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1. 发明授权

US07961844B2 Rotating irradiation therapy apparatus 有权
标题翻译：旋转照射治疗仪
公开(公告)号：US07961844B2
公开(公告)日：2011-06-14
申请号：US12438029
申请日：2007-08-29
申请人： Norio Takeda , Shigeji Kaneko , Tsutomu Yamashita , Hiroshi Saga
发明人： Norio Takeda , Shigeji Kaneko , Tsutomu Yamashita , Hiroshi Saga
IPC分类号： A61N5/10 , A61N5/00
CPC分类号： G21K5/10 , A61N5/10 , A61N5/1081 , A61N2005/1087
摘要： A rotating irradiation therapy apparatus used for particle beam therapy includes a rotating gantry equipped with a charged particle beam irradiation device beam transport devices for guiding a charged particle beam to the irradiation device and a roller in contact with a ring member included in the rotating gantry and supporting the gantry. A front ring is disposed in contact with the roller of a rotating body support device at one end in the axial direction of the rotating gantry, and a rear ring is disposed in contact with the roller at the other end in the axial direction of the rotating gantry. At least one intermediate ring is disposed in a position different in the axial direction of the gantry between the front and rear rings and in contact with the roller.
摘要翻译：用于粒子束治疗的旋转照射治疗装置包括：装备有带电粒子束照射装置的旋转台架，用于将带电粒子束引导到照射装置的光束传送装置和与包括在旋转台架中的环构件接触的辊; 支撑龙门架。在旋转机架的轴向的一端设置有与旋转体支撑装置的滚子接触的前环，在旋转轴的轴向的另一端设置有与滚子接触的后环龙门架至少一个中间环设置在前后环之间与台架的轴向不同的位置，并与辊接触。

2. 发明申请

US20100163755A1 ROTATING IRRADIATION THERAPY APPARATUS 有权
标题翻译：旋转辐射治疗装置
公开(公告)号：US20100163755A1
公开(公告)日：2010-07-01
申请号：US12438029
申请日：2007-08-29
申请人： Norio Takeda , Shigeji Kaneko , Tsutomu Yamashita , Hiroshi Saga
发明人： Norio Takeda , Shigeji Kaneko , Tsutomu Yamashita , Hiroshi Saga
IPC分类号： A61N5/01 , A61N5/10
CPC分类号： G21K5/10 , A61N5/10 , A61N5/1081 , A61N2005/1087
摘要： A rotating irradiation therapy apparatus used for particle beam therapy includes a rotating gantry equipped with a charged particle beam irradiation device beam transport devices for guiding a charged particle beam to the irradiation device and a roller in contact with a ring member included in the rotating gantry and supporting the gantry. A front ring is disposed in contact with the roller of a rotating body support device at one end in the axial direction of the rotating gantry and a rear ring is disposed in contact with the roller at the other end in the axial direction of the rotating gantry. At least one intermediate ring is disposed in a position different in the axial direction of the gantry between the front and rear rings and in contact with the roller.
摘要翻译：用于粒子束治疗的旋转照射治疗装置包括：装备有带电粒子束照射装置的旋转台架，用于将带电粒子束引导到照射装置的光束传送装置和与包括在旋转台架中的环构件接触的辊; 支撑龙门架。在旋转机架的轴向的一端设置有与旋转体支撑装置的辊接触的前环，并且在旋转机架的轴向上的另一端设置有与辊接触的后环。至少一个中间环设置在前后环之间与台架的轴向不同的位置，并与辊接触。

