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1. 发明授权

US5474892A Method for the stabilization of proteins using heat shock protein Hsp90 失效
标题翻译：使用热休克蛋白Hsp90稳定蛋白质的方法
公开(公告)号：US5474892A
公开(公告)日：1995-12-12
申请号：US5706
申请日：1993-01-19
申请人： Ursula Jakob , Johannes Buchner , Hans Wiech , Richard Zimmermann , Rainer Rudolph
发明人： Ursula Jakob , Johannes Buchner , Hans Wiech , Richard Zimmermann , Rainer Rudolph
IPC分类号： C07K14/005 , C07K1/00 , C07K1/113 , C07K14/195 , C07K16/00 , C07K16/06 , C12N9/88 , C12Q1/00 , G01N1/00
CPC分类号： C07K1/1133 , C07K16/065 , C12N9/88 , Y10S435/963 , Y10T436/10 , Y10T436/2525
摘要： The present invention concerns a method for the stabilization of proteins in an aqueous solution which is characterized in that one or several members of the heat shock protein (Hsp90) family are added to the aqueous solution containing protein.
摘要翻译：本发明涉及在水溶液中稳定蛋白质的方法，其特征在于将热休克蛋白（Hsp90）家族的一个或几个成员加入到含有蛋白质的水溶液中。

2. 发明申请

US20080258325A1 Method of and device for cooling blown film during the production of blown film 有权
标题翻译：吹塑薄膜制造时吹塑薄膜的冷却方法和装置
公开(公告)号：US20080258325A1
公开(公告)日：2008-10-23
申请号：US12148171
申请日：2008-04-17
申请人： Richard Zimmermann
发明人： Richard Zimmermann
IPC分类号： B29C47/88
CPC分类号： B29C47/8835 , B29C47/0026 , B29C47/0057 , B29C47/0059 , B29C47/883 , B29C47/903 , B29C47/906 , B29C47/908 , B29C47/92 , B29C2947/92152 , B29C2947/92428 , B29C2947/926 , B29C2947/92647 , B29C2947/92704 , B29C2947/92923 , B29L2023/001
摘要： A method of cooling blown film consisting of thermoplastic plastics during the production of blown film by means of a blown film extruder with a film blowing head which comprises an annular nozzle from which the blown film emerges and is guided away in an extraction direction, wherein at least two cooling gas flows are made to approach the blown film from the outside in at least two blowing-out planes located at a distance from the annular nozzle, wherein at least one cooling gas flow KG is blown out in the direction opposed to the extraction direction of the blown film and wherein at least one cooling gas flow KA is blown out in the extraction direction of the blown film, and wherein, at least one of the cooling gas flows KG, KA can be controlled around their circumference in sectors, at least in respect of its volume flow or temperature.
摘要翻译：一种在吹塑薄膜挤出机生产吹塑薄膜期间冷却由热塑性塑料组成的吹塑薄膜的方法，该吹塑薄膜挤出机具有一个吹膜头，该吹塑头包括一个环形喷嘴，吹出薄膜从该喷嘴吹出并沿着提取方向被引导离开，在距离环形喷嘴一定距离的至少两个吹出平面中，至少两个冷却气流从外部从外部接近吹塑薄膜，其中至少一个冷却气流K blown 在与吹塑薄膜的提取方向相反的方向上排出，并且其中至少一个冷却气流K A在吹塑薄膜的提取方向上吹出，其中，至少一个至少在其体积流量或温度方面，冷却气体流可以围绕其圆周在扇区中被控制。

