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1. 发明申请

US20160348175A1 A METHOD OF IDENTIFYING A NEONATE AT RISK OF HAVING OR DEVELOPING HYPOXIC-ISCHAEMIC ENCEPHALOPATHY (HIE) 审中-公开
标题翻译：鉴别患有或发展为高血压性心律失常（HIE）的风险的新生儿的方法
公开(公告)号：US20160348175A1
公开(公告)日：2016-12-01
申请号：US15112036
申请日：2015-01-16
申请人： UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
发明人： Deirdre Murray , Ann Marie Looney , Geraldine Boylan , John Cryan
IPC分类号： C12Q1/68 , A61F7/00
CPC分类号： C12Q1/6883 , A61F7/00 , C12Q2600/178
摘要： A method for screening a distressed neonate for risk of having or developing HIE comprises the steps of assaying a biological sample obtained from the distressed neonate, the mother of the neonate, or from the umbilical cord or placenta, for an abundance of miR-374a in the sample, and comparing the abundance of miR-374a in the sample with a reference abundance of miR-374a, wherein a reduced abundance of miR-374a in the sample compared with the reference abundance of miR-374a is indicative of the distressed neonate being at risk of having or developing HIE. Risk of severe HIE can be determined by assaying a biological sample from the distressed neonate identified as being at risk of HIE for an abundance of a plurality of metabolites including succinate, glycerol, acetone and 3-hydroxybutyrate, providing the sum of glycerol and succinate abundance and the sum of acetone and 3-hydroxybutyrate; and correlating the sums with risk of severe HIE.
摘要翻译：用于筛选患有或发展HIE风险的不良新生儿的方法包括以下步骤：测定从苦闷的新生儿，新生儿的母亲或从脐带或胎盘获得的生物样品，以获得丰富的miR-374a 样品，并将样品中miR-374a的丰度与miR-374a的参考丰度进行比较，其中与miR-374a的参考丰度相比，样品中miR-374a的丰度降低，表示不良新生儿为有发生或发展HIE的风险。严重HIE的风险可以通过测定来自被认定为具有HIE风险的危重新生儿的生物样品来确定大量多种代谢物，包括琥珀酸盐，甘油，丙酮和3-羟基丁酸盐，提供甘油和琥珀酸盐丰度的总和丙酮和3-羟基丁酸的总和; 并将这些总和与严重HIE的风险相关联。

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