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1. 发明授权

US06833382B2 Streptogramins and method for preparing same by mutasynthesis 失效
标题翻译：链霉素及其制备方法
公开(公告)号：US06833382B2
公开(公告)日：2004-12-21
申请号：US09987614
申请日：2001-11-15
申请人： Véronique Blanc , Denis Thibaut , Nathalie Bamas-Jacques , Francis Blanche , Joël Crouzet , Jean-Claude Barriere , Laurent Debussche , Alain Famechon , Jean-Marc Paris , Gilles Dutruc-Rosset
发明人： Véronique Blanc , Denis Thibaut , Nathalie Bamas-Jacques , Francis Blanche , Joël Crouzet , Jean-Claude Barriere , Laurent Debussche , Alain Famechon , Jean-Marc Paris , Gilles Dutruc-Rosset
IPC分类号： A61K3140
CPC分类号： C07D295/155 , A61K38/00 , C07C229/36 , C07C229/42 , C07C233/15 , C07C233/25 , C07C323/63 , C07K7/06 , C12N15/52 , C12N15/76
摘要： Novel group B streptogramin-like compounds of general formula (I), and a method for preparing streptogramines by mutasynthesis using a mutated micro-organism to influence the biosynthesis of at least one of the precursors of group B streptogramins are disclosed. Novel nucleotide sequences involved in the biosynthesis of said precursors, and their uses, are also disclosed.
摘要翻译：公开了通式（I）的新型B族链霉素样化合物，以及通过使用突变微生物进行突变的制备链霉菌素以影响至少一种B族链霉素前体的生物合成的方法。还公开了涉及所述前体的生物合成的新型核苷酸序列及其用途。

2. 发明授权

US06352839B1 Streptogramins for preparing same by mutasynthesis 失效
标题翻译：链霉素及其制备方法
公开(公告)号：US06352839B1
公开(公告)日：2002-03-05
申请号：US08765907
申请日：1997-03-20
申请人： Véronique Blanc , Denis Thibaut , Nathalie Bamas-Jacques , Francis Blanche , Joël Crouzet , Jean-Claude Barriere , Laurent Debussche , Alain Famechon , Jean-Marc Paris , Gilles Dutruc-Rosset
发明人： Véronique Blanc , Denis Thibaut , Nathalie Bamas-Jacques , Francis Blanche , Joël Crouzet , Jean-Claude Barriere , Laurent Debussche , Alain Famechon , Jean-Marc Paris , Gilles Dutruc-Rosset
IPC分类号： C12P100
CPC分类号： C07D295/155 , A61K38/00 , C07C229/36 , C07C229/42 , C07C233/15 , C07C233/25 , C07C323/63 , C07K7/06 , C12N15/52 , C12N15/76
摘要： The invention provides a method for preparing streptogramins using genetically-modified microorganisms to influence the biosynthesis of at least one of the precursors of the group B streptogramins. Cultures of the genetically-modified microorganisms are supplemented with a least one precursor that is different from the streptogramin precursor whose biosynthesis is altered and the streptogramins produced are recovered.
摘要翻译：本发明提供了使用遗传修饰的微生物来制备链霉素的方法，所述基因修饰的微生物影响B群链霉素的至少一种前体的生物合成。对经遗传修饰的微生物的培养物补充有至少一种不同于生物合成改变的链霉素前体的前体，并且生成的链霉蛋白酶被回收。

