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1. 发明申请

US20120088780A1 SUBSTITUTED [1,2,4]TRIAZOLO[1,5-a]PYRIMIDINES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS 有权
公开(公告)号：US20120088780A1
公开(公告)日：2012-04-12
申请号：US13258923
申请日：2010-03-30
申请人： Ulrik Svane Sørensen , Birgitte L. Eriksen , Charlotte Hougaard , Dorte Strøbaek , Palle Christophersen
发明人： Ulrik Svane Sørensen , Birgitte L. Eriksen , Charlotte Hougaard , Dorte Strøbaek , Palle Christophersen
IPC分类号： C07D487/04 , A61P25/00 , A61P25/08 , A61P25/28 , A61P9/10 , A61P9/06 , A61P25/22 , A61P13/10 , A61P35/04 , A61P1/00 , A61P1/04 , A61P9/12 , A61P25/24 , A61P25/16 , A61P13/12 , A61P37/00 , A61P3/10 , A61K31/519
CPC分类号： C07D487/04
摘要： This invention relates to novel substituted [1,2,4]triazolo[1,5-a]pyrimidines and their use as modulators of potassium channels. In other aspects the invention relates to the use of these compounds, in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

2. 发明申请

US20100035951A1 2-AMINO BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS 审中-公开
标题翻译： 2-氨基苯并咪唑衍生物及其作为小肠钙激活钾通道的调节剂
公开(公告)号：US20100035951A1
公开(公告)日：2010-02-11
申请号：US12307083
申请日：2007-07-05
申请人： Ulrik Svane Sørensen , Birgitte L. Eriksen , Lene Teuber , Dan Peters , Dorte Strøbaek , Tina Holm Johansen , Palle Christophersen
发明人： Ulrik Svane Sørensen , Birgitte L. Eriksen , Lene Teuber , Dan Peters , Dorte Strøbaek , Tina Holm Johansen , Palle Christophersen
IPC分类号： A61K31/4184 , C07D235/00
CPC分类号： C07D235/30
摘要： This invention relates to 2-amino benzimidazole derivatives of Formula 1a or 1b: which are useful as modulators of small-conductance calcium-activated potassium channels (SK channels). In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及式1a或1b的2-氨基苯并咪唑衍生物：其可用作小电导钙激活钾通道（SK通道）的调节剂。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

3. 发明授权

US08362024B2 Purinyl derivatives and their use as potassium channel modulators 有权
标题翻译：嘌呤衍生物及其作为钾通道调节剂的用途
公开(公告)号：US08362024B2
公开(公告)日：2013-01-29
申请号：US12593194
申请日：2008-03-27
申请人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Charlotte Hougaard , Dan Peters , Tina Holm Johansen , Palle Christophersen
发明人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Charlotte Hougaard , Dan Peters , Tina Holm Johansen , Palle Christophersen
IPC分类号： C07D473/16 , A61K31/52 , C07D473/40
CPC分类号： C07D473/16 , C07D473/24
摘要： This invention relates to novel purinyl derivatives of formula Ia or Ib Wherein the symbols are as defined in the Specification and of pharmaceutically acceptable salts thereof useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels, for the preparation of a medicament for such treatment and to pharmaceutical compositions containing such compounds.
摘要翻译：本发明涉及式Ia或Ib的新型嘌呤基衍生物，其中符号如本说明书中所定义，及其药学上可接受的盐可用于治疗或缓解与钾通道活性相关的疾病或病症，用于制备用于这种治疗的药物和含有这些化合物的药物组合物。

4. 发明授权

US08415358B2 Pyrazine derivatives and their use as potassium channel modulators 有权
标题翻译：吡嗪衍生物及其作为钾通道调节剂的用途
公开(公告)号：US08415358B2
公开(公告)日：2013-04-09
申请号：US12678244
申请日：2008-09-16
申请人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Charlotte Hougaard , Dan Peters , Palle Christophersen
发明人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Charlotte Hougaard , Dan Peters , Palle Christophersen
IPC分类号： A61K31/4965
CPC分类号： C07D403/04 , C07D401/04 , C07D405/14 , C07D417/04
摘要： Pyrazine compounds of the formula as well as stereoisomers thereof, N-oxides thereof, prodrugs thereof, and pharmaceutically acceptable salts thereof, wherein the variables in the formula are as defined in the specification. The compounds are useful as potassium channel modulating agents. Also, pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels, and methods of using the pharmaceutical compositions.
摘要翻译：下式的吡嗪化合物及其立体异构体，其N-氧化物，其前药及其药学上可接受的盐，其中式中的变量如说明书中所定义。该化合物可用作钾通道调节剂。此外，可用于治疗或缓解与钾通道活性相关的疾病或病症的药物组合物，以及使用该药物组合物的方法。

