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1. 发明授权

US08987285B2 Pharmaceutical compositions, dosage forms and new forms of the compound of formula (I), and methods of use thereof 有权
标题翻译：式（I）化合物的药物组合物，剂型和新形式及其使用方法
公开(公告)号：US08987285B2
公开(公告)日：2015-03-24
申请号：US13990632
申请日：2011-12-05
申请人： Ulrich Meier , Nicole Bieri , Dieter Becker , Julien Taillemite , Marie-Pierre Filliot , Tanja Meister
发明人： Ulrich Meier , Nicole Bieri , Dieter Becker , Julien Taillemite , Marie-Pierre Filliot , Tanja Meister
IPC分类号： A01N43/54 , A61K31/517 , C07D239/72 , A61K45/06 , C07D409/12
CPC分类号： A61K31/517 , A61K45/06 , C07D409/12
摘要： The present invention relates to a novel crystalline anhydrous form of [(5-chlorothiophene-2-ylsulfonylcarbamoyl)-(4-(6-fluoro-7-(methylamino)-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)phenyl)amide, potassium salt, and its use in the treatment or prevention of a condition or a disorder with platelet ADP receptor inhibition, in particular, P2Y12 inhibition, in animals, particularly humans. It also relates processes for making such a novel crystalline form. The present invention also relates to a solid, oral formulation of this novel crystalline form, its preparation and use thereof.
摘要翻译：本发明涉及[（5-氯噻吩-2-基磺酰基氨基甲酰基） - （4-（6-氟-7-（甲基氨基）-2,4-二氧代-1,2-二氢喹唑啉-3（ 4H） - 基）苯基）酰胺钾盐，以及其在动物，特别是人中治疗或预防血小板ADP受体抑制，特别是P2Y12抑制的病症或病症的用途。它还涉及制备这种新型结晶形式的方法。本发明还涉及这种新型结晶形式的固体，口服制剂及其制备和用途。

2. 发明申请

US20130252979A1 PHARMACEUTICAL COMPOSITIONS, DOSAGE FORMS AND NEW FORMS OF THE COMPOUND OF MULA (I), AND METHODS OF USE THEREOF 有权
标题翻译：药物组合物，剂型和多形式化合物的新形式（I）及其使用方法
公开(公告)号：US20130252979A1
公开(公告)日：2013-09-26
申请号：US13990632
申请日：2011-12-05
申请人： Ulrich Meier , Nicole Bieri , Dieter Becker , Julien Taillemite , Marie-Pierre Filliot , Tanja Meister
发明人： Ulrich Meier , Nicole Bieri , Dieter Becker , Julien Taillemite , Marie-Pierre Filliot , Tanja Meister
IPC分类号： A61K31/517 , A61K45/06 , C07D409/12
CPC分类号： A61K31/517 , A61K45/06 , C07D409/12
摘要： The present invention relates to a novel crystalline anhydrous form of [(5-chlorothiophene-2-ylsulfonylcarbamoyl)-(4-(6-fluoro-7-(methylamino)-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)phenyl)amide, potassium salt, and its use in the treatment or prevention of a condition or a disorder with platelet ADP receptor inhibition, in particular, P2Y12 inhibition, in animals, particularly humans. It also relates processes for making such a novel crystalline form. The present invention also relates to a solid, oral for mulation of this novel crystalline form, its preparation and use thereof.
摘要翻译：本发明涉及[（5-氯噻吩-2-基磺酰基氨基甲酰基） - （4-（6-氟-7-（甲基氨基）-2,4-二氧代-1,2-二氢喹唑啉-3（ 4H） - 基）苯基）酰胺钾盐，以及其在动物，特别是人中治疗或预防血小板ADP受体抑制，特别是P2Y12抑制的病症或病症的用途。它还涉及制备这种新型结晶形式的方法。本发明还涉及这种新型结晶形式的固体口服，其制备及其用途。

3. 发明申请

US20130316018A1 Manufacture process for the preparation of an iron containing phosphate adsorbent 审中-公开
标题翻译：制备含铁磷酸盐吸附剂的制备方法
公开(公告)号：US20130316018A1
公开(公告)日：2013-11-28
申请号：US13955433
申请日：2013-07-31
申请人： Daniel Kaufmann , Nicole Bieri , Ulrich Meier , Ranjit Thakur , Zdenek Zencak , Christa Hartmann , Andreas Meyer
发明人： Daniel Kaufmann , Nicole Bieri , Ulrich Meier , Ranjit Thakur , Zdenek Zencak , Christa Hartmann , Andreas Meyer
IPC分类号： B01J20/04
CPC分类号： B01J20/048 , A61K33/26 , A61M1/3486 , A61M1/3679 , B01J20/0229 , B01J20/06 , B01J20/24 , B01J2220/46 , B01J2220/4825 , B33Y80/00 , C01G49/06
摘要： The present invention relates to a new manufacture process for producing an iron containing phosphate adsorbent, in particular to a process for manufacturing and isolating an iron(III)-based phosphate adsorbent which exhibits valuable pharmacological properties.
摘要翻译：本发明涉及一种用于生产含铁磷酸盐吸附剂的新制造方法，特别涉及一种制备和分离具有有价值的药理学性质的基于铁（III）的磷酸盐吸附剂的方法。

