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1. 发明授权

US5783609A Process for recovering organoalkoxysilane from polyorganosiloxane 失效
标题翻译：从有机硅氧烷中回收有机烷氧基硅烷的方法
公开(公告)号：US5783609A
公开(公告)日：1998-07-21
申请号：US666458
申请日：1996-06-27
申请人： Tsurahide Cho , Yoshiro Ohta , Toshitsura Cho , Tohru Yamashita , Nobuaki Ohkawa , Makoto Nishida
发明人： Tsurahide Cho , Yoshiro Ohta , Toshitsura Cho , Tohru Yamashita , Nobuaki Ohkawa , Makoto Nishida
IPC分类号： C07F7/08 , C07F7/18 , C07F7/20 , C08G77/06 , C08G77/10 , C08J11/18 , C08G77/38
CPC分类号： C08J11/18 , C07F7/0878 , C07F7/1876 , C07F7/20 , C08G77/06 , C08G77/10 , C08J2383/04 , Y02P20/582 , Y02W30/706
摘要： A process which comprises reacting a high molecular weight polyorganosiloxane or a composition containing the same with an alkoxysilane and/or a partially hydrolyzed condensate thereof at a temperature of lower than 300.degree. C. in the presence of an alcoholate compound and recovering the resulting organoalkoxysilane and, in addition thereto, at least one of a distillable polyorganosiloxane low molecular weight compound, a non-volatile liquid polyorganosiloxane and a silica; and a process which comprises reacting a high molecular weight polyorganosiloxane or a composition containing the same with an alcoholate compound at a temperature of 50.degree. to 150.degree. C. in an anhydrous state and recovering the resulting distillable polyorganosiloxane low molecular weight compound and, in addition thereto, at least one of an organoalkoxysilane and a non-volatile liquid polyorganosiloxane.
摘要翻译： PCT No.PCT / JP94 / 02281 Sec。 371日期1996年6月27日第 102（e）日期1996年6月27日PCT 1994年12月28日PCT公布。出版物WO95 / 18174 日期1995年7月6日一种方法，其包括使高分子量聚有机硅氧烷或含有该组合物的组合物与烷氧基硅烷和/或其部分水解缩合物在醇化合物存在下在低于300℃的温度下反应，和回收得到的有机烷氧基硅烷，并且除此之外还含有可蒸馏的聚有机硅氧烷低分子量化合物，非挥发性液体聚有机硅氧烷和二氧化硅中的至少一种。以及包括使高分子量聚有机硅氧烷或含有该组合物的组合物与醇化合物在无水状态下在50至150℃下反应并回收所得的可蒸馏聚有机硅氧烷低分子量化合物的方法，至少一种有机烷氧基硅烷和非挥发性液体聚有机硅氧烷中的至少一种。

2. 发明授权

US08729102B2 Bicyclic compound 有权
标题翻译：双环化合物
公开(公告)号：US08729102B2
公开(公告)日：2014-05-20
申请号：US13306069
申请日：2011-11-29
申请人： Tsuneo Yasuma , Tohru Yamashita , Takuya Fujimoto , Zenichi Ikeda
发明人： Tsuneo Yasuma , Tohru Yamashita , Takuya Fujimoto , Zenichi Ikeda
IPC分类号： A61K31/4439 , C07D413/04
CPC分类号： C07D413/04 , C07D401/04 , C07D405/04 , C07D417/04
摘要： The present invention provides a compound having an ACC inhibitory action, which is useful as an agent for the prophylaxis or treatment of obesity, diabetes and the like, and having superior efficacy.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.
摘要翻译：本发明提供具有ACC抑制作用的化合物，其可用作预防或治疗肥胖症，糖尿病等并且具有优异的疗效。本发明涉及由式（I）表示的化合物：其中每个符号如说明书中所定义，或其盐。