3. 发明申请

US20080061460A1 Method and device for the production of blown tubular film 审中-公开
标题翻译：吹制管状薄膜的生产方法和装置
公开(公告)号：US20080061460A1
公开(公告)日：2008-03-13
申请号：US11518465
申请日：2006-09-08
申请人： Richard Zimmermann , Gerd Fahling
发明人： Richard Zimmermann , Gerd Fahling
IPC分类号： B29C47/92 , B29C55/28
CPC分类号： B29C55/28 , B29C48/10 , B29C48/9125 , B29C48/913 , B29C48/92 , B29C2948/92152 , B29C2948/92428 , B29C2948/926 , B29C2948/92647 , B29C2948/92704 , B29C2948/92904 , B29C2948/92923
摘要： A process of controlling the thickness profile of a blown tubular film, consisting of thermoplastic plastics, around the circumference of same when producing blown film by means of blown film extruders, having a film extrusion die, wherein a measuring device measures the film thickness of the tubular film around the circumference and wherein a control device variably controls the cooling gas flow as a function of the measured film thicknesses around the circumference in sectors, wherein cooling gas flows are supplied from the outside in the direction of production in two separate planes, and wherein the cooling gas flows are controlled variably and in circumferential sectors around the circumference in the two planes in respect of their physical parameters.
摘要翻译：一种通过吹塑薄膜挤出机制造具有薄膜挤出模头的吹塑薄膜时，围绕其周围的热塑性塑料组成的吹塑管状薄膜的厚度分布的方法，其中测量装置测量围绕圆周的管状膜，并且其中控制装置根据在扇区周围测量的膜厚可变地控制冷却气体流量，其中冷却气体流从生产方向从外部以两个分开的平面供应，以及其中冷却气流在其两个平面内相对于它们的物理参数可变地和围绕圆周的周向扇区被控制。

4. 发明授权

US4021211A Process and apparatus for separation of solvents from an air stream laden with solvent vapors 失效
标题翻译：用溶剂蒸汽分离溶剂与空气流分离的方法和装置
公开(公告)号：US4021211A
公开(公告)日：1977-05-03
申请号：US553100
申请日：1975-02-26
申请人： Klaus Turek , Martin Schumacher , Richard Zimmermann
发明人： Klaus Turek , Martin Schumacher , Richard Zimmermann
IPC分类号： B01D53/04
CPC分类号： B01D53/0454 , B01D2253/102 , B01D2257/704 , B01D2259/4009 , B01D2259/404
摘要： A process and apparatus for separation of solvents from an air stream laden with solvent vapors by adsorption using active carbon followed by regeneration of the carbon by desorption by steam using a plurality of active carbon chambers. The sequence of charging and regeneration of the active carbon is controlled automatically in dependence upon the concentration of solvent vapors in the air stream. During the change over from charging to regeneration the active carbon is first subjected to desorption by steaming with a large volume of steam and then, when steam breaks through on the outlet side of the carbon the volume of steam is reduced for the purpose of drying the carbon. The change over is effected by a measuring device arranged on the outlet side of the carbon chamber responsive to a pre-determined threshold concentration of solvent vapors in the outgoing stream.
摘要翻译：一种用于通过使用活性炭吸附然后通过使用多个活性炭室通过蒸汽解吸再生碳来分离溶剂与溶剂蒸汽的空气流的方法和装置。根据空气流中溶剂蒸气的浓度自动控制活性炭的充填和再生顺序。在从充电到再生的转变中，活性炭首先通过大量蒸汽蒸汽进行脱附，然后当蒸汽在碳出口侧穿过时，蒸汽的体积被减少以便干燥碳。改变是通过布置在碳室的出口侧的测量装置来实现的，该测量装置响应输出流中预定的浓度溶剂蒸气的阈值。

