专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US10526371B2 Hydrogel-forming peptides 有权
公开(公告)号：US10526371B2
公开(公告)日：2020-01-07
申请号：US15743357
申请日：2016-07-13
申请人： Universiteit Gent , Vrije Universiteit Brussel
发明人： Richard Hoogenboom , Annemieke Madder , Steven Ballet
IPC分类号： A61K47/42 , C07K7/02 , C07K7/06 , A61K31/496
摘要： Provided are hydrogel-forming peptides that comprise at least one dyad of hydrophobic amino acid residues in which one is a β3- or β2-homo amino acid residue. The hydrogels derived from these peptides can be loaded with biological materials and can be used in physiological conditions.

2. 发明授权

US10029020B2 Fullerene compositions 有权
公开(公告)号：US10029020B2
公开(公告)日：2018-07-24
申请号：US15567338
申请日：2016-04-22
申请人： UNIVERSITEIT GENT
发明人： Richard Hoogenboom , Joachim Van Guyse , Victor Retamero De La Rosa
IPC分类号： A61K47/69 , C09C3/10 , C08K3/04 , C01B32/154 , C08G73/02 , C09C1/56 , C01B32/156 , A61N5/06 , B82Y5/00
摘要： Provided herein are fullerene compositions, and methods of preparing fullerene compositions. More particularly, the fullerene compositions include a fullerene-polymer complex having a fullerene and a non-conjugated hydrophilic or amphiphilic polymer. The non-conjugated polymer is substituted with a substituent having a functional group capable of forming intermolecular interactions with the fullerene via pi-stacking.

3. 发明授权

US11293138B2 Methods for obtaining colored or chromic substrates 有权
公开(公告)号：US11293138B2
公开(公告)日：2022-04-05
申请号：US16070721
申请日：2017-01-19
申请人： UNIVERSITEIT GENT
发明人： Richard Hoogenboom , Gertjan Vancoillie
IPC分类号： C09B69/10 , C08J7/12 , D06P1/00 , D06P3/24 , D06P5/20 , G01N21/80 , D06P5/13 , D06P3/66 , D06P1/38 , C09K9/02 , C09B62/008 , D06P1/384 , G01N21/63
摘要： The present invention provides a post-fabrication modification approach for the fabrication of colored and chromic materials and sensors using plasma surface modification to covalently bind the coloring agent to the substrate, thus avoiding leaching of the dye. Advantageously, in said methods, said coloring agent is a dye or pigment linked to a radical sensitive functional group, such as an alkenyl or alkynyl functional group, and is applied to the substrate prior to the gas plasma treatment. The methods envisaged herein are generic in nature, which allow the covalent immobilization of various dyes on different materials. The covalently coated materials after plasma surface modification, particularly the covalently coated chromic materials and sensors, can be used in many different applications, such as protective textile and wound dressing applications.

4. 发明申请

US20220010068A1 POLY(2-OXAZOLINE)S AND METHODS FOR PREPARING THEM 有权
公开(公告)号：US20220010068A1
公开(公告)日：2022-01-13
申请号：US17293669
申请日：2019-11-14
申请人： Universiteit Gent
发明人： Richard Hoogenboom , Ondrej Sedlacek
IPC分类号： C08G73/02 , A61K9/16 , A61K47/34 , A61K47/59 , A61L29/08 , C08G85/00
摘要： The present invention, in general, relates to the field of poly(2-oxazolines) (PAOx), more in particular poly(2-methoxymethyl-2-oxazoline) (PMeOMeOX) and poly(2-dimethylamino-2-oxazoline) (PDMAOx). The present invention also provides methods for preparing these PAOx, as well as compositions and uses comprising said PAOx.

5. 发明授权

US10118991B2 Method for the preparation of uniform, high molar mass cyclic imino ether polymers 有权
公开(公告)号：US10118991B2
公开(公告)日：2018-11-06
申请号：US15326866
申请日：2015-07-10
申请人： Universiteit Gent
发明人： Richard Hoogenboom , Bryn Monnery
IPC分类号： C08G73/02 , C08L79/02 , A61K47/34 , A61K47/59 , A61K47/48
摘要： A method for production of a uniform polymer of high molar mass is provides, the method comprising: (a) polymerizing cyclic imino ether monomer in a first reaction mixture by cationic ring opening polymerization to produce a polymerized first reaction mixture containing (i) polymerized material and (ii) solvent and/or unreacted cyclic imino ether monomer; (b) separating solvent and/or unreacted cyclic imino ether monomer from polymerized material contained in the polymerized first reaction mixture; (c) copolyerizing by cationic ring opening polymerization a second liquid reaction mixture containing cyclic imino ether monomer and solvent by combining the separated unreacted cyclic imino ether monomer and/or the separated solvent with other components. Also disclosed are polyoxazoline polymers comprising at least 50 wt. % of repeating units derived from a 2-substituted 2-oxazoline monomer selected from 2-methyl-2-oxazoline, 2-ethyl-2-oxazoline, 2-n-propyl-2-oxazoline, 2-i-propyl-2-oxazoline and combinations thereof, said polymer having a DP of at least 250 and a very low dispersity.

6. 发明申请

US20180133344A1 FULLERENE COMPOSITIONS 审中-公开
公开(公告)号：US20180133344A1
公开(公告)日：2018-05-17
申请号：US15567338
申请日：2016-04-22
申请人： UNIVERSITEIT GENT
发明人： Richard Hoogenboom , Joachim Van Guyse , Victor Retamero De La Rosa
IPC分类号： A61K47/69 , C09C3/10 , C08K3/04 , C01B32/154 , C01B32/156 , C08G73/02 , C09C1/56
CPC分类号： A61K47/6933 , A61K47/6935 , A61N5/062 , B82Y5/00 , C01B32/154 , C01B32/156 , C01P2004/64 , C08G73/0233 , C08K3/045 , C08L79/02 , C09C1/56 , C09C3/10
摘要： Provided herein are fullerene compositions, and methods of preparing fullerene compositions. More particularly, the fullerene compositions include a fullerene-polymer complex having a fullerene and a non- conjugated hydrophilic or amphiphilic polymer. The non- conjugated polymer is substituted with a substituent having a functional group capable of forming intermolecular interactions with the fullerene via pi-stacking.

