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1. 发明授权

US10406227B2 Photoactivated molecules for light-induced modulation of the activity of electrically excitable cells and methods of using same 有权
公开(公告)号：US10406227B2
公开(公告)日：2019-09-10
申请号：US14650208
申请日：2013-12-18
申请人： University of Southern California , California Institute of Technology
发明人： Robert H. Chow , Mark S. Humayun , Harry B. Gray , Robert H. Grubbs , Dennis A. Dougherty , Mark E. Thompson , Lionel E. Cheruzel , Melanie A. Yen
IPC分类号： A61K41/00 , C12N13/00 , A61N5/06 , A61B3/113
摘要： Methods and compositions modulate the activity of electrically excitable cells. Photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells. These supplement and/or replace of vision based on the conversion of light energy to electrical energy within certain cells of the visual system. A “patch” or bridge to circumvent one or more defective, damaged, or diseased cells in the visual system. Additionally, in several embodiments, subjects with normal vision can benefit from the methods, compositions, systems, and/or devices disclosed herein as normal visual acuity can be heightened. The exposure induces an energy (e.g., a receipt of light energy, conversion to electrical energy, and passage of that electrical energy) from the photovoltaic compound to the cell, thereby altering the transmembrane potential of the cell and/or the opening of one or more ion channels, thereby modulating the activity of the electrically excitable cell.

2. 发明授权

US10232043B2 Photoactivated molecules for light-induced modulation of the activity of electrically excitable cells and methods of using the same 有权
公开(公告)号：US10232043B2
公开(公告)日：2019-03-19
申请号：US15240997
申请日：2016-08-18
申请人： UNIVERSITY OF SOUTHERN CALIFORNIA , CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人： Melanie A. Yen , Dennis A. Dougherty , Robert H. Grubbs , Harry B. Gray , Robert H. Chow , Mark S. Humayun , Mark E. Thompson , Lionel E. Cheruzel
IPC分类号： C12N13/00 , A61K41/00 , A61N5/06 , A61F9/007
摘要： Disclosed herein are methods and compositions for the modulation of the activity of electrically excitable cells. In particular, several embodiments relate to the use of photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells.

3. 发明申请

US20170189530A1 PHOTOACTIVATED MOLECULES FOR LIGHT INDUCED MODULATION OF THE ACTIVITY OF ELECTRICALLY EXCITABLE CELLS AND METHODS OF USING THE SAME 审中-公开
公开(公告)号：US20170189530A1
公开(公告)日：2017-07-06
申请号：US15240997
申请日：2016-08-18
申请人： UNIVERSITY OF SOUTHERN CALIFORNIA , CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人： Melanie A. Yen , Dennis A. Dougherty , Robert H. Grubbs , Harry B. Gray , Robert H. Chow , Mark S. Humayun , Mark Thompson , Oliver Shafaat , Erin Lamb
IPC分类号： A61K41/00 , A61F9/007 , A61N5/06
CPC分类号： A61K41/0057 , A61F9/0079 , A61K41/00 , A61N5/062 , A61N5/0622 , A61N2005/0626 , A61N2005/0648
摘要： Disclosed herein are methods and compositions for the modulation of the activity of electrically excitable cells. In particular, several embodiments relate to the use of photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells.