3. 发明授权

US06384014B1 Purified form of streptogramines, preparation of same and pharmaceutical compositions containing them 失效
标题翻译：纯化形式的链球菌素，其制备物和含有它们的药物组合物
公开(公告)号：US06384014B1
公开(公告)日：2002-05-07
申请号：US09522949
申请日：2000-03-10
申请人： Pascal Anger , Jean-Claude Barriere , Bertrand Bonnavaud , Patrick Lefevre , Jean-Marc Paris , Denis Thibaut
发明人： Pascal Anger , Jean-Claude Barriere , Bertrand Bonnavaud , Patrick Lefevre , Jean-Marc Paris , Denis Thibaut
IPC分类号： A61K3812
CPC分类号： C07K5/06182 , A61K38/00 , C07K7/06
摘要： Purified form of streptogramines, characterised in that it contains at least one component from group B streptogramines of general formula (I), wherein R1 is Me or Et, R2 is H or OH, and R3 is substituted benzyl of general formula (III), such that 1) if R2 is H, R is NR4R5, wherein one of R4 and R5 is H or an Me radical and the other is Me, and R′ is Cl or Br, or R is (C3-5)alkenyl if R4 and R5 are Me, or 2) R is H and R′ is halogen, alkylamino or dialkylamino, an ether-oxide residue, alkylthio, (C1-3)alkyl or trihalogenomethyl, or R is halogen, (C2-4)alkylamino, (C2-4)dialkylamino or methyl ethyl amino, pyrrolidino alkenyl alkyl amino, dialkylamino, an alkyl cycloalkylmethyl amino radical or in ether-oxide residue, alkylthio, alkylthiomethyl, (C1-6)alkyl, aryl or trihalogenomethyl, and R′ is H, or R is halogen, amino, alkylamino or dialkylamino, an ether-oxide residue, an alkylthio radical, (C1-6)alkyl or trihalogenomethyl and R′ is halogen, alkylamino or dialkylamino, an ether-oxide residue or alkylthio, (C1-3)alkyl, cocrystallised with one or more minor components of group A of general formula (II) wherein R″ is H, Me or Et.
摘要翻译：其特征在于，其含有至少一种通式（I）的B组链霉素的组分，其中R 1是Me或Et，R 2是H或OH，R 3是通式（III）的取代的苄基，使得1）如果R 2是H，R 4是NR 4 R 5，其中R 4和R 5之一是H或Me基团，而另一个是Me，R'是Cl或Br，或R 4是（C 3-5）烯基，如果R 4 和R 5是Me，或2）R是H，R'是卤素，烷基氨基或二烷基氨基，醚氧化物残基，烷硫基，（C 1-3）烷基或三卤代甲基，或R是卤素，（C 2-4）烷基氨基，（C 2-4）二烷基氨基或甲基乙基氨基，吡咯烷基链烯基烷基氨基，二烷基氨基，烷基环烷基甲基氨基或醚氧化物残基，烷硫基，烷硫基甲基，（C 1-6）烷基，芳基或三卤代甲基，R' ，或R是卤素，氨基，烷基氨基或二烷基氨基，醚氧化物残基，烷硫基，（C 1-6）烷基或三卤代甲基，R'是卤素，烷基氨基或二烷基氨基，醚氧化物残基或烷硫基，（C 1-3）烷基，与通式（II）的基团A的一种或多种次要组分共结晶，其中R“为H，Me或Et。

