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1. 发明申请

US20180021140A1 HIGH SPEED 3D PRINTING SYSTEM FOR WOUND AND TISSUE REPLACEMENT 审中-公开
公开(公告)号：US20180021140A1
公开(公告)日：2018-01-25
申请号：US15549083
申请日：2016-02-12
申请人： Samantha M. MARQUEZ , University of Florida Research Foundation, Inc. , Georgia Tech Research Corporation
发明人： Thomas Ettor Angelini , Wallace Gregory Sawyer , Kyle Gene Rowe , Tapomoy Bhattacharjee , Alberto Fernandez-Nieves , Ya-Wen Chang , Samantha M. Marquez
IPC分类号： A61F2/30 , A61L27/18 , A61L27/36 , A61L27/52 , C12N5/071 , A61L27/50 , A61L27/60 , A61L27/54 , C12N5/00 , A61L27/16 , A61L27/26
CPC分类号： A61F2/30942 , A61F2002/30962 , A61F2240/002 , A61K35/00 , A61L27/16 , A61L27/18 , A61L27/26 , A61L27/3604 , A61L27/3625 , A61L27/507 , A61L27/52 , A61L27/54 , A61L27/60 , A61L2300/414 , A61L2300/64 , A61L2430/20 , A61L2430/26 , B29C64/106 , B29L2031/7532 , B33Y70/00 , B33Y80/00 , C12N5/0062 , C12N5/0686 , C12N5/069 , C12N2513/00 , C12N2533/30 , C12N2533/74 , C12N2533/80
摘要： A method or apparatus for creating a three-dimensional tissue construct of a desired shape for repair or replacement of a portion of an organism. The method may comprise injecting at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The apparatus may comprise an injector configured to inject at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The first material may comprise a yield stress material, which may be a material exhibiting Herschel-Bulkley behavior. The tissue construct may have a smallest feature size of ten micrometers or less.

2. 发明授权

US11007705B2 High speed 3D printing system for wound and tissue replacement 有权
公开(公告)号：US11007705B2
公开(公告)日：2021-05-18
申请号：US15549083
申请日：2016-02-12
申请人： University of Florida Research Foundation, Inc. , Georgia Tech Research Corporation , Samantha M. Marquez
发明人： Thomas Ettor Angelini , Wallace Gregory Sawyer , Kyle Gene Rowe , Tapomoy Bhattacharjee , Alberto Fernandez-Nieves , Ya-Wen Chang , Samantha M. Marquez
IPC分类号： A61F2/30 , B29C64/118 , C12N5/00 , B33Y80/00 , B33Y70/00 , A61L27/16 , A61L27/18 , A61L27/26 , A61L27/36 , A61L27/50 , A61L27/52 , A61L27/54 , A61L27/60 , C12N5/071 , A61K35/00 , B29L31/00
摘要： A method or apparatus for creating a three-dimensional tissue construct of a desired shape for repair or replacement of a portion of an organism. The method may comprise injecting at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The apparatus may comprise an injector configured to inject at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The first material may comprise a yield stress material, which may be a material exhibiting Herschel-Bulkley behavior. The tissue construct may have a smallest feature size of ten micrometers or less.

3. 发明授权

US11654612B2 3D printing using phase changing materials as support 有权
公开(公告)号：US11654612B2
公开(公告)日：2023-05-23
申请号：US17519752
申请日：2021-11-05
申请人： University of Florida Research Foundation, Inc. , Georgia Tech Research Corporation
发明人： Alberto Fernandez-Nieves , Thomas Ettor Angelini , Ya-Wen Chang , Samantha M. Marquez
IPC分类号： B29C64/106 , B33Y70/00 , B33Y10/00 , B29C64/40 , B33Y30/00 , B29C64/259 , B29C64/153 , B29C64/209 , B29K33/00 , B29K105/00
CPC分类号： B29C64/106 , B29C64/153 , B29C64/209 , B29C64/259 , B29C64/40 , B33Y10/00 , B33Y30/00 , B33Y70/00 , B29K2023/06 , B29K2033/08 , B29K2033/26 , B29K2105/0061 , B29K2105/251
摘要： A method or apparatus for three-dimensionally printing. The method may comprise causing a phase change in a region of the first material by applying focused energy to the region using a focused energy source, and displacing the first material with a second material. The apparatus may comprise a container configured to hold a first material, a focused energy source configured to cause a phase change in a region of the first material by applying focused energy to the region, and an injector configured to displace the first material with a second material. The first material may comprise a yield stress material, which is a material exhibiting Herschel-Bulkley behavior. The yield stress material may comprise a soft granular gel. The second material may comprise one or more cells.