4. 发明申请

US20150328313A1 PHOTOACTIVATED MOLECULES FOR LIGHT-INDUCED MODULATION OF THE ACTIVITY OF ELECTRICALLY EXCITABLE CELLS AND METHODS OF USING SAME 审中-公开
标题翻译：用于光诱导电活化细胞活性的光诱导分子及其使用方法
公开(公告)号：US20150328313A1
公开(公告)日：2015-11-19
申请号：US14650208
申请日：2013-12-18
申请人： UNIVERSITY OF SOUTHERN CALIFORNIA , CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人： Robert H. Chow , Mark S. Humayun , Harry B. Gray , Robert H. Grubbs , Dennis Dougherty , Mark Thompson , Oliver Shafaat , Erin Lamb
IPC分类号： A61K41/00 , C12N13/00
CPC分类号： A61K41/00 , A61B3/113 , A61K41/0023 , A61N5/062 , A61N2005/0648 , C12N13/00
摘要： Methods and compositions modulate the activity of electrically excitable cells. Photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells. These supplement and/or replace of vision based on the conversion of light energy to electrical energy within certain cells of the visual system. A “patch” or bridge to circumvent one or more defective, damaged, or diseased cells in the visual system. Additionally, in several embodiments, subjects with normal vision can benefit from the methods, compositions, systems, and/or devices disclosed herein as normal visual acuity can be heightened. The exposure induces an energy (e.g., a receipt of light energy, conversion to electrical energy, and passage of that electrical energy) from the photovoltaic compound to the cell, thereby altering the transmembrane potential of the cell and/or the opening of one or more ion channels, thereby modulating the activity of the electrically excitable cell.
摘要翻译：方法和组合物调节电可兴奋细胞的活性。在暴露于光能下，增加或减少细胞的电活动的光伏化合物。这些补充和/或替代视觉基于视觉系统的某些单元内的光能转换为电能。用于规避视觉系统中一个或多个缺陷，损坏或病变细胞的“补丁”或桥梁。另外，在几个实施例中，具有正常视力的受试者可以受益于本文公开的方法，组合物，系统和/或装置，因为可以提高正常视力。曝光引起能量（例如，光能的接收，电能的转换和电能的传递）从光伏化合物到细胞，从而改变细胞的跨膜电位和/或开放一个或更多的离子通道，从而调节电可激发细胞的活性。

5. 发明授权

US09580451B2 Sulfonic esters of metal oxides and methods of their use 有权
标题翻译：金属氧化物的磺酸酯及其使用方法
公开(公告)号：US09580451B2
公开(公告)日：2017-02-28
申请号：US14604917
申请日：2015-01-26
申请人： California Institute of Technology , Children's Hospital of Los Angeles
发明人： Carl M. Blumenfeld , Harry B. Gray , Robert H. Grubbs , Karn Sorasaenee
IPC分类号： C07F7/28 , C07D487/22 , C07F5/00 , C07F5/06 , A61K49/00
CPC分类号： C07F7/28 , A61K49/0021 , A61K49/0065 , A61K49/0067 , B01J2531/025 , C07D487/22 , C07F5/003 , C07F5/069
摘要： The present invention is directed to sulfonic esters of metal oxides including those of formulas I and II:
摘要翻译：本发明涉及包括式I和II的金属氧化物的磺酸酯：

6. 发明申请

US20150141640A1 Sulfonic Esters Of Metal Oxides And Methods Of Their Use 审中-公开
标题翻译：金属氧化物的磺酸酯及其使用方法
公开(公告)号：US20150141640A1
公开(公告)日：2015-05-21
申请号：US14604917
申请日：2015-01-26
申请人： California Institute of Technology , Children's Hospital Of Los Angeles
发明人： Carl M. Blumenfeld , Harry B. Gray , Robert H. Grubbs , Karn Sorasaenee
IPC分类号： C07F7/28
CPC分类号： C07F7/28 , A61K49/0021 , A61K49/0065 , A61K49/0067 , B01J2531/025 , C07D487/22 , C07F5/003 , C07F5/069
摘要： The present invention is directed to sulfonic esters of metal oxides including those of formulas I and II:
摘要翻译：本发明涉及包括式I和II的金属氧化物的磺酸酯：

7. 发明申请

US20130178360A1 NICKEL-BASED ELECTROCATALYTIC PHOTOELECTRODES 审中-公开
标题翻译：镍基电化学光电
公开(公告)号：US20130178360A1
公开(公告)日：2013-07-11
申请号：US13734088
申请日：2013-01-04
申请人： California Institute of Technology
发明人： Nathan S. Lewis , James R. McKone , Harry B. Gray
IPC分类号： H01M4/90 , H01M4/88
CPC分类号： H01M4/9091 , C01B3/42 , C10G45/08 , H01M4/8825 , H01M4/9041
摘要： The disclosure provides methods and compositions comprising metal alloy powders. The disclosure also provides a photoelectrode, methods of making and using, including systems for water-splitting are provided. The photoelectrode can be a semiconductive material having a photocatalyst such as nickel or nickel-molybdenum coated on the material.
摘要翻译：本公开提供了包含金属合金粉末的方法和组合物。本公开还提供了一种光电极，其制造和使用方法，包括用于水分解的系统。该光电极可以是具有涂覆在该材料上的诸如镍或镍 - 钼的光催化剂的半导体材料。