4. 发明授权

US4775753A New process for the preparation of pristinamycin II.sub.B derivatives 失效
标题翻译：制备原始蛋白霉素IIB衍生物的新方法
公开(公告)号：US4775753A
公开(公告)日：1988-10-04
申请号：US70389
申请日：1987-07-07
申请人： Jean-Claude Barriere , Jean-Pierre Bastart , Jean-Marc Paris
发明人： Jean-Claude Barriere , Jean-Pierre Bastart , Jean-Marc Paris
IPC分类号： C07D498/18 , A61K31/42 , A61P31/04 , C07D498/14 , C07K5/06 , C07K5/078
CPC分类号： C07D498/14 , C07K5/06182
摘要： Pristinamycin II.sub.B derivatives of formula I in which R represents: ##STR1## either a 4- to 7-membered nitrogen-containing heterocyclic radical, optionally containing 1 or more other hetero atoms chosen from nitrogen, oxygen and sulphur in the sulphoxide or sulphone form, and unsubstituted or substituted by alkyl,or alkyl of 2 to 4 carbon atoms, substituted by 1 or 2 radicals chosen from phenyl, cycloalkylamino or N-alkyl-N-cycloalkylamino having 3 to 6 ring carbon atoms, alkylamino, dialkylamino or dialkylcarbamoyloxy (the alkyl parts of these last 2 radicals being optionally joined to form, with the nitrogen atom to which they are attached, a 4- to 7-membered saturated or unsaturated heterocycle optionally containing another hetero atom chosen from nitrogen, oxygen and sulphur in the sulphoxide or sulphone form, and unsubstituted or substituted by alkyl) or a said alkyl substituted by one or more 4- or 7-membered nitrogen-containing heterocycles optionally containing 1 or 2 other hetero atoms chosen from nitrogen, oxygen and sulphur in the sulphoxide or sulphone form and unsubstituted or substituted by an alkyl radical, the said heterocycles being attached to the alkyl via a carbon atom, at least one of the substituents carried by the alkyl being a nitrogen-containing substituent capable of forming salts,or a [(S)-1-methyl-2-pyrrolidinyl]methyl radical, the aforesaid alkyl radicals being straight-chain or branched and containing, unless otherwise stated, 1 to 10 carbon atoms each, including isomeric forms thereof and mixtures thereof, and the salts thereof, are made by oxidizing a pristinamycin II.sub.B derivative of formula II ##STR2## with potassium peroxymonosulphate.
摘要翻译：式I的普瑞霉素IIB衍生物，其中R表示：（I）4-元至7-元含氮杂环基，任选地含有1或多个选自亚砜中的氮，氧和硫的其它杂原子，或砜基形式，未取代的或被烷基取代或被2至4个碳原子的烷基取代，被1或2个选自苯基，环烷基氨基或具有3至6个环碳原子的N-烷基-N-环烷基氨基的基团取代，烷基氨基，二烷基氨基或二烷基氨基甲酰氧基（这些最后2个基团的烷基部分任选地连接形成与它们所连接的氮原子一起形成4-7元饱和或不饱和的杂环，任选地含有另外选自氮，氧和硫的杂原子）亚砜或砜形式，未取代或被烷基取代）或被一个或多个4-或7-元含氮杂环取代的所述烷基，任选地含有1或2个其它h 选自氮，氧和硫的亚杂原子或未被取代或被烷基取代的杂原子，所述杂环经由碳原子连接到烷基上，烷基所携带的至少一个取代基是氮（S）-1-甲基-2-吡咯烷基]甲基，上述烷基是直链或支链的并且除非另有说明，含有各自为1-10个碳原子，包括其异构体形式及其混合物及其盐通过用过氧单硫酸钾与过氧化硫酸盐钾一起氧化式II的嘌呤霉素IIB衍生物来制备。