4. 发明授权

US11766823B2 High speed 3D printing system for wound and tissue replacement 有权
公开(公告)号：US11766823B2
公开(公告)日：2023-09-26
申请号：US17233626
申请日：2021-04-19
申请人： University of Florida Research Foundation, Inc. , Georgia Tech Research Corporation
发明人： Thomas Ettor Angelini , Wallace Gregory Sawyer , Kyle Gene Rowe , Tapomoy Bhattacharjee , Alberto Fernandez-Nieves , Ya-Wen Chang , Samantha M. Marquez
IPC分类号： B29C64/118 , C12N5/00 , B33Y80/00 , B33Y70/00 , A61F2/30 , A61L27/16 , A61L27/18 , A61L27/26 , A61L27/36 , A61L27/50 , A61L27/52 , A61L27/54 , A61L27/60 , C12N5/071 , A61K35/00 , B29L31/00
CPC分类号： B29C64/118 , A61F2/30942 , A61L27/16 , A61L27/18 , A61L27/26 , A61L27/3604 , A61L27/3625 , A61L27/507 , A61L27/52 , A61L27/54 , A61L27/60 , B33Y70/00 , B33Y80/00 , C12N5/0062 , C12N5/069 , C12N5/0686 , A61F2002/30962 , A61F2240/002 , A61K35/00 , A61L2300/414 , A61L2300/64 , A61L2430/20 , A61L2430/26 , B29L2031/7532 , C12N2513/00 , C12N2533/30 , C12N2533/74 , C12N2533/80
摘要： A method or apparatus for creating a three-dimensional tissue construct of a desired shape for repair or replacement of a portion of an organism. The method may comprise injecting at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The apparatus may comprise an injector configured to inject at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The first material may comprise a yield stress material, which may be a material exhibiting Herschel-Bulkley behavior. The tissue construct may have a smallest feature size of ten micrometers or less.

5. 发明申请

US20220055287A1 3D PRINTING USING PHASE CHANGING MATERIALS AS SUPPORT 有权
公开(公告)号：US20220055287A1
公开(公告)日：2022-02-24
申请号：US17519752
申请日：2021-11-05
申请人： University of Florida Research Foundation, Inc. , Georgia Tech Research Corporation
发明人： Alberto Fernandez-Nieves , Thomas Eltor Angelini , Ya-Wen Chang , Samantha M. Marquez
IPC分类号： B29C64/106 , B33Y70/00 , B33Y10/00 , B29C64/40 , B33Y30/00 , B29C64/259 , B29C64/153 , B29C64/209
摘要： A method or apparatus for three-dimensionally printing. The method may comprise causing a phase change in a region of the first material by applying focused energy to the region using a focused energy source, and displacing the first material with a second material. The apparatus may comprise a container configured to hold a first material, a focused energy source configured to cause a phase change in a region of the first material by applying focused energy to the region, and an injector configured to displace the first material with a second material. The first material may comprise a yield stress material, which is a material exhibiting Herschel-Bulkley behavior. The yield stress material may comprise a soft granular gel. The second material may comprise one or more cells.

6. 发明授权

US11192292B2 3D printing using phase changing matertials as support 有权
公开(公告)号：US11192292B2
公开(公告)日：2021-12-07
申请号：US15533222
申请日：2015-12-04
申请人： University of Florida Research Foundation, Inc. , Georgia Tech Research Corporation
发明人： Alberto Fernandez-Nieves , Thomas Ettor Angelini , Ya-Wen Chang , Samantha M. Marquez
IPC分类号： B29C64/106 , B33Y70/00 , B33Y10/00 , B29C64/40 , B33Y30/00 , B29C64/259 , B29C64/153 , B29C64/209 , B29K33/00 , B29K105/00
摘要： A method or apparatus for three-dimensionally printing. The method may comprise causing a phase change in a region of the first material by applying focused energy to the region using a focused energy source, and displacing the first material with a second material. The apparatus may comprise a container configured to hold a first material, a focused energy source configured to cause a phase change in a region of the first material by applying focused energy to the region, and an injector configured to displace the first material with a second material. The first material may comprise a yield stress material, which is a material exhibiting Herschel-Bulkley behavior. The yield stress material may comprise a soft granular gel. The second material may comprise one or more cells.

