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1. 发明申请

US20100056584A1 NOVEL 2-AMINIO-PYRIDINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS 有权
标题翻译：新型2-氨基吡啶衍生物及其作为钾通道调节剂的用途
公开(公告)号：US20100056584A1
公开(公告)日：2010-03-04
申请号：US12514532
申请日：2007-11-12
申请人： Ulrik Svane Sorensen , Birgitte L. Eriksen , Lene Teuber , Dan Peters , Dorte Strobaek , Tina Holm , Palle Christophersen
发明人： Ulrik Svane Sorensen , Birgitte L. Eriksen , Lene Teuber , Dan Peters , Dorte Strobaek , Tina Holm , Palle Christophersen
IPC分类号： A61K31/44 , C07D211/72 , A61P25/06 , A61P25/22
CPC分类号： C07D213/74
摘要： This invention relates to novel 2-amino-pyridine derivative useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作小电导钙激活钾通道（SK通道）的调节剂的新型2-氨基 - 吡啶衍生物。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

2. 发明申请

US20090099208A1 NOVEL GUANIDINE DERIVATIVES AND THEIR MEDICAL USE 有权
标题翻译：新型药物衍生物及其医疗用途
公开(公告)号：US20090099208A1
公开(公告)日：2009-04-16
申请号：US12279928
申请日：2007-03-22
申请人： Ulrik Svane Sorensen , Birgitte L. Eriksen , Lene Teuber , Dan Peters , Dorte Strobaek , Tina Holm Johansen , Palle Christophersen
发明人： Ulrik Svane Sorensen , Birgitte L. Eriksen , Lene Teuber , Dan Peters , Dorte Strobaek , Tina Holm Johansen , Palle Christophersen
IPC分类号： C07D239/12 , C07D235/02 , A61K31/505 , A61K31/4168 , A61P1/00 , A61P25/28 , A61P25/00 , A61P11/00 , A61P3/10 , A61P29/00 , A61P35/00
CPC分类号： C07D233/46 , C07D235/30 , C07D239/14 , C07D239/84 , C07D243/04
摘要： This invention relates to novel guanidine derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作小电导钙激活钾通道（SK通道）的调节剂的新型胍衍生物。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

3. 发明申请

US20090239880A1 COMBINATIONS OF MONOAMINE REUPTAKE INHIBITORS AND POTASSIUM CHANNEL ACTIVATORS 审中-公开
标题翻译：单胺类抑制剂和钾通道激活剂的组合
公开(公告)号：US20090239880A1
公开(公告)日：2009-09-24
申请号：US12306890
申请日：2007-07-02
申请人： Ulrik Svane Sorensen , Birgitte L. Eriksen , Lene Teuber , Dan Peters , Dorte Strobaek , Tina Holm Johansen , Palle Christophersen , John Paul Redrobe
发明人： Ulrik Svane Sorensen , Birgitte L. Eriksen , Lene Teuber , Dan Peters , Dorte Strobaek , Tina Holm Johansen , Palle Christophersen , John Paul Redrobe
IPC分类号： A61K31/497 , C07D401/04 , A61K31/454
CPC分类号： A61K45/06 , A61K31/445 , A61K31/495 , A61K2300/00
摘要： This invention provides pharmaceutical compositions comprising therapeutically effective amounts of a monoamine reuptake inhibitor and an SK inhibitor. In another aspect the invention provides novel benzoimidazole derivatives for use according to the invention.
摘要翻译：本发明提供包含治疗有效量的单胺再摄取抑制剂和SK抑制剂的药物组合物。另一方面，本发明提供了用于本发明的新的苯并咪唑衍生物。

4. 发明申请

US20090048278A1 Novel Quinazoline-2,4-Diamine Derivatives and Their Use as Modulators of Small-Conductance Calcium-Activated Potassium Channels 审中-公开
标题翻译：新型喹唑啉-2,4-二胺衍生物及其作为小电导钙活化钾通道调节剂的应用
公开(公告)号：US20090048278A1
公开(公告)日：2009-02-19
申请号：US12095899
申请日：2006-12-06
申请人： Ulrik Svane Sorensen , Birgitte L. Eriksen , Lene Teuber , Dan Peters , Dorte Strobaek , Tina Holm Johansen , Palle Christophersen
发明人： Ulrik Svane Sorensen , Birgitte L. Eriksen , Lene Teuber , Dan Peters , Dorte Strobaek , Tina Holm Johansen , Palle Christophersen
IPC分类号： A61K31/517 , C07D239/95
CPC分类号： C07D239/95 , C07D401/04
摘要： This invention relates to novel quinazoline-2,4-diamine derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作小电导钙激活钾通道（SK通道）的调节剂的新型喹唑啉-2,4-二胺衍生物。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

