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1. 发明申请

US20150192604A1 HOLDER FOR PROBE MICROSCOPE, PROBE MICROSCOPE AND SPECIMEN MEASUREMENT METHOD 审中-公开
标题翻译：探针显微镜，探针显微镜和样本测量方法
公开(公告)号：US20150192604A1
公开(公告)日：2015-07-09
申请号：US14417407
申请日：2012-07-27
申请人： Tsuyoshi Yamamoto , Seiji Heike , Akira Nambu , Tomihiro Hashizume , Hideaki Koizumi
发明人： Tsuyoshi Yamamoto , Seiji Heike , Akira Nambu , Tomihiro Hashizume , Hideaki Koizumi
IPC分类号： G01Q30/20 , G01Q60/24
CPC分类号： G01Q30/20 , G01Q30/02 , G01Q30/10 , G01Q30/14 , G01Q60/24
摘要： At the time of carrying out measurement of a biological tissue with a probe microscope, measurement is to be realized while maintain survival conditions for a cell.As a holder for the probe microscope, a measurement holder including: a container in which a measurement object is housed; a first cover section which covers at least a part of the measurement object and has an aperture for inserting a measurement probe; and a second cover section which is connected to the first cover section, covers the container, and has an aperture for inserting the measurement probe, is used.
摘要翻译：在用探针显微镜进行生物体组织的测定时，要保持细胞的生存条件，进行测定。作为探针显微镜的保持器，测量保持器包括：容纳测量对象的容器; 第一覆盖部分，其覆盖所述测量对象的至少一部分并且具有用于插入测量探针的孔; 并且连接到第一盖部分的第二盖部分覆盖容器，并且具有用于插入测量探针的孔。

2. 发明授权

US09423416B2 Scanning probe microscope and measuring method using same 有权
标题翻译：扫描探针显微镜及其测量方法
公开(公告)号：US09423416B2
公开(公告)日：2016-08-23
申请号：US14416968
申请日：2012-08-28
申请人： Akira Nambu , Tsuyoshi Yamamoto , Hideaki Koizumi , Tomihiro Hashizume , Seiji Heike
发明人： Akira Nambu , Tsuyoshi Yamamoto , Hideaki Koizumi , Tomihiro Hashizume , Seiji Heike
IPC分类号： G01Q10/04 , G01Q30/02 , G01Q30/14 , G01Q60/22
CPC分类号： G01Q10/04 , G01Q30/02 , G01Q30/14 , G01Q60/22
摘要： Provided is a scanning probe microscope that takes measurements at high spatial resolution on physical information such as array structure of water molecules at a specimen-culture fluid interface in a culture fluid as well as irregularities of the surface of a specimen and composition distribution and array structure of molecules, proteins, etc. even in the atmosphere, an ambient air, vacuum, among others. The scanning probe microscope includes: a probing needle (1); a specimen holder (11) in which a specimen (3) is mounted; an oscillator (2) that produces a periodic oscillation to change the probing needle position; a pulse oscillation type laser light source (27, 28) that emits light toward a spot, which is put under measurement by the probing needle, on the specimen; a detector (25) that measures intensity of output light which is output from the specimen by energy spectroscopy; and a control device (26). The control device decreases amplitude of the periodic oscillation to change the probing needle position by the oscillator, shortens a relative distance between the probing needle and the specimen, and synchronizes shortening of the distance between the probing needle and the specimen and emission of pulse oscillation laser light, thus optimizing efficiency of tip-enhanced detection.
摘要翻译：提供了一种扫描探针显微镜，其以高空间分辨率对物理信息进行测量，例如在培养液中的标本培养液界面处的水分子的阵列结构以及样品表面的不规则性以及组成分布和阵列结构的分子，蛋白质等，甚至在大气中，环境空气，真空等。扫描探针显微镜包括：探针（1）; 其中安装有试样（3）的试样保持器（11）振荡器（2），其产生周期性振荡以改变探针位置; 对被检测体进行测量的点发光的脉冲振荡型激光光源（27,28）; 检测器（25），其通过能量谱测量从所述样本输出的输出光的强度; 和控制装置（26）。控制装置减小周期性振荡的振幅，通过振荡器改变探针位置，缩短探针与试样之间的相对距离，同步缩短探针与试样之间的距离，并发出脉冲振荡激光轻，从而优化提示增强检测的效率。