3. 发明授权

US08703758B2 Bicyclic compound 失效
标题翻译：双环化合物
公开(公告)号：US08703758B2
公开(公告)日：2014-04-22
申请号：US13094015
申请日：2011-04-26
申请人： Tohru Yamashita , Makoto Kamata , Hideki Hirose , Masataka Murakami , Takuya Fujimoto , Zenichi Ikeda , Tsuneo Yasuma , Ikuo Fujimori , Ryo Mizojiri , Tomoya Yukawa
发明人： Tohru Yamashita , Makoto Kamata , Hideki Hirose , Masataka Murakami , Takuya Fujimoto , Zenichi Ikeda , Tsuneo Yasuma , Ikuo Fujimori , Ryo Mizojiri , Tomoya Yukawa
IPC分类号： A01N43/00 , A61K31/00 , A01N43/42 , A61K31/44 , A01N43/76 , A61K31/42 , A01N43/56 , A61K31/415 , A01N43/08 , A61K31/34 , C07D413/14 , C07D405/02 , C07D401/02 , C07D401/14 , C07D403/02 , C07D491/048 , A61K31/41 , A61K31/439 , A61K31/444 , A61K31/4439
CPC分类号： C07D413/14 , A61K31/41 , A61K31/415 , A61K31/439 , A61K31/4439 , A61K31/444 , C07D231/54 , C07D263/56 , C07D263/58 , C07D307/81 , C07D401/02 , C07D401/14 , C07D403/02 , C07D405/02 , C07D413/04 , C07D417/04 , C07D487/08 , C07D491/048 , C07D498/04
摘要： The present invention provides to a compound having an ACC inhibitory action, which is useful as an agent for the prophylaxis or treatment of obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia, cancer and the like, and has superior efficacy.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification.
摘要翻译：本发明提供具有ACC抑制作用的化合物，其可用作预防或治疗肥胖症，糖尿病，高血压，高脂血症，心力衰竭，糖尿病并发症，代谢综合征，肌肉减少症，癌症等的药剂，以及具有优越的疗效。本发明涉及由式（I）表示的化合物：其中每个符号如说明书中所定义。

4. 发明申请

US20090281097A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND 审中-公开
标题翻译：含氮杂环化合物
公开(公告)号：US20090281097A1
公开(公告)日：2009-11-12
申请号：US12296874
申请日：2007-04-13
申请人： Kohji Fukatsu , Makoto Kamata , Tohru Yamashita , Satoshi Endo
发明人： Kohji Fukatsu , Makoto Kamata , Tohru Yamashita , Satoshi Endo
IPC分类号： A61K31/5377 , C07D413/14 , A61K31/4535 , C07D409/06 , C07D409/14 , A61K31/4545 , A61P3/10
CPC分类号： C07D401/04 , C07D409/06 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The object of the present invention is to provide a compound having an ACC inhibitory action, which is useful for the prophylaxis or treatment of obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and has superior properties such as efficacy, duration of activity, specificity, low toxicity and the like.The present invention provides a compound represented by the following formula wherein ring M is a 5- or 6-membered aromatic ring; W is C or N; K is an optionally substituted methylene group or an optionally substituted imino group; R is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted hydroxy group or an optionally substituted heterocyclic group; T and U are independently a hydrogen atom or a substituent or, T and U form, together with ring M, an optionally substituted bicyclic ring; D and G are independently a carbonyl group or a sulfonyl group; ring P is an optionally substituted piperidine or an optionally substituted piperazine; B is CH or N; ring Q is an optionally substituted monocyclic ring; A is C, CH or N; and J is an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group or an optionally substituted amino group, provided that when the W moiety of ring M is ═N— or —N═, then U should be absent, or a salt thereof.
摘要翻译：本发明的目的是提供具有ACC抑制作用的化合物，其可用于预防或治疗肥胖，糖尿病，高血压，高脂血症，心力衰竭，糖尿病并发症，代谢综合征，肌肉减少症等，并且具有优异的性质如功效，活性持续时间，特异性，低毒性等。本发明提供由下式表示的化合物，其中环M为5或6元芳环; W是C或N; K是任选取代的亚甲基或任选取代的亚氨基; R是氢原子，任选取代的烃基，任选取代的羟基或任选取代的杂环基; T和U独立地是氢原子或取代基，或者T和U与环M一起形成任选取代的双环; D和G独立地为羰基或磺酰基; 环P是任选取代的哌啶或任选取代的哌嗪; B是CH或N; 环Q是任选取代的单环; A是C，CH或N; 并且J是任选取代的烃基，任选取代的杂环基或任选取代的氨基，条件是当环M的W部分为-N-或-N-时，则U不应为其或其盐。

5. 发明申请

US20110263562A1 BICYCLIC COMPOUND 失效
标题翻译：双相化合物
公开(公告)号：US20110263562A1
公开(公告)日：2011-10-27
申请号：US13094015
申请日：2011-04-26
申请人： Tohru Yamashita , Makoto Kamata , Hideki Hirose , Masataka Murakami , Takuya Fujimoto , Zenichi Ikeda , Tsuneo Yasuma , Ikuo Fujimori , Ryo Mizojiri , Tomoya Yukawa
发明人： Tohru Yamashita , Makoto Kamata , Hideki Hirose , Masataka Murakami , Takuya Fujimoto , Zenichi Ikeda , Tsuneo Yasuma , Ikuo Fujimori , Ryo Mizojiri , Tomoya Yukawa
IPC分类号： A61K31/423 , A61K31/438 , A61K31/439 , C07D417/04 , A61K31/454 , A61K31/416 , A61K31/34 , C07D498/04 , C07D413/14 , C07D413/04 , C07D263/56 , C07D231/56 , C07D307/87 , A61P35/04 , A61P3/04 , A61P3/06 , A61P9/12 , A61P9/00 , A61P3/10 , A61P3/00 , A61K31/497
CPC分类号： C07D413/14 , A61K31/41 , A61K31/415 , A61K31/439 , A61K31/4439 , A61K31/444 , C07D231/54 , C07D263/56 , C07D263/58 , C07D307/81 , C07D401/02 , C07D401/14 , C07D403/02 , C07D405/02 , C07D413/04 , C07D417/04 , C07D487/08 , C07D491/048 , C07D498/04
摘要： The present invention provides to a compound having an ACC inhibitory action, which is useful as an agent for the prophylaxis or treatment of obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia, cancer and the like, and has superior efficacy.The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification.
摘要翻译：本发明提供具有ACC抑制作用的化合物，其可用作预防或治疗肥胖症，糖尿病，高血压，高脂血症，心力衰竭，糖尿病并发症，代谢综合征，肌肉减少症，癌症等的药剂，以及具有优越的疗效。本发明涉及由式（I）表示的化合物：其中每个符号如说明书中所定义。

