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1. 发明申请

US20070219271A1 Pharmaceutical Compositions Containing Pufa And At Least One Of An Immunosuppressive Agent Or An Antineoplastic Agent 审中-公开
标题翻译：含有Pufa和至少一种免疫抑制剂或抗肿瘤药物的药物组合物
公开(公告)号：US20070219271A1
公开(公告)日：2007-09-20
申请号：US11597712
申请日：2005-06-15
申请人： Ulrich Mittmann , Jean-Pierre Sachetto
发明人： Ulrich Mittmann , Jean-Pierre Sachetto
IPC分类号： A61K31/20
CPC分类号： A61K45/06 , A61K9/4891 , A61K31/202 , A61K2300/00
摘要： Polyunsaturated fatty acid (“PUFA”) or a pharmacologically acceptable salt or derivative thereof (such as EPA and/or DHA) is used in combination with at least one of an immunosuppressive agent or an antineoplastic agent or a pharmacologically acceptable salt or derivative thereof in the treatment of conditions involving acutely or chronically inadequate immune response by topical application of said active agents to at least a portion of the intestinal mucosa. Specific conditions that may be treated include chronic inflammatory disease (e.g. Chrohn's disease and ulcerative colitis) and tumour disease (e.g. bowel cancer and prostate cancer). One advantage of preferred embodiments of the invention is that bioavailability of immunosuppressive or antineoplastic agents is increased.
摘要翻译：多不饱和脂肪酸（“PUFA”）或其药理学上可接受的盐或其衍生物（例如EPA和/或DHA）与免疫抑制剂或抗肿瘤剂或其药理学上可接受的盐或衍生物中的至少一种联合使用通过将所述活性剂局部施用于至少一部分肠粘膜来治疗涉及急性或慢性不足的免疫应答的病症。可以治疗的具体情况包括慢性炎性疾病（例如，克罗恩氏病和溃疡性结肠炎）和肿瘤疾病（例如肠癌和前列腺癌）。本发明的优选实施方案的一个优点是增加了免疫抑制剂或抗肿瘤剂的生物利用度。

2. 发明申请

US20090018125A1 Pharmaceutical Composition and Its Use 审中-公开
标题翻译：药物成分及其用途
公开(公告)号：US20090018125A1
公开(公告)日：2009-01-15
申请号：US11629093
申请日：2005-06-15
申请人： Ulrich Mittmann , Jean-Pierre Sachetto
发明人： Ulrich Mittmann , Jean-Pierre Sachetto
IPC分类号： A61K31/4985 , A61K31/538 , A61P29/00
CPC分类号： A61K31/00 , A61K31/202 , A61K31/519 , A61K45/06 , A61K2300/00
摘要： Polyunsaturated fatty acid (“PUFA”) or a pharmacologically acceptable salt or derivative thereof (such as EPA and/or DHA) is used in combination with at least one of an immunosuppressive agent or an antineoplastic agent, said agent(s) having at least one amino acid residue, or a pharmacologically acceptable salt or derivative thereof (such as methotrexate or cyclosporin) in the treatment of conditions involving acutely or chronically inadequate immune response. Specific conditions that may be treated include chronic inflammatory diseases (e.g. Crohn's disease and ulcerative colitis) and tumour diseases (e.g. bowel cancer and prostate cancer). One advantage of preferred embodiments of the invention is that bioavailability of immunosuppressive or antineoplastic agents is increased.
摘要翻译：多不饱和脂肪酸（“PUFA”）或其药理学上可接受的盐或其衍生物（例如EPA和/或DHA）与免疫抑制剂或抗肿瘤剂中的至少一种组合使用，所述药剂至少具有一个氨基酸残基或其药理学上可接受的盐或其衍生物（如甲氨蝶呤或环孢菌素）治疗涉及急性或慢性不足的免疫应答的病症。可以治疗的具体病症包括慢性炎性疾病（例如克罗恩病和溃疡性结肠炎）和肿瘤疾病（例如肠癌和前列腺癌）。本发明的优选实施方案的一个优点是增加了免疫抑制剂或抗肿瘤剂的生物利用度。

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