3. 发明申请

US20150177275A1 SCANNING PROBE MICROSCOPE AND MEASURING METHOD USING SAME 有权
标题翻译：扫描探针显微镜和使用它的测量方法
公开(公告)号：US20150177275A1
公开(公告)日：2015-06-25
申请号：US14416968
申请日：2012-08-28
申请人： Akira Nambu , Tsuyoshi Yamamoto , Hideaki Koizumi , Tomihiro Hashizume , Seiji Heike
发明人： Akira Nambu , Tsuyoshi Yamamoto , Hideaki Koizumi , Tomihiro Hashizume , Seiji Heike
IPC分类号： G01Q10/04
CPC分类号： G01Q10/04 , G01Q30/02 , G01Q30/14 , G01Q60/22
摘要： Provided is a scanning probe microscope that takes measurements at high spatial resolution on physical information such as array structure of water molecules at a specimen-culture fluid interface in a culture fluid as well as irregularities of the surface of a specimen and composition distribution and array structure of molecules, proteins, etc. even in the atmosphere, an ambient air, vacuum, among others. The scanning probe microscope includes: a probing needle (1); a specimen holder (11) in which a specimen (3) is mounted; an oscillator (2) that produces a periodic oscillation to change the probing needle position; a pulse oscillation type laser light source (27, 28) that emits light toward a spot, which is put under measurement by the probing needle, on the specimen; a detector (25) that measures intensity of output light which is output from the specimen by energy spectroscopy; and a control device (26). The control device decreases amplitude of the periodic oscillation to change the probing needle position by the oscillator, shortens a relative distance between the probing needle and the specimen, and synchronizes shortening of the distance between the probing needle and the specimen and emission of pulse oscillation laser light, thus optimizing efficiency of tip-enhanced detection.
摘要翻译：提供了一种扫描探针显微镜，其以高空间分辨率对物理信息进行测量，例如在培养液中的标本培养液界面处的水分子的阵列结构以及样品表面的不规则性以及组成分布和阵列结构的分子，蛋白质等，甚至在大气中，环境空气，真空等。扫描探针显微镜包括：探针（1）; 其中安装有试样（3）的试样保持器（11）振荡器（2），其产生周期性振荡以改变探针位置; 对被检测体进行测量的点发光的脉冲振荡型激光光源（27,28）; 检测器（25），其通过能量谱测量从所述样本输出的输出光的强度; 和控制装置（26）。控制装置减小周期性振荡的振幅，通过振荡器改变探针位置，缩短探针与试样之间的相对距离，同步缩短探针与试样之间的距离，并发出脉冲振荡激光轻，从而优化提示增强检测的效率。

4. 发明授权

US06947779B2 Optical measurement device 失效
标题翻译：光学测量装置
公开(公告)号：US06947779B2
公开(公告)日：2005-09-20
申请号：US09873206
申请日：2001-06-05
申请人： Tsuyoshi Yamamoto , Atsushi Maki , Hideaki Koizumi
发明人： Tsuyoshi Yamamoto , Atsushi Maki , Hideaki Koizumi
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1455 , A61B10/00 , G01N21/17 , G01N21/31
CPC分类号： A61B5/7475 , A61B5/1455
摘要： Optical measurement that is optimum for improving spatial resolution is accomplished by making it possible to estimate a physical quantity of an object substance to be measured at any point on a subject. When any position to be evaluated, in an image shown in a window 1-1, is pointed and selected a mouse pointer 1-4, the value of the concentration or its change of the object substance at the point is displayed in the display area 1-7 of a window 1-3. The drawings represents an example in which one position is specified and there are two object substances to be measured. The value of the concentration or its change of each object substance to be measured is separately displayed.
摘要翻译：通过使得可以在对象的任何点估计待测物体的物理量来实现对于改善空间分辨率最佳的光学测量。当要评估的任何位置在窗口1至1所示的图像中被指向并选择了鼠标指针1-4时，该点处的物体的浓度值或其变化的值被显示在显示区域中 1 - 7的窗口1 - 3。附图表示其中指定了一个位置并且存在两个待测物体的示例。分别显示要测量的每种物质的浓度值或其变化值。

5. 发明授权

US06657183B2 Amusement system using living body measurement by light, head setter for the amusement system, and program for use in the amusement system 有权
标题翻译：娱乐系统使用活体测量的乐器，娱乐系统的头枕，以及娱乐系统中使用的节目
公开(公告)号：US06657183B2
公开(公告)日：2003-12-02
申请号：US09939601
申请日：2001-08-28
申请人： Tsuyoshi Yamamoto , Kosuke Ohashi , Hironari Nakata , Atsushi Maki , Hideaki Koizumi , Mitsuru Oonuma
发明人： Tsuyoshi Yamamoto , Kosuke Ohashi , Hironari Nakata , Atsushi Maki , Hideaki Koizumi , Mitsuru Oonuma
IPC分类号： H01J4014
CPC分类号： A63F13/212 , A63F13/10 , A63F13/213 , A63F2300/1012 , A63F2300/807
摘要： Disclosed herein is an amusement system that can be used and enjoyed by different persons without using the brain continuously and with little feeling of fatigue and which permits setting a probe at any spot on the head of the subject. The amusement system includes irradiators for irradiating the subject with light, light detectors for detection of the light that has been emitted from said irradiator and which has propagated through the living body, signal processors for processing the signal of light intensity detected by said detector and display units that show the processing results from the signal processor. The range of display of a change in intensity of said transmitted light according to the results of a test task carried out on said living body.
摘要翻译：本文公开了一种娱乐系统，其可以由不同的人使用和享用，而不用连续地使用大脑并且几乎没有疲劳的感觉，并且允许在受试者头部的任何位置设置探针。娱乐系统包括用于用光照射对象的照射器，用于检测已经从所述照射器发射并已经通过生物体传播的光的光检测器，用于处理由所述检测器检测的光强度的信号的信号处理器和显示器显示信号处理器处理结果的单位。根据在所述活体上进行的测试任务的结果，显示所述透射光的强度变化的范围。

