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1. 发明申请

US20110257495A1 Analyte Monitoring Device and Methods 有权
标题翻译：分析物监测装置及方法
公开(公告)号：US20110257495A1
公开(公告)日：2011-10-20
申请号：US13087190
申请日：2011-04-14
申请人： Udo Hoss , Benjamin J. Feldman , Zenghe Liu , Hyun Cho , Benjamin M. Rush
发明人： Udo Hoss , Benjamin J. Feldman , Zenghe Liu , Hyun Cho , Benjamin M. Rush
IPC分类号： A61B5/1468
CPC分类号： A61B5/1473 , A61B5/1451 , A61B5/14532 , A61B5/1468 , A61B5/7275 , A61B5/7405 , A61B5/742 , A61B5/7455 , A61B2560/0252 , A61B2560/0443
摘要： Method and system for determining real time analyte concentration including an analyte sensor having a portion in fluid contact with an interstitial fluid under a skin layer, an on-body electronics including a housing coupled to the analyte sensor and configured for positioning on the skin layer, the on-body electronics housing including a plurality of electrical contacts , on the housing; and a data analysis unit having a data analysis unit housing and a plurality of probes , on the housing. Each of the probes configured to electrically couple to a respective electrical contact when the data analysis unit is positioned in physical contact with the on-body electronics. The one or more signals on the probes correspond to one or more of a substantially real time monitored analyte concentration level (MACL), MACL over a predetermined time period, or a rate of change of the MACL, or combinations thereof, are provided.
摘要翻译：用于确定实时分析物浓度的方法和系统，包括分析物传感器，所述分析物传感器具有与皮肤层下面的间质液体流体接触的部分;体内电子器件，包括耦合到分析物传感器并被配置用于定位在皮肤层上的壳体，在壳体上包括多个电触头的体内电子壳体; 以及数据分析单元，具有在壳体上的数据分析单元外壳和多个探针。每个探针被配置为当数据分析单元与体内电子器件物理接触地定位时电耦合到相应的电接触。探针上的一个或多个信号对应于基本上实时监测的分析物浓度水平（MACL），预定时间段内的MACL或MACL的变化率或其组合中的一个或多个。

2. 发明授权

US08965477B2 Analyte monitoring device and methods 有权
标题翻译：分析物监测装置及方法
公开(公告)号：US08965477B2
公开(公告)日：2015-02-24
申请号：US13087190
申请日：2011-04-14
申请人： Udo Hoss , Benjamin J. Feldman , Zenghe Liu , Hyun Cho , Benjamin M. Rush
发明人： Udo Hoss , Benjamin J. Feldman , Zenghe Liu , Hyun Cho , Benjamin M. Rush
IPC分类号： A61B5/05 , A61B5/145 , A61B5/1473
CPC分类号： A61B5/1473 , A61B5/1451 , A61B5/14532 , A61B5/1468 , A61B5/7275 , A61B5/7405 , A61B5/742 , A61B5/7455 , A61B2560/0252 , A61B2560/0443
摘要： Method and system for determining real time analyte concentration including an analyte sensor having a portion in fluid contact with an interstitial fluid under a skin layer, an on-body electronics including a housing coupled to the analyte sensor and configured for positioning on the skin layer, the on-body electronics housing including a plurality of electrical contacts, on the housing; and a data analysis unit having a data analysis unit housing and a plurality of probes, on the housing. Each of the probes configured to electrically couple to a respective electrical contact when the data analysis unit is positioned in physical contact with the on-body electronics. The one or more signals on the probes correspond to one or more of a substantially real time monitored analyte concentration level (MACL), MACL over a predetermined time period, or a rate of change of the MACL, or combinations thereof, are provided.
摘要翻译：用于确定实时分析物浓度的方法和系统，包括分析物传感器，所述分析物传感器具有与皮肤层下面的间质液体流体接触的部分;体内电子器件，包括耦合到分析物传感器并被配置用于定位在皮肤层上的壳体，在壳体上包括多个电触头的体内电子壳体; 以及数据分析单元，具有在壳体上的数据分析单元外壳和多个探针。每个探针被配置为当数据分析单元与体内电子器件物理接触地定位时电耦合到相应的电接触。探针上的一个或多个信号对应于基本上实时监测的分析物浓度水平（MACL），预定时间段内的MACL或MACL的变化率或其组合中的一个或多个。

3. 发明申请

US20120330120A1 Analyte Monitoring: Stabilizer for Subcutaneous Glucose Sensor with Incorporated Antiglycolytic Agent 有权
标题翻译：分析物监测：含有抗溶血剂的皮下葡萄糖传感器稳定剂
公开(公告)号：US20120330120A1
公开(公告)日：2012-12-27
申请号：US13437681
申请日：2012-04-02
申请人： Tianmei Ouyang , Zenghe Liu , Hyun Cho , Benjamin J. Feldman
发明人： Tianmei Ouyang , Zenghe Liu , Hyun Cho , Benjamin J. Feldman
IPC分类号： A61B5/05
CPC分类号： A61B5/14532 , A61B5/0031 , A61B5/1473 , A61B5/1477 , A61B5/14865
摘要： An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring.
摘要翻译：包含抗溶血剂或其前体的分析物传感器和稳定靠近传感器的工作电极定位的抗糖酵解剂的螯合剂。还提供了在分析物监测中使用电化学分析物传感器的系统和方法。

