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1. 发明授权

US07171250B2 Living body light measurement system and signal processing method 失效
标题翻译：生活体光测量系统及信号处理方法
公开(公告)号：US07171250B2
公开(公告)日：2007-01-30
申请号：US11010668
申请日：2004-12-14
申请人： Tsuyoshi Yamamoto , Atsushi Maki , Takusige Katura , Hideo Kawaguchi
发明人： Tsuyoshi Yamamoto , Atsushi Maki , Takusige Katura , Hideo Kawaguchi
IPC分类号： A61B5/00
CPC分类号： A61B5/14553 , A61B5/0042 , A61B2562/0233 , A61B2562/046
摘要： An image generating methodology for displaying brain activation areas with improved accuracy in a living body light measurement system for generating an image of the changes in blood volume of the brain. A spatial intensity distribution of changes in blood volume can be generated by detecting brain activation in many sampling points, and a spatial interpolation process is executed on this data. A threshold process is executed on the distribution to extract the distribution of coordinates having a signal intensity of at least the predetermined threshold. The displacement between the brain activation area and the maximal location of the distribution is stored in a recording unit of the system in order to compensate for the distribution extracted by the threshold process. Accordingly, brain activation areas can be estimated with greater location accuracy, and the diagnosis and medial treatment for brain diseases can likewise be executed with greater accuracy.
摘要翻译：一种用于在生物体光测量系统中显示脑激活区域以提高准确度的图像产生方法，用于产生脑的血容量变化的图像。通过检测许多采样点的大脑激活可以产生血容量变化的空间强度分布，并对该数据执行空间插值处理。对分布执行阈值处理以提取具有至少预定阈值的信号强度的坐标分布。大脑激活区域和分布的最大位置之间的位移被存储在系统的记录单元中，以便补偿由阈值处理提取的分布。因此，可以以更高的定位精度估计脑激活区域，并且同样可以更准确地执行脑疾病的诊断和内侧治疗。

2. 发明申请

US20050192490A1 Living body light measurement system and signal processing method 失效
标题翻译：生活体光测量系统及信号处理方法
公开(公告)号：US20050192490A1
公开(公告)日：2005-09-01
申请号：US11010668
申请日：2004-12-14
申请人： Tsuyoshi Yamamoto , Atsushi Maki , Takusige Katura , Hideo Kawaguchi
发明人： Tsuyoshi Yamamoto , Atsushi Maki , Takusige Katura , Hideo Kawaguchi
IPC分类号： G01N21/17 , A61B5/00 , A61B10/00
CPC分类号： A61B5/14553 , A61B5/0042 , A61B2562/0233 , A61B2562/046
摘要： An image generating methodology for displaying brain activation areas with improved accuracy in a living body light measurement system for generating an image of the changes in blood volume of the brain. A spatial intensity distribution of changes in blood volume can be generated by detecting brain activation in many sampling points, and a spatial interpolation process is executed on this data. A threshold process is executed on the distribution to extract the distribution of coordinates having a signal intensity of at least the predetermined threshold. The displacement between the brain activation area and the maximal location of the distribution is stored in a recording unit of the system in order to compensate for the distribution extracted by the threshold process. Accordingly, brain activation areas can be estimated with greater location accuracy, and the diagnosis and medial treatment for brain diseases can likewise be executed with greater accuracy.
摘要翻译：一种用于在生物体光测量系统中显示脑激活区域以提高准确度的图像产生方法，用于产生脑的血容量变化的图像。通过检测许多采样点的大脑激活，可以产生血容量变化的空间强度分布，并对该数据执行空间插值处理。对分布执行阈值处理以提取具有至少预定阈值的信号强度的坐标的分布。大脑激活区域和分布的最大位置之间的位移被存储在系统的记录单元中，以便补偿由阈值处理提取的分布。因此，可以以更高的定位精度估计脑激活区域，并且同样可以更准确地执行脑疾病的诊断和内侧治疗。

