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1. 发明授权

US08260420B2 Method and device for processing cardiac signals 有权
标题翻译：用于处理心脏信号的方法和装置
公开(公告)号：US08260420B2
公开(公告)日：2012-09-04
申请号：US12557770
申请日：2009-09-11
申请人： Ulrich Busch , Andreas Neumann , Ulrich Tietze
发明人： Ulrich Busch , Andreas Neumann , Ulrich Tietze
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61B5/04011 , A61B5/0422 , A61B5/726 , A61N1/3682 , A61N1/37217
摘要： An electromedical implant having a far-field electrocardiogram detection unit connected or connectable to at least two implantable electrodes, at least one electrode of which is to be placed in the right atrium or right ventricle and is designed to record a far-field electrocardiogram via the terminal for the electrode to be placed in the right atrium or the right ventricle and one other electrode. The far-field electrocardiogram detection unit is connected to a far-field electrocardiogram evaluation unit, which is configured to detect signal features of the far-field electrocardiogram associated with an excitation or contraction of the left atrium and/or the left ventricle of the heart in a far-field electrocardiogram recorded by the far-field electrocardiogram detection unit.
摘要翻译：一种具有远场心电图检测单元的电离植入物，所述远场心电图检测单元连接或连接至至少两个可植入电极，其至少一个电极将被放置在右心房或右心室中，并被设计成通过该心电图记录远场心电图电极的末端放置在右心房或右心室和另一个电极中。远场心电图检测单元连接到远场心电图评估单元，其被配置为检测与心脏的左心房和/或左心室的激发或收缩相关联的远场心电图的信号特征在由远场心电图检测单元记录的远场心电图中。

2. 发明申请

US20100087886A1 METHOD AND DEVICE FOR PROCESSING CARDIAC SIGNALS 有权
标题翻译：用于处理心脏信号的方法和装置
公开(公告)号：US20100087886A1
公开(公告)日：2010-04-08
申请号：US12557770
申请日：2009-09-11
申请人： Ulrich Busch , Andreas Neumann , Ulrich Tietze
发明人： Ulrich Busch , Andreas Neumann , Ulrich Tietze
IPC分类号： A61N1/368 , A61N1/08
CPC分类号： A61N1/368 , A61B5/04011 , A61B5/0422 , A61B5/726 , A61N1/3682 , A61N1/37217
摘要： An electromedical implant having a far-field electrocardiogram detection unit connected or connectable to at least two implantable electrodes, at least one electrode of which is to be placed in the right atrium or right ventricle and is designed to record a far-field electrocardiogram via the terminal for the electrode to be placed in the right atrium or the right ventricle and one other electrode. The far-field electrocardiogram detection unit is connected to a far-field electrocardiogram evaluation unit, which is configured to detect signal features of the far-field electrocardiogram associated with an excitation or contraction of the left atrium and/or the left ventricle of the heart in a far-field electrocardiogram recorded by the far-field electrocardiogram detection unit.
摘要翻译：一种具有远场心电图检测单元的电离植入物，所述远场心电图检测单元连接或连接至至少两个可植入电极，其至少一个电极将被放置在右心房或右心室中，并被设计成通过该心电图记录远场心电图电极的末端放置在右心房或右心室和另一个电极中。远场心电图检测单元连接到远场心电图评估单元，其被配置为检测与心脏的左心房和/或左心室的激发或收缩相关联的远场心电图的信号特征在由远场心电图检测单元记录的远场心电图中。