5. 发明授权

US4755599A 3-phenyl-2-propeneamine derivatives, their preparation and composition containing them 失效
标题翻译： 3-苯基-2-丙烯胺衍生物，它们的制备方法和含有它们的组合物
公开(公告)号：US4755599A
公开(公告)日：1988-07-05
申请号：US10558
申请日：1987-02-03
申请人： Jean-Claude Barriere , Jean-Pierre Corbet , Claude Cotrel , Daniel Farge , Jean-Marc Paris
发明人： Jean-Claude Barriere , Jean-Pierre Corbet , Claude Cotrel , Daniel Farge , Jean-Marc Paris
IPC分类号： A61K31/135 , A61K31/10 , A61K31/137 , A61K31/21 , A61K31/22 , A61P25/24 , A61P25/26 , C07C67/00 , C07C213/00 , C07C213/02 , C07C215/28 , C07C215/30 , C07C215/42 , C07C219/22 , C07C219/32 , C07C239/00 , C07C271/20 , C07C313/00 , C07C317/28 , C07C317/36 , C07C319/20 , C07C323/27 , C07C323/32 , C07C323/65 , C07D207/08 , C07D213/38 , C07D213/70 , C07D295/084 , C07D295/092 , C07D307/32 , C07F9/40 , C07D279/04 , C07C149/24 , C07D205/04 , C07D223/04 , C07D275/02 , C07D277/04 , C07D401/06
CPC分类号： C07D207/08 , C07D213/38 , C07D213/70 , C07D295/092 , C07D307/32 , C07F9/4006
摘要： The invention provides compounds of formula: ##STR1## in which R=H, halogen, alkyl, alkyloxy, alkythio, NH.sub.2, alkylamino, dialkylamino or CF.sub.3, R.sub.3 =H or alkyl,either R.sub.4 and R.sub.5 =H and R.sub.1 and R.sub.2 =H or alkyl, optionally substituted by alkenyl (2 to 4 C) or alternatively R.sub.1 and R.sub.2 form together a saturated heterocyclic ring containing 4 to 7 ring members and optionally containing another heteroatom such as O, S or N optionally substituted by alkyl,or R.sub.4 =H, R.sub.1 =H or alkyl and R.sub.2 and R.sub.5 together form an alkylene (3 to 4 C) radical and(i) either A=alkyl or phenyl which is unsubstituted or substituted by one or two substituents chosen from halogen, alkyl, alkyloxy, alkylthio, NH.sub.2, alkylamino, dialkylamino, NO.sub.2 or CF.sub.3 or alternatively A=pyridyl, benzyl or cycloalkyl (3 to 6 C), Y=S, SO or SO.sub.2 or a radical: ##STR2## in which R.sub.6 =H or alkyl and R.sub.7 =H or alkylcarbonyl, alkyloxycarbonyl, alkylaminocarbonyl or benzoyl, optionally substituted by one or two halogen, alkyl, alkyloxy, alkylthio, NH.sub.2, alkylamino, dialkylamino, NO.sub.2 or CF.sub.3 groups,(ii) or Y and A together form a 1-hydroxycycloalkyl radical, the ring of which contains 5 or 6 C, optionally joined to a benzene ring,it being understood that the alkyl radicals and alkyl parts contains 1 to 4 C as a straight or branched chain, and that the invention relates to all the possible geometric and optical isomers as well as their mixtures.These compounds are useful as antidepressants.
摘要翻译：本发明提供下式的化合物：其中R = H，卤素，烷基，烷氧基，链烯基，NH 2，烷基氨基，二烷基氨基或CF 3，R 3 = H或烷基，R 4和R 5 = H，R 1和 R 2 = H或烷基，任选被烯基（2至4 C）取代，或者R 1和R 2一起形成含有4至7个环成员的饱和杂环，并任选地含有另外的杂原子，例如任选被烷基取代的O，S或N，或R4 = H，R1 = H或烷基，R2和R5一起形成亚烷基（3至4 C）基团，和（i）A =烷基或苯基，其未被取代或被一个或两个选自卤素，烷基，烷氧基，烷硫基，NH 2，烷基氨基，二烷基氨基，NO 2或CF 3，或者A =吡啶基，苄基或环烷基（3至6 C），Y = S，SO或SO 2或基团：其中R 6 = H或烷基，且R7 = H或烷基羰基，烷氧基羰基，烷基氨基羰基或苯甲酰基，任选被一个或两个卤素，烷基，烷氧基，烷硫基，NH 2，烷基氨基，二烷基氨基，NO 2或CF 3基团，（ii）或Y和A一起形成1-羟基环烷基，其环包含5或6个C，任选地连接到苯环，应理解烷基和烷基部分包含1至4 C作为直链或支链，本发明涉及所有可能的几何和光学异构体及其混合物。这些化合物可用作抗抑郁药。