3. 发明授权

US07150717B2 Optical measurement apparatus for a living body 有权
标题翻译：生物体光学测量装置
公开(公告)号：US07150717B2
公开(公告)日：2006-12-19
申请号：US10764561
申请日：2004-01-27
申请人： Takusige Katura , Atsushi Maki , Masashi Kiguchi
发明人： Takusige Katura , Atsushi Maki , Masashi Kiguchi
IPC分类号： A61B5/00
CPC分类号： A61B5/4884 , A61B5/02055 , A61B5/021 , A61B5/0261 , A61B5/0816 , A61B5/14553
摘要： Disclosed is an optical measurement apparatus for a living body to provide a means for measuring blood flow activity within a short time inside the body, even if the test subject cannot distinguish between the active task period and the rest period. An optical measurement apparatus for a living body comprises a light irradiating section, and a light detecting section for detecting light transmitting through or reflected from the interior of the body. The concentration of carbon dioxide gas taken into the body is controlled by the respiration of the test subject and the resulting change in output from the light detecting section is then evaluated.
摘要翻译：公开了一种生物体的光学测量装置，即使被检体不能区分活动任务期间和休止期间，也能够在体内短时间内测定血液流动活动的手段。用于生物体的光学测量装置包括光照射部分和用于检测透射到身体内部或从身体内部反射的光的光检测部分。进入身体的二氧化碳气体的浓度由受检对象的呼吸控制，然后评估所得到的光检测部分的输出变化。

4. 发明授权

US07285790B2 Optical measurement system for living bodies and method thereof 失效
标题翻译：生物体光学测量系统及其方法
公开(公告)号：US07285790B2
公开(公告)日：2007-10-23
申请号：US11044040
申请日：2005-01-28
申请人： Naoki Tanaka , Takusige Katura , Masashi Kiguchi , Hiroki Sato , Atsushi Maki
发明人： Naoki Tanaka , Takusige Katura , Masashi Kiguchi , Hiroki Sato , Atsushi Maki
IPC分类号： A61B5/00
CPC分类号： A61B5/16 , A61B5/14553 , A61B5/6814
摘要： A response period is determined arbitrarily. A satisfactory detecting ability may not be provided because of an artifact or the like contained in a signal. Therefore, an effective detection method and an effective display method of presenting results of detection must be developed. A series of tasks (stimuli) or a selected measurement signal is used as a reference signal, and a phase difference of any other measurement signal from the reference signal is calculated. The synchronousness of the phase of the measurement signal with the phase of the reference signal is numerically expressed. The thus obtained numerical value is statistically processed in order to numerically express a degree of reliability. Thus, a brain activity or a functional connectivity is visualized.
摘要翻译：响应时间是任意确定的。由于信号中包含的伪影等，不能提供令人满意的检测能力。因此，必须开发一种提供检测结果的有效检测方法和有效的显示方法。使用一系列任务（刺激）或所选择的测量信号作为参考信号，并且计算来自参考信号的任何其它测量信号的相位差。测量信号的相位与参考信号的相位的同步性被数字表示。对这样得到的数值进行统计处理，以便数值地表达可靠度。因此，大脑活动或功能连接可视化。

5. 发明申请

US20060100525A1 Biological optical measurement system 有权
公开(公告)号：US20060100525A1
公开(公告)日：2006-05-11
申请号：US11205160
申请日：2005-08-17
申请人： Takusige Katura , Naoki Tanaka , Hiroki Sato , Akiko Obata , Atsushi Maki
发明人： Takusige Katura , Naoki Tanaka , Hiroki Sato , Akiko Obata , Atsushi Maki
IPC分类号： A61B6/00
CPC分类号： A61B5/6814 , A61B5/0059 , A61B5/024 , A61B5/14553
摘要： A typical task assigned for measuring a brain activity signal lasts from 10 to 30 seconds. The frequency band of the Mayer wave noise signal is very close to the frequency bands of brain activity signals, a result, it is difficult to reduce the Mayer wave noise signal using a bandpass filter or a bandcut filter. Light irradiating units and light detecting units for detecting the emitted light that has been passed through or reflected within the tissue are provided. A biological signal measuring unit measures at least one of the pulsation, breathing, blood pressure, and temperature. The relationship between an optical signal obtained by the light detecting unit and a biological signal using non-linear analysis; and a computation for separating the biological noise signal from the optical signal on the basis of the obtained relationship.