5. 发明申请

US20120101112A1 SUBSTITUTED [1,2,4]TRIAZOLO[1,5-a]PYRIMIDINES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS 有权
标题翻译：取代[1,2,4]三唑并[1,5-a]吡嗪并将其用作钾通道调节剂
公开(公告)号：US20120101112A1
公开(公告)日：2012-04-26
申请号：US13258944
申请日：2010-03-30
申请人： Ulrik Svane Sørensen , Birgitte L. Eriksen , Charlotte Hougaard , Dorte Strøbæk , Palle Christophersen
发明人： Ulrik Svane Sørensen , Birgitte L. Eriksen , Charlotte Hougaard , Dorte Strøbæk , Palle Christophersen
IPC分类号： A61K31/519 , A61P11/06 , A61P25/28 , A61P9/10 , A61P9/06 , A61P25/22 , A61P17/14 , A61P13/10 , A61P35/00 , A61P25/00 , A61P9/00 , A61P1/00 , A61P11/00 , A61P25/24 , A61P3/10 , A61P25/08 , A61P25/16 , A61P13/12 , A61P15/06 , A61P25/18 , A61P15/10 , A61P9/12 , A61P27/16 , A61P1/12 , A61P27/02 , A61P37/06 , C07D487/04
CPC分类号： C07D487/04
摘要： This invention relates to novel substituted [1,2,4]triazolo[1,5-a]pyrimidines and their use as modulators of potassium channels. In other aspects the invention relates to the use of these compounds, in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及新的取代的[1,2,4]三唑并[1,5-a]嘧啶及其作为钾通道调节剂的用途。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

6. 发明申请

US20100152210A1 PURINYL DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS 审中-公开
公开(公告)号：US20100152210A1
公开(公告)日：2010-06-17
申请号：US12593218
申请日：2008-03-27
申请人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Charlotte Hougaard , Dan Peters , Tina Holm Johansen , Palle Christophersen
发明人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Charlotte Hougaard , Dan Peters , Tina Holm Johansen , Palle Christophersen
IPC分类号： A61K31/52 , C07D473/40 , A61P11/00 , A61P25/00 , A61P25/08 , A61P13/00 , A61P15/00 , A61P9/00 , A61P1/00 , A61P3/10 , A61P37/00 , A61P25/30 , A61P25/28
CPC分类号： C07D473/16 , C07D473/24
摘要： This invention relates to novel purinyl derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.

7. 发明授权

US08685987B2 Substituted [1,2,4]triazolo[1,5-a]pyrimidines and their use as potassium channel modulators 有权
标题翻译：取代的[1,2,4]三唑并[1,5-a]嘧啶及其作为钾通道调节剂的用途
公开(公告)号：US08685987B2
公开(公告)日：2014-04-01
申请号：US13258944
申请日：2010-03-30
申请人： Ulrik Svane Sørensen , Birgitte L. Eriksen , Charlotte Hougaard , Dorte Strøbæk , Palle Christophersen
发明人： Ulrik Svane Sørensen , Birgitte L. Eriksen , Charlotte Hougaard , Dorte Strøbæk , Palle Christophersen
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04
摘要： This invention relates to novel substituted [1,2,4]triazolo[1,5-a]pyrimidines and their use as modulators of potassium channels. In other aspects the invention relates to the use of these compounds, in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译：本发明涉及新的取代的[1,2,4]三唑并[1,5-a]嘧啶及其作为钾通道调节剂的用途。在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。