3. 发明申请

US20070023699A1 Rotating irradiation apparatus 有权
标题翻译：旋转照射装置
公开(公告)号：US20070023699A1
公开(公告)日：2007-02-01
申请号：US11472387
申请日：2006-06-22
申请人： Tsutomu Yamashita , Shigeji Kaneko , Hiroshi Saga , Norio Takeda
发明人： Tsutomu Yamashita , Shigeji Kaneko , Hiroshi Saga , Norio Takeda
IPC分类号： H01J37/08
CPC分类号： A61N5/1081 , A61N5/10 , A61N2005/1087
摘要： A rotating irradiation apparatus includes a rotating gantry 3 including a front ring 19 and a rear ring 20 and is provided with a beam delivery device 11 and an irradiation device 4. The beam delivery device 11 delivers an ion beam used for particle radiotherapy. Radial support devices 61A and 61B support the front ring 19 and radial support devices 61A and 61B support the rear ring 20. Each radial support device includes a linear guide 41, an upper support structure disposed above the linear guide 41, and a lower support structure disposed below the linear guide 41. The upper support structure is movably mounted on the lower support structure and is movable in the direction of the rotational axis of the rotating gantry 3.
摘要翻译：旋转照射装置包括旋转机架3，其包括前环19和后环20，并且设置有射束输送装置11和照射装置4.射束输送装置11输送用于粒子放射治疗的离子束。径向支撑装置61A和61B支撑前环19，并且径向支撑装置61A和61B支撑后环20.每个径向支撑装置包括线性导向件41，设置在线性导向件41上方的上支撑结构，以及下支撑结构设置在线性引导件41的下方。上支撑结构可移动地安装在下支撑结构上并且可沿旋转机架3的旋转轴线的方向移动。

4. 发明授权

US07381979B2 Rotating irradiation apparatus 有权
标题翻译：旋转照射装置
公开(公告)号：US07381979B2
公开(公告)日：2008-06-03
申请号：US11472387
申请日：2006-06-22
申请人： Tsutomu Yamashita , Shigeji Kaneko , Hiroshi Saga , Norio Takeda
发明人： Tsutomu Yamashita , Shigeji Kaneko , Hiroshi Saga , Norio Takeda
IPC分类号： A61N5/00 , A61N5/01
CPC分类号： A61N5/1081 , A61N5/10 , A61N2005/1087
摘要： A rotating irradiation apparatus includes a rotating gantry 3 including a front ring 19 and a rear ring 20 and is provided with a beam delivery device 11 and an irradiation device 4. The beam delivery device 11 delivers an ion beam used for particle radiotherapy. Radial support devices 61A and 61B support the front ring 19 and radial support devices 61A and 61B support the rear ring 20. Each radial support device includes a linear guide 41, an upper support structure disposed above the linear guide 41, and a lower support structure disposed below the linear guide 41. The upper support structure is movably mounted on the lower support structure and is movable in the direction of the rotational axis of the rotating gantry 3.
摘要翻译：旋转照射装置包括旋转机架3，其包括前环19和后环20，并且设置有射束输送装置11和照射装置4.射束输送装置11输送用于粒子放射治疗的离子束。径向支撑装置61A和61B支撑前环19，并且径向支撑装置61A和61B支撑后环20.每个径向支撑装置包括线性导向件41，设置在线性导向件41上方的上支撑结构，以及下支撑结构设置在线性引导件41的下方。上支撑结构可移动地安装在下支撑结构上并且可沿旋转机架3的旋转轴线的方向移动。

5. 发明申请

US20060192072A1 Rotating gantry of particle beam therapy system 有权
标题翻译：粒子束治疗系统的旋转台架
公开(公告)号：US20060192072A1
公开(公告)日：2006-08-31
申请号：US11359484
申请日：2006-02-23
申请人： Tsutomu Yamashita , Shigeji Kaneko , Yutaka Muramatsu , Hiroshi Saga
发明人： Tsutomu Yamashita , Shigeji Kaneko , Yutaka Muramatsu , Hiroshi Saga
IPC分类号： F16M5/00 , F16M7/00 , F16M1/00 , F16M11/00 , F16M3/00 , F16M9/00
CPC分类号： F16D55/40 , A61N5/10 , A61N5/1081 , A61N2005/1087 , F16D2121/12
摘要： A rotating gantry includes a link frame for supporting a plurality of rollers which rotatably support the rotating gantry, a brake for releasing a braking force applied to at least one of the rollers upon supply of air and applying the braking force to the one roller upon discharge of air, and a solenoid valve for sealing the supplied air in the brake when closed, and discharging the air from the brake when opened. The solenoid valve is supported by a solenoid valve support member mounted to the link frame such that the solenoid valve is positioned just near the brake. The rotating gantry can be more quickly braked and stopped while maintaining high irradiation accuracy.
摘要翻译：旋转机架包括用于支撑可旋转地支撑旋转机架的多个辊的连杆框架，用于在供应空气时释放施加到至少一个辊的制动力的制动器，并且在排出时向一个辊施加制动力的空气，以及用于在关闭时密封制动器中的供应空气的电磁阀，并且在打开时从制动器排出空气。电磁阀由安装到连杆架的电磁阀支撑件支撑，使得电磁阀恰好靠近制动器。旋转机架可以更快地制动和停止，同时保持高的照射精度。