6. 发明授权

US4686309A 3-phenyl-2-propeneamine derivatives, their preparation and compositions containing them 失效
标题翻译： 3-苯基-2-丙烯胺衍生物，它们的制备方法和含有它们的组合物
公开(公告)号：US4686309A
公开(公告)日：1987-08-11
申请号：US702088
申请日：1985-02-15
申请人： Jean-Claude Barriere , Jean-Pierre Corbet , Claude Cotrel , Daniel Farge , Jean-Marc Paris
发明人： Jean-Claude Barriere , Jean-Pierre Corbet , Claude Cotrel , Daniel Farge , Jean-Marc Paris
IPC分类号： A61K31/135 , A61K31/10 , A61K31/137 , A61K31/21 , A61K31/22 , A61P25/24 , A61P25/26 , C07C67/00 , C07C213/00 , C07C213/02 , C07C215/28 , C07C215/30 , C07C215/42 , C07C219/22 , C07C219/32 , C07C239/00 , C07C271/20 , C07C313/00 , C07C317/28 , C07C317/36 , C07C319/20 , C07C323/27 , C07C323/32 , C07C323/65 , C07D207/08 , C07D213/38 , C07D213/70 , C07D295/084 , C07D295/092 , C07D307/32 , C07F9/40 , C07C91/16 , C07C67/02 , C07D211/70
CPC分类号： C07D207/08 , C07D213/38 , C07D213/70 , C07D295/092 , C07D307/32 , C07F9/4006
摘要： The invention provides compounds of formula: ##STR1## in which R=H, halogen, alkyl, alkyloxy, alkythio, NH.sub.2, alkylamino, dialkylamino or CF.sub.3, R.sub.3 =H or alkyl, either R.sub.4 and R.sub.5 =H and R.sub.1 and R.sub.2 =H or alkyl, optionally substituted by alkenyl (2 to 4 C) or alternatively R.sub.1 and R.sub.2 form together a saturated heterocyclic ring containing 4 to 7 ring members and optionally containing another heteroatom such as O, S or N optionally substituted by alkyl, or R.sub.4 =H, R.sub.1 =H or alkyl and R.sub.2 and R.sub.5 together form an alkylene (3 to 4 C) radical and (i) either A=alkyl or phenyl which is unsubstituted or substituted by one or two substituents chosen from halogen, alkyl, alkyloxy, alkylthio, NH.sub.2, alkylamino, dialkylamino, NO.sub.2 or CF.sub.3 or alternatively A=pyridyl, benzyl or cycloalkyl (3 to 6C), Y=S, SO or SO.sub.2 or a radical: ##STR2## in which R.sub.6 =H or alkyl and R.sub.7 =H or alkylcarbonyl, alkyloxycarbonyl, alkylaminocarbonyl or benzoyl, optionally substituted by one or two halogen, alkyl, alkyloxy, alkylthio, NH.sub.2, alkylamino, dialkylamino, NO.sub.2 or CF.sub.3 groups, (ii) or Y and A together form a 1-hydroxycycloalkyl radical, the ring of which contains 5 or 6 C, optionally joined to a benzene ring, it being understood that the alkyl radicals and alkyl parts contain 1 to 4 C as a straight or branched chain, and that the invention relates to all the possible geometric and optical isomers as well as their mixtures.These compounds are useful as antidepressants.
摘要翻译：本发明提供下式的化合物：其中R = H，卤素，烷基，烷氧基，链烯基，NH 2，烷基氨基，二烷基氨基或CF 3，R 3 = H或烷基，R 4和R 5 = H，R 1和 R 2 = H或烷基，任选被烯基（2至4 C）取代，或者R 1和R 2一起形成含有4至7个环成员的饱和杂环，并任选地含有另外的杂原子，例如任选被烷基取代的O，S或N，或R4 = H，R1 = H或烷基，R2和R5一起形成亚烷基（3至4 C）基团，和（i）A =烷基或苯基，其未被取代或被一个或两个选自卤素，烷基，烷氧基，烷硫基，NH 2，烷基氨基，二烷基氨基，NO 2或CF 3，或者A =吡啶基，苄基或环烷基（3至6C），Y = S，SO或SO 2或基团：其中R 6 = H或烷基，R 7 = H或烷基羰基，烷氧基羰基，烷基氨基羰基或苯甲酰基，任选被一个或两个卤素，烷基，烷氧基，烷硫基，NH 2，烷基氨基，二烷基氨基，NO 2或CF 3基团，（ii）或Y和A一起形成1-羟基环烷基，其环含有5或6个C，任选地连接到苯环，应理解烷基和烷基部分含有1至4个C作为直链或支链，本发明涉及所有可能的几何和光学异构体及其混合物。这些化合物可用作抗抑郁药。