6. 发明授权

US06895269B2 Device for controlling equipment by using signals from a living body 失效
标题翻译：通过使用生物体信号控制设备的装置
公开(公告)号：US06895269B2
公开(公告)日：2005-05-17
申请号：US09987334
申请日：2001-11-14
申请人： Yoshitoshi Ito , Hideaki Koizumi , Atsushi Maki , Yuichi Yamashita , Tsuyoshi Yamamoto
发明人： Yoshitoshi Ito , Hideaki Koizumi , Atsushi Maki , Yuichi Yamashita , Tsuyoshi Yamamoto
IPC分类号： G06F3/00 , G06F3/01 , A61B6/00
CPC分类号： G06F3/015
摘要： A device for controlling equipment includes at least one light projector adapted to project light onto a head of a living body. A light collecting section for collecting the light having passed through the head, a light measuring section for measuring an intensity of the light collected by the light collecting section, a memory section for storing a previous history of changes of the intensity of the light measured, a signal judging section for judging if both the intensity of the light measured by said light measuring section and the previous history of changes of the intensity of the light satisfy a predetermined condition, a displaying section for displaying the intensity of the light measured and a result obtained by the signal judging section, and a control signal generating section for generating a control signal for external equipment.
摘要翻译：一种用于控制设备的设备包括至少一个适于将光投射到生物体的头部上的投影仪。用于收集通过头部的光的聚光部分，用于测量由聚光部分收集的光的强度的光测量部分，用于存储测量的光的强度变化的先前历史的存储部分，信号判断部分，用于判断由所述光测量部分测量的光的强度和光的强度变化的先前历史是否都满足预定条件;显示部分，用于显示所测量的光的强度和结果由信号判定部获得的控制信号生成部，生成外部设备的控制信号。

7. 发明授权

US07359825B2 Optical measurement instrument and optical measurement method 有权
标题翻译：光学测量仪器和光学测量方法
公开(公告)号：US07359825B2
公开(公告)日：2008-04-15
申请号：US11378448
申请日：2006-03-20
申请人： Atsushi Maki , Yuuichi Yamashita , Tsuyoshi Yamamoto , Hideaki Koizumi
发明人： Atsushi Maki , Yuuichi Yamashita , Tsuyoshi Yamamoto , Hideaki Koizumi
IPC分类号： G01C17/00
CPC分类号： G01N21/49 , A61B5/0042 , A61B5/14553 , A61B5/7435
摘要： In order to provide an optical measurement system and an optical measurement method which is suitable for optically measuring a body to be inspected and easily obtaining an image of a desired item based on information obtained by the measurement, an optical measurement method including an initial display process for selectively instructing any one of selection of optical measurement, analysis of said optical measurement result and completion of a program; a process for inputting items of condition including a measurement mode; a process for displaying a light irradiation position and a light detection position and a state expressing measurement position relationship together with said mode; a process for instructing to form a file for storing said optical measurement result; a process for instructing a measurement condition to detect light signals from the inside of a body to be inspected which is irradiated by a multi-wavelength multi-channel; and a process for displaying said signals for each channel detected according to said instructed result.
摘要翻译：为了提供一种光学测量系统和光学测量方法，该光学测量系统和光学测量方法适合于光学测量待检查的物体，并且基于通过测量获得的信息容易地获得期望项目的图像，包括初始显示处理用于选择性地指示光学测量的选择，所述光学测量结果的分析和程序的完成中的任何一个; 用于输入包括测量模式的条件项目的处理; 用于显示光照射位置和光检测位置以及表示测量位置关系的状态与所述模式的过程; 用于指示形成用于存储所述光学测量结果的文件的处理; 用于指示测量条件从多波长多通道照射的被检体的内部检测光信号的处理; 以及用于显示根据所述指示结果检测的每个通道的所述信号的处理。

