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1. 发明申请

US20120308478A1 ANTIBODIES SPECIFIC FOR CLAUDIN 6 (CLDN6) 有权
标题翻译： CLAUDIN 6的特定抗体（CLDN6）
公开(公告)号：US20120308478A1
公开(公告)日：2012-12-06
申请号：US13503461
申请日：2010-11-11
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Stefan Woll , Maria Kreuzberg , Bernd Hubner , Michael Erdeljan
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Stefan Woll , Maria Kreuzberg , Bernd Hubner , Michael Erdeljan
IPC分类号： C07K16/30 , A61K51/10 , A61P35/04 , C12N5/09 , A61P35/00 , C12N5/18 , A61K39/395
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/30 , C07K2317/14 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing Claudin-6 (CLDN6), including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
摘要翻译：本发明提供了可用作治疗和/或预防与表达紧密连接蛋白-6（CLDN6）的细胞相关的疾病的治疗剂的抗体，包括肿瘤相关疾病如卵巢癌，肺癌，胃癌，乳腺癌，肝癌，胰腺癌，皮肤癌，恶性黑素瘤，头颈癌，肉瘤，胆管癌，膀胱癌，肾癌，结肠癌，胎盘绒毛膜癌，子宫颈癌，睾丸癌和子宫癌。

2. 发明授权

US09487584B2 Antibodies specific for claudin 6 (CLDN6) 有权
标题翻译：针对claudin 6（CLDN6）特异性抗体
公开(公告)号：US09487584B2
公开(公告)日：2016-11-08
申请号：US13503461
申请日：2010-11-11
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Stefan Woll , Maria Kreuzberg , Bernd Hubner , Michael Erdeljan
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Stefan Woll , Maria Kreuzberg , Bernd Hubner , Michael Erdeljan
IPC分类号： C07K16/30 , A61K39/00 , C07K16/28
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/30 , C07K2317/14 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing Claudin-6 (CLDN6), including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
摘要翻译：本发明提供了可用作治疗和/或预防与表达紧密连接蛋白-6（CLDN6）的细胞相关的疾病的治疗剂的抗体，包括肿瘤相关疾病如卵巢癌，肺癌，胃癌，乳腺癌，肝癌，胰腺癌，皮肤癌，恶性黑素瘤，头颈癌，肉瘤，胆管癌，膀胱癌，肾癌，结肠癌，胎盘绒毛膜癌，子宫颈癌，睾丸癌和子宫癌。

3. 发明授权

US09321842B2 Antibodies for treatment of cancer 有权
标题翻译：用于治疗癌症的抗体
公开(公告)号：US09321842B2
公开(公告)日：2016-04-26
申请号：US14117118
申请日：2012-04-20
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Stefan Woll , Maria Kreuzberg , Bernd Hubner , Michael Erdeljan , Michael Weichel
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Stefan Woll , Maria Kreuzberg , Bernd Hubner , Michael Erdeljan , Michael Weichel
IPC分类号： C07K16/28 , C07K16/30 , A61K39/395 , A61K39/00
CPC分类号： C07K16/30 , A61K39/39591 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLDN6, including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
摘要翻译：本发明提供了可用作治疗和/或预防与表达CLDN6的细胞相关的疾病的治疗剂的抗体，包括肿瘤相关疾病如卵巢癌，肺癌，胃癌，乳腺癌，肝癌，胰腺癌，皮肤癌，恶性肿瘤黑素瘤，头颈癌，肉瘤，胆管癌，膀胱癌，肾癌，结肠癌，胎盘绒毛膜癌，子宫颈癌，睾丸癌和子宫癌。

4. 发明申请

US20140127219A1 ANTIBODIES FOR TREATMENT OF CANCER 有权
标题翻译：治疗癌症的抗体
公开(公告)号：US20140127219A1
公开(公告)日：2014-05-08
申请号：US14117118
申请日：2012-04-20
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Stefan Wöll , Maria Kreuzberg , Bernd Hubner , Michael Erdeljan , Michael Weichel
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Stefan Wöll , Maria Kreuzberg , Bernd Hubner , Michael Erdeljan , Michael Weichel
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A61K39/39591 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLDN6, including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
摘要翻译：本发明提供了可用作治疗和/或预防与表达CLDN6的细胞相关的疾病的治疗剂的抗体，包括肿瘤相关疾病如卵巢癌，肺癌，胃癌，乳腺癌，肝癌，胰腺癌，皮肤癌，恶性肿瘤黑素瘤，头颈癌，肉瘤，胆管癌，膀胱癌，肾癌，结肠癌，胎盘绒毛膜癌，子宫颈癌，睾丸癌和子宫癌。