5. 发明授权

US08956136B2 Method of and device for cooling blown film during the production of blown film 有权
标题翻译：吹塑薄膜制造时吹塑薄膜的冷却方法和装置
公开(公告)号：US08956136B2
公开(公告)日：2015-02-17
申请号：US12148171
申请日：2008-04-17
申请人： Richard Zimmermann
发明人： Richard Zimmermann
IPC分类号： B29C47/88 , B29C47/90 , B29C47/92 , B29C47/00 , B29L23/00
CPC分类号： B29C47/8835 , B29C47/0026 , B29C47/0057 , B29C47/0059 , B29C47/883 , B29C47/903 , B29C47/906 , B29C47/908 , B29C47/92 , B29C2947/92152 , B29C2947/92428 , B29C2947/926 , B29C2947/92647 , B29C2947/92704 , B29C2947/92923 , B29L2023/001
摘要： A method of cooling blown film consisting of thermoplastic plastics during the production of blown film by means of a blown film extruder with a film blowing head which comprises an annular nozzle from which the blown film emerges and is guided away in an extraction direction, wherein at least two cooling gas flows are made to approach the blown film from the outside in at least two blowing-out planes located at a distance from the annular nozzle, wherein at least one cooling gas flow KG is blown out in the direction opposed to the extraction direction of the blown film and wherein at least one cooling gas flow KA is blown out in the extraction direction of the blown film, and wherein, at least one of the cooling gas flows KG, KA can be controlled around their circumference in sectors, at least in respect of its volume flow or temperature.
摘要翻译：一种在吹塑薄膜挤出机生产吹塑薄膜期间冷却由热塑性塑料组成的吹塑薄膜的方法，该吹塑薄膜挤出机具有一个吹膜头，该吹塑头包括一个环形喷嘴，吹出薄膜从该喷嘴吹出并沿着提取方向被引导离开，在距离环形喷嘴一定距离的至少两个吹出平面中，至少两个冷却气流从外部从外部接近，其中至少一个冷却气流KG沿与提取相反的方向吹出吹塑薄膜的方向，并且其中至少一个冷却气流KA沿吹塑薄膜的提取方向吹出，并且其中至少一个冷却气体流KG，KA可以围绕其圆周在扇区中，在至少在其体积流量或温度方面。

6. 发明授权

US4933336A Thiadiazinone, oxadiazinone and triazinone derivatives, and their use for treating acute or chronic heart disease 失效
标题翻译：噻二嗪酮，恶二酮和三嗪酮衍生物及其用于治疗急性或慢性心脏病的用途
公开(公告)号：US4933336A
公开(公告)日：1990-06-12
申请号：US230314
申请日：1988-08-09
申请人： Michel Martin , Guy Nadler , Richard Zimmermann
发明人： Michel Martin , Guy Nadler , Richard Zimmermann
IPC分类号： C07D487/10 , A61K31/53 , A61K31/535 , A61K31/54 , A61P9/00 , A61P11/00 , A61P11/08 , C07D209/34 , C07D209/96 , C07D215/22 , C07D215/227 , C07D401/04 , C07D403/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D487/04 , C07D495/10
CPC分类号： C07D215/227 , C07D209/34 , C07D209/96 , C07D403/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D487/04 , C07D495/10
摘要： A compound of formula (I), or a pharmaceutically acceptable salt thereof, ##STR1## in which, R.sub.1 is hydrogen, lower alkyl or CH.sub.2 OR.sub.6 ;R.sub.2 is hydrogen or lower alkyl;R.sub.3 is hydrogen or lower alkyl;each of W and Z, which are different, represents --CR.sub.4 R.sub.5 -- or --(CR.sub.x R.sub.y).sub.n --, in which,R.sub.4 is hydrogen, C.sub.1-3 alkyl, C.sub.1-3 alkylthio or C.sub.1-3 alkoxy;R.sub.5 is C.sub.1-3 alkyl, C.sub.1-3 alkylthio or C.sub.1-3 alkoxy; or together R.sub.4 and R.sub.5 form a 3 to 6 membered carbocyclic ring, or a heterocyclic ring containing one or two ring oxygen, nitrogen or sulphur atoms;or R.sub.4 and R.sub.5 together form an oxo or methylene group;each of R.sub.x and R.sub.y is hydrogen or C.sub.1-3 alkyl; n is zero or 1;R.sub.6 is hydrogen, lower alkyl, lower alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, heteroarylcarbonyl, optionally substituted aminocarbonyl, lower alkoxycarbonyl and aryloxycarbonyl;R.sub.7 is hydrogen or lower alkyl;X is oxygen or sulphur;and A is sulphur, oxygen or --NH--, is useful for the treatment of heart disease.