7. 发明授权

US5326782A Salts derived from 26-(dialkylaminoalkylsulphonyl)pristinamycin IIB 失效
标题翻译：衍生自26-（二烷基氨基烷基磺酰基）丙霉素IIB的盐
公开(公告)号：US5326782A
公开(公告)日：1994-07-05
申请号：US961925
申请日：1993-01-04
申请人： Jean-Claude Barriere , Jean-Pierre Corbet , Jean-Marc Paris , Xavier Radisson
发明人： Jean-Claude Barriere , Jean-Pierre Corbet , Jean-Marc Paris , Xavier Radisson
IPC分类号： A61K31/42 , A61K31/122 , A61K31/424 , A61K38/00 , A61P31/00 , A61P31/04 , C07D498/18 , C07K5/078 , C07D498/16
CPC分类号： C07K5/06182 , A61K38/00
摘要： Di-p-toluoyl tartrate, di-t-butylacetyl tartrate, di-butyryl tartrate and di-i-valeryl tartrate of (dialkylamino-2 alkyl)sulphonyl-26 pristinamycin II.sub.B having general formula (I) wherein Alk represents a straight or branched alkylene radical and R represents straight or branched alkyl radicals, said radicals having from 1 to 10 carbon atoms.
摘要翻译： PCT No.PCT / FR91 / 00582 Sec。 371日期：1993年1月4日 102（e）日期1993年1月4日PCT PCT 1991年7月15日PCT公布。出版物WO92 / 01694 （二烷基氨基-2-烷基）磺酰基-26嘌呤霉素IIB的具有通式（I）的酒石酸二 - 对甲苯酰酯，酒石酸二 - 叔丁基乙酯，酒石酸二丁酯和酒石酸二异戊酯，其中Alk表示直链或支链亚烷基，R表示直链或支链烷基，所述基团具有1至10个碳原子。

8. 发明授权

US4668669A Pristinamycin II.sub.B derivatives and compositions containing them 失效
标题翻译：普瑞霉素IIB衍生物和含有它们的组合物
公开(公告)号：US4668669A
公开(公告)日：1987-05-26
申请号：US817548
申请日：1986-01-10
申请人： Jean-Claude Barriere , Claude Cotrel , Jean-Marc Paris
发明人： Jean-Claude Barriere , Claude Cotrel , Jean-Marc Paris
IPC分类号： C07D498/18 , A61K31/42 , A61P31/04 , C07D498/14 , C07K5/078 , C07K5/12
CPC分类号： C07K5/06182 , Y10S930/19 , Y10S930/27
摘要： Pristinamycin II.sub.B derivatives of formula: ##STR1## in which R denotes a nitrogen-containing 4 to 7-membered heterocyclic ring optionally substituted by alkyl; or alkyl (2 to 4 C) substituted by 1 or 2 phenyl, cycloalkylamino or N-alkyl-N-cycloalkylamino (3 to 6 ring atoms), alkylamino, dialkylamino or dialkylcarbamoyloxy radicals (the dialkylamino moieties of these 2 latter radicals being capable of forming a 4 to 7-membered cyclic ring optionally substituted by alkyl) or substituted by 1 or 2 nitrogen-containing 4 to 7 membered heterocyclic rings, optionally substituted by alkyl, at least one of the above substituents being a nitrogen-containing substituent capable of forming salts and n is 1 or 2, all the alkyls being linear or branched and containing (unless stated otherwise) 1 to 10 carbon atoms, their isomers, their salts and their preparation. These compounds, optionally in combination with known synergistins or synergistins of formula: ##STR2## are useful as antimicrobial agents.
摘要翻译：其中R表示任选被烷基取代的含氮4〜7元杂环的普拉霉素IIB衍生物：或被1或2个苯基，环烷基氨基或N-烷基-N-环烷基氨基（3至6个环原子），烷基氨基，二烷基氨基或二烷基氨基甲酰氧基取代的（2至4 C）烷基（这2个后基团的二烷基氨基部分能够形成任选被烷基取代的4至7元环）或被1或2个含氮的4至7元杂环取代，任选被烷基取代，至少一个上述取代基是含氮取代基，其能够形成盐，n为1或2，所有烷基均为直链或支链，并含有（除非另有说明）1至10个碳原子，它们的异构体及其盐及其制备。这些化合物，任选地与已知的增效剂或下式的协同增效剂组合：可用作抗微生物剂。

