专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20180044416A1 Polymeric Fc proteins and methods of screening to alter their functional characteristics 审中-公开
公开(公告)号：US20180044416A1
公开(公告)日：2018-02-15
申请号：US15554478
申请日：2016-03-04
申请人： UCB Biopharma SPRL
发明人： David Paul Humphreys , Shirley Jane Peters
IPC分类号： C07K16/28 , G01N33/53 , G01N33/68
CPC分类号： C07K16/283 , A61K2039/505 , A61K2039/507 , C07K16/00 , C07K16/2848 , C07K2317/35 , C07K2317/41 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/60 , C07K2317/70 , C07K2317/71 , C07K2317/92 , C07K2319/00 , C07K2319/02 , C07K2319/30 , C07K2319/74 , G01N33/53 , G01N33/6866 , G01N2333/57 , G01N2333/70535
摘要： The invention relates to polymeric Fc proteins which bind to human Fc-receptors and methods of screening said polymeric Fc proteins to alter their functional characteristics. The invention also relates to therapeutic compositions comprising the polymeric Fc proteins, and their use in the treatment of immune disorders.

2. 发明授权

US11059911B2 Sequence symmetric modified IgG4 bispecific antibodies 有权
公开(公告)号：US11059911B2
公开(公告)日：2021-07-13
申请号：US16242378
申请日：2019-01-08
申请人： UCB Biopharma SPRL
发明人： David Paul Humphreys , Shirley Jane Peters
IPC分类号： C07K16/46 , C07K16/00
摘要： The present disclosure relates to a symmetric bispecific antibody of the class IgG4 comprising two heavy chains which each comprise a variable domain, CH1 domain and a hinge region, wherein in each heavy chain:
the cysteine in the CH1 domain which forms an inter-chain disulphide bond with a cysteine in a light chain is substituted with another amino acid; and
optionally one or more of the amino acids positioned in the upper hinge region is substituted with cysteine, wherein the constant region sequence of each heavy chain is similar or identical and the variable region in each heavy chain is different, formulations comprising the same, the use of each of the above in treatment and processes for preparing said antibodies and formulations.

3. 发明申请

US20200377578A1 NEUTRALISING ANTIBODIES TO THE MAJOR EXOTOXINS TCDA AND TCDB OF CLOSTRIDIUM DIFFICILE 审中-公开
公开(公告)号：US20200377578A1
公开(公告)日：2020-12-03
申请号：US16919576
申请日：2020-07-02
申请人： UCB Biopharma SPRL
发明人： David Paul Humphreys , Daniel John Lightwood , Kerry Louise Tyson , David Edward Ormonde Knight , Karine Jeannine Madeleine Hervé , Joanne Elizabeth Compson , Matthew Jon Timothy Page , Andrew Charles Payne , Nicola Louise Fisher , Brendon MacKenzie , Matthew Cox
IPC分类号： C07K16/12 , A61K39/40 , A61K45/06 , G01N33/569 , G01N33/573 , G01N33/68
摘要： This present invention describes the derivation and selection of antibodies capable of neutralising the major exotoxins; TcdA and TcdB of Clostridium difficile. The invention also describes novel neutralisation and antigen binding properties of individual Mabs and mixtures thereof.

4. 发明授权

US10457748B2 Single linker FabFv antibodies and methods of producing same 有权
公开(公告)号：US10457748B2
公开(公告)日：2019-10-29
申请号：US14654240
申请日：2013-12-20
申请人： UCB Biopharma SPRL
发明人： Emma Dave , Sam Philip Heywood , David Paul Humphreys
IPC分类号： C07K16/18 , C07K16/46 , C07K16/28
摘要： The present disclosure relates to a multi-specific antibody molecule comprising or consisting of three polypeptides: a) a polypeptide chain of formula (I): (Vxx)nVx-Cx-X-V1; and b) a polypeptide chain of formula (II): (Vyy)nVy-Cy c) a polypeptide of formula (III): V2 wherein Vx represents a variable domain, Vxx represents a variable domain, Cx represents a constant region, X represents a linker, V represents a variable domain, Vy represents a variable domain, Vyy represents a variable domain, Cy represents a constant region, V2 represents a variable domain, n independently represents 0 or 1, wherein the polypeptide chain of formula (I) and the polypeptide chain of formula (II) is aligned such that the constant regions Cx and Cy are paired and the variable domains Vx and Vy are paired to form a binding domain and optionally a disulphide bond is present between V and V2, in particular where a disulphide bond is present. The disclosure also extends to pharmaceutical formulation comprising the construct, DNA encoding the constructs and vectors comprising same. The disclosure further extends to a method of expressing the constructs, for example in a host cell and methods for formulating same as a pharmaceutical composition. The disclosure also relates to use of the constructs and formulations in treatment.