6. 发明授权

US07372053B2 Rotating gantry of particle beam therapy system 有权
标题翻译：粒子束治疗系统的旋转台架
公开(公告)号：US07372053B2
公开(公告)日：2008-05-13
申请号：US11359484
申请日：2006-02-23
申请人： Tsutomu Yamashita , Shigeji Kaneko , Yutaka Muramatsu , Hiroshi Saga
发明人： Tsutomu Yamashita , Shigeji Kaneko , Yutaka Muramatsu , Hiroshi Saga
IPC分类号： A61N5/01 , A61N5/10
CPC分类号： F16D55/40 , A61N5/10 , A61N5/1081 , A61N2005/1087 , F16D2121/12
摘要： A rotating gantry includes a link frame for supporting a plurality of rollers which rotatably support the rotating gantry, a brake for releasing a braking force applied to at least one of the rollers upon supply of air and applying the braking force to the one roller upon discharge of air, and a solenoid valve for sealing the supplied air in the brake when closed, and discharging the air from the brake when opened. The solenoid valve is supported by a solenoid valve support member mounted to the link frame such that the solenoid valve is positioned just near the brake. The rotating gantry can be more quickly braked and stopped while maintaining high irradiation accuracy.
摘要翻译：旋转机架包括用于支撑可旋转地支撑旋转机架的多个辊的连杆框架，用于在供应空气时释放施加到至少一个辊的制动力的制动器，并且在排出时向一个辊施加制动力的空气，以及用于在关闭时密封制动器中的供应空气的电磁阀，并且在打开时从制动器排出空气。电磁阀由安装到连杆架的电磁阀支撑件支撑，使得电磁阀恰好靠近制动器。旋转机架可以更快地制动和停止，同时保持高的照射精度。

7. 发明授权

US07825109B2 Compound capable of binding S1P receptor and pharmaceutical use thereof 有权
标题翻译：能够结合S1P受体的化合物及其药物用途
公开(公告)号：US07825109B2
公开(公告)日：2010-11-02
申请号：US10569831
申请日：2004-08-27
申请人： Shinji Nakade , Hirotaka Mizuno , Takeji Ono , Masashi Minami , Hiroshi Saga , Hiroshi Hagiya , Takaki Komiya , Hiromu Habashita , Haruto Kurata , Kazuhiro Ohtsuki , Kensuke Kusumi
发明人： Shinji Nakade , Hirotaka Mizuno , Takeji Ono , Masashi Minami , Hiroshi Saga , Hiroshi Hagiya , Takaki Komiya , Hiromu Habashita , Haruto Kurata , Kazuhiro Ohtsuki , Kensuke Kusumi
IPC分类号： C07D205/00 , A61K31/397
CPC分类号： C07D205/04 , C07C229/14 , C07C229/22 , C07C229/36 , C07C233/47 , C07C255/16 , C07C255/41 , C07C271/22 , C07C323/12 , C07C2601/08 , C07C2601/14 , C07D211/70 , C07D217/04
摘要： A compound having an ability to bind to an S1P receptor (particularly EDG-6, preferably EDG-1 and EDG-6), for example, the compound represented by formula (I) of the present invention, a salt thereof, a solvate thereof or a prodrug thereof is useful for prevention and/or treatment of rejection of transplantation, graft-versus-host disease, autoimmune disease, allergic disease and the like. wherein ring A is a cyclic group; ring B is a cyclic group which may have substituent(s); X is a spacer having 1 to 8 atoms in its main chain, etc.; Y is a spacer having 1 to 10 atoms in its main chain, etc.; n is 0 or 1, wherein when n is 0, m is 1 and R1 is a hydrogen atom or a substituent, and wherein when n is 1, m is 0 or an integer of 1 to 7 and R1 is a substituent, and wherein m is 2 or more, R1s are the same or different.
摘要翻译：具有与S1P受体（特别是EDG-6，优选EDG-1和EDG-6）结合的能力的化合物，例如本发明的式（I）表示的化合物，其盐，其溶剂合物或其前药可用于预防和/或治疗移植排斥反应，移植物抗宿主病，自身免疫性疾病，过敏性疾病等。其中环A是环状基团; 环B是可以具有取代基的环状基团; X是其主链中具有1至8个原子的间隔物等; Y是其主链中具有1至10个原子的间隔物等; n为0或1，其中当n为0时，m为1，R 1为氢原子或取代基，n为1时，m为0或1〜7的整数，R 1为取代基，其中， m为2以上，R 1相同或不同。