4. 发明申请

US20110086097A1 Manufacture process for the preparation of an iron containing phosphate adsorbent 审中-公开
标题翻译：制备含铁磷酸盐吸附剂的制备方法
公开(公告)号：US20110086097A1
公开(公告)日：2011-04-14
申请号：US12997447
申请日：2009-06-12
申请人： Daniel Kaufmann , Nicole Bieri , Ulrich Meier , Ranjit Thakur , Zdenek Zencak , Christa Hartmann , Andreas Meyer
发明人： Daniel Kaufmann , Nicole Bieri , Ulrich Meier , Ranjit Thakur , Zdenek Zencak , Christa Hartmann , Andreas Meyer
IPC分类号： A61K33/42 , A61K9/28 , A61P9/00 , A61P5/00 , A61P13/12
CPC分类号： B01J20/048 , A61K33/26 , A61M1/3486 , A61M1/3679 , B01J20/0229 , B01J20/06 , B01J20/24 , B01J2220/46 , B01J2220/4825 , B33Y80/00 , C01G49/06
摘要： The present invention relates to a new manufacture process for producing an iron containing phosphate adsorbent, in particular to a process for manufacturing and isolating an iron(III)-based phosphate adsorbent which exhibits valuable pharmacological properties.
摘要翻译：本发明涉及一种用于生产含铁磷酸盐吸附剂的新制造方法，特别涉及一种制备和分离具有有价值的药理学性质的基于铁（III）的磷酸盐吸附剂的方法。

5. 发明申请

US20090253811A1 MANUFACTURE PROCESS OF ORGANIC COMPOUNDS 有权
标题翻译：有机化合物的制造工艺
公开(公告)号：US20090253811A1
公开(公告)日：2009-10-08
申请号：US11721817
申请日：2005-12-14
申请人： Bernhard Riss , Ulrich Meier
发明人： Bernhard Riss , Ulrich Meier
IPC分类号： A61K47/12 , C07C233/64 , C07D265/26 , A61P43/00
CPC分类号： C07C235/60 , C07D265/26
摘要： The present invention relates to a method of preparing N-substituted salicylamides or derivatives thereof, and their salts, hydrates and solvates. In particular, the present invention relates to a method of preparing N-(5-chlorosalicyloyl)-8-aminocaprylic acid (5-CNAC) and its corresponding disodium monohydrate.
摘要翻译：本发明涉及制备N-取代的水杨酰胺或其衍生物及其盐，水合物和溶剂合物的方法。特别地，本发明涉及制备N-（5-氯水杨酰基）-8-氨基己酸（5-CNAC）及其相应的一水合二钠的方法。

6. 发明申请

US20070176421A1 Rapid coupling 有权
标题翻译：快速耦合
公开(公告)号：US20070176421A1
公开(公告)日：2007-08-02
申请号：US10578678
申请日：2003-11-11
申请人： Ulrich Meier , Hans Greminger
发明人： Ulrich Meier , Hans Greminger
IPC分类号： F16L39/00
CPC分类号： F16L37/088
摘要： In a rapid coupling, an end section of a pipe nipple engages in a through-hole of a sleeve. A groove provided on the pipe nipple serves to engage a resilient locking ring formed in the sleeve in order to lock the coupled state. The locking ring is located in an annular recess formed close to the insertion end of the sleeve. If the pipe nipple is not inserted into the bush to such an extent that the locking ring latches in the groove, the pipe nipple is pushed outward by a compression spring provided in the through-hole of the sleeve, so that the groove is readily visible outside the sleeve. The groove thus serves not only for locking in the properly coupled state but also as an indicator for indicating a state which is not properly coupled.
摘要翻译：在快速联接中，管接头的端部接合在套筒的通孔中。设置在管接头上的槽用于接合形成在套筒中的弹性锁定环，以锁定连接状态。锁定环位于靠近套筒的插入端形成的环形凹部中。如果管接头没有插入衬套中，使得锁定环锁定在槽中，则通过设置在套筒的通孔中的压缩弹簧将管接头向外推动，使得凹槽容易可见外套。因此，凹槽不仅用于锁定在适当耦合状态，而且用作指示未正确耦合的状态的指示器。