7. 发明申请

US20050285315A1 Process of and device for producing blown film 失效
标题翻译：生产吹膜的方法和装置
公开(公告)号：US20050285315A1
公开(公告)日：2005-12-29
申请号：US10875519
申请日：2004-06-24
申请人： Gerd Fahling , Richard Zimmermann
发明人： Gerd Fahling , Richard Zimmermann
IPC分类号： B29C47/88 , B29C47/90 , B29C49/70
CPC分类号： B29C47/90 , B29C47/0026 , B29C47/8835 , B29C47/903 , B29C47/908
摘要： A process for the manufacture of a thermoplastic blown film is disclosed. The process includes the step of extruding a blown film tube of a thermoplastic material. The outside surface of the film tube is treated with a cooling gas to solidify the film tube. This cooling gas is directed to the tube from an annular ring around the tube and the cooling gas is directed at the tube in a flow direction parallel to a wall of the film tube. The cooling gas is drawn off the tube by means of a suction ring positioned around the tube prior to flattening the tube to form a film.
摘要翻译：公开了一种制造热塑性吹塑薄膜的方法。该方法包括挤出热塑性材料的吹塑薄膜管的步骤。用冷却气体处理薄膜管的外表面，使薄膜管固化。该冷却气体从围绕管的环形环引导到管，并且冷却气体以平行于膜管的壁的流动方向指向管。在使管平坦化之前，将冷却气体通过位于管周围的吸引环从管中抽出以形成膜。

8. 发明授权

US06398534B1 Take-off apparatus for blown, plastic sheets 有权
标题翻译：吹塑设备，塑料片
公开(公告)号：US06398534B1
公开(公告)日：2002-06-04
申请号：US09413345
申请日：1999-10-06
申请人： Gerd Faehling , Gerd Kasselmann , Richard Zimmermann
发明人： Gerd Faehling , Gerd Kasselmann , Richard Zimmermann
IPC分类号： B29C5320
CPC分类号： B65H23/32 , B29C47/0026 , B29C47/0057 , B29C47/0059 , B65H2301/3423 , B65H2406/111
摘要： A take-off apparatus for plastic blown sheet that is collapsed has a deflecting roller rotatably mounted for transporting the blown sheet and an air turning bar for receiving the blown sheet from the deflecting bar along a transport plane defined therebetween. The blown sheet passes around a peripheral portion of the air turning bar thereby defining a support arc region of the at least one air turning bar about which the blown sheet is supported. The air turning bar has air outlet openings disposed in the support arc region through which compressed air is ejected to support the blown sheet. The air turning bar has an arc-shaped axis defining a plane of curvature which is oriented such that the peripheral portion presents a concave surface in which the air outlet openings are disposed and which opposes the blown sheet.
摘要翻译：用于挤压的塑料吹塑薄片的取出装置具有可旋转地安装用于输送吹塑薄片的偏转辊和用于沿着其间限定的传送平面从偏转杆接收吹塑薄片的空气转动杆。吹制片材绕过空气转向杆的周边部分，从而限定了至少一个空气转向杆的支撑弧形区域，吹塑片材围绕该支撑弧形区域被支撑。空气转向杆具有设置在支撑弧区域中的排气口，通过该空气排出口压缩空气被喷射以支撑吹塑片材。空气转动杆具有限定曲率平面的弧形轴线，其被定向为使得周边部分呈现出凹部表面，空气出口开口设置在该凹面中并与吹塑片材相对。

