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1. 发明授权

US06310007B1 7,10,12-trihydroxy-8(E)-octadecenoic acid and derivatives and uses thereof 失效
标题翻译： 7,10,12-三羟基-8（E） - 十八碳烯酸及其衍生物和用途
公开(公告)号：US06310007B1
公开(公告)日：2001-10-30
申请号：US09523330
申请日：2000-03-10
申请人： Tsung Min Kuo , Ching T. Hou
发明人： Tsung Min Kuo , Ching T. Hou
IPC分类号： A01N3700
CPC分类号： A01N37/36
摘要： The compound 7,10,12-trihydroxy-8(E)-octadecenoic acid (TOD) has been produced by bioconversion of ricinoleic acid by Pseudomonas aeruginosa PR3. TOD and derivatives thereof are useful for controlling biological organisms, such as fungi and insects.
摘要翻译：化合物7,10,12-三羟基-8（E） - 十八碳烯酸（TOD）已经通过绿脓假单胞菌PR3生物转化蓖麻油酸而产生。 TOD及其衍生物可用于控制生物体，如真菌和昆虫。

2. 发明授权

US5852196A 12,13,17-trihydroxy-9(z)-octadeoenoic acid and derivatives and microbial isolate for production of the acid 失效
标题翻译： 12,13,17-三羟基-9（z） - 邻二十碳烯酸及其生成酸的微生物分离物
公开(公告)号：US5852196A
公开(公告)日：1998-12-22
申请号：US814674
申请日：1997-03-11
申请人： Ching T. Hou
发明人： Ching T. Hou
IPC分类号： A01N37/36 , C07C59/42 , C07C229/00
CPC分类号： C07C59/42 , A01N37/36 , Y10S435/842
摘要： A novel compound, 12,13,17-trihydroxy-9(Z)-octadecenoic acid (THOA) was produced from linoleic acid by microbial transformation at 25% yield. The newly isolated microbial strain catalyzing this transformation was identified as Clavibacter sp. ALA2 (Accession No. NRRL B-21660). THOA and its derivatives have application as antifungal agents.
摘要翻译：通过微生物转化，以25％的产率从亚油酸生产新化合物12,13,17-三羟基-9（Z） - 十八碳烯酸（THOA）。催化该转化的新分离的微生物菌株被鉴定为Clavibacter sp。 ALA2（登录号NRRL B-21660）。 THOA及其衍生物可用作抗真菌剂。

3. 发明授权

US5900496A Microbial production of a novel compound 7,10-dihydroxy-8-octadecenoic acid from oleic acid 失效
标题翻译：从油酸生产新型化合物7,10-二羟基-8-十八烯酸的微生物
公开(公告)号：US5900496A
公开(公告)日：1999-05-04
申请号：US665600
申请日：1996-06-18
申请人： Ching T. Hou
发明人： Ching T. Hou
IPC分类号： C07C59/42 , C12P7/64 , C07C51/00
CPC分类号： C12P7/6409 , C07C59/42 , C12R1/68 , Y10S435/874 , Y10S435/875
摘要： A strain of Pseudomonas Sp. bacterium (NRRL B-18602) has been discovered which is capable of converting oleic acid to the novel compound, 7,10-dihydroxy-8-octadecenoic acid (DOD). The production of DOD is unique in that it involves a hydroxylation at two positions and a rearrangement of the double bond of the substrate molecule. The new multifunctional, long-chain aliphatic acid has potential utility as a plasticizer and as a source of intermediates in the synthesis of specialty chemicals.
摘要翻译：一株假单胞菌已经发现能够将油酸转化为新化合物7,10-二羟基-8-十八碳烯酸（DOD）的细菌（NRRL B-18602）。 DOD的生产是独特的，因为它涉及两个位置的羟基化和底物分子双键的重排。新的多功能长链脂肪酸具有潜在的用途，作为增塑剂和合成特种化学品的中间体来源。

4. 发明授权

US4348476A Production of epoxides such as propylene oxide using packed catalytic bed containing moist resting cells exhibiting oxygenase activity 失效
标题翻译：使用包含显示加氧酶活性的潮湿静息细胞的填充催化床生产环氧化物如环氧丙烷
公开(公告)号：US4348476A
公开(公告)日：1982-09-07
申请号：US227135
申请日：1981-01-22
申请人： Ching T. Hou
发明人： Ching T. Hou
IPC分类号： C07D301/02 , C07D301/04 , C12M1/40 , C12P17/02
CPC分类号： C07D301/02 , C07D301/04 , C12M21/18 , C12M25/18 , C12M29/24 , C12M41/22 , C12P17/02
摘要： Process and equipment for advancing the oxidation state of a gaseous oxidizable organic substrate through contact with oxygen and a solid state biocatalyst. The process comprises passing through a stationary catalytic bed comprising moist, resting cells exhibiting oxygenase activity, a gaseous, oxidizable organic substrate and a gaseous source of oxygen, until the oxidative state of at least a portion of said substrate is increased, while maintaining the relative humidity in said bed at such a level that said cells remain moist and viable, and while maintaining the temperature in the vapor state. The process uses an oxygenase enzyme as a catalyst, for the incorporation of molecular oxygen directly into a specific organic molecule. The invention is of particular interest for the conversion of propylene to propylene oxide, and similar reactions that are catalyzed by mono-oxygenase enzymes.
摘要翻译：用于通过与氧和固态生物催化剂接触来促进气态可氧化有机基质的氧化态的方法和设备。该方法包括通过包含显示加氧酶活性的潮湿静息细胞的固定催化床，气态可氧化有机底物和气态氧源，直到所述底物的至少一部分的氧化状态增加，同时保持相对在所述床中的湿度以使得所述细胞保持潮湿和活力并且同时将温度保持在蒸汽状态的水平。该方法使用加氧酶作为催化剂，用于将分子氧直接引入特定有机分子中。本发明特别令人感兴趣的是将丙烯转化为环氧丙烷，以及由单加氧酶催化的类似反应。

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