowe
发明人： John Lowe
IPC分类号： H04L12/58 , H04L29/06 , H04L29/08 , G06F15/16
CPC分类号： H04L67/36 , H04L29/06 , H04L51/14 , H04L51/34 , H04L69/329
摘要： An email review tool gives users a simple, quick, and safe method of initiating review of an email document. The email review tool may provide a window to a user which allows the user to select another person to review the email or skip the review process and send the email directly to the recipients. Transmission of the email is thus deferred until the email has been reviewed.
摘要翻译：电子邮件审查工具为用户提供了一种简单，快速和安全的方式来启动对电子邮件文档的审查。电子邮件审查工具可以向用户提供窗口，其允许用户选择另一个人来审查电子邮件或跳过审查过程并将邮件直接发送给接收者。因此，电子邮件的传输会延迟到电子邮件审核。

7. 发明授权

US06761889B2 Anti-IgE antibodies 有权
标题翻译：抗IgE抗体
公开(公告)号：US06761889B2
公开(公告)日：2004-07-13
申请号：US10113996
申请日：2002-04-01
申请人： Henry B. Lowman , Leonard G. Presta , Paula M. Jardieu , John Lowe
发明人： Henry B. Lowman , Leonard G. Presta , Paula M. Jardieu , John Lowe
IPC分类号： A61K39395
CPC分类号： C07K16/00 , A61K38/00 , C07K16/4291 , C07K2317/24 , Y10S424/81 , Y10S530/868
摘要： The present invention relates to a method for adjusting the affinity of a polypeptide to a target molecule by a combination of steps, including: (1) the identification of aspartyl residues which are prone to isomerization; (2) the substitution of alternative residues and screening the resulting mutants for affinity against the target molecule. In a preferred embodiment, the method of subtituting residues is affinity maturation with phage display (AMPD). In a further preferred embodiment the polypeptide is an antibody and the target molecule is an antigen. In a further preferred embodiment, the antibody is anti-lgE and the target molecule is lgE. In another embodiment, the invention relates to an anti-IgE antibody having improved affinity to IgE.
摘要翻译：本发明涉及通过以下步骤的组合来调节多肽与靶分子的亲和力的方法，包括：（1）鉴定易于异构化的天冬氨酰残基; （2）替代替代残基并筛选得到的突变体对靶分子的亲合力。在优选的实施方案中，残基残基的方法是用噬菌体展示（AMPD）进行亲和力成熟。在另一优选实施方案中，多肽是抗体，靶分子是抗原。在另一个优选的实施方案中，抗体是抗-IgE，靶分子是IgG。在另一个实施方案中，本发明涉及对IgE具有改善的亲和力的抗IgE抗体。

8. 发明授权

US06682735B2 Anti-IgE antibodies 有权
标题翻译：抗IgE抗体
公开(公告)号：US06682735B2
公开(公告)日：2004-01-27
申请号：US09920171
申请日：2001-08-01
申请人： Henry B. Lowman , Leonard G. Presta , Paula M. Jardieu , John Lowe
发明人： Henry B. Lowman , Leonard G. Presta , Paula M. Jardieu , John Lowe
IPC分类号： A61K39395
CPC分类号： C07K16/00 , A61K38/00 , C07K16/4291 , C07K2317/24 , Y10S424/81 , Y10S530/868
摘要： The present invention relates to a method for adjusting the affinity of a polypeptide to a target molecule by a combination of steps, including: (1) the identification of aspartyl residues which are prone to isomerization; (2) the substitution of alternative residues and screening the resulting mutants for affinity against the target molecule. In a preferred embodiment, the method of subtituting residues is affinity maturation with phage display (AMPD). In a further preferred embodiment the polypeptide is an antibody and the target molecule is an antigen. In a further preferred embodiment, the antibody is anti-IgE and the target molecule is IgE. In another embodiment, the invention relates to an anti-IgE antibody having improved affinity to IgE.
摘要翻译：本发明涉及通过以下步骤的组合来调节多肽与靶分子的亲和力的方法，包括：（1）鉴定易于异构化的天冬氨酰残基; （2）替代替代残基并筛选得到的突变体对靶分子的亲合力。在优选的实施方案中，取代残基的方法是用噬菌体展示（AMPD）进行亲和力成熟。在另一优选实施方案中，多肽是抗体，靶分子是抗原。在另一个优选的实施方案中，抗体是抗IgE，靶分子是IgE。在另一个实施方案中，本发明涉及对IgE具有改善的亲和力的抗IgE抗体。

9. 发明授权

US06172213B2 Anti-IgE antibodies and method of improving polypeptides 失效
标题翻译：抗IgE抗体和改善多肽的方法
公开(公告)号：US06172213B2
公开(公告)日：2001-01-09
申请号：US09109207
申请日：1998-06-30
申请人： Henry B. Lowman , Leonard G. Presta , Paula M. Jardieu , John Lowe
发明人： Henry B. Lowman , Leonard G. Presta , Paula M. Jardieu , John Lowe
IPC分类号： C07H2104
CPC分类号： C07K16/4291 , A61K39/39566 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , A61K2300/00
摘要： The present invention relates to a method for adjusting the affinity of a polypeptide to a target molecule by a combination of steps, including: (1) the identification of aspartyl residues which are prone to isomerization; (2) the substitution of alternative residues and screening the resulting mutants for affinity against the target molecule. In a preferred embodiment, the method of substituting residues is affinity maturation with phage display (AMPD). In a further preferred embodiment the polypeptide is an antibody and the target molecule is an antigen. In a further preferred embodiment, the antibody is anti-IgE and the target molecule is IgE. In another embodiment, the invention relates to an anti-IgE antibody having improved affinity to IgE.
摘要翻译：本发明涉及通过以下步骤的组合来调节多肽与靶分子的亲和力的方法，包括：（1）鉴定易于异构化的天冬氨酰残基; （2）替代替代残基并筛选得到的突变体对靶分子的亲合力。在优选的实施方案中，取代残基的方法是用噬菌体展示（AMPD）进行亲和力成熟。在另一优选实施方案中，多肽是抗体，靶分子是抗原。在另一个优选的实施方案中，抗体是抗IgE，靶分子是IgE。在另一个实施方案中，本发明涉及对IgE具有改善的亲和力的抗IgE抗体。

10. 发明授权

US4146766A Actuating mechanisms for vacuum interrupters 失效
标题翻译：真空中断器的启动机构
公开(公告)号：US4146766A
公开(公告)日：1979-03-27
申请号：US790334
申请日：1977-04-25
申请人： Jack T. Forrester , John Lowe
发明人： Jack T. Forrester , John Lowe
IPC分类号： H01H1/00 , H01H33/666 , H01H3/46
CPC分类号： H01H33/666 , H01H1/0015 , Y10S200/42
摘要： An actuating mechanism for a vacuum interrupter incorporates a pivotable bell crank mechanism and a displacement structure for imparting movement of the bell crank mechanism to a coupling structure which is connectable to a contact stem carrying the movable contact of the interrupter for moving the contact into and out of engagement with another contact of the interrupter. After movement of the coupling structure for a sufficient distance in a direction which causes closure of the contacts the displacement structure is capable of being moved for a further distance to disengage it from a cooperating surface of the coupling structure. On the return movement the displacement structure is traveling at high velocity when it re-engages the cooperating surface of the coupling structure which produces a rapid acceleration of the latter and hence, in use, of the movable contact of the interrupter to the open position.

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