3. 发明申请

US20110196249A1 CARDIOVERTER/DEFIBRILLATOR AND SIGNAL PROCESSING DEVICE FOR CLASSIFYING INTRACARDIAC SIGNALS 有权
标题翻译： CARDIOVERTER / DEFIBRILLATOR AND SIGNAL PROCESSING DEVICE FOR CLASSIFYING INTRACARDIAC SIGNALS
公开(公告)号：US20110196249A1
公开(公告)日：2011-08-11
申请号：US13023894
申请日：2011-02-09
申请人： Philipp Staeuber , Andreas Neumann , Ulrich Busch , Peter Wohlgemuth
发明人： Philipp Staeuber , Andreas Neumann , Ulrich Busch , Peter Wohlgemuth
IPC分类号： A61B5/0464 , A61N1/365
CPC分类号： A61N1/3925 , A61B5/04525 , A61B5/0464 , A61B5/7264
摘要： The invention relates to methods of differentiating between ventricular tachycardias (VTs) and supraventricular tachycardias (SVT) with the assistance of morphology detection, and signal processing devices implementing such methods.
摘要翻译：本发明涉及在形态学检测的帮助下区分室性心动过速（VT）和室上性心动过速（SVT）的方法，以及实施这种方法的信号处理装置。

4. 发明授权

US08812094B2 Cardioverter/defibrillator and signal processing device for classifying intracardiac signals 有权
标题翻译：心脏转移器/除颤器和用于分类心内信号的信号处理装置
公开(公告)号：US08812094B2
公开(公告)日：2014-08-19
申请号：US13023894
申请日：2011-02-09
申请人： Philipp Staeuber , Andreas Neumann , Ulrich Busch , Peter Wohlgemuth
发明人： Philipp Staeuber , Andreas Neumann , Ulrich Busch , Peter Wohlgemuth
IPC分类号： A61B5/02 , A61B5/04
CPC分类号： A61N1/3925 , A61B5/04525 , A61B5/0464 , A61B5/7264
摘要： The invention relates to methods of differentiating between ventricular tachycardias (VTs) and supraventricular tachycardias (SVT) with the assistance of morphology detection, and signal processing devices implementing such methods.
摘要翻译：本发明涉及在形态学检测的帮助下区分室性心动过速（VT）和室上性心动过速（SVT）的方法，以及实施这种方法的信号处理装置。

5. 发明授权

US08355781B2 Biventricular heart stimulator 有权
标题翻译：双心室心脏刺激器
公开(公告)号：US08355781B2
公开(公告)日：2013-01-15
申请号：US12271908
申请日：2008-11-16
申请人： Bruno Ismer , Thomas Koerber , Wolfgang Voss , Georg Heinrich von Knorre , Bjoern Riedel , Andreas Neumann , Ulrich Busch , Juergen Pilz , Thomas Brueggemann , Ralf Peters
发明人： Bruno Ismer , Thomas Koerber , Wolfgang Voss , Georg Heinrich von Knorre , Bjoern Riedel , Andreas Neumann , Ulrich Busch , Juergen Pilz , Thomas Brueggemann , Ralf Peters
IPC分类号： A61N1/00
CPC分类号： A61N1/368 , A61B5/0452 , A61B5/726 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3702
摘要： An implantable heart stimulator (10), which has a right-atrial sensing unit (62), which is connected or is to be connected to a right-atrial electrode for recording electrical potentials of the myocardium of a right atrium, and is implemented to process electrical signals recorded via the right-atrial electrode, and to detect signal features characterizing a right-atrial stimulation and contraction in the electrical signal recorded via the right-atrial electrode. The heart stimulator (10) additionally has a left-ventricular sensing unit (66), which is connected or is to be connected to a left-ventricular electrode for recording electrical potentials of the myocardium of a left ventricle of a heart and is implemented to process electrical signals recorded via the left-ventricular electrode. The left-ventricular sensing unit (66) is implemented to detect signal features in the electrical signal recorded via the left-ventricular electrode which characterize a left-atrial contraction.
摘要翻译：具有右心房感测单元（62）的可植入心脏刺激器（10），其连接或连接到右心房电极，用于记录右心房心肌的电位，并被实施为处理通过右心房电极记录的电信号，并且检测表征通过右心房电极记录的电信号中的右心房刺激和收缩的信号特征。心脏刺激器（10）还具有左心室感测单元（66），其连接或连接到左心室电极，用于记录心脏左心室的心肌的电位，并被实施为处理通过左心室电极记录的电信号。实施左心室感测单元（66）以检测表征左心房收缩的经左心室电极记录的电信号中的信号特征。