5. 发明申请

US20090124645A1 Novel Pyrimidine-2,4-Diamine Derivatives and their Use as Modulators of Small-Conductance Calcium-Activated Potassium Channels 审中-公开
标题翻译：新型嘧啶-2,4-二胺衍生物及其作为小电导钙活化钾通道调节剂的用途
公开(公告)号：US20090124645A1
公开(公告)日：2009-05-14
申请号：US12083433
申请日：2006-10-13
申请人： Ulrik Svane Sorensen , Birgitte L. Eriksen , Lene Teuber , Dan Peters , Dorte Strobaek , Tina Holm Johansen , Palle Christophersen
发明人： Ulrik Svane Sorensen , Birgitte L. Eriksen , Lene Teuber , Dan Peters , Dorte Strobaek , Tina Holm Johansen , Palle Christophersen
IPC分类号： A61K31/505 , C07D239/24 , A61P25/18 , A61P25/28 , A61P9/10 , A61P11/06 , A61P9/06 , A61P13/10 , A61P9/00 , A61P1/00 , A61P27/02
CPC分类号： C07D239/48
摘要： This invention relates to novel pyrimidine-2,4-diamine derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作小电导钙激活钾通道（SK通道）的调节剂的新型嘧啶-2,4-二胺衍生物。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

6. 发明申请

US20090076106A1 2-(Phenylamino) Benzimidazole Derivatives and Their Use as Modulators of Small- Conductance Calcuim-Activated Potassium Channels 有权
标题翻译： 2-（苯基氨基）苯并咪唑衍生物及其作为小电导钙活化钾通道调节剂的用途
公开(公告)号：US20090076106A1
公开(公告)日：2009-03-19
申请号：US11919708
申请日：2006-06-21
申请人： Ulrik Svane Sorensen , Lene Teuber , Dan Peters , Dorte Strobaek , Tina Holm Johansen , Karin Sandager Nielsen , Palle Christophersen
发明人： Ulrik Svane Sorensen , Lene Teuber , Dan Peters , Dorte Strobaek , Tina Holm Johansen , Karin Sandager Nielsen , Palle Christophersen
IPC分类号： A61K31/4184 , C07D235/30 , A61P25/00 , A61P9/00 , A61P3/10 , A61P1/00
CPC分类号： C07D235/30
摘要： This invention relates to novel 2-(phenylamino)benzimidazole derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels).In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作小电导钙激活钾通道（SK通道）的调节剂的新型2-（苯基氨基）苯并咪唑衍生物。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

7. 发明申请

US20080200529A1 Novel 2-Amino Benzimidazole Derivatives and Their Use As Modulators Of Small-Conductance Calcium-Activated Potassium Channels 有权
标题翻译：新型2-氨基苯并咪唑衍生物及其作为小电导钙活化钾通道调节剂的用途
公开(公告)号：US20080200529A1
公开(公告)日：2008-08-21
申请号：US11795018
申请日：2006-01-10
申请人： Ulrik Svane Sorensen , Lene Teuber , Dan Peters , Dorte Strobaek , Tina Holm Johansen , Karin Sandager Nielsen , Palle Christophersen
发明人： Ulrik Svane Sorensen , Lene Teuber , Dan Peters , Dorte Strobaek , Tina Holm Johansen , Karin Sandager Nielsen , Palle Christophersen
IPC分类号： A61K31/4184 , C07D235/30 , A61P25/16 , A61P25/08 , A61P9/10
CPC分类号： C07D235/30
摘要： This invention relates to novel 2-amino benzimidazole derivatives useful as modulators of small-conductance calcium-activated potassium channels (SK channels).In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及可用作小电导钙激活钾通道（SK通道）的调节剂的新型2-氨基苯并咪唑衍生物。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