7. 发明申请

US20170361534A1 3D PRINTING USING PHASE CHANGING MATERIALS AS SUPPORT 审中-公开
公开(公告)号：US20170361534A1
公开(公告)日：2017-12-21
申请号：US15533222
申请日：2015-12-04
申请人： University of Florida Research Foundation, Inc. , Georgia Tech Research Corporation
发明人： Alberto Fernandez-Nieves , Thomas Ettor Angelini , Ya-Wen Chang , Samantha M. Marquez
IPC分类号： B29C64/259 , B33Y70/00 , B29C64/209 , B33Y10/00 , B33Y30/00 , B29C64/153 , B29K105/00 , B29K33/00
CPC分类号： B29C64/259 , B29C64/106 , B29C64/153 , B29C64/209 , B29C64/40 , B29K2023/06 , B29K2033/08 , B29K2033/26 , B29K2105/0061 , B29K2105/251 , B33Y10/00 , B33Y30/00 , B33Y70/00
摘要： A method or apparatus for three-dimensionally printing. The method may comprise causing a phase change in a region of the first material by applying focused energy to the region using a focused energy source, and displacing the first material with a second material. The apparatus may comprise a container configured to hold a first material, a focused energy source configured to cause a phase change in a region of the first material by applying focused energy to the region, and an injector configured to displace the first material with a second material. The first material may comprise a yield stress material, which is a material exhibiting Herschel-Bulkley behavior. The yield stress material may comprise a soft granular gel. The second material may comprise one or more cells.

8. 发明申请

US20150290362A1 HYBRID FIBRIN-MICROGEL CONSTRUCTS FOR TISSUE REPAIR AND REGENERATION 审中-公开
标题翻译：用于组织修复和再生的混合纤维蛋白 - 微孔结构
公开(公告)号：US20150290362A1
公开(公告)日：2015-10-15
申请号：US14683538
申请日：2015-04-10
申请人： Georgia Tech Research Corporation
发明人： Alison Douglas , Thomas Barker , Louis Andrew Lyons , Alberto Fernandez-Nieves
IPC分类号： A61L27/54 , A61L27/44
CPC分类号： A61L27/54 , A61L27/3834 , A61L27/48 , A61L2300/412 , A61L2430/00
摘要： Composite constructs of polymer matrices and polymeric microgels, and methods of making and using thereof, are described. The addition of the microgels to polymeric matrices retains the overall mechanical properties of the matrices and enables cell spreading, invasion and vascularization. Using fibrin as a model system, composite fibrin constructs with microgels are described, in which microgels form unique interconnected pockets within the fibrin matrix. The microgel assembly is driven by the polymerization dynamics of fibrin, and the architecture of these interconnected pockets can be tuned. The composite constructs support cell spreading, migration and infiltration more efficiently than do control matrices. The composite constructs can be used attract cells and/or to deliver therapeutic, diagnostic, nutraceutical, prophylactic and cosmetic agents to a desired site.
摘要翻译：描述了聚合物基质和聚合物微凝胶的复合构造物及其制备和使用方法。将微凝胶添加到聚合物基质中保留了基质的总体机械性能，并使细胞扩散，侵入和血管形成。使用纤维蛋白作为模型系统，描述了具有微凝胶的复合纤维蛋白构建体，其中微凝胶在纤维蛋白基质内形成独特的互连口袋。微凝胶组件由纤维蛋白的聚合动力学驱动，并且可以调节这些相互连接的口袋的结构。复合结构比控制矩阵更有效地支持细胞扩散，迁移和渗透。可以使用复合构建体来吸引细胞和/或将治疗，诊断，营养保健，预防和美容剂递送至期望的部位。

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