5. 发明授权

US10221251B2 Sequence symmetric modified IGG4 bispecific antibodies 有权
公开(公告)号：US10221251B2
公开(公告)日：2019-03-05
申请号：US14380309
申请日：2013-02-22
申请人： UCB Biopharma SPRL
发明人： David Paul Humphreys , Shirley Jane Peters
IPC分类号： C07K16/00 , C07K16/46
摘要： The present disclosure relates to a symmetric bispecific antibody of the class IgG4 comprising two heavy chains which each comprise a variable domain, CH1 domain and a hinge region, wherein in each heavy chain: the cysteine in the CH1 domain which forms an inter-chain disulphide bond with a cysteine in a light chain is substituted with another amino acid; and optionally one or more of the amino acids positioned in the upper hinge region is substituted with cysteine, wherein the constant region sequence of each heavy chain is similar or identical and the variable region in each heavy chain is different, formulations comprising the same, the use of each of the above in treatment and processes for preparing said antibodies and formulations.

6. 发明申请

US20160017057A1 Single Linker FabFv Antibodies and Methods of Producing Same 审中-公开
标题翻译：单链接FabFv抗体及其生产方法
公开(公告)号：US20160017057A1
公开(公告)日：2016-01-21
申请号：US14654240
申请日：2013-12-20
申请人： UCB BIOPHARMA SPRL
发明人： Emma Dave , Sam Philip Heywood , David Paul Humphreys
IPC分类号： C07K16/46
CPC分类号： C07K16/468 , C07K16/18 , C07K16/2878 , C07K2317/55 , C07K2317/56 , C07K2317/624 , C07K2317/64 , C07K2317/92 , C07K2319/00
摘要： The present disclosure relates to a multi-specific antibody molecule comprising or consisting of three polypeptides: a) a polypeptide chain of formula (I): (Vxx)nVx-Cx-X—V1; and b) a polypeptide chain of formula (II): (Vyy)nVy-Cy c) a polypeptide of formula (III):V2 wherein Vx represents a variable domain, Vxx represents a variable domain, Cx represents a constant region, X represents a linker, V represents a variable domain, Vy represents a variable domain, Vyy represents a variable domain, Cy represents a constant region, V2 represents a variable domain, n independently represents 0 or 1, wherein the polypeptide chain of formula (I) and the polypeptide chain of formula (II) is aligned such that the constant regions Cx and Cy are paired and the variable domains Vx and Vy are paired to form a binding domain and optionally a disulphide bond is present between V and V2, in particular where a disulphide bond is present. The disclosure also extends to pharmaceutical formulation comprising the construct, DNA encoding the constructs and vectors comprising same. The disclosure further extends to a method of expressing the constructs, for example in a host cell and methods for formulating same as a pharmaceutical composition. The disclosure also relates to use of the constructs and formulations in treatment.
摘要翻译：本公开涉及包含三种多肽或由以下三种多肽组成的多特异性抗体分子：a）式（I）的多肽链：（Vxx）nVx-Cx-X-V1; b）式（II）的多肽链：（Vyy）nVy-Cy c）式（III）的多肽：V2其中Vx表示可变结构域，Vxx表示可变结构域，Cx表示恒定区，X表示接头，V表示可变结构域，Vy表示可变结构域，Vyy表示可变结构域，Cy表示恒定区，V2表示可变结构域，n独立地表示0或1，其中式（I）的多肽链和排列式（II）的多肽链使得恒定区Cx和Cy配对，并且可变结构域Vx和Vy配对形成结合结构域，并且任选地在V和V 2之间存在二硫键，特别是其中存在二硫键。本公开还延伸到包含构建体的药物制剂，编码构建体的DNA和包含其的载体。本公开进一步扩展到表达构建体的方法，例如在宿主细胞中的方法以及用于配制药物组合物的方法。本公开还涉及在治疗中使用构建体和制剂。