9. 发明授权

US5786449A Streptogramin derivatives, their preparation and pharmaceutical compositions which contain them 失效
标题翻译：链球菌素衍生物，它们的制备和含有它们的药物组合物
公开(公告)号：US5786449A
公开(公告)日：1998-07-28
申请号：US776665
申请日：1997-01-31
申请人： Jean-Claude Barriere , Jean-Marc Paris , Gerard Puchault
发明人： Jean-Claude Barriere , Jean-Marc Paris , Gerard Puchault
IPC分类号： A61K38/00 , A61P31/04 , A61P43/00 , C07K7/06 , C07K11/02 , A61K38/12 , C07K5/00 , C07K7/00 , C07K17/00
CPC分类号： C07K7/06 , A61K38/00
摘要： Streptogramine derivatives of general formula (I) below, wherein the radical R.sub.1 is a methyl or ethyl radical, the radical R.sub.2 is a bromine or chlorine atom, or is an alkenyl radical with 3 to 5 carbon atoms when R.sub.3 and R.sub.4 are methyl, and one of R.sub.3 and R.sub.4 is a hydrogen atom or a methyl radical and the other is a methyl radical are disclosed. The streptogramine derivatives of general formula (I) have particularly useful antibacterial properties, and may be used in combination with a pristinamycin II derivative. ##STR1##
摘要翻译： PCT No.PCT / FR95 / 01025 Sec。 371日期1997年1月31日 102（e）日期1997年1月31日PCT提交1995年7月31日PCT公布。第WO96 / 04299号公报日期：1996年2月15日下面通式（I）的直链衍生物，其中基团R 1是甲基或乙基，基团R 2是溴或氯原子，或者当R 3和R 3是具有3至5个碳原子的烯基时 R4是甲基，R3和R4之一是氢原子或甲基，另一个是甲基。通式（I）的链霉素衍生物具有特别有用的抗菌性质，并且可以与普瑞霉素II衍生物组合使用。

10. 发明授权

US5310900A Streptogramin derivatives and their preparation 失效
标题翻译：链球菌素衍生物及其制备
公开(公告)号：US5310900A
公开(公告)日：1994-05-10
申请号：US961924
申请日：1993-01-04
申请人： Jean-Claude Barriere , Marie-Christine Dubroueucq , Maurice Fleury , Martine Largeron , Jean-Marc Paris
发明人： Jean-Claude Barriere , Marie-Christine Dubroueucq , Maurice Fleury , Martine Largeron , Jean-Marc Paris
IPC分类号： C07D498/18 , C07K7/06 , C07D471/14 , A61K31/395
CPC分类号： C07K7/06
摘要： A Streptogramine derivative of formula (I) is disclosed, wherein the symbol Y is a hydrogen atom, a methyl amino or dimethylamino radical, or a protected methylamino radical, and the symbol R represents a methyl or ethyl radical. ##STR1##
摘要翻译： PCT No.PCT / FR91 / 00590 Sec。 371日期：1993年1月4日 102（e）日期1993年1月4日PCT PCT 1991年7月18日PCT公布。出版物WO92 / 01691 日本公开了1992年2月6日。公开了式（I）的链霉素衍生物，其中符号Y是氢原子，甲基氨基或二甲基氨基或被保护的甲基氨基，符号R表示甲基或乙基。（一）

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