4. 发明授权

US08268143B2 Oxygen-effect free analyte sensor 有权
标题翻译：无氧效应的分析物传感器
公开(公告)号：US08268143B2
公开(公告)日：2012-09-18
申请号：US12172589
申请日：2008-07-14
申请人： Zenghe Liu , Tianmei Ouyang , Hyun Cho , Yohannes Goti , Benjamin J. Feldman , Fei Mao , Adam Heller
发明人： Zenghe Liu , Tianmei Ouyang , Hyun Cho , Yohannes Goti , Benjamin J. Feldman , Fei Mao , Adam Heller
IPC分类号： C12Q1/32
CPC分类号： A61B5/14532 , A61B5/002 , A61B5/14865 , A61B5/4839 , A61B2560/0223 , A61B2560/0252 , A61B2560/0276 , A61M5/1723 , A61M2205/3576 , A61M2205/3584 , A61M2205/505 , A61M2230/201 , C12Q1/004 , C12Q1/32
摘要： The present invention provides an electrochemical sensor having a sensing chemistry that operates substantially free of any “oxygen effect”. The electrochemical sensors are useful in determining the level of an analyte in a biological sample from a subject. The present invention also provides sensor assemblies including the electrochemical sensors as well as methods of using the same.
摘要翻译：本发明提供一种电化学传感器，其具有基本上没有任何“氧效应”的感测化学物质。电化学传感器可用于确定来自受试者的生物样品中分析物的水平。本发明还提供了包括电化学传感器的传感器组件及其使用方法。

5. 发明授权

US08515518B2 Analyte monitoring 有权
标题翻译：分析物监测
公开(公告)号：US08515518B2
公开(公告)日：2013-08-20
申请号：US11322165
申请日：2005-12-28
申请人： Tianmei Ouyang , Zenghe Liu , Hyun Cho , Benjamin J. Feldman
发明人： Tianmei Ouyang , Zenghe Liu , Hyun Cho , Benjamin J. Feldman
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/14865 , A61B5/0031 , A61B5/14532 , G06F19/00
摘要： Devices and methods for determining the concentration of an analyte are provided. Embodiments of the subject devices include analyte monitoring systems that include an analyte sensor capable of providing clinically accurate analyte data without a substantial time delay after operably positioning the sensor in a patient. Embodiments of the subject methods include operably positioning an analyte sensor in a patient and obtaining clinically accurate analyte data without a substantial time delay after the positioning. Also provided are systems and kits for use in analyte monitoring.
摘要翻译：提供了用于确定分析物浓度的装置和方法。本发明装置的实施方案包括分析物监测系统，其包括分析物传感器，其能够在将传感器可操作地定位在患者体内之后提供临床上准确的分析物数据而没有相当长的时间延迟。本发明方法的实施方案包括将分析物传感器可操作地定位在患者体内，并且在定位之后获得临床上准确的分析物数据而没有相当长的时间延迟。还提供了用于分析物监测的系统和试剂盒。

6. 发明授权

US08160670B2 Analyte monitoring: stabilizer for subcutaneous glucose sensor with incorporated antiglycolytic agent 有权
标题翻译：分析物监测：含有抗凝血酶的皮下葡萄糖传感器的稳定剂
公开(公告)号：US08160670B2
公开(公告)日：2012-04-17
申请号：US12167820
申请日：2008-07-03
申请人： Tianmei Ouyang , Zenghe Liu , Hyun Cho , Benjamin J. Feldman
发明人： Tianmei Ouyang , Zenghe Liu , Hyun Cho , Benjamin J. Feldman
IPC分类号： G01N27/26 , C12Q1/00 , A61B5/05
CPC分类号： A61B5/14532 , A61B5/0031 , A61B5/1473 , A61B5/1477 , A61B5/14865
摘要： An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring.
摘要翻译：包含抗溶血剂或其前体的分析物传感器和稳定靠近传感器的工作电极定位的抗糖酵解剂的螯合剂。还提供了在分析物监测中使用电化学分析物传感器的系统和方法。