7. 发明授权

US10889685B2 Methods for the preparation of cyclic imino ether polymers 有权
公开(公告)号：US10889685B2
公开(公告)日：2021-01-12
申请号：US16095606
申请日：2017-04-21
申请人： UNIVERSITEIT GENT , UNIVERSITEIT HASSELT
发明人： Victor Retamero De La Rosa , Evelien Baeten , Richard Hoogenboom , Tanja Junkers
IPC分类号： C08G73/02
摘要： Cyclic imino ether polymers, such as polyoxazolines or polyoxazines, having a low polydispersity index can be obtained in a tubular flow reactor by applying a sufficiently high linear flow velocity of the reaction mixture in the tubular flow reactor, such as a flow velocity of least 100 cm/min or at least 120 cm/min. Also, methods to control the polydispersity of a cyclic imino ether polymer during polymerization are provided.

8. 发明申请

US20200246472A1 HYDROGEL-FORMING COMPOSITION FOR CONTROLLED RELEASE 审中-公开
公开(公告)号：US20200246472A1
公开(公告)日：2020-08-06
申请号：US15998916
申请日：2017-02-16
申请人： Vrije Universiteit Brussel , Universiteit Gent
发明人： Charlotte Martin , Annemieke Madder , Steven Ballet , Richard Hoogenboom
IPC分类号： A61K47/64 , A61K9/06 , A61K9/00 , A61K51/08 , A61K51/12 , A61K49/00 , A61P25/04 , A61K31/485
摘要： The present invention provides peptide hydrogelators capable of forming hydrogels as carriers of active ingredients and acting as sustained or controlled release drug delivery systems.

9. 发明申请

US20180201648A1 HYDROGEL-FORMING PEPTIDES 审中-公开
公开(公告)号：US20180201648A1
公开(公告)日：2018-07-19
申请号：US15743357
申请日：2016-07-13
申请人： Universiteit Gent , Vrije Universiteit Brussel
发明人： Richard Hoogenboom , Annemieke Madder , Steven Ballet
IPC分类号： C07K7/06 , A61K47/42 , A61K31/496
摘要： Provided are hydrogel-forming peptides that comprise at least one dyad of hydrophobic amino acid residues in which one is a β3- or β2-homo amino acid residue. The hydrogels derived from these peptides can be loaded with biological materials and can be used in physiological conditions.

10. 发明申请

US20150025196A1 POLYOXAZOLINE POLYMERS AND METHODS FOR THEIR PREPARATION, CONJUGATES OF THESE POLYMERS AND MEDICAL USES THEREOF 有权
标题翻译：聚氧乙烯聚合物及其制备方法，这些聚合物的结合及其医疗用途
公开(公告)号：US20150025196A1
公开(公告)日：2015-01-22
申请号：US14370181
申请日：2012-12-28
申请人： Universiteit Gent
发明人： Richard Hoogenboom
IPC分类号： A61K47/48 , A61K51/06 , A61K31/704
CPC分类号： A61K47/48192 , A61K47/34 , A61K47/50 , A61K47/51 , A61K47/56 , A61K47/59 , A61K47/64 , A61K51/06 , A61K51/065 , C08G73/0233 , C08L79/02
摘要： The present invention relates to functionalized ploy(2-oxazoline) polymers, which are very suitable as a carrier and/or delivery vehicle (conjugate) of drugs, such as small therapeutic molecules and bio-pharmaceuticals. These polymers are characterized in that they comprise repeating units that are represented by the following formula —[N(R1)—(CHR2)m]- wherein R1 is R3—(CHR4)n-CONH—R5; R2 is selected from H and optionally substituted C1-5alkyl; R3 is CH2CO, C(O)O, C(O)NH OR C(S)NH; R4 is selected from H and optionally substituted C1-5alkyl; R5 is H; an C1-5alkyl; aryl; or a moiety comprising a functional group that can be used for conjugation; m is 2 or 3 and n is 1-5; or n is 0 and R3 is CH2. The invention relates further to a conjugate of these polyoxazoline polymers with at least one active moiety, such as a therapeutic moiety, a targeting moiety and/or diagnostic moiety, and to the use of these conjugates in the therapeutic treatment or prophylactic treatment or diagnosis of a disease or disorder.
摘要翻译：本发明涉及非常适合作为药物如小的治疗分子和生物药物的载体和/或递送载体（缀合物）的官能化的（2-恶唑啉）聚合物。这些聚合物的特征在于它们包含由下式表示的重复单元 - [N（R1） - （CHR2）m] - ，其中R1是R3-（CHR4）n-CONH-R5; R2选自H和任选取代的C 1-5烷基; R 3是CH 2 CO，C（O）O，C（O）NH OR C（S）NH; R4选自H和任选取代的C 1-5烷基; R5是H; C 1-5烷基; 芳基; 或包含可用于缀合的官能团的部分; m为2或3，n为1-5; 或n为0且R 3为CH 2。本发明还涉及这些聚恶唑啉聚合物与至少一个活性部分（例如治疗部分，靶向部分和/或诊断部分）的缀合物，以及这些缀合物在治疗性或预防性治疗或诊断中的用途疾病或病症

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式