8. 发明申请

US20070167425A1 Compound capable of binding s1p receptor and pharmaceutical use thereof 有权
标题翻译：能够结合s1p受体的化合物及其药物用途
公开(公告)号：US20070167425A1
公开(公告)日：2007-07-19
申请号：US10569831
申请日：2004-08-27
申请人： Shinji Nakade , Hirotaka Mizuno , Takeji Ono , Masashi Minami , Hiroshi Saga , Hiroshi Hagiya , Takaki Komiya , Hiromu Habashita , Haruto Kurata , Kazuhiro Ohtsuki , Kensuke Kusumi
发明人： Shinji Nakade , Hirotaka Mizuno , Takeji Ono , Masashi Minami , Hiroshi Saga , Hiroshi Hagiya , Takaki Komiya , Hiromu Habashita , Haruto Kurata , Kazuhiro Ohtsuki , Kensuke Kusumi
IPC分类号： A61K31/445 , A61K31/405 , A61K31/197 , A61K31/397 , A61K31/198
CPC分类号： C07D205/04 , C07C229/14 , C07C229/22 , C07C229/36 , C07C233/47 , C07C255/16 , C07C255/41 , C07C271/22 , C07C323/12 , C07C2601/08 , C07C2601/14 , C07D211/70 , C07D217/04
摘要： A compound having an ability to bind to an S1P receptor (particularly EDG-6, preferably EDG-1 and EDG-6), for example, the compound represented by formula (I) of the present invention, a salt thereof, a solvate thereof or a prodrug thereof is useful for prevention and/or treatment of rejection of transplantation, graft-versus-host disease, autoimmune disease, allergic disease and the like. wherein ring A is a cyclic group; ring B is a cyclic group which may have substituent(s); X is a spacer having 1 to 8 atoms in its main chain, etc.; Y is a spacer having 1 to 10 atoms in its main chain, etc.; n is 0 or 1, wherein when n is 0, m is 1 and R1 is a hydrogen atom or a substituent, and wherein when n is 1, m is 0 or an integer of 1 to 7 and R1 is a substituent, and wherein m is 2 or more, R1s are the same or different.
摘要翻译：具有与S 1 P受体（特别是EDG-6，优选EDG-1和EDG-6）结合的能力的化合物，例如本发明的式（I）表示的化合物，其盐，其溶剂合物或其前药可用于预防和/或治疗移植排斥反应，移植物抗宿主病，自身免疫性疾病，过敏性疾病等。其中环A是环状基团; 环B是可以具有取代基的环状基团; X是其主链中具有1至8个原子的间隔物等; Y是其主链中具有1至10个原子的间隔物等; n为0或1，其中当n为0时，m为1，R 1为氢原子或取代基，n为1时，m为0或1〜7的整数 R 1是取代基，m是2以上，R 1相同或不同。