7. 发明授权

US06598269B2 Hose clamp 失效
标题翻译：软管夹
公开(公告)号：US06598269B2
公开(公告)日：2003-07-29
申请号：US10168330
申请日：2002-06-20
申请人： Hans Oetiker , Ulrich Meier
发明人： Hans Oetiker , Ulrich Meier
IPC分类号： B65D6302
CPC分类号： F16L33/035 , F16L33/025 , Y10T24/1457 , Y10T24/1478
摘要： In an open hose clamp with overlapping band ends, the outer band part comprises, starting from its end, an opening, an undulation, an Oetiker ear, an aperture, and a hook, while the inner band part comprises, starting from its end, a hook for engagement in the opening, a smooth area spanning the undulation and the ear, and a tongue with an attachment which passes through the aperture. The attachment serves to guide the tongue in the aperture and thus to ensure correct mutual positioning of the two band parts, transverse to the longitudinal direction of the band, in addition to securing the hose clamp in the engaged state, and cooperating with the hook provided on the outer band part for opening the tightened clamp.
摘要翻译：在具有重叠带端部的开放的软管夹中，外带部分从其端部开始包括开口，起伏，Oetiker耳，孔和钩，而内带部分包括从其端部开始，用于接合在开口中的钩子，跨越起伏和耳朵的平滑区域，以及具有穿过孔的附件的舌头。该附件用于将舌片引导到孔中，并且因此除了将软管夹具固定在接合状态之外，还确保两个带部件横向于带的纵向方向的正确相互定位，并与提供的钩配合在外带部分上打开紧固夹。

8. 发明授权

US08461385B2 Manufacture process of organic compounds 有权
标题翻译：有机化合物的制造过程
公开(公告)号：US08461385B2
公开(公告)日：2013-06-11
申请号：US11721817
申请日：2005-12-14
申请人： Bernhard Riss , Ulrich Meier
发明人： Bernhard Riss , Ulrich Meier
IPC分类号： C07C233/65
CPC分类号： C07C235/60 , C07D265/26
摘要： The present invention relates to a method of preparing N-substituted salicylamides or derivatives thereof, and their salts, hydrates and solvates. In particular, the present invention relates to a method of preparing N-(5-chlorosalicyloyl)-8-aminocaprylic acid (5-CNAC) and its corresponding disodium monohydrate.
摘要翻译：本发明涉及制备N-取代的水杨酰胺或其衍生物及其盐，水合物和溶剂合物的方法。特别地，本发明涉及制备N-（5-氯水杨酰基）-8-氨基己酸（5-CNAC）及其相应的一水合二钠的方法。

9. 发明授权

US08252310B2 Manufacture process 有权
标题翻译：制造过程
公开(公告)号：US08252310B2
公开(公告)日：2012-08-28
申请号：US12001132
申请日：2007-12-10
申请人： Michael Ambühl , Corine Gessier-Vial , Christa Hartmann , Daniel Kaufmann , Ernst Küsters , Ulrich Meier , Andreas Meyer , Nabila Sekkat
发明人： Michael Ambühl , Corine Gessier-Vial , Christa Hartmann , Daniel Kaufmann , Ernst Küsters , Ulrich Meier , Andreas Meyer , Nabila Sekkat
IPC分类号： A61K33/26
CPC分类号： A61K33/26 , B01J20/223 , B01J20/2803 , C01G49/0018 , C01G49/02
摘要： The present invention relates to a new iron containing phosphate adsorbent and its use e.g. for treating hyperphosphataemia.
摘要翻译：本发明涉及一种新的含磷磷酸盐吸附剂及其用途。用于治疗高磷血症。

10. 发明申请

US20070272892A1 Plug-in Safety Coupling for Pressure Pipes, Comprising a Pivoted Blocking Member 失效
标题翻译：用于压力管道的插入式安全联轴器，包括枢轴阻塞构件
公开(公告)号：US20070272892A1
公开(公告)日：2007-11-29
申请号：US10597037
申请日：2004-12-28
申请人： Ulrich Meier , Hans Greminger
发明人： Ulrich Meier , Hans Greminger
IPC分类号： F16L29/00
CPC分类号： F16L37/47
摘要： A plug-in safety coupling for pressure pipes consists of a coupler box with a blocking member pivotally mounted therein. The latter has a diametrical through bore in which a plug can be inserted, in a depressurized state, at an acute to a right angle to the conducting position. The blocking member can be brought into the conducting position by pivoting the plug. A cupped locking sleeve shaving a hemispherical front end is placed over the coupler box with the pivoting member. This hemispherical front end comprises a spherically extending oblong hole that extends along a great circle on the hemispherical end from the center thereof. The locking sleeve is rotatably mounted on the coupler box and is biased by a spring to such an extent that its oblong hole extends with an offset by 90° relative to the pivoting plane of the blocking member of the plug. Only when the locking sleeve is pivoted, a plug can be inserted. Once the plug is pivoted into the conducting position, the locking sleeve, by the force of the spring, is pivoted by 90° and secures the plug from pivoting back.
摘要翻译：用于压力管的插入式安全联接器包括一个联接器盒，其中一个阻挡件枢转地安装在其中。后者具有直径通孔，其中插塞可以以减压状态与导通位置成锐角地成直角地插入。可以通过使插头旋转而使阻挡构件进入导通位置。剃须半球形前端的杯形锁定套筒与枢转构件放置在联接器盒上方。该半球形前端包括球形延伸的椭圆形孔，该椭圆形孔从其中心沿着半球形端部的大圆形延伸。锁定套筒可旋转地安装在耦合器盒上并被弹簧偏压到一个程度，使得其长孔相对于插头的阻挡构件的枢转平面偏移90°。只有当锁定套筒枢转时，才能插入一个插头。一旦插头枢转到导电位置，锁定套筒就被弹簧的力枢转90°并固定插头从而枢转回来。

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