8. 发明授权

US08222262B2 Indazolyl derivatives useful as potassium channel modulating agents 有权
标题翻译：可用作钾通道调节剂的吲唑基衍生物
公开(公告)号：US08222262B2
公开(公告)日：2012-07-17
申请号：US12444344
申请日：2007-10-03
申请人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Charlotte Hougaard , Lene Teuber , Dan Peters , Palle Christophersen , Tina Holm Johansen
发明人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Charlotte Hougaard , Lene Teuber , Dan Peters , Palle Christophersen , Tina Holm Johansen
IPC分类号： A61K31/517
CPC分类号： C07D403/04 , C07D401/04
摘要： Potassium channel modulating agents of Formula Ia or Ib and enantiomers and mixtures enantiomers and N-oxides thereof, and pharmaceutically acceptable salts thereof, and their use in the preparation of pharmaceutical compositions. Also, pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels, e.g., respiratory diseases, epilepsy, convulsions, vascular spasms, coronary artery spasms, renal disorders, polycystic kidney disease, bladder spasms, urinary incontinence, bladder outflow obstruction, irritable bowel syndrome, gastrointestinal dysfunction, secretory diarrhoea, ischaemia, cerebral ischaemia, ischaemic heart disease, angina pectoris, coronary heart disease, traumatic brain injury, psychosis, schizophrenia, anxiety, depression, dementia, memory and attention deficits, Alzheimer's disease, dysmenorrhea, narcolepsy, Reynaud's disease, intermittent claudication, Sjorgren's syndrome, migraine, arrhythmia, hypertension, absence seizures, myotonic muscle dystrophia, xerostomi, diabetes type II, hyperinsulinemia, premature labor, baldness, cancer, immune suppression, or pain.
摘要翻译：式Ia或Ib的钾通道调节剂及其对映异构体及其混合物对映异构体和N-氧化物及其药学上可接受的盐及其在制备药物组合物中的用途。此外，可用于治疗或缓解与钾通道活动相关的疾病或病症的药物组合物，例如呼吸系统疾病，癫痫，惊厥，血管痉挛，冠状动脉痉挛，肾脏疾病，多囊肾病，膀胱痉挛，尿失禁，膀胱流出阻塞，肠易激综合征，胃肠功能障碍，分泌性腹泻，局部缺血，脑缺血，缺血性心脏病，心绞痛，冠心病，创伤性脑损伤，精神病，精神分裂症，焦虑症，抑郁症，痴呆，记忆和注意力缺陷，老年痴呆症，痛经，发作性睡眠，雷诺病，间歇性跛行，Sjorgren综合征，偏头痛，心律失常，高血压，不存在癫痫发作，强直肌营养不良，口干燥症，II型糖尿病，高胰岛素血症，早产，秃发，癌症，免疫抑制或疼痛。

9. 发明授权

US08765770B2 Substituted [1,2,4]triazolo[1,5-a]pyrimidines and their use as potassium channel modulators 有权
公开(公告)号：US08765770B2
公开(公告)日：2014-07-01
申请号：US13258923
申请日：2010-03-30
申请人： Ulrik Svane Sørensen , Birgitte L. Eriksen , Charlotte Hougaard , Dotre Strøbæk , Palle Christophersen
发明人： Ulrik Svane Sørensen , Birgitte L. Eriksen , Charlotte Hougaard , Dotre Strøbæk , Palle Christophersen
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00
CPC分类号： C07D487/04
摘要： This invention relates to novel substituted [1,2,4]triazolo[1,5-a]pyrimidines and their use as modulators of potassium channels. In other aspects the invention relates to the use of these compounds, in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.

10. 发明申请

US20100286161A1 PYRAZINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS 有权
标题翻译：吡嗪衍生物及其作为钾通道调节剂的用途
公开(公告)号：US20100286161A1
公开(公告)日：2010-11-11
申请号：US12678244
申请日：2008-09-16
申请人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Charlotte Hougaard , Dan Peters , Palle Christophersen
发明人： Birgitte L. Eriksen , Ulrik Svane Sørensen , Charlotte Hougaard , Dan Peters , Palle Christophersen
IPC分类号： A61K31/497 , C07D403/04 , A61P3/10 , A61P35/00 , A61P25/28 , A61P9/10 , A61P15/00 , A61P25/22 , A61P25/32 , A61P25/24 , A61P25/18 , A61P9/12
CPC分类号： C07D403/04 , C07D401/04 , C07D405/14 , C07D417/04
摘要： This invention relates to novel pyrazine derivatives and their use as potassium channel modulating agents. Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels.
摘要翻译：本发明涉及新颖的吡嗪衍生物及其作为钾通道调节剂的用途。此外，本发明涉及可用于治疗或缓解与钾通道活性相关的疾病或病症的药物组合物。

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