8. 发明申请

US20090325989A1 INDAZOLYL DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS 有权
标题翻译：有用的盐酸衍生物作为钾通道调节剂
公开(公告)号：US20090325989A1
公开(公告)日：2009-12-31
申请号：US12444344
申请日：2007-10-03
申请人： Birgitte L. Eriksen , Ulrik Svane Sorensen , Charlotte Hougaard , Lene Teuber , Dan Peters , Palle Christophersen , Tina Holm Johansen
发明人： Birgitte L. Eriksen , Ulrik Svane Sorensen , Charlotte Hougaard , Lene Teuber , Dan Peters , Palle Christophersen , Tina Holm Johansen
IPC分类号： A61K31/506 , C07D401/04 , A61P9/10
CPC分类号： C07D403/04 , C07D401/04
摘要： This invention relates to novel indazolyl derivatives useful as potassium channel modulating agents, and their use in the preparation of pharmaceutical compositions.Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels, in particular respiratory diseases, epilepsy, convulsions, seizures, absence seizures, vascular spasms, coronary artery spasms, renal disorders, polycystic kidney disease, bladder spasms, urinary incontinence, bladder outflow obstruction, erectile dysfunction, gastrointestinal dysfunction, secretory diarrhoea, ischaemia, cerebral ischaemia, ischaemic heart disease, angina pectoris, coronary heart disease, autism, ataxia, traumatic brain injury, Parkinson's disease, bipolar disorder, psychosis, schizophrenia, anxiety, depression, mania, mood disorders, dementia, memory and attention deficits, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), dysmenorrhea, narcolepsy, Reynaud's disease, intermittent claudication, Sjorgren's syndrome, arrhythmia, hypertension, myotonic muscle dystrophia, spasticity, xerostomi, diabetes type II, hyperinsulinemia, premature labour, baldness, cancer, irritable bowel syndrome, immune suppression, migraine and pain.
摘要翻译：本发明涉及可用作钾通道调节剂的新的吲唑基衍生物及其在制备药物组合物中的用途。此外，本发明涉及可用于治疗或减轻与钾通道活性相关的疾病或病症的药物组合物，特别是呼吸系统疾病，癫痫，抽搐，癫痫发作，不发作，痉挛，血管痉挛，冠状动脉痉挛，肾脏疾病，多囊肾病，膀胱痉挛，尿失禁，膀胱流出阻塞，勃起功能障碍，胃肠功能障碍，分泌性腹泻，局部缺血，脑局部缺血，缺血性心脏病，心绞痛，冠心病，自闭症，共济失调，创伤性脑损伤，帕金森病，双相障碍，精神病，精神分裂症，焦虑症，抑郁症，躁狂症，情绪障碍，痴呆，记忆和注意力缺陷，阿尔茨海默病，肌萎缩性侧索硬化（ALS），痛经，发作性睡眠，雷诺病，间歇性跛行，Sjorgren综合征，心律失常，高血压，肌筋膜肌营养不良，痉挛，x 老年糖尿病，II型糖尿病，高胰岛素血症，早产，秃发，癌症，肠易激综合征，免疫抑制，偏头痛和疼痛。

9. 发明申请

US20110144140A1 PYRIDINYL-PYRIMIDINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS 审中-公开
标题翻译：适用于钾通道调节剂的吡啶基吡啶衍生物
公开(公告)号：US20110144140A1
公开(公告)日：2011-06-16
申请号：US12377392
申请日：2007-09-06
申请人： Birgitte L. Eriksen , Ulrik Svane Sorensen , Charlotte Hougaard , Lene Teuber , Dan Peters , Falle Christophersen , Tina Holm Johansen
发明人： Birgitte L. Eriksen , Ulrik Svane Sorensen , Charlotte Hougaard , Lene Teuber , Dan Peters , Falle Christophersen , Tina Holm Johansen
IPC分类号： A61K31/506 , C07D401/04 , A61P11/00 , A61P13/00 , A61P15/10 , A61P25/22 , A61P25/08 , A61P25/18 , A61P29/00
CPC分类号： C07D401/04
摘要： This invention relates to novel pyridinyl-pyrimidine derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.
摘要翻译：本发明涉及新的吡啶基 - 嘧啶衍生物及其作为钾通道调节剂的用途。此外，本发明涉及可用于治疗或缓解与钾通道活性相关的疾病或病症的药物组合物。

10. 发明申请

US20120004246A1 PURINYL DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS 审中-公开
标题翻译：嘌呤衍生物及其作为钾通道调节剂的用途
公开(公告)号：US20120004246A1
公开(公告)日：2012-01-05
申请号：US12593220
申请日：2008-03-27
申请人： Birgitte L. Eriksen , Ulrik Svane Sorensen , Charlotte Hougaard , Dan Peters , Palle Christophersen
发明人： Birgitte L. Eriksen , Ulrik Svane Sorensen , Charlotte Hougaard , Dan Peters , Palle Christophersen
IPC分类号： A61K31/52 , A61P11/00 , A61P25/08 , A61P9/00 , A61P13/12 , A61P13/10 , A61P13/00 , A61P15/10 , A61P1/12 , A61P9/10 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P9/06 , A61P9/12 , A61P3/10 , A61P35/00 , A61P17/14 , A61P25/06 , A61P25/32 , A61P25/36 , A61P25/30 , C07D473/16
CPC分类号： C07D473/04 , C07D473/16 , C07D473/24
摘要： This invention relates to novel purinyl derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.
摘要翻译：本发明涉及新的嘌呤基衍生物及其作为钾通道调节剂的用途。此外，本发明涉及可用于治疗或缓解与钾通道活性相关的疾病或病症的药物组合物。

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