6. 发明申请

US20090163967A1 BIVENTRICULAR HEART STIMULATOR 有权
标题翻译：双向心脏刺激器
公开(公告)号：US20090163967A1
公开(公告)日：2009-06-25
申请号：US12271908
申请日：2008-11-16
申请人： Bruno ISMER , Thomas Koerber , Wolfgang Voss , Georg Heinrich von Knorre , Bjoern Riedel , Andreas Neumann , Ulrich Busch , Juergen Pilz , Thomas Brueggemann , Ralf Peters
发明人： Bruno ISMER , Thomas Koerber , Wolfgang Voss , Georg Heinrich von Knorre , Bjoern Riedel , Andreas Neumann , Ulrich Busch , Juergen Pilz , Thomas Brueggemann , Ralf Peters
IPC分类号： A61N1/37 , A61N1/39
CPC分类号： A61N1/368 , A61B5/0452 , A61B5/726 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3702
摘要： An implantable heart stimulator (10), which has a right-atrial sensing unit (62), which is connected or is to be connected to a right-atrial electrode for recording electrical potentials of the myocardium of a right atrium, and is implemented to process electrical signals recorded via the right-atrial electrode, and to detect signal features characterizing a right-atrial stimulation and contraction in the electrical signal recorded via the right-atrial electrode. The heart stimulator (10) additionally has a left-ventricular sensing unit (66), which is connected or is to be connected to a left-ventricular electrode for recording electrical potentials of the myocardium of a left ventricle of a heart and is implemented to process electrical signals recorded via the left-ventricular electrode. The left-ventricular sensing unit (66) is implemented to detect signal features in the electrical signal recorded via the left-ventricular electrode which characterize a left-atrial contraction.
摘要翻译：具有右心房感测单元（62）的可植入心脏刺激器（10），其连接或连接到右心房电极，用于记录右心房心肌的电位，并被实施为处理通过右心房电极记录的电信号，并且检测表征通过右心房电极记录的电信号中的右心房刺激和收缩的信号特征。心脏刺激器（10）还具有左心室感测单元（66），其连接或连接到左心室电极，用于记录心脏左心室的心肌的电位，并被实施为处理通过左心室电极记录的电信号。实施左心室感测单元（66）以检测表征左心房收缩的经左心室电极记录的电信号中的信号特征。

7. 发明授权

US07189743B2 Prodrugs of 1-methyl-2-(4-amidinophenylaminomethyl)-benzimidazol-5-yl-carboxylic acid-(N-2-pyridyl-N-2-hydroxycarbonylethyl)-amide 有权
标题翻译： 1-甲基-2-（4-脒基苯基氨基甲基） - 苯并咪唑-5-基 - 羧酸 - （N-2-吡啶基-N-2-羟基羰基乙基） - 酰胺的前药
公开(公告)号：US07189743B2
公开(公告)日：2007-03-13
申请号：US11056029
申请日：2005-02-11
申请人： Norbert Hauel , Florian Colbatzky , Ulrich Busch
发明人： Norbert Hauel , Florian Colbatzky , Ulrich Busch
IPC分类号： A61K31/44
CPC分类号： C07D401/12
摘要： The present invention relates to new compounds of general formula having thrombin-inhibiting activity. Exemplary are: 1-Methyl-2-[4-(N-hydroxyamidino)-phenylaminomethyl]-benzimidazol-5-yl-carboxylic acid-(N-2-pyridyl-N-2-ethoxycarbonylethyl)-amide, and 1-Methyl-2-[4-(N-methoxycarbonylamidino)-phenylaminomethyl]-benzimidazol-5-yl-carboxylic acid-(N-2-pyridyl-N-2-hydroxycarbonylethyl)-amide.
摘要翻译：本发明涉及具有凝血酶抑制活性的新型通式化合物。示例性的是：1-甲基-2- [4-（N-羟基脒基） - 苯基氨基甲基] - 苯并咪唑-5-基 - 羧酸 - （N-2-吡啶基-N-2-乙氧基羰基乙基） - 酰胺和1-甲基 -2- [4-（N-甲氧基羰基脒基） - 苯基氨基甲基] - 苯并咪唑-5-基 - 羧酸 - （N-2-吡啶基-N-2-羟基羰基乙基） - 酰胺。

