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1. 发明授权

US11920292B2 Methods for obtaining colored or chromic substrates 有权
公开(公告)号：US11920292B2
公开(公告)日：2024-03-05
申请号：US17685308
申请日：2022-03-02
申请人： UNIVERSITEIT GENT
发明人： Richard Hoogenboom , Gertjan Vancoillie
IPC分类号： D06P1/00 , C08J7/12 , C09B62/008 , C09B69/10 , C09K9/02 , D06P1/38 , D06P1/384 , D06P3/24 , D06P3/66 , D06P5/13 , D06P5/20 , G01N21/80 , G01N21/63
CPC分类号： D06P1/0012 , C08J7/123 , C09B62/0081 , C09B69/106 , C09B69/109 , C09K9/02 , D06P1/38 , D06P1/384 , D06P3/248 , D06P3/66 , D06P3/666 , D06P5/138 , D06P5/2005 , D06P5/2011 , G01N21/80 , C08J2301/02 , C08J2323/06 , C08J2323/12 , C08J2327/18 , C08J2377/00 , C09K2211/1011 , D10B2505/10 , D10B2509/022 , G01N2021/635
摘要： The present invention provides a post-fabrication modification approach for the fabrication of colored and chromic materials and sensors using plasma surface modification to covalently bind the coloring agent to the substrate, thus avoiding leaching of the dye. Advantageously, in said methods, said coloring agent is a dye or pigment linked to a radical sensitive functional group, such as an alkenyl or alkynyl functional group, and is applied to the substrate prior to the gas plasma treatment. The methods envisaged herein are generic in nature, which allow the covalent immobilization of various dyes on different materials. The covalently coated materials after plasma surface modification, particularly the covalently coated chromic materials and sensors, can be used in many different applications, such as protective textile and wound dressing applications.

2. 发明授权

US11793878B2 Drug formulations comprising polyoxazolines as matrix excipient 有权
公开(公告)号：US11793878B2
公开(公告)日：2023-10-24
申请号：US16980651
申请日：2019-03-18
申请人： Universiteit Gent
发明人： Maarten Vergaelen , Richard Hoogenboom , Victor Retamero de la Rosa , Chris Vervaet , Aseel Samaro , Valérie Vanhoorne
IPC分类号： A61K47/34 , A61K31/138 , A61K31/155 , A61K31/522
CPC分类号： A61K47/34 , A61K31/138 , A61K31/155 , A61K31/522
摘要： The present invention relates to polyoxazoline polymers, polymer combinations and compositions comprising those polymers or combinations of polymers. The invention further relates to the use of said polyoxazoline polymers, said combinations and compositions comprising such polymers and combinations for the sustained release of one or more active ingredients, in particular one or more active pharmaceutical ingredients. It further relates to the use of polyoxazoline polymers or polymer combinations as drug carrier.

3. 发明授权

US10869930B2 Poly(cyclic imino ether)s 有权
公开(公告)号：US10869930B2
公开(公告)日：2020-12-22
申请号：US16312219
申请日：2017-07-03
申请人： UNIVERSITEIT GENT
发明人： Richard Hoogenboom , Bart Verbraeken
IPC分类号： A61K47/59 , C08G73/02 , A61K47/69 , C12N15/87 , A61K48/00
CPC分类号： A61K47/59 , A61K47/6907 , A61K48/0008 , C08G73/0233 , C12N15/87
摘要： The invention relates to invention relates to a statistical copolymer represented by the following formula (I): Ini-[Ox]m-[Oz]n-Nuc (I) wherein: Ini represents a residue of an initiator of cationic polymerization, Nuc represents a residue of a nucleophilic agent, Ox represents N(R1)CHRaCHRa; each R1 independently represents H or C(O)R11; and R11 independently represents optionally substituted C1-12 alkyl, optionally substituted cycloalkyl, optionally substituted aralkyl or optionally substituted aryl; Oz represents N(R2)CHRaCHRaCHRa; each R2 independently represents C(O)R21 or H; and R21 independently represents optionally substituted C1-12 alkyl, optionally substituted cycloalkyl, optionally substituted aralkyl or optionally substituted aryl; each Ra independently represents H, linear or branched C1-3 alkyl; m≥5; n≥5; m+n≥20; 3:97≤m:n≤97:3. The statistical copolymers of the present invention exhibit useful properties that can be exploited in the medical field, especially in polymer micelles for drug delivery and polyplexes for DNA delivery.