6. 发明授权

US08311600B2 Optical measurement instrument for living body 有权
标题翻译：生物体光学测量仪器
公开(公告)号：US08311600B2
公开(公告)日：2012-11-13
申请号：US11954627
申请日：2007-12-12
申请人： Takusige Katura , Naoki Tanaka , Atsushi Maki
发明人： Takusige Katura , Naoki Tanaka , Atsushi Maki
IPC分类号： A61B5/1455
CPC分类号： A61B5/0059 , A61B5/02028 , A61B5/6814 , A61B5/7207 , G06K9/6243
摘要： An optical measurement instrument for living body includes: a plurality of light irradiation means for irradiating an object being tested with light; a plurality of light reception means for detecting the light that is irradiated to the object being tested and propagates inside the object being tested; and a calculation unit for calculating hemodynamics of a plurality of factors inside the object being tested from the detection signal detected by the light reception means, wherein the calculation unit includes a separation calculation unit for separating a plurality of signals from the detection signals; a selection unit for calculating a correlation coefficient between a plurality of the signals separated to select a signal in which a correlation coefficient is a predetermined value or greater as a noise signal; and a reconstruction calculation unit for reconfiguring the detection signal excluding the noise signal selected by the selection unit.
摘要翻译：一种用于生物体的光学测量仪器包括：多个光照射装置，用于用光照射被测物体; 多个光接收装置，用于检测照射到被测试物体上的光并在待测物体的内部传播; 以及计算单元，用于根据由光接收装置检测的检测信号计算被测物体内的多个因子的血液动力学，其中所述计算单元包括分离计算单元，用于从所述检测信号中分离出多个信号; 选择单元，用于计算分离以选择其中相关系数为预定值或更大的信号的多个信号之间的相关系数作为噪声信号; 以及重建计算单元，用于重新配置除了由选择单元选择的噪声信号之外的检测信号。

7. 发明授权

US07565192B2 Biological optical measurement system 有权
标题翻译：生物光学测量系统
公开(公告)号：US07565192B2
公开(公告)日：2009-07-21
申请号：US11205160
申请日：2005-08-17
申请人： Takusige Katura , Naoki Tanaka , Hiroki Sato , Akiko Obata , Atsushi Maki
发明人： Takusige Katura , Naoki Tanaka , Hiroki Sato , Akiko Obata , Atsushi Maki
IPC分类号： A61B5/00
CPC分类号： A61B5/6814 , A61B5/0059 , A61B5/024 , A61B5/14553
摘要： A typical task assigned for measuring a brain activity signal lasts from 10 to 30 seconds. The frequency band of the Mayer wave noise signal is very close to the frequency bands of brain activity signals, a result, it is difficult to reduce the Mayer wave noise signal using a bandpass filter or a bandcut filter. Light irradiating units and light detecting units for detecting the emitted light that has been passed through or reflected within the tissue are provided. A biological signal measuring unit measures at least one of the pulsation, breathing, blood pressure, and temperature. The relationship between an optical signal obtained by the light detecting unit and a biological signal using non-linear analysis; and a computation for separating the biological noise signal from the optical signal on the basis of the obtained relationship.
摘要翻译：分配给测量大脑活动信号的典型任务持续10到30秒。梅耶尔波噪声信号的频带非常接近脑活动信号的频带，结果是难以使用带通滤波器或带通滤波器来减少梅耶波噪声信号。提供了用于检测已经通过或反射在组织内的发射光的光照射单元和光检测单元。生物信号测量单元测量脉动，呼吸，血压和温度中的至少一个。由光检测单元获得的光信号与使用非线性分析的生物信号之间的关系; 以及基于所获得的关系从生物噪声信号与光信号分离的计算。

8. 发明申请

US20060006343A1 Optical measurement system for living bodies and method thereof 失效
标题翻译：生物体光学测量系统及其方法
公开(公告)号：US20060006343A1
公开(公告)日：2006-01-12
申请号：US11044040
申请日：2005-01-28
申请人： Naoki Tanaka , Takusige Katura , Masashi Kiguchi , Hiroki Sato , Atsushi Maki
发明人： Naoki Tanaka , Takusige Katura , Masashi Kiguchi , Hiroki Sato , Atsushi Maki
IPC分类号： A61B8/06
CPC分类号： A61B5/16 , A61B5/14553 , A61B5/6814
摘要： A response period is determined arbitrarily. A satisfactory detecting ability may not be provided because of an artifact or the like contained in a signal. Therefore, an effective detection method and an effective display method of presenting results of detection must be developed. A series of tasks (stimuli) or a selected measurement signal is used as a reference signal, and a phase difference of any other measurement signal from the reference signal is calculated. The synchronousness of the phase of the measurement signal with the phase of the reference signal is numerically expressed. The thus obtained numerical value is statistically processed in order to numerically express a degree of reliability. Thus, a brain activity or a functional connectivity is visualized.
摘要翻译：响应时间是任意确定的。由于信号中包含的伪影等，不能提供令人满意的检测能力。因此，必须开发一种提供检测结果的有效检测方法和有效的显示方法。使用一系列任务（刺激）或所选择的测量信号作为参考信号，并且计算来自参考信号的任何其它测量信号的相位差。测量信号的相位与参考信号的相位的同步性被数字表示。对这样得到的数值进行统计处理，以便数值地表达可靠度。因此，大脑活动或功能连接可视化。