9. 发明申请

US20130087462A1 CONTINUOUSLY CHEMICALLY RESISTANT SPACER TEXTILE 审中-公开
标题翻译：连续耐化学间隔纤维
公开(公告)号：US20130087462A1
公开(公告)日：2013-04-11
申请号：US13603829
申请日：2012-09-05
申请人： Hendrik Rabe , Richard Zimmermann , Martin Olesch , Joerg Zschetzsche , Katerina Machova
发明人： Hendrik Rabe , Richard Zimmermann , Martin Olesch , Joerg Zschetzsche , Katerina Machova
IPC分类号： D04B1/22 , C25D17/10 , D04B1/14
CPC分类号： D04B1/225 , C25D17/10 , C25D17/12 , D04B1/14 , D04B21/16 , D10B2321/042 , D10B2403/021
摘要： The invention relates to a spacer textile (1) including a top textile (2), a bottom textile (3) and a spacer layer (5), wherein the top textile (2) and the bottom textile (3) are connected together by the spacer layer (5). The top textile (2), the bottom textile (3) and the spacer layer (5) are monofilament fibers from inert fluorocarbons. The invention relates additionally to the use of the spacer textile (1) according to the invention as at least in part sheathing of an electrode (13, 14) in an electroplating bath (11), as a lining of operating, bearing and/or transport surfaces (31), or as filter or support material in chemically aggressive media.
摘要翻译：本发明涉及一种包括顶部织物（2），底部织物（3）和间隔层（5）的间隔织物（1），其中顶部织物（2）和底部织物（3）通过间隔层（5）。顶部织物（2），底部织物（3）和间隔层（5）是来自惰性碳氟化合物的单丝纤维。本发明另外涉及根据本发明的间隔织物（1）的用途，至少部分地包括在电镀浴（11）中的电极（13,14），作为操作，轴承和/或运输表面（31），或作为化学腐蚀性介质中的过滤器或支撑材料。

10. 发明授权

US5051417A Indolythiadiazines for treating heart failure 失效
标题翻译：吲哚噻嗪用于治疗心力衰竭
公开(公告)号：US5051417A
公开(公告)日：1991-09-24
申请号：US379626
申请日：1989-07-13
申请人： Guy Nadler , Michel Martin , Richard Zimmermann
发明人： Guy Nadler , Michel Martin , Richard Zimmermann
IPC分类号： C07D403/04 , A61K31/54 , A61P9/04 , C07D413/04 , C07D417/00 , C07D417/04 , C07D417/14
CPC分类号： C07D417/04 , C07D417/14
摘要： A compound of formula (I) or a pharmaceutically acceptable salt thereof, ##STR1## in which, R.sub.1 is hydrogen or lower alkyl;R.sub.2 is hydrogen or lower alkyl;R.sub.4 and R.sub.4 ' together form a group .dbd.N--Ra, or .dbd.CRaRb, where Ra is hydrogen, lower alkyl, aryl, aryloxy, lower alkylcarbonyl, arylcarbonyl, aryloxycarbonyl, lower alkoxy, lower alkoxy carbonyl, lower alkoxy carbonyl alkoxy, lower thioalkoxy, hydroxy, nitrile, heterocyclyl, or --NRcRd, where Rc is hydrogen, lower alkyl, cycloalkyl, aryl, aralkyl, lower alkylcarbonyl, arylcarbonyl, aminocarbonyl, aminothiocarbonyl, aminoiminocarbonyl, lower alkoxycarbonyl, lower alkoxythiocarbonyl, aryloxycarbonyl, thiocarbonyl, nitrile, carboxyl, heterocyclyl or heterocyclylcarbonyl, and Rd is hydrogen or lower alkyl; Rb is hydrogen, lower alkyl, aryl, lower alkylcarbonyl, lower alkoxycarbonyl, nitrile or nitro;or R.sub.4 is --NH--Ra, in which Ra is as defined above, and R.sub.4 ' is hydrogen or lower alkyl;each of R.sub.3 and R.sub.5 is independently hydrogen, lower alkyl, aryl, lower alkylcarbonyl, arylcarbonyl, aralkylcarbonyl, heterocyclylcarbonyl, optionally substituted aminocarbonyl, lower alkoxycarbonyl or aryloxycarbonyl;R.sub.6 is hydrogen, lower alkyl or halogen; and A is sulphur, oxygen, --NH-- or --CH.sub.2 --, is useful for the treatment of heart disease.

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