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    • 1. 发明授权
    • Organic compounds
    • 有机化合物
    • US3642992A
    • 1972-02-15
    • US3642992D
    • 1967-09-08
    • UPJOHN CO
    • BABCOCK JOHN CCAMPBELL J ALLAN
    • C07J1/00C07J75/00C07C169/08
    • C07J1/00C07J75/00Y10S435/843Y10S435/911
    • THIS INVENTION RELATES TO NOVEL 7 A-METHYL-17A-ALKYNYLESTRADIOLS AND PROCESSES FOR THEIR PREPARATION; MORE PARTICULARLY TO THOSE COMPOUNDS EMBRACED BY THE FORMULA II

      3-(R-O-),7-(CH3-),17-(R''-C*C-),17-(R"-O-)

      ESTRA-1,3,5(10)-TRIENE

      WHEREIN R IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, THE ACYL RADICAL OF A HYDROCARBON CARBOXYLIC ACID CONTAINING FROM ONE THROUGH TWELVE CARBON ATOMS, AN ALKYL RADICAL CONTAINING FROM ONE THROUGH EIGHT CARBON ATOMS, TETRAHYDROFURANYL, TETRAHYDROPYRANYL, 5-SUBSTITUTED TETRAHYDROPYRANYL AND A SILYL RADICAL OF THE FORMULA

      R1-SI(-R2)-R3

      WHEREIN R1 R2 AND R3 ARE SELECTED FROM THE GROUP CONSISTING OF ALKYL OF ONE THROUGH SIX CARBON ATOMS AND PHENYL, R'' IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND AN ALKYL RADICAL CONTAINING FROM ONE THROUGH FOUR CARBON ATOMS AND R" IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, THE ACYL RADICAL OF A HYDROCARBON CARBOXYLIC ACID CONTAINING FROM ONE THROUGH TWELVE CARBON ATOMS, AND A SILYL RADICAL OF THE FORMULA

      R1-SI(-R2)-R3

      WHEREIN R1, R2 AND R3 HAVE THE SAME MEANING AS ABOVE.