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    • 7. 发明申请
    • Method for producing fluorene derivative
    • 芴衍生物的制备方法
    • US20070100170A1
    • 2007-05-03
    • US10501890
    • 2002-01-29
    • Hiroaki MuraseMitsuaki YamadaYasuhiro SudaKazuyuki Ogata
    • Hiroaki MuraseMitsuaki YamadaYasuhiro SudaKazuyuki Ogata
    • C07C43/20C07C39/12
    • C07C37/20C07C2603/18C07C39/17
    • Fluorenone and a phenolic compound (e.g., a 2-C1-4alkylphenol) is subjected to a condensation reaction in coexistence with a thiol compound and a hydrochloric acid aqueous solution to produce a fluorene derivative [e.g., 9,9-bis(C1-4alkylhydroxyphenyl)fluorene]. The proportion (weight ratio) of fluorenone relative to the thiol compound [fluorenone/the thiol compound] is about 1/0.01 to 1/0.5, and the proportion (weight ratio) of the thiol compound relative to hydrochloric acid (HCl) in the hydrochloric acid aqueous solution [the thiol compound/hydrochloric acid] is about 1/0.1 to 1/3. As the thiol compound, a mercaptocarboxylic acid (β-mercaptopropionic acid) may be used. According to the method, a highly purified fluorene derivative excellent in transparency can be obtained inexpensively and simply without using a hydrogen chloride gas having handling difficulty.
    • 芴酮和酚类化合物(例如2-C 1-4烷基酚)与硫醇化合物和盐酸水溶液共存以进行缩合反应,生成芴衍生物[例如, 9,9-双(C 1-4烷基羟基苯基)芴]。 芴酮相对于硫醇化合物[芴酮/硫醇化合物]的比例(重量比)为约1 / 0.01〜1 / 0.5,硫醇化合物相对于盐酸(HCl)的比例(重量比)为 盐酸水溶液[硫醇化合物/盐酸]为约1 / 0.1〜1/3。 作为硫醇化合物,可以使用巯基羧酸(β-巯基丙酸)。 根据该方法,可以廉价且简单地获得透明性优异的芴衍生物,而不使用具有处理难度的氯化氢气体。