7. 发明授权

US08792956B2 Analyte monitoring: stabilizer for subcutaneous glucose sensor with incorporated antiglycolytic agent 有权
标题翻译：分析物监测：含有抗凝血酶的皮下葡萄糖传感器的稳定剂
公开(公告)号：US08792956B2
公开(公告)日：2014-07-29
申请号：US13437681
申请日：2012-04-02
申请人： Tianmei Ouyang , Zenghe Liu , Hyun Cho , Benjamin J. Feldman
发明人： Tianmei Ouyang , Zenghe Liu , Hyun Cho , Benjamin J. Feldman
IPC分类号： A61B5/05 , A61B5/1473 , A61B5/145
CPC分类号： A61B5/14532 , A61B5/0031 , A61B5/1473 , A61B5/1477 , A61B5/14865
摘要： An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring.
摘要翻译：包含抗溶血剂或其前体的分析物传感器和稳定靠近传感器的工作电极定位的抗糖酵解剂的螯合剂。还提供了在分析物监测中使用电化学分析物传感器的系统和方法。

8. 发明申请

US20090099434A1 OXYGEN-EFFECT FREE ANALYTE SENSOR 有权
标题翻译：氧气效应免费分析仪传感器
公开(公告)号：US20090099434A1
公开(公告)日：2009-04-16
申请号：US12172589
申请日：2008-07-14
申请人： Zenghe Liu , Tianmei Ouyang , Hyun Cho , Yohannes Goti , Benjamin J. Feldman , Fei Mao , Adam Heller
发明人： Zenghe Liu , Tianmei Ouyang , Hyun Cho , Yohannes Goti , Benjamin J. Feldman , Fei Mao , Adam Heller
IPC分类号： A61B5/1473 , G01N27/26 , A61M37/00 , A61K38/28
CPC分类号： A61B5/14532 , A61B5/002 , A61B5/14865 , A61B5/4839 , A61B2560/0223 , A61B2560/0252 , A61B2560/0276 , A61M5/1723 , A61M2205/3576 , A61M2205/3584 , A61M2205/505 , A61M2230/201 , C12Q1/004 , C12Q1/32
摘要： The present invention provides an electrochemical sensor having a sensing chemistry that operates substantially free of any “oxygen effect”. The electrochemical sensors are useful in determining the level of an analyte in a biological sample from a subject. The present invention also provides sensor assemblies including the electrochemical sensors as well as methods of using the same.
摘要翻译：本发明提供一种电化学传感器，其具有基本上没有任何“氧效应”的感测化学物质。电化学传感器可用于确定来自受试者的生物样品中分析物的水平。本发明还提供了包括电化学传感器的传感器组件及其使用方法。

9. 发明授权

US09974472B2 Temperature-compensated analyte monitoring devices, systems, and methods thereof 有权
公开(公告)号：US09974472B2
公开(公告)日：2018-05-22
申请号：US13526394
申请日：2012-06-18
申请人： Gary A. Hayter , Daniel M. Bernstein , Martin J. Fennell , Michael R. Love , Kenneth J. Doniger , Songbiao Zhang , Mark K. Sloan , Hyun Cho , Theodore J. Kunich , Jean-Pierre Cole , Christopher A. Thomas , Erwin S. Budiman , David L. Li , Royce Cheng , Udo Hoss
发明人： Gary A. Hayter , Daniel M. Bernstein , Martin J. Fennell , Michael R. Love , Kenneth J. Doniger , Songbiao Zhang , Mark K. Sloan , Hyun Cho , Theodore J. Kunich , Jean-Pierre Cole , Christopher A. Thomas , Erwin S. Budiman , David L. Li , Royce Cheng , Udo Hoss
IPC分类号： A61B5/05 , A61B5/145 , A61B5/01 , A61B5/00 , A61B5/1473
CPC分类号： A61B5/14532 , A61B5/01 , A61B5/14503 , A61B5/1473 , A61B5/7225 , A61B2560/0252 , A61B2562/0271
摘要： Methods, devices and systems related providing accurate glucose levels in view of temperatures that may adversely affect glucose value.

10. 发明申请

US20090259118A1 Shallow Implantable Analyte Sensor with Rapid Physiological Response 审中-公开
标题翻译：具有快速生理反应的浅植入式分析物传感器
公开(公告)号：US20090259118A1
公开(公告)日：2009-10-15
申请号：US12416126
申请日：2009-03-31
申请人： Benjamin Jay Feldman , Udo Hoss , Hyun Cho
发明人： Benjamin Jay Feldman , Udo Hoss , Hyun Cho
IPC分类号： A61B5/1473
CPC分类号： A61B5/14865 , A61B5/002 , A61B5/14532 , A61B5/14546 , A61B5/1495 , A61B5/685 , A61B5/746 , A61B2560/0223 , A61B2560/0252 , A61B2562/0295
摘要： Methods and devices to detect analyte in body fluid are provided. Embodiments include analyte sensors designed so that at least a portion of the sensor is positionable beneath a skin surface in the dermal layer.
摘要翻译：提供了检测体液中分析物的方法和装置。实施例包括被设计成使得传感器的至少一部分可定位在真皮层中的皮肤表面下方的分析物传感器。

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