8. 发明授权

US11352705B2 Hydrocarbon oxidation by water oxidation electrocatalysts in non-aqueous solvents 有权
公开(公告)号：US11352705B2
公开(公告)日：2022-06-07
申请号：US15675065
申请日：2017-08-11
申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY
发明人： Bryan M. Hunter , Harry B. Gray
IPC分类号： C25B3/07 , C25B3/23 , C25B11/091 , C25B11/051 , C25B11/057
摘要： Processes and systems for oxidation of a hydrocarbon reactant to generate an oxidized hydrocarbon product may include: contacting a water oxidation electrocatalyst with the hydrocarbon reactant and water in the presence of a non-aqueous solvent; wherein an anodic bias is applied to the water oxidation electrocatalyst, thereby generating the oxidized hydrocarbon product; and wherein the water oxidation electrocatalyst comprises one or more transition metals other than Ru. Optionally, the water is provided in the non-aqueous solvent at a concentration less than or equal to 0.5 vol. %. Optionally, the magnitude of the anodic bias is selected to generate the oxidized hydrocarbon product characterized by selected product distribution.

9. 发明授权

US09243015B2 Metallocorroles 有权
标题翻译：金属堇
公开(公告)号：US09243015B2
公开(公告)日：2016-01-26
申请号：US14177064
申请日：2014-02-10
申请人： California Institute of Technology
发明人： Joshua H. Palmer , Zeev Gross , Harry B. Gray
IPC分类号： C07D487/22 , C07F15/00
CPC分类号： C07F15/0033 , C07F15/0053 , C07F15/0093
摘要： Metallocorrole complexes of third row transition metals (see Formula I below) may be used as therapeutic agents, catalysts, components of oxygen detectors, and components of light emitting diodes. In particular, metallocorrole complexes of third row transition metals may be used as improved photosenitizers in photodynamic therapy; as improved catalysts in aziridination, epoxidation, and water splitting reactions; as improved in vivo imaging agents; and as improved components in the emissive layer of OLEDs. Due to their strongly sigma-donating nature, corroles are able to stabilize third row transition metals in high oxidation states. Third row transition metals are significantly more electropositive than their first and second row counterparts and may therefore act as improved catalysts. In addition, the high spin-orbit coupling constants of third row transition metals may lead to easier singlet-triplet inter-system crossing in the excited state, which in turn may allow for long-wavelength phosphorescence that is desirable for many applications.
摘要翻译：可以使用第三排过渡金属的金属络合物（参见下面的式I）作为治疗剂，催化剂，氧检测器的组分和发光二极管的组分。特别地，第三排过渡金属的金属络合物可用作光动力疗法中的改进的光敏剂; 作为氮丙啶化，环氧化和水分解反应中改进的催化剂; 作为改进的体内成像剂; 并且作为OLED的发射层中的改进的组分。由于它们具有强烈的西格玛特性，因此腐蚀能够稳定高氧化态的第三排过渡金属。第三排过渡金属比其第一和第二排对应物显着更多的正电性，因此可以用作改进的催化剂。此外，第三行过渡金属的高自旋轨道耦合常数可能导致在激发态下更容易的单线 - 三线态跨系统交叉，这又可能允许对于许多应用是期望的长波长磷光。

10. 发明申请

US20140227187A1 Sulfonic Esters Of Metal Oxides And Methods Of Their Use 有权
标题翻译：金属氧化物的磺酸酯及其使用方法
公开(公告)号：US20140227187A1
公开(公告)日：2014-08-14
申请号：US14178592
申请日：2014-02-12
申请人： Children's Hospital Of Los Angeles , California Institute of Technology
发明人： Carl M. Blumenfeld , Harry B. Gray , Robert H. Grubbs , Karn Sorasaenee
IPC分类号： C07F7/28 , A61K49/00
CPC分类号： C07F7/28 , A61K49/0021 , A61K49/0065 , A61K49/0067 , B01J2531/025 , C07D487/22 , C07F5/003 , C07F5/069
摘要： The present invention is directed to sulfonic esters of metal oxides including those of formulas I and II:
摘要翻译：本发明涉及包括式I和II的金属氧化物的磺酸酯：

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