9. 发明授权

US4987180A Silicone-based fabric finishing agent 失效
标题翻译：硅基织物整理剂
公开(公告)号：US4987180A
公开(公告)日：1991-01-22
申请号：US288903
申请日：1988-12-23
申请人： Hiroyuki Ohata , Masaki Tanaka , Hiroshi Ohashi , Kiyoji Suemoto , Hidekazu Iida , Hiroshi Saga
发明人： Hiroyuki Ohata , Masaki Tanaka , Hiroshi Ohashi , Kiyoji Suemoto , Hidekazu Iida , Hiroshi Saga
IPC分类号： D06M15/263 , C08F283/12 , C08L51/08 , C09D183/04 , D06M13/02 , D06M13/51 , D06M13/513 , D06M15/643 , D06M15/65 , C08L83/04
CPC分类号： D06M15/6433 , C08F283/122 , C08F283/124 , D06M15/643 , D06M15/65
摘要： An excellently pleasant feeling of softness and elastic resilience can be imparted to a fabric material treated with the inventive fabric finishing agent which is an aqueous emulsion of a copolymer obtained by the emulsion polymerization, in an aqueous emulsion of an organopolysiloxane having radical-polymerizable groups, e.g., vinyl groups, or mercapto-substituted hydrocarbon groups, e.g., 3-mercaptopropyl groups, as the polymerization medium of an acrylic or methacrylic monomer, e.g., alkyl acrylates and methacrylates, in a specified amount relative to the amount of the organopolysiloxane. The acrylic or methacrylic monomer may be partly replaced with a polyfunctional monomer, e.g., acrylic and methacrylic acids, N-methylol acrylamide, glycidyl methacrylate, 2-hydroxyethyl methacrylate and the like, and/or a monomer of the third class, e.g., styrene and acrylonitrile. The emulsion may be further admixed with an organohydrogen polysiloxane as a crosslinking agent and a catalyst for the crosslinking reaction.
摘要翻译：可以通过本发明的织物整理剂（其是通过乳液聚合获得的共聚物的水性乳液）在具有可自由基聚合基团的有机聚硅氧烷的水性乳液中处理柔软性和弹性回弹性的令人愉快的感觉，例如乙烯基或巯基取代的烃基，例如3-巯基丙基，作为丙烯酸或甲基丙烯酸单体的聚合介质，例如丙烯酸烷基酯和甲基丙烯酸烷基酯，相对于有机聚硅氧烷的量为规定量。丙烯酸或甲基丙烯酸单体可以部分地被多官能单体例如丙烯酸和甲基丙烯酸，N-羟甲基丙烯酰胺，甲基丙烯酸缩水甘油酯，甲基丙烯酸2-羟乙酯等，和/或第三类的单体例如苯乙烯和丙烯腈。乳液可以进一步与作为交联剂的有机氢聚硅氧烷和用于交联反应的催化剂混合。

10. 发明授权

US08791159B2 Compound capable of binding S1P receptor and pharmaceutical use thereof 有权
标题翻译：能够结合S1P受体的化合物及其药物用途
公开(公告)号：US08791159B2
公开(公告)日：2014-07-29
申请号：US12879158
申请日：2010-09-10
申请人： Shinji Nakade , Hirotaka Mizuno , Takeji Ono , Masashi Minami , Hiroshi Saga , Hiroshi Hagiya , Takaki Komiya , Hiromu Habashita , Haruto Kurata , Kazuhiro Ohtsuki , Kensuke Kusumi
发明人： Shinji Nakade , Hirotaka Mizuno , Takeji Ono , Masashi Minami , Hiroshi Saga , Hiroshi Hagiya , Takaki Komiya , Hiromu Habashita , Haruto Kurata , Kazuhiro Ohtsuki , Kensuke Kusumi
IPC分类号： C07C227/36 , A61K31/235 , A61K31/197
CPC分类号： C07C229/36 , A61K31/197 , A61K31/198 , A61K31/397 , A61K31/401 , A61K31/44 , A61K31/445 , A61K45/06 , C07C229/14 , C07C229/22 , C07C229/34 , C07C233/47 , C07C255/16 , C07C255/41 , C07C271/22 , C07C323/12 , C07D205/04 , C07D207/16 , C07D211/62 , C07D211/70 , C07D217/04
摘要： A compound having an ability to bind to an SIP receptor and represented by formula (I), a salt thereof, a solvate thereof or a prodrug thereof is useful for prevention and/or treatment of rejection of transplantation, graft-versus-host disease, autoimmune disease, allergic disease and the like: wherein ring A is a cyclic group; ring B is a cyclic group which may have substituent(s); X is a spacer having 1 to 8 atoms in its main chain, etc.; Y is a spacer having 1 to 10 atoms in its main chain, etc.; n is 0 or 1, wherein when n is 0, m is 1 and R1 is a hydrogen atom or a substituent, and wherein when n is 1, m is 0 or an integer of 1 to 7 and R1 is a substituent, and wherein m is 2 or more, R1s are the same or different.
摘要翻译：具有结合SIP受体并由式（I）表示的能力的化合物，其盐，其溶剂合物或其前药可用于预防和/或治疗移植排斥反应，移植物抗宿主病，自身免疫性疾病，过敏性疾病等：其中环A为环状基团; 环B是可以具有取代基的环状基团; X是其主链中具有1至8个原子的间隔基等; Y是其主链中具有1至10个原子的间隔物等; n为0或1，其中当n为0时，m为1，R 1为氢原子或取代基，n为1时，m为0或1〜7的整数，R 1为取代基，其中， m为2以上，R 1相同或不同。

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