4. 发明授权

US10526371B2 Hydrogel-forming peptides 有权
公开(公告)号：US10526371B2
公开(公告)日：2020-01-07
申请号：US15743357
申请日：2016-07-13
申请人： Universiteit Gent , Vrije Universiteit Brussel
发明人： Richard Hoogenboom , Annemieke Madder , Steven Ballet
IPC分类号： A61K47/42 , C07K7/02 , C07K7/06 , A61K31/496
摘要： Provided are hydrogel-forming peptides that comprise at least one dyad of hydrophobic amino acid residues in which one is a β3- or β2-homo amino acid residue. The hydrogels derived from these peptides can be loaded with biological materials and can be used in physiological conditions.

5. 发明授权

US10029020B2 Fullerene compositions 有权
公开(公告)号：US10029020B2
公开(公告)日：2018-07-24
申请号：US15567338
申请日：2016-04-22
申请人： UNIVERSITEIT GENT
发明人： Richard Hoogenboom , Joachim Van Guyse , Victor Retamero De La Rosa
IPC分类号： A61K47/69 , C09C3/10 , C08K3/04 , C01B32/154 , C08G73/02 , C09C1/56 , C01B32/156 , A61N5/06 , B82Y5/00
摘要： Provided herein are fullerene compositions, and methods of preparing fullerene compositions. More particularly, the fullerene compositions include a fullerene-polymer complex having a fullerene and a non-conjugated hydrophilic or amphiphilic polymer. The non-conjugated polymer is substituted with a substituent having a functional group capable of forming intermolecular interactions with the fullerene via pi-stacking.

6. 发明授权

US10889685B2 Methods for the preparation of cyclic imino ether polymers 有权
公开(公告)号：US10889685B2
公开(公告)日：2021-01-12
申请号：US16095606
申请日：2017-04-21
申请人： UNIVERSITEIT GENT , UNIVERSITEIT HASSELT
发明人： Victor Retamero De La Rosa , Evelien Baeten , Richard Hoogenboom , Tanja Junkers
IPC分类号： C08G73/02
摘要： Cyclic imino ether polymers, such as polyoxazolines or polyoxazines, having a low polydispersity index can be obtained in a tubular flow reactor by applying a sufficiently high linear flow velocity of the reaction mixture in the tubular flow reactor, such as a flow velocity of least 100 cm/min or at least 120 cm/min. Also, methods to control the polydispersity of a cyclic imino ether polymer during polymerization are provided.

7. 发明申请

US20200246472A1 HYDROGEL-FORMING COMPOSITION FOR CONTROLLED RELEASE 审中-公开
公开(公告)号：US20200246472A1
公开(公告)日：2020-08-06
申请号：US15998916
申请日：2017-02-16
申请人： Vrije Universiteit Brussel , Universiteit Gent
发明人： Charlotte Martin , Annemieke Madder , Steven Ballet , Richard Hoogenboom
IPC分类号： A61K47/64 , A61K9/06 , A61K9/00 , A61K51/08 , A61K51/12 , A61K49/00 , A61P25/04 , A61K31/485
摘要： The present invention provides peptide hydrogelators capable of forming hydrogels as carriers of active ingredients and acting as sustained or controlled release drug delivery systems.