9. 发明授权

US09198624B2 Biological photometric device and biological photometry method using same 有权
标题翻译：生物光度测定装置及其生物测光方法
公开(公告)号：US09198624B2
公开(公告)日：2015-12-01
申请号：US13806790
申请日：2011-07-06
申请人： Tsukasa Funane , Hirokazu Atsumori , Takusige Katura , Masashi Kiguchi , Tsuyoshi Takatera , Michiyuki Fujiwara
发明人： Tsukasa Funane , Hirokazu Atsumori , Takusige Katura , Masashi Kiguchi , Tsuyoshi Takatera , Michiyuki Fujiwara
IPC分类号： A61B6/00 , A61B5/00 , G01N21/359 , G01N21/49
CPC分类号： A61B6/00 , A61B5/0042 , A61B5/0075 , A61B5/6814 , G01N21/359 , G01N21/49
摘要： The present invention is capable of separating/removing the influence of skin blood flow contained in near infrared spectroscopy (NIRS) signals and extracting a brain- or brain cortex-origin signal. Moreover, the present invention enables versatile separation of brain-origin and skin-origin signals in view of differences among individuals. A biological photometric device, wherein light transmitters and light receivers are located in such a manner that measurement can be conducted at a plurality of source-detector (SD) distances and light received by the individual light-receivers can pass through the gray matter to thereby separate a brain-origin signal and a skin-origin signal. Individual component analysis (ICA) is conducted on data obtained at the individual measurement points. Then, it is determined whether each individual component originates in the brain or in the skin with the use of the SD distance-dependency of the weighted value of each of the separated components.
摘要翻译：本发明能够分离/去除包含在近红外光谱（NIRS）信号中的皮肤血流的影响并提取脑或脑皮层起始信号。此外，鉴于个体之间的差异，本发明能够多功能地分离脑起源和皮肤起始信号。一种生物测光装置，其中光发射器和光接收器以这样的方式定位，使得可以在多个源 - 检测器（SD）距离处进行测量，并且由各个光接收器接收的光可以通过灰质，从而分离脑起始信号和皮肤起始信号。对各个测量点获得的数据进行单独分量分析（ICA）。然后，使用每个分离的组分的加权值的SD距离相关性来确定每个单独组分是否来自大脑或皮肤。

10. 发明申请

US20130102907A1 BIOLOGICAL PHOTOMETRIC DEVICE AND BIOLOGICAL PHOTOMETRY METHOD USING SAME 有权
标题翻译：生物光学设备和使用相同的生物光度测定方法
公开(公告)号：US20130102907A1
公开(公告)日：2013-04-25
申请号：US13806790
申请日：2011-07-06
申请人： Tsukasa Funane , Hirokazu Atsumori , Takusige Katura , Masashi Kiguchi , Tsuyoshi Takatera , Michiyuki Fujiwara
发明人： Tsukasa Funane , Hirokazu Atsumori , Takusige Katura , Masashi Kiguchi , Tsuyoshi Takatera , Michiyuki Fujiwara
IPC分类号： A61B6/00
CPC分类号： A61B6/00 , A61B5/0042 , A61B5/0075 , A61B5/6814 , G01N21/359 , G01N21/49
摘要： The present invention is capable of separating/removing the influence of skin blood flow contained in near infrared spectroscopy (NIRS) signals and extracting a brain- or brain cortex-origin signal. Moreover, the present invention enables versatile separation of brain-origin and skin-origin signals in view of differences among individuals. A biological photometric device, wherein light transmitters and light receivers are located in such a manner that measurement can be conducted at a plurality of source-detector (SD) distances and light received by the individual light-receivers can pass through the gray matter to thereby separate a brain-origin signal and a skin-origin signal. Individual component analysis (ICA) is conducted on data obtained at the individual measurement points. Then, it is determined whether each individual component originates in the brain or in the skin with the use of the SD distance-dependency of the weighted value of each of the separated components.
摘要翻译：本发明能够分离/去除包含在近红外光谱（NIRS）信号中的皮肤血流的影响并提取脑或脑皮层起始信号。此外，鉴于个体之间的差异，本发明能够多功能地分离脑起源和皮肤起始信号。一种生物测光装置，其中光发射器和光接收器以这样的方式定位，使得可以在多个源 - 检测器（SD）距离处进行测量，并且由各个光接收器接收的光可以通过灰质，从而分离脑起始信号和皮肤起始信号。对各个测量点获得的数据进行单独分量分析（ICA）。然后，使用每个分离的组分的加权值的SD距离相关性来确定每个单独组分是否来自大脑或皮肤。

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