8. 发明授权

US06591134B2 Implantable medical device 有权
标题翻译：植入式医疗器械
公开(公告)号：US06591134B2
公开(公告)日：2003-07-08
申请号：US09768794
申请日：2001-01-25
申请人： Ulrich Busch , Gregor Niewalda
发明人： Ulrich Busch , Gregor Niewalda
IPC分类号： A61N118
CPC分类号： A61N1/37211 , A61N1/3702 , A61N1/37276
摘要： An implantable medical device incorporates a central control unit (14) for controlling the internal and external functions of the device, a memory unit comprising program memory, main and/or data memory (20, 21, 22) for the central control unit (14), having at least one non-volatile read-write memory unit that is based on an optical storage medium and holds the stored information energy-free, and an off-the-line power supply (18) for the implantable device.
摘要翻译：可植入医疗装置包括用于控制装置的内部和外部功能的中央控制单元（14），包括用于中央控制单元（14）的程序存储器，主和/或数据存储器（20,21,22）的存储单元，具有至少一个非易失性读写存储器单元，其基于光学存储介质并保存所存储的信息无能量，以及用于可植入设备的离线电源（18）。

9. 发明授权

US06304781B1 Electrostimulator 失效
标题翻译：电动机
公开(公告)号：US06304781B1
公开(公告)日：2001-10-16
申请号：US09182419
申请日：1998-10-30
申请人： Ulrich Busch , Klaus Bartels
发明人： Ulrich Busch , Klaus Bartels
IPC分类号： A61N137
CPC分类号： A61N1/371 , A61N1/3706
摘要： Electrostimulator (2), comprising an interface for connecting a working electrode (2), as well as a pulse generator that is connected on the output side to the interface for transmitting electrical pulses to the working electrode (10), with a first measuring instrument (10) that is connected to the interface for measuring the electrical voltage present at the interface and/or the electrical current flowing over the interface, as well as an arithmetic unit, connected on the input side to the first measuring instrument, for computing an output signal reflecting the capacity of the working electrode in dependence on the current and/or voltage at the interface.
摘要翻译：电动刺激器（2），包括用于连接工作电极（2）的接口以及连接在输出侧的用于将电脉冲传送到工作电极（10）的接口的脉冲发生器，具有第一测量仪器（10），其连接到用于测量界面处存在的电压和/或在界面上流动的电流的接口以及连接到输入侧的运算单元到第一测量仪器，用于计算输出信号根据接口的电流和/或电压反映工作电极的容量。

10. 发明申请

US20050137233A1 Prodrugs of 1-methyl-2-(4-amidinophenylaminomethyl)-benzimidazol-5-yl-carboxylic acid-(N-2-pyridyl-N-2-hydroxycarbonylethyl)-amide 有权
公开(公告)号：US20050137233A1
公开(公告)日：2005-06-23
申请号：US11056029
申请日：2005-02-11
申请人： Norbert Hauel , Florian Colbatzky , Ulrich Busch
发明人： Norbert Hauel , Florian Colbatzky , Ulrich Busch
IPC分类号： A61K31/4439 , A61P7/02 , A61P43/00 , C07D401/12 , C07D43/02
CPC分类号： C07D401/12
摘要： The present invention relates to new compounds of general formula having thrombin-inhibiting activity. Exemplary are: 1-Methyl-2-[4-(N-hydroxyamidino)-phenylaminomethyl]-benzimidazol-5-yl-carboxylic acid-(N-2-pyridyl-N-2-ethoxycarbonylethyl)-amide, and 1-Methyl-2-[4-(N-methoxycarbonylamidino)-phenylaminomethyl]-benzimidazol-5-yl-carboxylic acid-(N-2-pyridyl-N-2-hydroxycarbonylethyl)-amide.

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