6. 发明申请

US20100160255A1 SPIRO-CYCLIC COMPOUND 审中-公开
标题翻译：螺旋环化合物
公开(公告)号：US20100160255A1
公开(公告)日：2010-06-24
申请号：US11997021
申请日：2006-07-28
申请人： Makoto Kamata , Kohji Fukatsu , Tohru Yamashita , Naoki Furuyama , Satoshi Endo
发明人： Makoto Kamata , Kohji Fukatsu , Tohru Yamashita , Naoki Furuyama , Satoshi Endo
IPC分类号： A61K31/695 , C07D471/10 , A61K31/4545 , C07D211/06 , A61P3/04 , A61P9/12 , A61P3/06 , A61P9/00 , A61P3/10 , C07D498/10 , A61K31/5386 , C07D487/10 , A61K31/499 , C07F7/02 , C07D413/14 , A61K31/5377
CPC分类号： C07D513/10 , C07D221/20 , C07D401/04 , C07D471/10 , C07D487/10 , C07D491/10 , C07F7/1804
摘要： The present invention provides a compound represented by the formula (I): wherein E is an optionally substituted cyclic group; D is a carbonyl group or a sulfonyl group; A is CH or N; ring P is an optionally further substituted 5- to 7-membered ring; ring Q is an optionally further substituted 5- to 7-membered nonaromatic ring; and ring R is an optionally further substituted and optionally condensed 5- to 7-membered nonaromatic ring, or a salt thereof. The compound of the present invention has an ACC inhibitory activity, is useful for the prophylaxis or treatment of obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and has superior properties in the efficacy, duration of activity, specificity, low toxicity and the like.
摘要翻译：本发明提供由式（I）表示的化合物：其中E为任选取代的环状基团; D是羰基或磺酰基; A是CH或N; 环P是任选进一步取代的5-至7-元环; 环Q是任选进一步取代的5-至7-元非芳族环; 并且环R是任选进一步取代的和任选缩合的5-至7-元非芳族环或其盐。本发明化合物具有ACC抑制活性，可用于预防或治疗肥胖症，糖尿病，高血压，高脂血症，心力衰竭，糖尿病并发症，代谢综合征，肌肉减少症等，并且具有优异的功效特性，活动持续时间，特异性，低毒性等。

7. 发明申请

US20070013837A1 Liquid crystal display apparatus having reflective layer 有权
标题翻译：具有反射层的液晶显示装置
公开(公告)号：US20070013837A1
公开(公告)日：2007-01-18
申请号：US11522871
申请日：2006-09-18
申请人： Shinji Ogawa , Kazuhiro Inoue , Norio Koma , Nobuhiko Oda , Satoshi Ishida , Tsutomu Yamada , Tohru Yamashita
发明人： Shinji Ogawa , Kazuhiro Inoue , Norio Koma , Nobuhiko Oda , Satoshi Ishida , Tsutomu Yamada , Tohru Yamashita
IPC分类号： G02F1/1335
CPC分类号： G02F1/133555 , G02F1/133553
摘要： A reflective layer for reflecting light incident from a second substrate side and transmitting through a second electrode made of ITO or the like is formed above a first substrate, a switching element provided for each pixel, and an insulating film covering the switching element, the reflective layer being insulated from the switching element. A first electrode having a work function similar to the second electrode and made of a transparent conductive material such as ITO is formed more proximate to a liquid crystal layer than is the reflective layer and is connected to the switching element. The thickness of the first electrode is set to 100 Å or less or in a range approximately from 750 Å to 1250 Å. Alternatively, the switching element maybe connected to the reflective electrode, the first electrode and the reflective electrode which are formed with an insulating film therebetween may be capacitively coupled, and the first electrode may be driven by the reflective electrode via the capacitor.
摘要翻译：用于反射从第二基板侧入射并通过由ITO等制成的第二电极透射的光的反射层形成在第一基板上，设置在每个像素上的开关元件和覆盖开关元件的绝缘膜，反射层层与开关元件绝缘。具有与第二电极类似的功能类似于ITO等透明导电材料的功函的第一电极比反射层更靠近液晶层，并与开关元件连接。第一电极的厚度设定为大于或等于或大于750埃至1250埃。或者，开关元件可以连接到反射电极，在其间形成有绝缘膜的第一电极和反射电极可以电容耦合，并且第一电极可以由反射电极经由电容器驱动。