5. 发明授权

US07303340B2 Optoelectronic transmitter module and method for the production thereof 有权
标题翻译：光电发射模块及其生产方法
公开(公告)号：US07303340B2
公开(公告)日：2007-12-04
申请号：US10471964
申请日：2002-03-14
申请人： Bernd Hubner
发明人： Bernd Hubner
IPC分类号： G02B6/42
CPC分类号： G02B6/4225 , G02B6/266 , G02B6/4201 , G02B6/4202 , G02B6/4234 , G02B6/4248
摘要： The invention relates to an optoelectronic emission module comprising a housing (B), which has electrical terminal contacts (5) for supplying and/or carrying away electric signals or for supplying electrical power. Said emission module also has at least one optical emission element (13), which is arranged inside the housing (3), and has at least one optical waveguide (17), which is held inside or on the housing (3) and in whose injection end (19) the light emitted by the at least one optical emission element (13) can be injected. The at least one optical emission element (13) and the injection end (19) of the at least one optical waveguide (17) are mounted on a supporting element. The invention also relates to a method for producing an emission module of the aforementioned type.
摘要翻译：本发明涉及一种包括壳体（B）的光电子发射模块，该壳体具有用于提供和/或携带电信号或用于提供电力的电端子触点（5）。所述发射模块还具有布置在壳体（3）内部的至少一个光发射元件（13），并且具有至少一个保持在壳体（3）内部或壳体（3）上的光波导（17）注射端（19）可以注射由至少一个光发射元件（13）发射的光。至少一个光波导（17）的至少一个光发射元件（13）和注射端（19）安装在支撑元件上。本发明还涉及上述类型的发射模块的制造方法。

6. 发明授权

US07356055B2 Method and device for regulating the average wavelength of a laser, especially a semiconductor laser 有权
标题翻译：用于调节激光器，特别是半导体激光器的平均波长的方法和装置
公开(公告)号：US07356055B2
公开(公告)日：2008-04-08
申请号：US10473942
申请日：2002-04-12
申请人： Bernd Hubner
发明人： Bernd Hubner
IPC分类号： H01S3/13 , H01S3/00
CPC分类号： H01S5/146 , H01S5/02248 , H01S5/02284 , H01S5/02446 , H01S5/06804 , H01S5/0687
摘要： The invention relates to a method for regulating the average wavelength of a laser, especially a semiconductor laser, comprising a wavelength-selective, at least partially reflecting optical element (27) and being operated in a unimodal manner. The inventive method involves the following steps: a control variable influencing the optical resonator length (Lopt) of the laser (29) over a pre-determined range is modified continuously or step-by-step; the characteristic of the optical monitoring power (Pmon) which is influenced in this way and emerges on the side opposite the optical output of the laser (29), or the characteristic of a detection variable dependent on the optical monitoring power, is detected continuously or step-by-step; and the control variable influencing the optical resonator length (Lopt) is regulated in such a way that a pre-defined value of the increase of the characteristic of the optical monitoring power (Pmon) or the characteristic of the detection variable dependent on the optical monitoring power, is reached in a point inside the control variable range, or a pre-defined value of a functional dependence (F(dPmon/dLopt)) is reached, containing the increase of the characteristic of the optical monitoring power (Pmon) or of the characteristic of the detection variable dependent on the optical monitoring power. Furthermore, the invention relates to a device for carrying out the inventive method.
摘要翻译：本发明涉及一种用于调节激光器，特别是半导体激光器的平均波长的方法，所述激光器包括波长选择性的至少部分反射的光学元件（27）并且以单峰方式操作。本发明的方法包括以下步骤：在预定范围内影响激光器（29）的光学谐振器长度（L opt opt）的控制变量被连续地或逐步地修改; 以这种方式影响并出现在与激光（29）的光输出相反的一侧的光学监视功率（P＆lt;＆gt; 1＆gt;）的特性，或者取决于激光光学监测功率，连续或逐步检测; 并且调节影响光学谐振器长度（L opt opt）的控制变量，使得光学监视功率的特性的增加的预定义值（P＆lt; / SUB>）或取决于光学监视功率的检测变量的特性在控制可变范围内的一点或功能依赖性的预定义值（F（dP＆lt; SUB＆gt; > / dL ）），其包含光学监视功率的特性的增加（P ）或检测变量的特性取决于光学监控电源。此外，本发明涉及一种用于实施本发明的方法的装置。

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