8. 发明授权

US07072700B2 Biological photometric device 失效
公开(公告)号：US07072700B2
公开(公告)日：2006-07-04
申请号：US10148991
申请日：2000-11-29
申请人： Tsuyoshi Yamamoto , Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Michiyuki Fujiwara , Mikihiro Kaga
发明人： Tsuyoshi Yamamoto , Atsushi Maki , Hideaki Koizumi , Fumio Kawaguchi , Michiyuki Fujiwara , Mikihiro Kaga
IPC分类号： A61B5/00
CPC分类号： A61B5/14546 , A61B5/0059 , A61B5/0261 , A61B5/14553 , A61B2562/0233 , A61B2562/046
摘要： The invention provides a biological photometric device characterized by a method of disposing a light source and a light detector, capable of measuring a distribution of concentrations at different depths and changes in the concentration in the case of measuring and forming an image of the concentration of metabolites in an organ and changes in the concentration. The light sources and light detectors are disposed on the subject so that, in the case of measuring a concentration of metabolites in an organ and changes in the concentration in a shallow portion in the subject by using an about midpoint position between each of the light sources and each of the light detectors as a sampling point, measurement is performed by using a sampling point of a pair of the light source and said light detector which are disposed at a small interval. In the case of measurement in a deep portion in the subject, a sampling point of a pair of the light source and the light detector which are disposed at a large interval is used.

9. 发明授权

US07047149B1 Optical measurement instrument and optical measurement method 失效
标题翻译：光学测量仪器和光学测量方法
公开(公告)号：US07047149B1
公开(公告)日：2006-05-16
申请号：US09674008
申请日：1999-04-26
申请人： Atsushi Maki , Yuuichi Yamashita , Tsuyoshi Yamamoto , Hideaki Koizumi
发明人： Atsushi Maki , Yuuichi Yamashita , Tsuyoshi Yamamoto , Hideaki Koizumi
IPC分类号： G01C17/00
CPC分类号： G01N21/49 , A61B5/0042 , A61B5/14553 , A61B5/7435
摘要： An optical measurement system for optically measuring a body to be inspected and obtaining an image of a desired item based on information obtained by the measurement includes means for displaying a number of measurement points, means for indicating a light irradiation position and a light detecting position and means for displaying a measurement position and a state of allocating a number to the measurement position. The system further includes means for displaying measuring time sequence data, means for setting a condition of acquiring data, means for displaying a status of acquiring the data, means for instructing control of measurement and means for marking a mark at a position measuring time sequence data.
摘要翻译：一种光学测量系统，用于光学测量待检查的物体，并且基于通过测量获得的信息获得期望项目的图像，包括显示多个测量点的装置，用于指示光照射位置和光检测位置的装置，以及用于显示测量位置和向测量位置分配数字的状态的装置。该系统还包括用于显示测量时间序列数据的装置，用于设置获取数据的条件的装置，用于显示获取数据的状态的装置，用于指示测量的控制的装置和用于在测量时间序列数据的位置处标记标记的装置。

10. 发明授权

US06901284B1 Optical measuring instrument 失效
标题翻译：光学测量仪器
公开(公告)号：US06901284B1
公开(公告)日：2005-05-31
申请号：US09913323
申请日：2000-02-18
申请人： Atsushi Maki , Tsuyoshi Yamamoto , Hideaki Koizumi , Yuichi Yamashita
发明人： Atsushi Maki , Tsuyoshi Yamamoto , Hideaki Koizumi , Yuichi Yamashita
IPC分类号： A61B10/00 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B6/00 , G01N21/17
CPC分类号： A61B5/14553 , A61B5/0042 , A61B5/7445 , A61B2562/0233 , A61B2562/046
摘要： An optical measuring apparatus for optically measuring a sample includes a plurality of parts for applying light beams to the sample, a plurality of detecting parts for detecting light beams from the light applying parts which come through the sample, a memory part which receives signals from the detecting parts, converts them into digital signals and stores the digital signals as measuring positions between the light applying part and the light detecting part. Further, there is provided a first display part which shows a relationship between positions on the sample and measuring positions corresponding to the positions of the detecting parts on the sample, and a second display part which shows a relationship between positions on the sample and measuring positions corresponding to the positions of the detecting parts which are shown on the first display part.
摘要翻译：用于光学测量样品的光学测量装置包括用于向样品施加光束的多个部件，用于检测来自样品的光施加部分的光束的多个检测部分，检测部件将它们转换为数字信号，并将数字信号存储在光施加部分和光检测部分之间的测量位置。此外，提供了示出样品上的位置与样品上检测部位的位置对应的测量位置之间的关系的第一显示部分和示出样品和测量位置之间的关系的第二显示部分对应于在第一显示部分上示出的检测部件的位置。

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