8. 发明授权

US4878137A Disk file device 失效
标题翻译：磁盘文件设备
公开(公告)号：US4878137A
公开(公告)日：1989-10-31
申请号：US151665
申请日：1988-02-02
申请人： Tohru Yamashita , Takaharu Takematsu
发明人： Tohru Yamashita , Takaharu Takematsu
IPC分类号： G11B17/22
CPC分类号： G11B17/225
摘要： A disk file device includes a stocker for accommodating a plurality of cartridges each holding a disk. A cartridge displacing mechanism with a cartridge rceiving container passes a cartridge through an opening formed in the casing. A carrier moves a cartridge between the cartridge displacing mechanism and the stocker and between the stocker and a disk. The opening formed in the casing is on the side of the stocker and the cartridge displacing mechanism has an electric motor for turning the cartridge receiving container through 180.degree. when a cartridge is passed through the opening so that the carrier and the cartridge receiving container are prevented from colliding.

9. 发明申请

US20060285036A1 Liquid crystal display apparatus 审中-公开
公开(公告)号：US20060285036A1
公开(公告)日：2006-12-21
申请号：US11508712
申请日：2006-08-23
申请人： Kazuhiro Inoue , Norio Koma , Shinji Ogawa , Tohru Yamashita , Nobuhiko Oda , Satoshi Ishida , Tsutomu Yamada
发明人： Kazuhiro Inoue , Norio Koma , Shinji Ogawa , Tohru Yamashita , Nobuhiko Oda , Satoshi Ishida , Tsutomu Yamada
IPC分类号： G02F1/1335
CPC分类号： G02F1/133371 , G02F1/133555 , G02F1/136227 , G02F1/1368 , G09G2300/0456 , G09G2320/0247
摘要： An LCD apparatus having a liquid crystal layer sealed between a first substrate having a first electrode and a second substrate having a second electrode, wherein the first substrate comprises a reflective layer formed only in a subregion within a pixel region, for reflecting light. A transparent conductive material is used for the first electrode and the first electrode made of the transparent conductive material is layered to cover a transmissive region within a pixel region and over the reflective layer in a reflective region within the pixel region to directly cover the reflective layer. Optimum cell gaps dr and dt are set in the reflective and the transmissive regions, respectively, based on a twist angle, which is a difference between the alignment directions of liquid crystal at the side of the first electrode and of liquid crystal at the side of the second electrode so that an optimum reflectivity and an optimum transmittance are realized in each region to allow enhancements in the quality of a transflective LCD. A configuration may be employed in which a switching element is formed over the first substrate and the reflective layer is placed in the reflective region of a pixel region on an insulating film which covers the switching element, the reflective layer being insulated from the switching element, the work functions for the first electrode and for the second electrode are similar.

10. 发明申请

US20060262254A1 Display apparatus and method for manufacturing the same 审中-公开
公开(公告)号：US20060262254A1
公开(公告)日：2006-11-23
申请号：US11494366
申请日：2006-07-26
申请人： Kazuhiro Inoue , Norio Koma , Shinji Ogawa , Tohru Yamashita , Nobuhiko Oda , Satoshi Ishida , Tsutomu Yamada
发明人： Kazuhiro Inoue , Norio Koma , Shinji Ogawa , Tohru Yamashita , Nobuhiko Oda , Satoshi Ishida , Tsutomu Yamada
IPC分类号： G02F1/1335
CPC分类号： H01L51/5234 , G02F1/133553 , G02F1/133555 , G02F1/13439 , G02F1/136227 , G02F2201/121 , G02F2203/01 , H01L27/3244 , H01L27/3248 , H01L27/3272 , H01L51/5271 , H01L2251/5315
摘要： On a first substrate, a TFT which is a switching element is provided for each pixel, and above an insulating film covering this TFT, a reflective layer which is insulated from the TFT and which reflects light entering a second substrate and transmitting through a second electrode made of ITO is formed. Further, a first electrode having a work function similar to that of the second electrode and made of a transparent conductive material such as ITO is formed closer to a liquid crystal layer than the reflective layer, and this first electrode is connected with the TFT. With this configuration, the liquid crystal layer can be symmetrically AC driven by the first and second electrodes. A reliable connection between the first electrode and the TFT is provided through a connection metal layer made of a refractory metal.

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