7. 发明申请

US20200055959A1 Single Linker FabFv Antibodies and Methods of Producing Same 审中-公开
公开(公告)号：US20200055959A1
公开(公告)日：2020-02-20
申请号：US16573893
申请日：2019-09-17
申请人： UCB Biopharma SPRL
发明人： Emma Dave , Sam Philip Heywood , David Paul Humphreys
IPC分类号： C07K16/46 , C07K16/18 , C07K16/28
摘要： The present disclosure relates to a multi-specific antibody molecule comprising or consisting of three polypeptides: a) a polypeptide chain of formula (I):(Vxx)nVx-Cx-X-V1; and b) a polypeptide chain of formula (II): (Vyy)nVy-Cy c) a polypeptide of formula (III):V2 wherein Vx represents a variable domain, Vxx represents a variable domain, Cx represents a constant region, X represents a linker, V represents a variable domain, Vy represents a variable domain, Vyy represents a variable domain, Cy represents a constant region, V2 represents a variable domain, nindependently represents 0 or 1, wherein the polypeptide chain of formula (I) and the polypeptide chain of formula (II) is aligned such that the constant regions Cx and Cy are paired and the variable domains Vx and Vy are paired to form a binding domain and optionally a disulphide bond is present between V1 and V2, in particular where a disulphide bond is present. The disclosure also extends to pharmaceutical formulation comprising the construct, DNA encoding the constructs and vectors comprising same. The disclosure further extends to a method of expressing the constructs, for example in a host cell and methods for formulating same as a pharmaceutical composition. The disclosure also relates to use of the constructs and formulations in treatment.

8. 发明授权

US09873735B2 Method of treatment with antibodies having specificity for human OX40 有权
公开(公告)号：US09873735B2
公开(公告)日：2018-01-23
申请号：US14697142
申请日：2015-04-27
申请人： UCB Biopharma SPRL
发明人： Ralph Adams , Pallavi Bhatta , Sam Philip Heywood , David Paul Humphreys
IPC分类号： A61K39/395 , C07K16/18 , C07K16/28 , A61K39/00
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , C07K16/2866 , C07K16/2878 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2317/624 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

9. 发明申请

US20160031974A1 ANTIBODY MOLECULES HAVING SPECIFICITY FOR HUMAN 0X40 有权
标题翻译：具有人类0X40特异性的抗体分子
公开(公告)号：US20160031974A1
公开(公告)日：2016-02-04
申请号：US14697142
申请日：2015-04-27
申请人： UCB Biopharma SPRL
发明人： Ralph Adams , Pallavi Bhatta , Sam Philip Heywood , David Paul Humphreys
IPC分类号： C07K16/18 , A61K39/395 , C07K16/28
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , C07K16/2866 , C07K16/2878 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2317/624 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
摘要翻译：本发明涉及对人OX40的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途以及产生所述抗体分子的方法。

10. 发明授权

US11352414B2 Multimeric Fc proteins 有权
公开(公告)号：US11352414B2
公开(公告)日：2022-06-07
申请号：US15123038
申请日：2015-03-05
申请人： UCB BIOPHARMA SPRL
发明人： Farnaz Fallah-Arani , Robert Anthony Griffin , David Paul Humphreys , Shirley Jane Peters , Bryan John Smith , Paul Edward Stephens
IPC分类号： C07K1/00 , A61K39/00 , C07K16/00 , C07K16/46 , C12N15/62 , C12P21/02
摘要： The invention relates to multimeric fusion proteins which bind to human Fc receptors. The invention also relates to therapeutic compositions comprising the proteins, and their use in the treatment of immune disorders.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式