8. 发明申请

US20180201648A1 HYDROGEL-FORMING PEPTIDES 审中-公开
公开(公告)号：US20180201648A1
公开(公告)日：2018-07-19
申请号：US15743357
申请日：2016-07-13
申请人： Universiteit Gent , Vrije Universiteit Brussel
发明人： Richard Hoogenboom , Annemieke Madder , Steven Ballet
IPC分类号： C07K7/06 , A61K47/42 , A61K31/496
摘要： Provided are hydrogel-forming peptides that comprise at least one dyad of hydrophobic amino acid residues in which one is a β3- or β2-homo amino acid residue. The hydrogels derived from these peptides can be loaded with biological materials and can be used in physiological conditions.

9. 发明申请

US20150025196A1 POLYOXAZOLINE POLYMERS AND METHODS FOR THEIR PREPARATION, CONJUGATES OF THESE POLYMERS AND MEDICAL USES THEREOF 有权
标题翻译：聚氧乙烯聚合物及其制备方法，这些聚合物的结合及其医疗用途
公开(公告)号：US20150025196A1
公开(公告)日：2015-01-22
申请号：US14370181
申请日：2012-12-28
申请人： Universiteit Gent
发明人： Richard Hoogenboom
IPC分类号： A61K47/48 , A61K51/06 , A61K31/704
CPC分类号： A61K47/48192 , A61K47/34 , A61K47/50 , A61K47/51 , A61K47/56 , A61K47/59 , A61K47/64 , A61K51/06 , A61K51/065 , C08G73/0233 , C08L79/02
摘要： The present invention relates to functionalized ploy(2-oxazoline) polymers, which are very suitable as a carrier and/or delivery vehicle (conjugate) of drugs, such as small therapeutic molecules and bio-pharmaceuticals. These polymers are characterized in that they comprise repeating units that are represented by the following formula —[N(R1)—(CHR2)m]- wherein R1 is R3—(CHR4)n-CONH—R5; R2 is selected from H and optionally substituted C1-5alkyl; R3 is CH2CO, C(O)O, C(O)NH OR C(S)NH; R4 is selected from H and optionally substituted C1-5alkyl; R5 is H; an C1-5alkyl; aryl; or a moiety comprising a functional group that can be used for conjugation; m is 2 or 3 and n is 1-5; or n is 0 and R3 is CH2. The invention relates further to a conjugate of these polyoxazoline polymers with at least one active moiety, such as a therapeutic moiety, a targeting moiety and/or diagnostic moiety, and to the use of these conjugates in the therapeutic treatment or prophylactic treatment or diagnosis of a disease or disorder.
摘要翻译：本发明涉及非常适合作为药物如小的治疗分子和生物药物的载体和/或递送载体（缀合物）的官能化的（2-恶唑啉）聚合物。这些聚合物的特征在于它们包含由下式表示的重复单元 - [N（R1） - （CHR2）m] - ，其中R1是R3-（CHR4）n-CONH-R5; R2选自H和任选取代的C 1-5烷基; R 3是CH 2 CO，C（O）O，C（O）NH OR C（S）NH; R4选自H和任选取代的C 1-5烷基; R5是H; C 1-5烷基; 芳基; 或包含可用于缀合的官能团的部分; m为2或3，n为1-5; 或n为0且R 3为CH 2。本发明还涉及这些聚恶唑啉聚合物与至少一个活性部分（例如治疗部分，靶向部分和/或诊断部分）的缀合物，以及这些缀合物在治疗性或预防性治疗或诊断中的用途疾病或病症

10. 发明授权

US11332554B2 Amidation of polymers containing ester side chains using functionalized amines 有权
公开(公告)号：US11332554B2
公开(公告)日：2022-05-17
申请号：US17057904
申请日：2019-05-24
申请人： Universiteit Gent
发明人： Richard Hoogenboom , Joachim Van Guyse
IPC分类号： C08F8/32 , C08F20/14 , C08F20/18 , C08F12/22 , C08G73/02 , C08K5/17 , C08K5/43 , B01J31/02
摘要： The invention entails the combination of basic catalysts, specifically guanidine-based catalysts, such as TBD, in conjunction with functionalized amines having a hydrogen bond donating or accepting functionality, to facilitate the accelerated transamidation of polymer compounds with non-activated ester side chains.

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