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    • 4. 发明申请
    • Artificial Salivary Gland
    • 人造唾液腺
    • US20160278909A1
    • 2016-09-29
    • US15080140
    • 2016-03-24
    • University of Connecticut
    • John Robert KellyDouglas J. AdamsMartin Allen Freilich
    • A61F2/02A61C8/00A61F2/28
    • A61F2/022A61C5/50A61C8/00A61C8/0018A61C8/003A61C8/0039A61C13/08A61C19/06A61C19/063A61F2/2803A61F2220/0033
    • Artificial salivary gland devices and assemblies are provided. The present disclosure provides artificial salivary pump/gland devices and assemblies, and related methods of use. One embodiment utilizes the interstitial/marrow fluid reservoir within the underlying mandibular or maxillary bone as a source for replacement saliva. The salivary pump/assembly, which is implantable in the mandibular or maxillary bone as a dental implant and driven by incidental tooth contact and masticatory forces, harvests interstitial/marrow fluid and treats it via semi-permeable membrane technology and soluble particles as a continuously available saliva replacement. Masticatory forces and tooth contact power the pump to both harvest interstitial/marrow fluid and drive flow through a bed of ion-exchange resins and/or soluble particles to adjust fluid chemistry providing a continuously available saliva-like solution. Exemplary devices and assemblies can also be utilized to introduce beneficial bacteria into the oral cavity and/or be utilized as a delivery system for drugs/therapeutic agents.
    • 提供人工唾液腺装置和组件。 本公开提供了人造唾液泵/腺体装置和组件以及相关的使用方法。 一个实施例利用下颌骨或上颌骨内的间质/骨髓液储存器作为替代唾液的来源。 唾液泵/组件可植入下颌骨或上颌骨作为牙科植入物并由偶然的牙齿接触和咀嚼力驱动,收获间质/骨髓液,并通过半透膜技术和可溶性颗粒作为连续可用的 唾液更换 咀嚼力和牙齿接触力使泵能够收获间质/骨髓液,并驱使流过离子交换树脂和/或可溶性颗粒床以调节流体化学,从而提供连续可用的唾液样溶液。 示例性的装置和组件也可用于将有益细菌引入口腔和/或用作药物/治疗剂的递送系统。